Receptor-interacting Protein 140 Directly Recruits Histone Deacetylases for Gene Silencing
Open accessAbstract
Receptor-interacting protein 140 (RIP140) encodes a histone deacetylase (HDAC) inhibitor-sensitive repressive activity. Direct interaction of RIP140 with HDAC1 and HDAC3 occurs in vitro and in vivo as demonstrated in co-immunoprecipitation and glutathione S-transferase pull-down experiments. The HDAC-interacting domain of RIP140 is mapped to its N-terminal domain, between amino acids 78 and 303 based upon glutathione S-transferase pull-down experiments. In chromatin immunoprecipitation assays, it is demonstrated that histone deacetylation occurs at the chromatin region of the Gal4 binding sites as a result of Gal4 DNA binding domain-tethered RIP expression. The immunocomplexes of RIP140 from cells transfected with RIP140 and HDAC are able to deacetylate histone proteins in vitro. This study presents the first evidence for RIP140 as a negative coregulator for nuclear receptor actions by directly recruiting histone deacetylases and categorizes RIP140 as a novel negative coregulator that is able to directly interact with HDACs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
At the end of the transcriptional response, liganded RARs have been shown to recruit unconventional coregulators with LxxLL motifs, such as RIP140 and PRAME.
“At the end of the transcriptional response, liganded RARs have been shown to recruit unconventional coregulators with LxxLL motifs, such as RIP140 and PRAME ( Fig. 4C ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [108]
In contrast to the classical p160 coregulators, RIP140 and PRAME inhibit the transcriptional activity of RARs through the recruitment of HDACs and PcG proteins respectively.
“In contrast to the classical p160 coregulators, RIP140 and PRAME inhibit the transcriptional activity of RARs through the recruitment of HDACs ( 108 ) and PcG proteins ( 63 ) respectively.”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [108]
Cites
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952 · see citing works
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S., Tsai, S., Tsai, M.-J., & O'Malley, B. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,507 · see citing works
Chamberlain, J. P. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90716-4 · Cited by 1,970 · see citing works
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
Nolte, R. T., Wisely, G. B., Westin, S. K., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., & Milburn, M. V. (1998) · Nature · doi:10.1038/25931 · Cited by 1,955 · see citing works
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
Yang, X., Ogryzko, V. V., Nishikawa, J., Howard, B. H., & Nakatani, Y. (1996) · Nature · doi:10.1038/382319a0 · Cited by 1,473 · see citing works
Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80516-4 · Cited by 1,465 · see citing works
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
Torchia, J., Rose, D. W., Inostroza, J. A., Kamei, Y., Westin, S. K., Glass, C. K., & Rosenfeld, M. G. (1997) · Nature · doi:10.1038/42652 · Cited by 1,283 · see citing works
Steroid receptor coactivator-1 is a histone acetyltransferase
Spencer, T. E., Jenster, G. W., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Oñate, S. A., Tsai, S. Y., Tsai, M., et al. (1997) · Nature · doi:10.1038/38304 · Cited by 1,242 · see citing works
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works
Self-citationVoegel, J. J., Heine, M. J., Zechel, C., Chambon, P., & Gronemeyer, H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00736.x · Cited by 1,080 · see citing works
Rb Interacts with Histone Deacetylase to Repress Transcription
Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 957 · see citing works
Nuclear receptor coactivators and corepressors
Horwitz, K. B., Jackson, T. A., Bain, D. L., Richer, J. K., Takimoto, G. S., & Tung, L. W. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.10.9121485 · Cited by 943 · see citing works
p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage
Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., & Berger, S. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1202 · Cited by 776 · see citing works
Three proteins define a class of human histone deacetylases related to yeast Hda1p
Grozinger, C. M., Hassig, C. A., & Schreiber, S. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4868 · Cited by 770 · see citing works
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Cavaillès, V., Dauvois, S., L’Horset, F., Lopez, G. N., Hoare, S., Kushner, P. J., & Parker, M. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00044.x · Cited by 740 · see citing works
Hong, H., Kohli, K. K., Trivedi, A. A., Johnson, D. L., & Stallcup, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4948 · Cited by 694 · see citing works
