Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson, P., Thorén, S., Morgenstern, R., & Samuelsson, B. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7220 · Cited by 995

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Dixon, R. A. F., Diehl, R. E., Opas, E. E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., & Miller, D. K. (1990) · Nature · doi:10.1038/343282a0 · Cited by 772

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572

Glutathione S-Transferases - A Review

Salinas, A. E., & Wong, M. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220208213032 · Cited by 556

Functional requirement of p23 and Hsp90 in telomerase complexesPreprint

Holt, S. E., Aisner, D. L., Baur, J. A., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J. B., Morin, G. B., Toft, D. O., Shay, J. W., et al. (1999) · Genes & Development · doi:10.1101/gad.13.7.817 · Cited by 543

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M. V., Tischfield, J. A., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14411 · Cited by 366

Common structural features of mapeg—a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Jakobsson, P., Morgenstern, R., Mancini, J. A., Ford‐Hutchinson, A. W., & Persson, B. (1999) · Protein Science · doi:10.1110/ps.8.3.689 · Cited by 366

Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

Murakami, M., Kambe, T., Shimbara, S., & Kudo, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3103 · Cited by 348

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

Båge, T., Lindberg, J., Lundeberg, J., Modéer, T., & Yucel‐Lindberg, T. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-241 · Cited by 58

Eicosanoids in Skin Wound Healing

Yasukawa, K., Okuno, T., & Yokomizo, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228435 · Cited by 60

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2 synthase-1

Koeberle, A., Haberl, E.-M., Rossi, A., Pergola, C., Dehm, F., Northoff, H., Troschuetz, R., Sautebin, L., & Werz, O. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.10.025 · Cited by 56

Expression and Localization of Prostaglandin E Synthase Isoforms in Human Fetal Membranes in Term and Preterm Labor

Meadows, J. W., Eis, A., Brockman, D. E., & Myatt, L. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021061 · Cited by 57

Lipopolysaccharide-Induced Increase of Prostaglandin E2 Is Mediated by Inducible Nitric Oxide Synthase Activation of the Constitutive Cyclooxygenase and Induction of Membrane-Associated Prostaglandin E Synthase

Devaux, Y., Seguin‐Devaux, C., Grosjean, S. A., de Talancé, N., Camaeti, V., Burlet, A. J., Zannad, F. M., Meistelman, C., Mertès, P., & Longrois, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.3962 · Cited by 56

Prostaglandin E2protects lower airways against bronchoconstriction

Hartney, J. M., Coggins, K. G., Tilley, S. L., Jania, L. A., Lovgren, A. K., Audoly, L., & Koller, B. H. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00221.2005 · Cited by 55

Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2γ-deficient mice

Yoda, E., Hachisu, K., Taketomi, Y., Yoshida, K., Nakamura, M., Ikeda, K., Taguchi, R., Nakatani, Y., Kuwata, H., Murakami, M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m008060 · Cited by 55

Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett’s metaplasia induced by duodenal contents reflux

Jang, T. J., Min, S. K., Bae, J. D., Jung, K. H., Lee, J. I., Kim, J. R., & Ahn, W. S. (2003) · Gut · doi:10.1136/gut.53.1.27 · Cited by 55

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors

Korotkova, M., & Jakobsson, P. (2013) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12162 · Cited by 54

EP4 receptor as a novel promising therapeutic target in colon cancer

Karpisheh, V., Joshi, N., Zekiy, A. O., Beyzai, B., Hojjat‐Farsangi, M., Namdar, A., Edalati, M., & Jadidi‐Niaragh, F. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153247 · Cited by 54

An Insect Prostaglandin E2 Synthase Acts in Immunity and Reproduction

Ahmed, S., STANLEY, D. W., & Kim, Y. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01231 · Cited by 53

Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils

Mosca, M., Polentarutti, N., Mangano, G., Apicella, C., Doni, A., Mancini, F., Bortoli, M. D., Coletta, I., Polenzani, L., Santoni, G., et al. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906576 · Cited by 53

The Effects of COX-2 Inhibitor During Osteogenic Differentiation of Bone Marrow-Derived Human Mesenchymal Stem Cells

