Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Corpse clearance defines the meaning of cell death

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

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Phagocytosis and clearance of apoptotic cells is mediated by MER

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Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

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Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

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Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

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Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts*

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Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

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Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes

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Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

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A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells

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CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).

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CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

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Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells.

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Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

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Amyloid β42Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

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Mechanisms of phagocytosis

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Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation

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Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ

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Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells

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Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases

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Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

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Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon γ and Inhibits Tumor Necrosis Factor α–induced IL-8 Release

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The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2 Specifically Activates Neutrophils through FPRL1/Lipoxin A4 Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2

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Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis

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Differential Requirement for Classic and Novel PKC Isoforms in Respiratory Burst and Phagocytosis in RAW 264.7 Cells

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Distinct Modes of Macrophage Recognition for Apoptotic and Necrotic Cells Are Not Specified Exclusively by Phosphatidylserine Exposure

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Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines

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Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac

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Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosis

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Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast

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Regulation of Macrophage Phagocytosis of Apoptotic Cells by cAMP

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Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis

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Lipoxins: revelations on resolution

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Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.

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Cutting Edge: The Neurotoxic Prion Peptide Fragment PrP106–126 Is a Chemotactic Agonist for the G Protein-Coupled Receptor Formyl Peptide Receptor-Like 1

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Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis

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Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

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Lipoxin A4 Antagonizes the Mitogenic Effects of Leukotriene D4 in Human Renal Mesangial Cells

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Lipoxin B 4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B 4 analogs with increased biologic activity

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Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization

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Lipoxins Induce Actin Reorganization in Monocytes and Macrophages But Not in Neutrophils

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

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Resolution of inflammation: the beginning programs the end

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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

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Resolvins and protectins in inflammation resolution

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MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

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Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX

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Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution

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Mechanisms of Resolution of Inflammation: A Focus on Cardiovascular Disease

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Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology

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Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

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Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

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