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
Hu, X., & Lazar, M. A. (1999) · Nature · doi:10.1038/47069 · Cited by 642 · see citing works
Self-citationRundlett, S. E., Carmen, A. A., Kobayashi, R., Bavykin, S. G., Turner, B. M., & Grunstein, M. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14503 · Cited by 618 · see citing works
RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
Li, H., Gomes, P. J., & Chen, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8479 · Cited by 579 · see citing works
Kadosh, D., & Struhl, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80217-2 · Cited by 536 · see citing works
Molecular determinants of nuclear receptor-corepressor interactionPreprint
Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., L., L. M., Milburn, M. V., Glass, C. K., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.24.3198 · Cited by 514 · see citing works
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
Yao, T., Ku, G., Zhou, N., Scully, R., & Livingston, D. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10626 · Cited by 453 · see citing works
Ng (2000) · doi:10.1016/s0968-0004(00)01551-6 · Cited by 427 · see citing works
Mechanism of corepressor binding and release from nuclear hormone receptorsPreprint
Nagy, L., Kao, H., Love, J. D., Li, C. W., Banayo, E., Gooch, J. T., Krishna, V., Chatterjee, K., Evans, R. M., & Schwabe, J. W. R. (1999) · Genes & Development · doi:10.1101/gad.13.24.3209 · Cited by 419 · see citing works
Histone acetylation and control of gene expression
Turner, B. M. (1991) · Journal of Cell Science · doi:10.1242/jcs.99.1.13 · Cited by 340 · see citing works
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
Westin, S. K., Kurokawa, R., Nolte, R. T., Wisely, G. B., McInerney, E. M., Rose, D. W., Milburn, M. V., Rosenfeld, M. G., & Glass, C. K. (1998) · Nature · doi:10.1038/26040 · Cited by 333 · see citing works
Steroid receptor induction of gene transcription: A two-step model
Jenster, G. W., Spencer, T. E., Burcin, M. M., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7879 · Cited by 263 · see citing works
Henttu, P. M. A., Kalkhoven, E., & Parker, M. G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1832 · Cited by 212 · see citing works
Masuyama, H., Brownfield, C. M., St‐Arnaud, R., & MacDonald, P. N. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9990 · Cited by 157 · see citing works
Biochemical Methods for Analysis of Histone Deacetylases
Kölle, D., Brosch, G., Lechner, T., Lusser, A., & Loidl, P. (1998) · Methods · doi:10.1006/meth.1998.0636 · Cited by 146 · see citing works
Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2
Lee, C., Chinpaisal, C., & Wei, L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6745 · Cited by 139 · see citing works
Self-citationZamir, I., Dawson, J., Lavinsky, R. M., Glass, C. K., Rosenfeld, M. G., & Lazar, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14400 · Cited by 135 · see citing works
Chen, W., & Townes, T. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.377 · Cited by 125 · see citing works
Subramaniam, N., Treuter, E., & Okret, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.18121 · Cited by 99 · see citing works
Miyata, K., McCaw, S. E., Meertens, L. M., Patel, H. V., Rachubinski, R. A., & Capone, J. P. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00196-8 · Cited by 71 · see citing works
Characterization of Receptor-interacting Protein 140 in Retinoid Receptor Activities
Lee, C., & Wei, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31320 · Cited by 64 · see citing works
Self-citationEng, F. C. S., Barsalou, A., Akutsu, N., Mercier, I., Zechel, C., Mader, S., & White, J. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28371 · Cited by 61 · see citing works
Chuang, F. M., West, B. L., Baxter, J. D., & Schaufele, F. (1997) · Molecular Endocrinology · doi:10.1210/me.11.9.1332 · Cited by 56 · see citing works
Dudley, M. W., Sheeler, C. Q., Wang, H., & Khan, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3696 · Cited by 54 · see citing works
A SAGA of histone acetylation and gene expression
Hampsey, M. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01292-4 · Cited by 34 · see citing works
Identification and Analysis of Native Nucleosomal Histone Acetyltransferase Complexes
Grant, P. A., Berger, S. L., & Workman, J. L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-681-9:311 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532 · see citing works
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408 · see citing works
Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Nuclear receptor corepressor RIP140 regulates fat accumulation
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works
The role of corepressors in transcriptional regulation by nuclear hormone receptors.