Yoon, D. S., Yoo, J. H., Kim, Y. H., Paik, S., Han, C. D., & Lee, J. W. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0393 · Cited by 52

The Link between Prostanoids and Cardiovascular Diseases

Beccacece, L., Abondio, P., Bini, C., Pelotti, S., & Luiselli, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044193 · Cited by 51

Human Fallopian Tubes Express Prostacyclin (PGI) Synthase and Cyclooxygenases and Synthesize Abundant PGI

Huang, J.-C., Arbab, F., Tumbusch, K. J., Goldsby, J. S., Matijevic‐Aleksic, N., & Wu, K. K. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020199 · Cited by 51

LPS-activated complement, not LPS per se, triggers the early release of PGE2by Kupffer cells

Perlík, V., Li, Z., Goorha, S., Ballou, L. R., & Blatteis, C. M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00567.2004 · Cited by 51

Differential Inhibition by Nimesulide of the Early and Late Phases of Intravenous- and Intracerebroventricular-LPS-Induced Fever in Guinea Pigs

Steiner, A. A., Li, S., Llanos-Q., J., & Blatteis, C. M. (2001) · Neuroimmunomodulation · doi:10.1159/000054289 · Cited by 50

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E2 synthase-1

Koeberle, A., Bauer, J., Verhoff, M., Hoffmann, M., Northoff, H., & Werz, O. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.005 · Cited by 50

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE2 Production in Bone Marrow Derived Macrophages

Xiao, L., Ornatowska, M., Zhao, G., Cao, H., Yu, R., Deng, J., Li, Y., Zhao, Q., Sadikot, R. T., & Christman, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050244 · Cited by 49

Management of cytoskeleton architecture by molecular chaperones and immunophilins

Quintá, H. R., Galigniana, N. M., Erlejman, A. G., Lagadari, M., Pilipuk, G. P., & Galigniana, M. D. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.07.023 · Cited by 51

Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia

Zhang, J., Fujii, S., Wu, Z., Hashioka, S., Tanaka, Y., Shiratsuchi, A., Nakanishi, Y., & Nakanishi, H. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.11.008 · Cited by 50

Role of Cytosolic Phospholipase A2 in Prostaglandin E2 Production by Lung Fibroblasts

Ghosh, M., Stewart, A., Tucker, D. E., Bonventre, J. V., Murphy, R. C., & Leslie, C. C. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0005oc · Cited by 50

Role of the HSP90-Associated Cochaperone p23 in Enhancing Activity of the Androgen Receptor and Significance for Prostate Cancer

Reebye, V., Querol Cano, L., Lavery, D. N., Brooke, G. N., Powell, S. M., Chotai, D., Walker, M. M., Whitaker, H. C., Wait, R., Hurst, H. C., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1056 · Cited by 47

mPGES-1 Protects Against DOCA-Salt Hypertension via Inhibition of Oxidative Stress or Stimulation of NO/cGMP

Jia, Z., Aoyagi, T., & Yang, T. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.144840 · Cited by 49

Inhibitors of Microsomal Prostaglandin E 2 Synthase‐1 Enzyme as Emerging Anti‐Inflammatory Candidates

Bahia, M. S., Katare, Y. K., Silakari, O., Vyas, B., & Silakari, P. (2014) · Medicinal Research Reviews · doi:10.1002/med.21306 · Cited by 49

Prostanoid function and cardiovascular disease

Iñiguez, M. A., Cacheiro‐Llaguno, C., Cuesta, N., Díaz‐Muñoz, M. D., & Fresno, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802180882 · Cited by 49

Prostaglandin E2 pathway in head and neck squamous cell carcinoma

Camacho, M., León, X., Fernández‐Figueras, M. T., Quer, M., & Vila, L. (2008) · Head & Neck · doi:10.1002/hed.20850 · Cited by 50

Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E2–dependent activation of type II protein kinase A

Payner, T. D., LEAVER, H. A., Knapp, B., Whittle, I. R., Trifan, O. C., Miller, S. J., & Rizzo, M. T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0548 · Cited by 49

Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase‐2 in astrocytes: Synergy with interleukin‐1β, tumor necrosis factor‐α, and bacterial lipopolysaccharide

Repovic, P., Mi, K., & Benveniste, E. N. (2003) · Glia · doi:10.1002/glia.10182 · Cited by 49

Eicosanoids and the Vascular Endothelium

Egan, K. M., & FitzGerald, G. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_6 · Cited by 52

COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.

