Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson, P., Thorén, S., Morgenstern, R., & Samuelsson, B. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7220 · Cited by 995

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Dixon, R. A. F., Diehl, R. E., Opas, E. E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., & Miller, D. K. (1990) · Nature · doi:10.1038/343282a0 · Cited by 772

Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2

Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572

Glutathione S-Transferases - A Review

Salinas, A. E., & Wong, M. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220208213032 · Cited by 556

Functional requirement of p23 and Hsp90 in telomerase complexesPreprint

Holt, S. E., Aisner, D. L., Baur, J. A., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J. B., Morin, G. B., Toft, D. O., Shay, J. W., et al. (1999) · Genes & Development · doi:10.1101/gad.13.7.817 · Cited by 543

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M. V., Tischfield, J. A., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14411 · Cited by 366

Common structural features of mapeg—a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Jakobsson, P., Morgenstern, R., Mancini, J. A., Ford‐Hutchinson, A. W., & Persson, B. (1999) · Protein Science · doi:10.1110/ps.8.3.689 · Cited by 366

Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

Murakami, M., Kambe, T., Shimbara, S., & Kudo, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3103 · Cited by 348

Green, Black and Rooibos Tea Inhibit Prostaglandin E2 Formation in Human Monocytes by Inhibiting Expression of Enzymes in the Prostaglandin E2 Pathway

Hedbrant, A., Persson, I. A. ‐., Erlandsson, A., & Wijkander, J. (2022) · Molecules · doi:10.3390/molecules27020397 · Cited by 11

Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2

Kihara, T., Shimmyo, Y., Akaike, A., Niidome, T., & Sugimoto, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.069 · Cited by 11

NADPH Oxidase NOX5-S and Nuclear Factor κB1 Mediate Acid-Induced Microsomal Prostaglandin E Synthase-1 Expression in Barrett’s Esophageal Adenocarcinoma Cells

Zhou, X., Li, D., Resnick, M. B., Wands, J. R., & Cao, W. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.083287 · Cited by 11

Genes Regulating Maternal Recognition of Pregnancy in Domestic Animals: an Update

Mor, A., Mondal, S., Reddy, I. J., & Soumya, N. P. (2015) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-89132015060284 · Cited by 11

The molecular basis of fever

Cartmell, T., & Mitchell, D. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80056-2 · Cited by 10

Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ

Walters, J. N., Bickford, J. S., Newsom, K. J., Beachy, D. E., Barilovits, S. J., Herlihy, J.-D. H., & Nick, H. S. (2012) · Biochemical Journal · doi:10.1042/bj20111801 · Cited by 11

P23 Acts as Functional RBP in the Macrophage Inflammation Response

de Vries, S., Beneš, V., Vries, I. S. N., Rücklé, C., Zarnack, K., Marx, G., Ostareck, D. H., & Ostareck‐Lederer, A. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.625608 · Cited by 12

Cyclooxygenase‐2/microsomal prostaglandin E synthase‐1 complex in the preoptic‐anterior hypothalamus of the mouse: involvement through fever to intravenous lipopolysaccharide

Gaetano, L., Watanabe, K., Barogi, S., & Coceani, F. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02157.x · Cited by 11

Cellular sources of cyclooxygenase‐1 and ‐2 up‐regulation in the spinal dorsal horn after spinal nerve ligation

Lau, Y. M., Wong, S. C., Tsang, S. W., Lau, W. K., Lu, A. P., & Zhang, H. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12078 · Cited by 11

Methylmercury Neurotoxicity: Exploring Potential Novel Targets

Aschner, J. L., & Aschner, M. (2007) · The Open Toxicology Journal · doi:10.2174/1874340400701010001 · Cited by 11

Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library

Kim, W.-I., Choi, K.-A., Do, H.-S., & Yu, Y.-G. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.11.808 · Cited by 11

mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

Nonaka, K. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i38.4846 · Cited by 11

Rehmannia Glutinosa Pharmacopuncture Solution Regulates Functional Activation, FcεRI Expression, and Signaling Events in Mast Cells

Kang, K., Lee, K.-H., Yoon, H.-M., Jang, K.-J., Song, C.-H., & Kim, C.-H. (2012) · Journal of pharmacopuncture · doi:10.3831/kpi.2012.15.015 · Cited by 11