Privalsky, M. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032802.155556 · Cited by 335 · see citing works
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
Rochette‐Egly, C., & Germain, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07005 · Cited by 244 · see citing works
Estrogen receptors: orchestrators of pleiotropic cellular responses
Moggs, J. G., & Orphanides, G. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve185 · Cited by 234 · see citing works
Coactivators in PPAR-Regulated Gene Expression
Viswakarma, N., Jia, Y., Bai, L., Vluggens, A., Borensztajn, J., Xu, J., & Reddy, J. K. (2010) · PPAR Research · doi:10.1155/2010/250126 · Cited by 232 · see citing works
Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy
Shao, W., & Brown, M. A. (2003) · Breast Cancer Research · doi:10.1186/bcr742 · Cited by 201 · see citing works
Cancer Drug Discovery and Development
Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195 · see citing works
Nuclear hormone receptor co-repressors: Structure and function
Watson, P. J., Fairall, L., & Schwabe, J. W. R. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.033 · Cited by 164 · see citing works
Vo, N., Fjeld, C. C., & Goodman, R. H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6181-6188.2001 · Cited by 154 · see citing works
Tsai, N., Lin, Y., & Wei, L. (2009) · Biochemical Journal · doi:10.1042/bj20090915 · Cited by 145 · see citing works
Self-citationThe Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ
Pardee, K., Xu, X., Reinking, J., Schuetz, A., Dong, A., Liu, S., Zhang, R., Tiefenbach, J., Lajoie, G., Plotnikov, A. N., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000043 · Cited by 133 · see citing works
Estrogen receptor corepressors -- a role in human breast cancer?
Dobrzycka, K. M., Townson, S., Jiang, S., & Oesterreich, S. (2003) · Endocrine-Related Cancer · doi:10.1677/erc.0.0100517 · Cited by 138 · see citing works
Li, F., Wu, R., Cui, X., Zha, L., Yu, L., Shi, H., & Xue, B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.677930 · Cited by 118 · see citing works
Retinoid Receptors and Their Coregulators
Wei, L. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140301 · Cited by 116 · see citing works
Self-citationKurtev, V., Margueron, R., Kroboth, K., Ogris, E., Cavaillès, V., & Seiser, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312300200 · Cited by 112 · see citing works
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
Kiskinis, E., Hallberg, M., Christian, M., Olofsson, M., Dilworth, S. M., White, R., & Parker, M. G. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601908 · Cited by 111 · see citing works
Castet‐Nicolas, A., Herlédan, A., Bonnet, S., Jalaguier, S., Vanacker, J.-M., & Cavaillès, V. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0227 · Cited by 111 · see citing works
Coregulators: From Whence Came These “Master Genes”
O’Malley, B. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0012 · Cited by 110 · see citing works
Ho, P., Tsui, Y.-C., Feng, X., Greaves, D. R., & Wei, L. (2012) · Nature Immunology · doi:10.1038/ni.2238 · Cited by 108 · see citing works
Self-citationZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
Lopez-Garcia, J., Periyasamy, M., Thomas, R. S., Christian, M., Leao, M., Jat, P., Kindle, K. B., Heery, D. M., Parker, M. G., Buluwela, L., et al. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl875 · Cited by 106 · see citing works
Metabolic regulation by the nuclear receptor corepressor RIP140
Christian, M., White, R., & Parker, M. G. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.06.008 · Cited by 106 · see citing works
Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation
Huq, M. D. M., Gupta, P. K., Tsai, N., White, R., Parker, M. G., & Wei, L. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601389 · Cited by 107 · see citing works
Self-citationMinireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism
Lin, J. D. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0344 · Cited by 101 · see citing works
Jin, C., Li, K., Murata, T., Sun, K., Horikoshi, M., Chiu, R., & Yokoyama, K. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4815-4826.2002 · Cited by 103 · see citing works
TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
Nakajima, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh741 · Cited by 102 · see citing works
Negative regulation by nuclear receptors: a plethora of mechanisms
Santos, G. M., Fairall, L., & Schwabe, J. W. R. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.11.004 · Cited by 96 · see citing works
