The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ
Open accessAbstract
Phospholipid scramblase induces nonspecific bidirectional movement of phospholipids across the membrane during cell activation and has been proposed to mediate the appearance of phosphatidylserine (PS) in the plasma membrane outer leaflet during apoptosis, a cell surface change that is critical for apoptotic cell removal. We report here that protein kinase C (PKC) delta plays an important role in activated transbilayer movement of phospholipids and surface PS exposure by directly enhancing the activity of phospholipid scramblase. Specific inhibition of PKCdelta by rottlerin prevented both apoptosis- and activation-induced scramblase activity. PKCdelta was either selectively cleaved and activated in a caspase 3-dependent manner (during apoptosis) or translocated to the plasma membrane (in stimulated cells) and could directly phosphorylate scramblase immunoprecipitated from Jurkat cells. Furthermore, reconstitution of PKCdelta and scramblase, but not scramblase or PKCdelta alone in Chinese hamster ovary cells demonstrated enhanced scramblase activity.
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Cites
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
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Cited by
Protein kinase C and other diacylglycerol effectors in cancer
Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978
Clearance of apoptotic cells by phagocytes
Erwig, L.-P., & Henson, P. M. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402184 · Cited by 422
Self-citationKagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Potapovich, A. I., Kini, V., Amoscato, A. A., & Fujii, Y. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.016 · Cited by 342
Mitchell, S., Thomas, G., Harvey, K., Cottell, D., Reville, K., Berlasconi, G., Petasis, N. A., Erwig, L., Rees, A. J., Savill, J., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000032417.73640.72 · Cited by 287
Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells
Balciunaite, E., Spektor, A., Lents, N. H., Cam, H., te Riele, H., Scime, A., Rudnicki, M. A., Young, R., & Dynlacht, B. D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8166-8178.2005 · Cited by 116
Metadata
- Authors
- Frasch, S. C., Henson, P. M., Kailey, J. M., Richter, D. A., Janes, M. S., Fadok, V. A., & Bratton, D. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 275
- Issue
- 30
- Pages
- 23065-23073
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2020572083
- Cited by
- 234
- References
- 1
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Frasch, S. C., Henson, P. M., Kailey, J. M., Richter, D. A., Janes, M. S., Fadok, V. A., & Bratton, D. L. (2000). Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m003116200
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