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

Li, H., Melnyk, J. E., Fu, B. X. H., Shrestha, R., Zhang, M., Sjöström, M., Feng, S., Anderson, J. A., Han, W., Chesner, L. N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02388-8 · Cited by 10

Genome-Wide Analysis Indicates a Complete Prostaglandin Pathway from Synthesis to Inactivation in Pacific White Shrimp, Litopenaeus vannamei

Yang, H., Chen, X., Li, Z., Wu, X., Zhou, M., Zhang, X., Liu, Y., Sun, Y., Zhu, C., Guo, Q., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031654 · Cited by 10

Effect of Diethylcarbamazine (DEC) on prostaglandin levels in Wuchereria bancrofti infected microfilaraemics

Sankari, T., Hoti, S. L., Das, L. K., Govindaraj, V., & Das, P. K. (2013) · Parasitology Research · doi:10.1007/s00436-013-3399-y · Cited by 10

A Facilitated Approach to Evaluate the Inhibitor Mode and Potency of Compounds Targeting Microsomal Prostaglandin E Synthase-1

Spahiu, L., Stenberg, P., Larsson, C., Wannberg, J., Alterman, M., Kull, B., Nekhotiaeva, N., & Morgenstern, R. (2011) · Assay and Drug Development Technologies · doi:10.1089/adt.2010.0350 · Cited by 10

Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines

Sandee, D., Sivanuntakorn, S., Vichai, V., Kramyu, J., & Kirtikara, K. (2008) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2008.12.001 · Cited by 10

Murine mPGES-1 3D Structure Elucidation and Inhibitors Binding Mode Predictions by Homology Modeling and Site-Directed Mutagenesis

Corso, G., Coletta, I., & Ombrato, R. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci400180f · Cited by 10

Principles, Mechanisms of Action, and Future Prospects of Anti-inflammatory Drugs

Rius, B., & Clària, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-33889-7_2 · Cited by 11

Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23

Madon-Simon, M., Grad, I., Bayo, P., Pérez, P., & Picard, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180035 · Cited by 10

Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGE 2 in an in vitro equine inflammation model

Martin, E. M., & Jones, S. L. (2017) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2017.09.008 · Cited by 10

Down-Regulation of p23 in Normal Lung Epithelial Cells Reduces Toxicities From Exposure to Benzo[a]pyrene and Cigarette Smoke Condensate via an Aryl Hydrocarbon Receptor-Dependent Mechanism

Chen, J., Yakkundi, P., & Chan, W. K. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy234 · Cited by 10

Targeting the COX/mPGES-1/PGE2 Pathway in Neuroblastoma

Larsson, K., Kock, A., Kogner, P., & Jakobsson, P. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_9 · Cited by 10

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor

Takahashi, N., Okuno, T., Fujii, H., Makino, S., Takahashi, M., Ohba, M., Saeki, K., Itakura, A., Takeda, S., & Yokomizo, T. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250638 · Cited by 10

Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells

Suzuki-Yamamoto, T., Tanaka, S., Tsukayama, I., Takafuji, M., Hanada, T., Arakawa, T., Kawakami, Y., Kimoto, M., & Takahashi, Y. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.14-25 · Cited by 10

Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Alter Ozone-Induced Airway Hyper-Responsiveness

Wang, M., Cooper, P. R., Jiang, M., Zhao, H., Hui, Y., Yao, Y., Tate, J. C., Damera, G., Lawson, J. A., Jester, W. F., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.166678 · Cited by 10

Immunocytochemical localization of prostaglandin F synthase II in the rat spinal cord

Suzuki-Yamamoto, T., Toida, K., Watanabe, K., & Ishimura, K. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04244-0 · Cited by 10

Oxaliplatin induces prostaglandin E2 release in vascular endothelial cells

Matsunuma, S., Handa, S., Kamei, D., Yamamoto, H., Okuyama, K., & Kato, Y. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03901-7 · Cited by 9

Expression of enzymes involved in the synthesis of prostaglandin E2 in early- and late-cleaved bovine embryos at different stages of preimplantation development

Boruszewska, D., Grycmacher, K., Kowalczyk‐Zieba, I., Sinderewicz, E., Staszkiewicz‐Chodor, J., & Wocławek-Potocka, I. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.04.032 · Cited by 9

Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett’s Esophagus

Li, D., Deconda, D., Li, A., Habr, F. G., & Cao, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-52800-7 · Cited by 9

Expression of Enzymes Associated with Prostaglandin Synthesis in Equine Conceptuses

Budik, S., Walter, I., Leitner, M.-C., Ertl, R., & Aurich, C. (2021) · Animals · doi:10.3390/ani11041180 · Cited by 9

Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor

Yoon, S., Cho, D.-Y., Choi, S., Lee, J., Choi, D., Kim, E., & Park, J. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b20-00991 · Cited by 9

Compensatory Cellular Reactions to Nonsteroidal Anti-Inflammatory Drugs on Osteogenic Differentiation in Canine Bone Marrow-Derived Mesenchymal Stem Cells

Namgil, O. H., Kim, S., Hosoya, K., & Okumura, M. (2014) · Journal of Veterinary Medical Science · doi:10.1292/jvms.13-0482 · Cited by 9

New insights into the catalytic mechanism of Bombyx mori prostaglandin E synthase gained from structure–function analysis

Yamamoto, K., Suzuki, M., Higashiura, A., Aritake, K., Urade, Y., Uodome, N., Hossain, M. T., & Nakagawa, A. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.001 · Cited by 9

A Novel Multi‐step Virtual Screening for the Identification ofHumanandMousemPGES‐1 Inhibitors

Corso, G., Alisi, A., Cazzolla, N., Coletta, I., Furlotti, G., Garofalo, B., Mangano, G., Mancini, F., Vitiello, M., & Ombrato, R. (2016) · Molecular Informatics · doi:10.1002/minf.201600024 · Cited by 9

Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase–Substrate Interaction Involving Intrinsically Disordered Regions

Martini, C., Bédard, M., Lavigne, P., & Denault, J. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00298 · Cited by 10

Regulation of Membrane-Associated Prostaglandin E2 Synthase 1 in Pregnant Sheep Intrauterine Tissues by Glucocorticoid and Estradiol

Zhang, Q., Collins, V., Chakrabarty, K. H., Wolf, R. F., Unno, N., Howe, D. C., Rose, J. C., & Wu, W. X. (2006) · Endocrinology · doi:10.1210/en.2006-0293 · Cited by 9

Developmental regulation of prostaglandin E2synthase in porcine ductus arteriosus

Bouayad, A., Fouron, J., Hou, X., Beauchamp, M., Quiniou, C., Abran, D., Peri, K. G., Clyman, R. I., Varma, D. R., & Chemtob, S. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00437.2003 · Cited by 9

PTGES3 proteolysis using the liposomal peptide-PROTAC approach

Liu, S., Yuan, F., Dong, H., Zhang, J., Mao, X., Liu, Y., & Li, H. (2024) · Biology Direct · doi:10.1186/s13062-024-00580-0 · Cited by 8

Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium

Cabrera, R. A., Dozier, B. L., & Duffy, D. M. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.022 · Cited by 8

Molecular structure of a prostaglandin D synthase requiring glutathione from the brown planthopper, Nilaparvata lugens

Yamamoto, K., Higashiura, A., Suzuki, M., Aritake, K., Urade, Y., & Nakagawa, A. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.032 · Cited by 8

mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas

Armas, R. D., Durand, K., Guillaudeau, A., Weinbreck, N., Robert, S., Moreau, J.-J., Caire, F., Acosta, G., Pebet, M., Chaunavel, A., et al. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.03.017 · Cited by 8

A Cybernetic Approach to Modeling Lipid Metabolism in Mammalian Cells

Aboulmouna, L., Gupta, S., Maurya, M. R., DeVilbiss, F. T., Subramaniam, S., & Ramkrishna, D. (2018) · Processes · doi:10.3390/pr6080126 · Cited by 8

Glutathione Transferases☆

Tsuchida, S., & Yamada, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04351-8 · Cited by 10

Expression of COX-2 and PGE synthase and synthesis of PGE2in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors

Jabbour, H. N., Milne, S. A., Williams, A. R. W., Anderson, R. A., & Boddy, S. C. (2001) · British Journal of Cancer · doi:10.1038/sj.bjc.6692033 · Cited by 8

Characterization and expression of p23 gene in the amphioxus Branchiostoma belcheri