Herzog, B., Hallberg, M., Seth, A., Woods, A., White, R., & Parker, M. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0213 · Cited by 95 · see citing works
Distinct functions for RIP140 in development, inflammation, and metabolism
Nautiyal, J., Christian, M., & Parker, M. G. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.001 · Cited by 94 · see citing works
Lee, W. S., & Kim, J. (2015) · PPAR Research · doi:10.1155/2015/271983 · Cited by 93 · see citing works
ASXL1 Represses Retinoic Acid Receptor-mediated Transcription through Associating with HP1 and LSD1
Lee, S.-W., Cho, Y.-S., Na, J.-M., Park, U., Kang, M., Kim, E., & Um, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.065862 · Cited by 90 · see citing works
RetractedSuzuki, A., Sanda, N., Miyawaki, Y., Fujimori, Y., Yamada, T., Takagi, A., Murate, T., Saito, H., & Kojima, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062430 · Cited by 90 · see citing works
CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor β Signaling Pathway
Sabbah, M., Prunier, C., Ferrand, N., Megalophonos, V., Lambein, K., De Wever, O., Nazaret, N., Lachuer, J., Dumont, S., & Redeuilh, G. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01316-10 · Cited by 89 · see citing works
Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition
Castet‐Nicolas, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh524 · Cited by 83 · see citing works
Abu, J., Batuwangala, M., Herbert, K. E., & Symonds, P. R. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70319-3 · Cited by 84 · see citing works
Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation
Huq, M. D. M., Tsai, N., Lin, Y.-P., Higgins, L., & Wei, L. (2007) · Nature Chemical Biology · doi:10.1038/nchembio861 · Cited by 81 · see citing works
Self-citationThe Roles of Peroxisome Proliferator-Activated Receptors in the Metabolic Syndrome
Mansour, M. M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00007-7 · Cited by 80 · see citing works
Corepressor Recruitment by Agonist-Bound Nuclear Receptors
White, J. H., Fernandes, I., Mader, S., & Yang, X. (2004) · Vitamins and hormones · doi:10.1016/s0083-6729(04)68004-6 · Cited by 77 · see citing works
The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis
Bird, R. P. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.11.004 · Cited by 73 · see citing works
Role of RIP140 in metabolic tissues: Connections to disease
White, R., Morganstein, D. L., Christian, M., Seth, A., Herzog, B., & Parker, M. G. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.017 · Cited by 71 · see citing works
The metabolic coregulator RIP140: an update
Fritah, A., Christian, M., & Parker, M. G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00243.2010 · Cited by 71 · see citing works
Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer
Choi, H., Joo, H.-S., Won, H., Min, K., Kim, H.-Y., Son, T., Oh, Y., Lee, J., & Kong, G. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx207 · Cited by 71 · see citing works
Zilliacus, J., Holter, E., Wakui, H., Tazawa, H., Treuter, E., & Gustafsson, J.-Α. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.4.0624 · Cited by 70 · see citing works
Christian, M., Tullet, J. M. A., & Parker, M. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313906200 · Cited by 67 · see citing works
Jeong, B., Hong, C. Y., Chattopadhyay, S., Park, J., Gong, E., Kim, H., Chun, S., & Lee, K. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0065 · Cited by 67 · see citing works
Kerley-Hamilton, J. S., Olsen, S. L., Freemantle, S. J., & Spinella, M. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5274 · Cited by 67 · see citing works
NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome
Izzo, A., Manco, R., Bonfiglio, F., Calı̀, G., de Cristofaro, T., Patergnani, S., Cicatiello, R., Scrima, R., Zannini, M., Pinton, P., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu157 · Cited by 64 · see citing works
Légaré, S., & Basik, M. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1072 · Cited by 63 · see citing works
Emerging roles for TNIP1 in regulating post-receptor signaling
Ramirez, V. P., Gurevich, I., & Aneskievich, B. J. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.002 · Cited by 62 · see citing works
The nuclear receptor transcriptional coregulator RIP140
Augereau, P., Badia, É., Carascossa, S., Castet‐Nicolas, A., Fritsch, S., Harmand, P.-O., Jalaguier, S., & Cavaillès, V. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04024 · Cited by 59 · see citing works