Yin, J., Xia, W., Li, Y., Guo, C.-C., Zhang, Y., Huang, S., Jia, Z., & Zhang, A. (2017) · Europe PMC (PubMed Central) · Cited by 48

Expression and Contribution of Three Different Isoforms of Prostaglandin E Synthase in the Bovine Endometrium1

Parent, J., & Fortier, M. A. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.037036 · Cited by 47

Trophic Effects of the Cyclooxygenase-2 Product Prostaglandin E 2 in Cardiac Myocytes

Méndez, M., & LaPointe, M. C. (2002) · Hypertension · doi:10.1161/hy02t2.102808 · Cited by 47

The differential role of prostaglandin E2 receptors EP3 and EP4 in regulation of fever

Lazarus, M. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500207 · Cited by 46

Prostaglandin E2 in the Regulation of Water Transport in Renal Collecting Ducts

Li, Y., Wei, Y., Zheng, F., Guan, Y., & Zhang, X. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122539 · Cited by 45

PROSTAGLANDIN BIOLOGY

Crofford, L. J. (2001) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70217-x · Cited by 45

Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts

Kuwata, H., Yoshimura, M., Sasaki, Y., Yoda, E., Nakatani, Y., Kudo, I., & Hara, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.015 · Cited by 44

Prostaglandins in pathogenesis and treatment of multiple sclerosis

Mirshafiey, A., & Jadidi‐Niaragh, F. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923971003667627 · Cited by 44

MicroRNA-146a Negatively Regulates the Immunoregulatory Activity of Bone Marrow Stem Cells by Targeting Prostaglandin E2 Synthase-2

Matysiak, M., Fortak-Michalska, M., Szymańska, B., Orłowski, W., Jurewicz, A., & Selmaj, K. W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202397 · Cited by 44

Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes

Mansouri, F. E. E., Nebbaki, S. S., Kapoor, M., Afif, H., Martel‐Pelletier, J., Pelletier, J., Benderdour, M., & Fahmi, H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4564 · Cited by 44

Differentiation‐dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins

Xie, Y., Kang, X., Ackerman, W. E., Belury, M. A., Koster, C., Rovin, B. H., Landon, M. B., & Kniss, D. A. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00472.x · Cited by 44

Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour

Astle, S., Newton, R. C., Thornton, S., Vatish, M., & Slater, D. M. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal093 · Cited by 48

Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2

Kino, Y., Kojima, F., Kiguchi, K., Igarashi, R., Ishizuka, B., & Kawai, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.014 · Cited by 44

Splenic PGE2-releasing macrophages regulate Th1 and Th2 immune responses in mice treated with heat-killed BCG

Shibata, Y., Henriksen, R. A., Honda, I., Nakamura, R. M., & Myrvik, Q. N. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605321 · Cited by 44

Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells

Sciulli, M. G., Seta, F., Tacconelli, S., Capone, M. L., Ricciotti, E., Pistritto, G., & Patrignani, P. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705078 · Cited by 44

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors

Shiro, T., Takahashi, H., Kakiguchi, K., Inoue, Y., Masuda, K., Nagata, H., & Tobe, M. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.11.015 · Cited by 43

Localization of various secretory phospholipase A2 enzymes in male reproductive organs

Masuda, S., Murakami, M., Matsumoto, S., Eguchi, N., Urade, Y., Lambeau, G. J., Gelb, M. H., Ishikawa, Y., Ishii, T., & Kudo, I. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.08.017 · Cited by 43

Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis

Korbecki, J., Rębacz‐Maron, E., Kupnicka, P., Chlubek, D., & Baranowska‐Bosiacka, I. (2023) · Cancers · doi:10.3390/cancers15030946 · Cited by 44

Arachidonic acid pathways in nociception.