Zhao, B., Zhang, S., Wang, Y., Liu, Z., & De, K. (2006) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2006.05.011 · Cited by 8

Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4+ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis

Takemiya, T., Takeuchi, C., & Kawakami, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122758 · Cited by 7

“Tuning” the ATPase Activity of Hsp90

Prodromou, C., & Morgan, R. M. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-24780-9_23 · Cited by 7

Nonsteroidal Anti-inflammatory Drugs

Ballou, L. R., & Wang, B. W. E. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10054-3 · Cited by 7

Prostaglandins and Other Lipid Mediators in Reproductive Medicine

Funk, C. D., Song, W., & FitzGerald, G. A. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00006-1 · Cited by 7

Prostaglandins and Bone Metabolism

Pilbeam, C. C., Choudhary, S., Blackwell, K. A., & Raisz, L. G. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00072-0 · Cited by 9

Regulatory Functions of Prostaglandin E2 Synthases

Kudo, I., & Murakami, M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9194-2_20 · Cited by 7

Historical Aspects of COX-2

Herschman, H. R. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-302-6_2 · Cited by 7

Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene: ESSENTIAL ROLE OF THE TRANSCRIPTION FACTOR EGR-1

Naraba, H. (2004) · Inflammation and Regeneration · doi:10.2492/jsir.24.100 · Cited by 7

The effects of prostaglandin E2 on gonadal development and germ cell proliferation, and its presence during the gonadal cycle in the sea cucumber, Holothuria scabra

Nontunha, N., Tinikul, R., Chaiyamoon, A., Vetkama, W., Thongbuakaew, T., Chaichotranunt, S., Poomtong, T., Sobhon, P., & Tinikul, Y. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738201 · Cited by 6

Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease

Kotsos, D., & Τζιόμαλος, Κ. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24033049 · Cited by 6

Iristectorigenin C suppresses LPS-induced macrophages activation by regulating mPGES-1 expression and p38/JNK pathway

Guo, X., Yao, Y.-D., Kang, J.-L., Luo, F.-K., Mu, X.-J., Zhang, Y., Chen, M., Liu, M., Lao, C.-C., Tan, Z.-H., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116706 · Cited by 6

Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3

Abbey, C. A., Duran, C. L., Chen, Z., Chen, Y., Roy, S., Coffell, A., Sveeggen, T. M., Chakraborty, S., Wells, G. B., Chang, J., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320599 · Cited by 7

Induction of prostaglandin E synthase by gastroesophageal reflux contents in normal esophageal epithelial cells and esophageal cancer cells

Soma, T., Shimada, Y., Kawabe, A., Kaganoi, J., Kondo, K., Imamura, M., & Uemoto, S. (2007) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2007.00657.x · Cited by 6

The Zinc-Binding Protein Chordc1 Undergoes Complex Diurnal Changes in mRNA Expression During Mouse Brain Development

Gerstner, J. R., & Landry, C. F. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9271-z · Cited by 6

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Nagarajan, M., Deshmukh, S., Tambe, M. S., Pisal, D., Tondlekar, S., Shaikh, M. S., Sarode, N., Kattige, V. G., Sawant, P., Pisat, M., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.02.048 · Cited by 6

A defective prostaglandin E synthase could affect egg formation in the silkworm Bombyx mori

Yamamoto, K., Tsubota, T., Uno, T., Tsujita, Y., Yokota, S., Sezutsu, H., & Mita, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.121 · Cited by 6

Seasonal plasticity in immunocompetent cytokines (IL-2, IL-6, and TNF-α), myeloid progenitor cell (CFU-GM) proliferation, and LPS-induced oxido-inflammatory aberrations in a tropical rodent Funambulus pennanti: role of melatonin

Rastogi, S., & Haldar, C. (2022) · Cell Stress and Chaperones · doi:10.1007/s12192-022-01313-w · Cited by 6

Secreted metabolome of porcine blastocysts encapsulated within in vitro 3D alginate hydrogel culture systems undergoing morphological changes provides insights into specific mechanisms involved in the initiation of porcine conceptus elongation

Walsh, S. C., Miles, J. R., Broeckling, C. D., Rempel, L. A., Wright-Johnson, E. C., & Pannier, A. K. (2023) · Reproduction Fertility and Development · doi:10.1071/rd22210 · Cited by 6

