Clearance of apoptotic cells by phagocytes

Erwig, L-P; Henson, P M

doi:10.1038/sj.cdd.4402184

Cited by 422Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

Clearance of apoptotic cells by phagocytes

Erwig, L-P, Henson, P M·2008·Cell Death & Differentiation

DOI 10.1038/sj.cdd.4402184

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Abstract

Phagocytic clearance of apoptotic cells may be considered to consist of four distinct steps: accumulation of phagocytes at the site where apoptotic cells are located; recognition of dying cells through a number of bridge molecules and receptors; engulfment by a unique uptake process; and processing of engulfed cells within phagocytes. Here, we will discuss these individual steps that collectively are essential for the effective removal of apoptotic cells. This will illustrate our relative lack of knowledge about the initial attraction signals, the specific mechanisms of engulfment and processing in comparison to the extensive literature on recognition mechanisms. There is now mounting evidence that clearance defects are responsible for chronic inflammatory disease and contribute to autoimmunity. Therefore, a better understanding of all aspects of the clearance process is required before it can truly be manipulated for therapeutic gain.

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From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [129]

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Authors: Erwig, L.-P., & Henson, P. M.
Affiliations: University of Aberdeen (GB)
National Jewish Health (US)
Corresponding author: Erwig, L-P
ORCID: Henson, P M
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2007-06-15
Volume: 15
Issue: 2
Pages: 243-250
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/sj.cdd.4402184
OpenAlex: W2025695096
Cited by: 422
References: 65
Citations by year: 2026: 8 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 16 · 2021: 17 · 2020: 20 · 2019: 19 · 2018: 9 · 2017: 26 · 2016: 23 · 2015: 31 · 2014: 26 · 2013: 39 · 2012: 34
FWCI: 2.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (073566)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: efferocytosis, phagocytes, phagocytosis, phagocyte recruitment, engulfment, chronic inflammation, autoimmunity
MeSH terms: Animals, Dendritic Cells, Humans, Inflammation, Macrophages, Phagocytosis, Autoimmunity, Apoptosis, Apoptosis Regulatory Proteins, Toll-Like Receptors

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Clearance of apoptotic cells by phagocytes

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