Smith, H. S. (2006) · PubMed · Cited by 42

Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease

Maida, M. E., Hurley, S. D., Daeschner, J., Moore, A. H., & O’Banion, M. K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.048 · Cited by 42

Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance

Zhang, Y., Yao, Y.-D., Luo, J.-F., Liu, Z., Huang, Y., Wu, F., Sun, Q.-H., Liu, J.-X., & Zhou, H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105977 · Cited by 42

Cytosolic phospholipase A2α regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation

Sapirstein, A., Saito, H., Texel, S. J., Samad, T. A., O’Leary, E., & Bonventre, J. V. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00815.2004 · Cited by 42

Prostaglandin E Synthases in Zebrafish

Pini, B., Großer, T., Lawson, J. A., Price, T. S., Pack, M. A., & FitzGerald, G. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000152355.97808.10 · Cited by 42

Expression and Regulation of Cytosolic Prostaglandin E Synthase in Mouse Uterus During the Peri-Implantation Period1

Ni, H., Sun, T., Ma, X., & Yang, Z. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.007328 · Cited by 42

Expression of interferon‐stimulated gene 15‐kDa protein, cyclooxygenase (COX) 1, COX‐2, aldo‐keto reductase family 1, member B1, and prostaglandin E synthase in the spleen during early pregnancy in sheep

Yang, L., Liu, Y., Lv, W., Wang, P., Wang, B., Xue, J., & Zhang, L. (2018) · Animal Science Journal · doi:10.1111/asj.13101 · Cited by 41

Sequential induction of prostaglandin E and D synthases in inflammation

Schuligoi, R., Grill, M., Heinemann, Á., Peskar, B. A., & Amann, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.130 · Cited by 41

Cyclooxygenase‐1 and cyclooxygenase‐2 in the mouse ductus arteriosus: individual activity and functional coupling with nitric oxide synthase

Baragatti, B., Brizzi, F., Ackerley, C., Barogi, S., Ballou, L., & Coceani, F. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705391 · Cited by 41

Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis

Matsumoto, C., Oda, T., Yokoyama, S., Tominari, T., Hirata, M., Miyaura, C., & Inada, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.016 · Cited by 40

Endothelial microsomal prostaglandin E synthase‐1 exacerbates neuronal loss induced by kainate

Takemiya, T., Matsumura, K., Sugiura, H., Maehara, M., Yasuda, S., Uematsu, S., Akira, S., & Yamagata, K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22195 · Cited by 40

Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90

Picard, D. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.10.009 · Cited by 40

Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer

Hidalgo-Estévez, A. M., Stamatakis, K., Jiménez-Martínez, M., López‐Pérez, R., & Fresno, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00533 · Cited by 42

The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids

Santini, G., Patrignani, P., Sciulli, M. G., Seta, F., Tacconelli, S., Panara, M. R., Ricciotti, E., Capone, M. L., & Patrono, C. (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.119213 · Cited by 40

The Impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure Is Determined by Genetic Background

Facemire, C. S., Griffiths, R., Audoly, L., Koller, B. H., & Coffman, T. M. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145631 · Cited by 39

Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia

Poulard, C., Kim, H. N., Fang, M., Kruth, K., Gagnieux, C., Gerke, D. S., Bhojwani, D., Kim, Y., Kampmann, M., Stallcup, M. R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816254116 · Cited by 39

PGH2 Degradation Pathway Catalyzed by GSH−Heme Complex Bound Microsomal Prostaglandin E2 Synthase Type 2: The First Example of a Dual-Function Enzyme,

Yamada, T., & Takusagawa, F. (2007) · Biochemistry · doi:10.1021/bi700605m · Cited by 39

Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines

Sharma, P. K., Singh, K., Kumar, S., Kumar, P., Dhawan, S. N., Lal, S., Ulbrich, H. K., & Dannhardt, G. (2010) · Medicinal Chemistry Research · doi:10.1007/s00044-010-9312-7 · Cited by 39

Roles of Lipid Mediators in Kidney Injury

Hao, C., & Breyer, M. D. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2007.02.008 · Cited by 39

Nuclear prostaglandin receptors: role in pregnancy and parturition?