The whole - genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge

Wieczfińska, J., Kacprzak, D., Pospiech, K., Sokołowska, M., Nowakowska, M., Pniewska, E., Bednarek, A. K., Kuprys-Lipinska, I. R., Kuna, P., & Pawliczak, R. (2015) · Respiratory Research · doi:10.1186/s12931-015-0305-4 · Cited by 6

Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung

Selg, E., Låstbom, L., Ryrfeldt, Å., Kumlin, M., & Dahlén, S. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.01.001 · Cited by 6

Role of Cyclooxygenase Enzymes in a Murine Model of Experimental Cholera

Gessell-Lee, D. L., Popov, V. L., Boldogh, I. R., Olano, J. P., & Peterson, J. W. (2003) · Infection and Immunity · doi:10.1128/iai.71.11.6234-6242.2003 · Cited by 6

Prostaglandin Mediators

Smyth, E. M., & FitzGerald, G. A. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50528-3 · Cited by 6

Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

Mellentine, S. Q., Ramsey, A. S., Li, J., Brown, H. N., & Tootle, T. L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1257751 · Cited by 5

Covalent modulation of mPGES1 activity via α,β-unsaturated aldehyde group: Implications for downregulating PGE2 expression and antipyretic response

Chi, F., Zhang, M., Han, Y., Shen, F., Peng, S., Su, B., Hou, Y., & Bai, G. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109913 · Cited by 5

Analysis of differentially expressed proteins in Yersinia enterocolitica-infected HeLa cells

Alugubelly, N., Hercík, K., Kibler, P., Nanduri, B., & Edelmann, M. J. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.02.004 · Cited by 5

Analgesic effects of a highly selective mPGES-1 inhibitor

Stewart, M. J., Weaver, L. M., Ding, K., Kyomuhangi, A., Loftin, C. D., Zheng, F., & Zhan, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-30164-3 · Cited by 5

Cyclooxygenase Metabolites in the Kidney

Harris, R. C., & Zhang, M. (2011) · Comprehensive physiology · doi:10.1002/j.2040-4603.2011.tb00382.x · Cited by 5

Evaluation of Vaginal Misoprostol Effect on Pregnancy Rate after Intrauterine Insemination

Moslemizad, N., Moghaddam, T. G., & Peyvandi, S. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2009.64.68 · Cited by 5

The roles of prostanoids in inflammation, allergy, and immunity

Matsuoka, T., & Narumiya, S. (2008) · Inflammation and Regeneration · doi:10.2492/inflammregen.28.423 · Cited by 5

Establishment of a cell-based drug screening system for identifying selective down-regulators of mPGES-1

Guo, L., Lian, J. H., Ji, W., Hu, W. R., Wu, G., & Gong, B.-Q. (2006) · Inflammation Research · doi:10.1007/s00011-005-0061-x · Cited by 5

Molecular cloning and tissue distribution of microsomal-1 and cytosolic prostaglandin E synthases in macaque

Parent, J., Chapdelaine, P., & Fortier, M. A. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.02.005 · Cited by 5

Prostaglandin E2 synthases.

Nakatani, Y., & Kudo, I. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.120.373 · Cited by 5

Insights into the potential pathogenesis and therapeutic implications of ferroptosis in brain microvascular endothelial cells during stroke

Qin, W., Zhao, Y., Du, J., Zhang, Q., Wei, G., Wang, S., Yu, Z., Xu, J., Yang, J., & Gao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1787418 · Cited by 4

The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production

Xiao, X., Zhen, W., Bai, D., Zheng, B., Wang, Y., Ma, X., Xie, X., Zhang, Y., Guo, F., Ito, K., et al. (2026) · Poultry Science · doi:10.1016/j.psj.2026.106909 · Cited by 6

CO-CHAPERONE P23 INHIBITS FERROPTOSIS IN SEPSIS-ASSOCIATED ACUTE KIDNEY INJURY BY REGULATING GPX4 STABILITY

Luo, M., Xu, Q., Sun, Y., He, N., Wen, Z., Wang, Z., Zhao, J., & Liu, Y. (2025) · Shock · doi:10.1097/shk.0000000000002623 · Cited by 5

Expression of Microsomal Prostaglandin E Synthase-1 in Fibroblasts of Rabbit Alkali-Burned Corneas

