Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson, P., Thorén, S., Morgenstern, R., & Samuelsson, B. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7220 · Cited by 995

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Dixon, R. A. F., Diehl, R. E., Opas, E. E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., & Miller, D. K. (1990) · Nature · doi:10.1038/343282a0 · Cited by 772

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572

Glutathione S-Transferases - A Review

Salinas, A. E., & Wong, M. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220208213032 · Cited by 556

Functional requirement of p23 and Hsp90 in telomerase complexesPreprint

Holt, S. E., Aisner, D. L., Baur, J. A., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J. B., Morin, G. B., Toft, D. O., Shay, J. W., et al. (1999) · Genes & Development · doi:10.1101/gad.13.7.817 · Cited by 543

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M. V., Tischfield, J. A., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14411 · Cited by 366

Common structural features of mapeg—a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Jakobsson, P., Morgenstern, R., Mancini, J. A., Ford‐Hutchinson, A. W., & Persson, B. (1999) · Protein Science · doi:10.1110/ps.8.3.689 · Cited by 366

Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

Murakami, M., Kambe, T., Shimbara, S., & Kudo, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3103 · Cited by 348

Prostaglandins and Inflammation

Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 4,035

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.

Czock, D., Keller, F., Rasche, F. M., & H??ussler, U. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544010-00003 · Cited by 886

Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases

Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793

Why there are two cyclooxygenase isozymes

Smith, W. L., & Langenbach, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13271 · Cited by 612

Cytokines, Prostaglandins and Parturition—A Review

Keelan, J. A., Blumenstein, M., Helliwell, R. J. A., Sato, T., Marvin, K. W., & Mitchell, M. D. (2003) · Placenta · doi:10.1053/plac.2002.0948 · Cited by 617

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Trebino, C. E., Stock, J. L., Gibbons, C. P., Naiman, B. M., Wachtmann, T. S., Umland, J. P., Pandher, K., Lapointe, J., Saha, S., Roach, M. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332766100 · Cited by 552

Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

Samuelsson, B. O., Morgenstern, R., & Jakobsson, P. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.1 · Cited by 537

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

Buczynski, M. W., Dumlao, D. S., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900004-jlr200 · Cited by 545

COX-2 and beyond: approaches to prostaglandin inhibition in human disease

FitzGerald, G. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1225 · Cited by 518

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

Smith, W. L., Urade, Y., & Jakobsson, P. (2011) · Chemical Reviews · doi:10.1021/cr2002992 · Cited by 512

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders

Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 470

Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever

Yamagata, K., Matsumura, K., Inoue, W., Shiraki, T., Suzuki, K., Yasuda, S., Sugiura, H., Cao, C., Watanabe, Y., & Kobayashi, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02669.2001 · Cited by 372

Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway

Murakami, M., & Kudo, I. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00037-7 · Cited by 376

Cyclooxygenases, prostanoids, and tumor progression

Wang, M., Honn, K. V., & Nie, D. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9096-5 · Cited by 344

Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2

Murakami, M., Nakashima, K., Kamei, D., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., & Kudo, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305108200 · Cited by 350

Hsp90: Structure and Function

Jackson, S. (2012) · Topics in current chemistry · doi:10.1007/128_2012_356 · Cited by 347

Cyclooxygenase-2 and prostaglandins in articular tissues

Martel‐Pelletier, J., Pelletier, J., & Fahmi, H. (2003) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(03)00134-3 · Cited by 334

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

Engblom, D., Saha, S., Engström, L., Westman, M., Audoly, L., Jakobsson, P., & Blomqvist, A. G. (2003) · Nature Neuroscience · doi:10.1038/nn1137 · Cited by 310

Lipopolysaccharide-Dependent Prostaglandin E2 Production Is Regulated by the Glutathione-Dependent Prostaglandin E2 Synthase Gene Induced by the Toll-Like Receptor 4/MyD88/NF-IL6 Pathway

Uematsu, S., Matsumoto, M., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5811 · Cited by 308

Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase

Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., & Watanabe, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6531 · Cited by 304

Roles of Cyclooxygenase (COX)-1 and COX-2 in Prostanoid Production by Human Endothelial Cells: Selective Up-Regulation of Prostacyclin Synthesis by COX-2

Caughey, G. E., Cleland, L. G., Penglis, P. S., Gamble, J. R., & James, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2831 · Cited by 283

Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh‐ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., Ohuchi, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400199200 · Cited by 278

Microsomal Prostaglandin E Synthase Is Regulated by Proinflammatory Cytokines and Glucocorticoids in Primary Rheumatoid Synovial Cells

Stichtenoth, D. O., Thorén, S., Bian, H., Peters-Golden, M. L., Jakobsson, P., & Crofford, L. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.469 · Cited by 269

Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1

Guay, J., Bateman, K. P., Gordon, R., Mancini, J. A., & Riendeau, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403106200 · Cited by 267

The Anti-Inflammatory Effects of Prostaglandins

Scher, J. U., & Pillinger, M. H. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31819aaa76 · Cited by 261

Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation

Boyce, J. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00512.x · Cited by 255

Physiological Regulation of Prostaglandins in the Kidney

Hao, C., & Breyer, M. D. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100614 · Cited by 249

The Regulation of Chondrocyte Function by Proinflammatory Mediators

Goldring, M. B., & Berenbaum, F. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144484.69656.e4 · Cited by 245

Prostaglandin E2 as a mediator of fever: synthesis and catabolism

Andrei, I. I. (2004) · Frontiers in bioscience · doi:10.2741/1383 · Cited by 239

Regulated formation of eicosanoids

Fitzpatrick, F. A., & Soberman, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13241 · Cited by 232

Prostaglandin E synthase

Murakami, M., Nakatani, Y., Tanioka, T., & Kudo, I. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00043-6 · Cited by 231

Leukotriene B4: Metabolism and Signal Transduction

Yokomizo, T., Izumi, T., & Shimizu, T. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2168 · Cited by 231

Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2synthase in human lung fibroblasts: implications for lung inflammation and cancer

Martey, C. A., Pollock, S. J., Turner, C. K., O’Reilly, K. M., Baglole, C. J., Phipps, R. P., & Sime, P. J. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00239.2003 · Cited by 207

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

Neufang, G., Fürstenberger, G., Heidt, M., Marks, F., & Müller‐Decker, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121574098 · Cited by 204

Prostaglandin synthases: recent developments and a novel hypothesis

Helliwell, R. J. A., Adams, L. F., & Mitchell, M. D. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.04.002 · Cited by 203

Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis

Kamei, D., Murakami, M., Nakatani, Y., Ishikawa, Y., Ishii, T., & Kudo, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213290200 · Cited by 198

Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin

Ito, S., Okuda‐Ashitaka, E., & Minami, T. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00289-9 · Cited by 196

The Role of IL‐1 and IL‐1Ra in Joint Inflammation and Cartilage Degradation

Jacques, C., Gosset, M., Berenbaum, F., & Gabay, C. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74016-x · Cited by 202

Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2

Ueno, N., Murakami, M., Tanioka, T., Fujimori, K., Tanabe, T., Urade, Y., & Kudo, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100429200 · Cited by 195

Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System

Yagami, T., Koma, H., & Yamamoto, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9355-3 · Cited by 192

An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with Inflammation

Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T., & Itô, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030015 · Cited by 185

Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension

Tang, E. H. C., & Vanhoutte, P. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2007 · Cited by 186

Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

Claveau, D., Sirinyan, M., Guay, J., Gordon, R. J., Chan, C., Bureau, Y., Riendeau, D., & Mancini, J. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4738 · Cited by 182

Endotoxic fever: New concepts of its regulation suggest new approaches to its management

Blatteis, C. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.013 · Cited by 173

Prostaglandins as inflammatory messengers across the blood-brain barrier

Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167

The roles of NADPH oxidase and phospholipases A2in oxidative and inflammatory responses in neurodegenerative diseases

Sun, G. Y., Horrocks, L. A., & Farooqui, A. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04670.x · Cited by 170

The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease

Fries, G. R., Gassen, N. C., & Rein, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122614 · Cited by 170

The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review

Shiro, T., Fukaya, T., & Tobe, M. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.12.004 · Cited by 167

Physiologic and pathophysiologic roles of lipid mediators in the kidney

Hao, C., & Breyer, M. D. (2007) · Kidney International · doi:10.1038/sj.ki.5002192 · Cited by 170

Human Microsomal Prostaglandin E Synthase-1

Thorén, S., Weinander, R., Saha, S., Jegerschöld, C., Pettersson, P. L., Samuelsson, B. O., Hebert, H., Hámberg, M., Morgenstern, R., & Jakobsson, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303227200 · Cited by 167

Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis

Kudo, I., & Murakami, M. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.6.633 · Cited by 165

The role of prostaglandin E2 in human vascular inflammation

Gomez, I., Foudi, N., Longrois, D., & Norel, X. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.04.004 · Cited by 164

The organization and consequences of eicosanoid signaling

Soberman, R. J., & Christmas, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18338 · Cited by 166

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., & Murakami, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.007 · Cited by 156

The Pseudomonas Autoinducer N-(3-Oxododecanoyl) Homoserine Lactone Induces Cyclooxygenase-2 and Prostaglandin E2 Production in Human Lung Fibroblasts: Implications for Inflammation

Smith, R. S., KELLY, R. W., Iglewski, B. H., & Phipps, R. P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2636 · Cited by 154

Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis

Kojima, F., Naraba, H., Miyamoto, S., Beppu, M., Aoki, H., & Kawai, S. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1195 · Cited by 154

Up-regulation of Prostaglandin E2 Synthesis by Interleukin-1β in Human Orbital Fibroblasts Involves Coordinate Induction of Prostaglandin-Endoperoxide H Synthase-2 and Glutathione-dependent Prostaglandin E2 Synthase Expression

Han, R., Tsui, S., & Smith, T. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111246200 · Cited by 152

Prostaglandin E2-synthesizing enzymes in fever: differential transcriptional regulation

Ivanov, A. I., Pero, R. S., Scheck, A. C., & Romanovsky, A. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00347.2002 · Cited by 152

Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease

Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 150

Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene

Naraba, H., Yokoyama, C., Tago, N., Murakami, M., Kudo, I., Fueki, M., Oh‐ishi, S., & Tanabe, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203618200 · Cited by 145

Defective endometrial prostaglandin synthesis identified in patients with repeated implantation failure undergoing in vitro fertilization

Achache, H., Tsafrir, A., Prus, D., Reich, R., & Revel, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.1668 · Cited by 145

Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer

Chell, S. D., Кади, А., Williams, A. C., & Paraskeva, C. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.05.002 · Cited by 144

Up‐regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: Critical roles of the ERK‐1/2 and p38 signaling pathways

Masuko, K., Berenbaum, F., Humbert, L., Salvat, C., Goldring, M. B., & Thirion, S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20437 · Cited by 139

Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

Wang, M., Lee, E., Song, W., Ricciotti, E., Rader, D. J., Lawson, J. A., Puré, E., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.731398 · Cited by 138

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs

LEE, Y., KIM, H., WU, T., WANG, X., & Ra, D. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.01.013 · Cited by 138

Regulation of bone morphogenetic protein‐2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells

Arikawa, T., 健, 小., & Morita, I. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20031 · Cited by 136

Prostaglandins and sickness behavior: Old story, new insights

Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135

Expression of COX-2 and PGE synthase and synthesis of PGE2 in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors

Jabbour, H. N., Milne, S. A., Williams, A. R. W., Anderson, R. A., & Boddy, S. C. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2033 · Cited by 135

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions

Ajmone‐Cat, M. A., Bernardo, A., Greco, A., & Minghetti, L. (2010) · Pharmaceuticals · doi:10.3390/ph3061949 · Cited by 134

Characterization of four mammalian 3‐hydroxyacyl‐CoA dehydratases involved in very long‐chain fatty acid synthesis

Ikeda, M., Kanao, Y., Yamanaka, M., Sakuraba, H., Mizutani, Y., Igarashi, Y., & Kihara, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.007 · Cited by 132

Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma

Pierzchalska, M., Szabó, Z., Sanak, M., Soja, J., & Szczeklik, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1491 · Cited by 132

Membrane-Bound Prostaglandin E Synthase-1-Mediated Prostaglandin E2 Production by Osteoblast Plays a Critical Role in Lipopolysaccharide-Induced Bone Loss Associated with Inflammation

Inada, M., Matsumoto, C., Uematsu, S., Akira, S., & Miyaura, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1879 · Cited by 129

Mechanisms of Enhanced Macrophage-Mediated Prostaglandin E2 Production and Its Suppressive Role in Th1 Activation in Th2-Dominant BALB/c Mice

Kuroda, E., & Yamashita, U. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.757 · Cited by 128

Coupling between cyclooxygenases and terminal prostanoid synthases

Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., & Murakami, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.152 · Cited by 128

COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis

Lovgren, A. K., Jania, L. A., Hartney, J. M., Parsons, K. K., Audoly, L., FitzGerald, G. A., Tilley, S. L., & Koller, B. H. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00492.2005 · Cited by 127

The role of cyclooxygenase-2 in breast cancer: review

Singh‐Ranger, G., Salhab, M., & Mokbel, K. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9641-5 · Cited by 126

Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues

Monfort, J., Pelletier, J.-P., García‐Giralt, N., & Pelletier, J. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.068882 · Cited by 129

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

Koeberle, A., & Werz, O. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.022 · Cited by 124

Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile

Boulet, L., Ouellet, M., Bateman, K. P., Ethier, D., Percival, M. D., Riendeau, D., Mancini, J. A., & Méthot, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400443200 · Cited by 120

Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria

Rao, R., Zhang, M., Zhao, M., Cai, H., Harris, R. C., Breyer, M. D., & Hao, C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00287.2004 · Cited by 119

Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium

Westman, M., Korotkova, M., af Klint, E., Stark, A., Audoly, L., Klareskog, L., Ulfgren, A.-K., & Jakobsson, P. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20286 · Cited by 118

The skeletal muscle arachidonic acid cascade in health and inflammatory disease

Korotkova, M., & Lundberg, I. E. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.2 · Cited by 117

p23, a simple protein with complex activities

Felts, S. J., & Toft, D. O. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)008 · Cited by 116

Prostaglandins and bone metabolism

Choudhary, S., & Pilbeam, C. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00051-8 · Cited by 116

The role of prostaglandins in allergic lung inflammation and asthma

Claar, D. D., Hartert, T. V., & Peebles, R. S. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.992783 · Cited by 113

The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease

Hikiji, H., Takato, T., Shimizu, T., & Ishii, S. (2007) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.003 · Cited by 114

Is osteoarthritis a disease involving only cartilage or other articular tissues?

Martel‐Pelletier, J., & Pelletier, J. P. (2010) · PubMed · Cited by 113

Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1

Cheng, S., Afif, H., Martel‐Pelletier, J., Pelletier, J., Li, X., Farrajota, K., Lavigne, M. J. F., & Fahmi, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402828200 · Cited by 112

Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Hurley, S. D., Olschowka, J. A., & O'Banion, M. K. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753460196 · Cited by 110

Prostaglandin E 2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes

Liu, T., Laidlaw, T. M., Katz, H. R., & Boyce, J. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313185110 · Cited by 110

Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis

Seo, M., & Oh, D. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.04.003 · Cited by 110

EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia

Quan, Y., Jiang, J., & Dingledine, R. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.455816 · Cited by 108

Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems

Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107

Cyclooxygenase and prostaglandin synthases in atherosclerosis: Recent insights and future perspectives

Cipollone, F., Cicolini, G., & Bucci, M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.002 · Cited by 112

Prostaglandins and Rheumatoid Arthritis

Fattahi, M. J., & Mirshafiey, A. (2012) · Arthritis · doi:10.1155/2012/239310 · Cited by 110

IL‐1β‐dependent activation of NF‐κB mediates PGE2 release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase

Catley, M. C., Chivers, J. E., Cambridge, L. M., Holden, N. S., Slater, D. M., Staples, K. J., Bergmann, M. W., Löser, P., Barnes, P. J., & Newton, R. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00672-0 · Cited by 104

Cyclooxygenase and 5‐lipoxygenase pathways in the vessel wall: Role in atherosclerosis

Vila, L. (2004) · Medicinal Research Reviews · doi:10.1002/med.10065 · Cited by 102

Prostaglandins in asthma and allergic diseases

Peebles, R. S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.001 · Cited by 100

Prostaglandin E2 synthase

Nakatani, Y., Murakami, M., & Kudo, I. (2000) · Inflammation and Regeneration · doi:10.2492/jsir.21.577 · Cited by 9

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Prostaglandin E2 synthases.

Nakatani, Y., & Kudo, I. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.120.373 · Cited by 5

Regulation of Cytosolic Prostaglandin E Synthase

Nakatani, Y. (2007) · Eisei kagaku · doi:10.1248/jhs.53.251 · Cited by 3

Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23

Nakatani, Y., & Kudo, I. (2009) · Springer eBooks · doi:10.1007/978-4-431-76428-1_8