Helliwell, R. J. A., Berry, E. B. E., O’Carroll, S. J., & Mitchell, M. D. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.04.005 · Cited by 38

Gestational Age-Dependent Up-Regulation of Prostaglandin D Synthase (PGDS) and Production of PGDS-Derived Antiinflammatory Prostaglandins in Human Placenta

Helliwell, R. J. A., Keelan, J. A., Marvin, K. W., Adams, L. F., Chang, M. C., Anand, A., Sato, T. A., O’Carroll, S. J., Chaiworapongsa, T., Romero, R. J., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1982 · Cited by 39

New thoughts on the pathophysiology of osteoarthritis: One more step toward new therapeutic targets

Martel‐Pelletier, J., Lajeunesse, D., Fahmi, H., Tardif, G., & Pelletier, J. (2006) · Current Rheumatology Reports · doi:10.1007/s11926-006-0022-6 · Cited by 39

Adipose Differentiation-Related Protein: A Gonadotropin- and Prostaglandin-Regulated Protein in Primate Periovulatory Follicles1

Seachord, C. L., VandeVoort, C. A., & Duffy, D. M. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.037523 · Cited by 39

Prostaglandin E2 Is a Product of Induced Prostaglandin-endoperoxide Synthase 2 and Microsomal-type Prostaglandin E Synthase at the Implantation Site of the Hamster

Wang, X., Su, Y., Deb, K. D., Raposo, M., Morrow, J. D., Reese, J., & Paria, B. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400573200 · Cited by 39

Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer

Lim, S., Cho, H., Lee, T. B., Choi, C. H., Min, Y., Kim, S. S., & Kim, K. J. (2010) · Yonsei Medical Journal · doi:10.3349/ymj.2010.51.5.692 · Cited by 38

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H2 into Prostaglandin F2α*

Hammarberg, T., Hámberg, M., Wetterholm, A., Hansson, H., Samuelsson, B. O., & Haeggstro¨m, J. Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808365200 · Cited by 38

7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors

Shiro, T., Kakiguchi, K., Takahashi, H., Nagata, H., & Tobe, M. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.069 · Cited by 38

Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1

Wang, M., & FitzGerald, G. A. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2011.04.002 · Cited by 39

Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts

Giannico, G. A., Méndez, M., & LaPointe, M. C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00726.2004 · Cited by 38

Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor

Sjöström, M., Jakobsson, P., Juremalm, M., Ahmed, A., Nilsson, G. P., Macchia, L., & Haeggström, J. Z. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00160-9 · Cited by 38

Cyclooxygenase Metabolites in the Kidney

Harris, R. C., & Zhang, M. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100077 · Cited by 38

FcεRI, but Not FcγR, Signals Induce Prostaglandin D2 and E2 Production from Basophils

Ugajin, T., Satoh, T., Kanamori, T., Aritake, K., Urade, Y., & Yokozeki, H. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.023 · Cited by 37

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis

Korotkova, M., Helmers, S. B., Loell, I., Alexanderson, H., Grundtman, C., Dorph, C., Lundberg, I. E., & Jakobsson, P. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.079525 · Cited by 37

Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period

Cong, J., Diao, H., Zhao, Y., Ni, H., Yan, Y., & Yang, Z. (2005) · Reproduction · doi:10.1530/rep.1.00861 · Cited by 37

Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis

Jang, T. J. (2004) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-004-1104-3 · Cited by 37

Cyclooxygenase-2, Not Microsomal Prostaglandin E Synthase-1, Is the Mechanism for Interleukin-1β-induced Prostaglandin E2 Production and Inhibition of Insulin Secretion in Pancreatic Islets

Parazzoli, S. D., Harmon, J. S., Vallerie, S. N., Zhang, T., Zhou, H., & Robertson, R. P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364612 · Cited by 37

A Novel Role of Group VIB Calcium-independent Phospholipase A2 (iPLA2γ) in the Inducible Expression of Group IIA Secretory PLA2 in Rat Fibroblastic Cells

Kuwata, H., Fujimoto, C., Yoda, E., Shimbara, S., Nakatani, Y., Hara, S., Murakami, M., & Kudo, I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611883200 · Cited by 36