Kawamura, A., Tatsuguchi, A., Ishizaki, M., Takahashi, H., & Fukuda, Y. (2008) · Cornea · doi:10.1097/ico.0b013e318180e53e · Cited by 4

Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA2

Ebrahimi, M., Firuzi, O., Miri, R., Razzaghi‐Asl, N., & Ebadi, A. (2016) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-016-0197-0 · Cited by 4

Mechanisms Behind Illness-Induced Anorexia

Nilsson, A. (2016) · Linköping University medical dissertations · doi:10.3384/diss.diva-132640 · Cited by 4

Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification

Kodaka, Y., Futagami, S., Tatsuguchi, A., Yamawaki, H., Sato, H., Hashimoto, S., Kawagoe, T., Ueki, N., Nagoya, H., Maruki, Y., et al. (2017) · Digestion · doi:10.1159/000479864 · Cited by 4

A complete prostaglandin pathway from synthesis to inactivation in the oral gland of the jawless vertebrate lamprey, Lethenteron camtschaticum

Wang, Y., Dong, Y., Duan, X., Luan, Y., Li, Q., Pang, Y., Sun, F., & Gou, M. (2023) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2023.104903 · Cited by 4

The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells

Iwata, Y., Miyao, M., Hirotsu, A., Tatsumi, K., Matsuyama, T., Uetsuki, N., & Tanaka, T. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07759 · Cited by 4

Roles of Prostaglandin E2 in Endometriosis

Hsiao, K., Wu, M.-H., & Tsai, S. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_9 · Cited by 4

On the mechanism of microsomal prostaglandin E synthase type-2—A theoretical study of endoperoxide reaction with MeS−

Li, Y., Angelastro, M. R., Shimshock, S., Reiling, S., & Vaz, R. J. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.10.100 · Cited by 4

Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels

Boomgaarden, I., Bosy‐Westphal, A., Müller, M. J., & Döring, F. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.02.001 · Cited by 4

Theoretical studies on model reaction pathways of prostaglandin H2 isomerization to prostaglandin D2/E2

Yamaguchi, N., Naiki, T., Kohzuma, T., Takada, T., Sakata, F., & Mori, S. (2010) · Theoretical Chemistry Accounts · doi:10.1007/s00214-010-0814-7 · Cited by 4

Effects of varying levels of n-6:n-3 fatty acid ratio on plasma fatty acid composition and prostanoid synthesis in pregnant rats

K, A. A. B., Zuki, A. B. Z., Goh, Y. M., Mustapha, N. M., & Ebrahimi, M. M. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb10.1233 · Cited by 4

Microsomal Prostaglandin E2 Synthase-1

Koeberle, A., & Werz, O. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735346-00001 · Cited by 4

Structure and functions of glutathione transferases

Fedets, O. M. (2014) · The Ukrainian Biochemical Journal · doi:10.15407/ubj86.03.023 · Cited by 4

Aspirin Intolerance: Experimental Models for Bed-to-Bench

Yamashita, M. (2016) · Current Drug Targets · doi:10.2174/1389450117666161005152327 · Cited by 4

Prostaglandin-E Synthase

Pahl, A. M. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.63686-4 · Cited by 4

Beyond cyclooxygenase

Breyer, M. D. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00645.x · Cited by 4

Metabolism and Roles of Eicosanoids in Brain

Farooqui, A. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9940-5_1 · Cited by 3

The Prostanoid Receptors: Molecular Approaches to Drug Development. Role of EP4 receptor in bone resorption induced by PGE.

Miyaura, C. (2001) · Folia Pharmacologica Japonica · doi:10.1254/fpj.117.293 · Cited by 3

Prostaglandin E2 synthase

Nakatani, Y., Murakami, M., & Kudo, I. (2000) · Inflammation and Regeneration · doi:10.2492/jsir.21.577 · Cited by 9

Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2

Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964

Prostaglandin E2 synthases.

Nakatani, Y., & Kudo, I. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.120.373 · Cited by 5

Regulation of Cytosolic Prostaglandin E Synthase

Nakatani, Y. (2007) · Eisei kagaku · doi:10.1248/jhs.53.251 · Cited by 3

Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23

Nakatani, Y., & Kudo, I. (2009) · Springer eBooks · doi:10.1007/978-4-431-76428-1_8