Prostaglandin E2synthase inhibition as a therapeutic target

Iyer, J. P., Srivastava, P. K., Dev, R., Dastidar, S. G., & Ray, A. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903018932 · Cited by 36

Simultaneous Inhibition of PGE2and PGI2Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

Sugita, R., Kuwabara, H., Kubota, K., Sugimoto, K., Kiho, T., Tengeiji, A., Kawakami, K., & Shimada, K. (2016) · Mediators of Inflammation · doi:10.1155/2016/9847840 · Cited by 36

Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis

Rakhila, H., Carli, C., Daris, M., Lemyre, M., Lebœuf, M., & Akoum, A. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.016 · Cited by 36

Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase–1 expression in murine microglia by glioma-derived soluble factors

Nakano, Y., Kuroda, E., Kito, T., Uematsu, S., Akira, S., Yokota, A., Nishizawa, S., & Yamashita, U. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/108/2/0311 · Cited by 36

Regulation of prostaglandin E2 synthesis after brain irradiation

Moore, A. H., Olschowka, J. A., Williams, J. P., Okunieff, P., & O’Banion, M. K. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.01.035 · Cited by 36

Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1

Prage, E. B., Pawelzik, S., Busenlehner, L. S., Kim, K.-H., Morgenstern, R., Jakobsson, P., & Armstrong, R. N. (2011) · Biochemistry · doi:10.1021/bi2010448 · Cited by 35

mPGES-1 deletion impairs diuretic response to acute water loading

Soodvilai, S., Jia, Z., Wang, M.-H., Dong, Z., & Yang, T. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90478.2008 · Cited by 35

Prostaglandin terminal synthases as novel therapeutic targets

Hara, S. (2017) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.93.044 · Cited by 35

PGE2 in fibrosis and cancer: Insights into fibroblast activation

Elwakeel, E., Brüne, B., & Weigert, A. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106339 · Cited by 39

Microsomal prostaglandin E synthase‐1 and cyclooxygenase‐2 are both required for ischaemic excitotoxicity

Ikeda‐Matsuo, Y., Hirayama, Y., Ota, A., Uematsu, S., Akira, S., & Sasaki, Y. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00595.x · Cited by 37

Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2

Watanabe, K., Ohkubo, H., Niwa, H., Tanikawa, N., Koda, N., Ito, S., & Ohmiya, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01025-8 · Cited by 35

Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients

Seo, T., Tatsuguchi, A., Shinji, S., Yonezawa, M., Mitsui, K., Tanaka, S., Fujimori, S., Gudis, K., Fukuda, Y., & Sakamoto, C. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0777-z · Cited by 35

Down‐regulation of Microsomal Prostaglandin E2 Synthase‐1 in Adipose Tissue by High‐fat Feeding

Hétu, P., & Riendeau, D. (2007) · Obesity · doi:10.1038/oby.2007.514 · Cited by 35

Intracellular Signal Transduction and Modification of the Tumor Microenvironment Induced by RET/PTCs in Papillary Thyroid Carcinoma

Menicali, E., Moretti, S., Voce, P., Romagnoli, S., Avenia, N., & Puxeddu, E. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00067 · Cited by 35

Contribution of membrane‐associated prostaglandin E2 synthase to bone resorption

Saegusa, M., Murakami, M., Nakatani, Y., Yamakawa, K., Katagiri, M., Matsuda, K., Nakamura, K., Kudo, I., & Kawaguchi, H. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10356 · Cited by 35

Prostaglandin E2 synthase

Nakatani, Y., Murakami, M., & Kudo, I. (2000) · Inflammation and Regeneration · doi:10.2492/jsir.21.577 · Cited by 9

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Prostaglandin E2 synthases.

Nakatani, Y., & Kudo, I. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.120.373 · Cited by 5

Regulation of Cytosolic Prostaglandin E Synthase

Nakatani, Y. (2007) · Eisei kagaku · doi:10.1248/jhs.53.251 · Cited by 3

Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23

Nakatani, Y., & Kudo, I. (2009) · Springer eBooks · doi:10.1007/978-4-431-76428-1_8