Jahnke, P., Xu, W., Wulling, M., Albrecht, M., Gabriel, H., Gillessen‐Kaesbach, G., & Kaiser, F. J. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn688 · Cited by 58 · see citing works
SUMOylation Modulates the Transcription Repressor Function of RIP140
Rytinki, M. M., & Palvimo, J. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709359200 · Cited by 56 · see citing works
Role of nuclear receptor corepressor RIP140 in metabolic syndrome
Rosell, M., Jones, M. C., & Parker, M. G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.016 · Cited by 52 · see citing works
Minireview: Role of Protein Methylation and Demethylation in Nuclear Hormone Signaling
Wu, S. C., & Zhang, Y. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0131 · Cited by 52 · see citing works
Negative regulation of hormone signaling by RIP140
Augereau, P., Badia, É., Balaguer, P., Carascossa, S., Castet‐Nicolas, A., Jalaguier, S., & Cavaillès, V. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.005 · Cited by 52 · see citing works
Jiang, S., Meyer, R., Kang, K., Osborne, C. K., Wong, J., & Oesterreich, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0100 · Cited by 51 · see citing works
Gupta, P. K., Huq, M. D. M., Khan, S. A., Tsai, N., & Wei, L. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500236-mcp200 · Cited by 51 · see citing works
Self-citationNuclear Receptor Recruitment of Histone-Modifying Enzymes to Target Gene Promoters
Tsai, C., & Fondell, J. D. (2004) · Vitamins and hormones · doi:10.1016/s0083-6729(04)68003-4 · Cited by 50 · see citing works
Teyssier, C., Belguise, K., Galtier, F., Cavaillès, V., & Chalbos, D. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0324 · Cited by 48 · see citing works
Wei, L., Farooqui, M., & Hu, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010185200 · Cited by 49 · see citing works
Self-citationEpigenetic Regulation of TRAIL Signaling: Implication for Cancer Therapy
Elmallah, M. I. Y., & Micheau, O. (2019) · Cancers · doi:10.3390/cancers11060850 · Cited by 47 · see citing works
Receptor-Interacting Protein 140 Is a Repressor of the Androgen Receptor Activity
Carascossa, S., Gobinet, J., Georget, V., Lucas, A., Badia, É., Castet‐Nicolas, A., White, R., Nicolas, J., Cavaillès, V., & Jalaguier, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0286 · Cited by 47 · see citing works
Tazawa, H., Osman, W., Shoji, Y., Treuter, E., Gustafsson, J.-Α., & Zilliacus, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4187-4198.2003 · Cited by 46 · see citing works
Stouth, D. W., vanLieshout, T. L., Shen, N. Y., & Ljubicic, V. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00870 · Cited by 46 · see citing works
Role of the RIP140 corepressor in ovulation and adipose biology
Steel, J. H., White, R., & Parker, M. G. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05896 · Cited by 46 · see citing works
Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter
Chuang, Y.-S., Huang, W.-H., Park, S. W., Persaud, S. D., Hung, C.-H., Ho, P., & Wei, L. (2011) · Stem Cells · doi:10.1002/stem.623 · Cited by 44 · see citing works
Self-citationPeroxisome proliferator‐activated receptor‐γ cofactors in neurodegeneration
Katsouri, L., Blondrath, K., & Sastre, M. (2012) · IUBMB Life · doi:10.1002/iub.1097 · Cited by 43 · see citing works
A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction
Speltz, T. E., Danes, J. M., Stender, J. D., Frasor, J. M., & Moore, T. W. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b01016 · Cited by 42 · see citing works
Sanyal, S., Matthews, J. B., Bouton, D., Kim, H.-J., Choi, H., Treuter, E., & Gustafsson, J.-Α. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0165 · Cited by 42 · see citing works
Huq, M. D. M., & Wei, L. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500015-mcp200 · Cited by 41 · see citing works
Self-citationHo, P., Gupta, P. K., Tsui, Y.-C., Ha, S. G., Huq, M. D. M., & Wei, L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.07.001 · Cited by 40 · see citing works
Self-citationCognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression
Duclot, F., Lapierre, M., Fritsch, S., White, R., Parker, M. G., Maurice, T., & Cavaillès, V. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00731.x · Cited by 39 · see citing works
Gupta, P. K., Ho, P., Huq, M. D. M., Khan, A. A., Tsai, N., & Wei, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002658 · Cited by 36 · see citing works
Self-citationEpigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance.
Raha, P., Thomas, S., & Munster, P. (2011) · Epigenomics · doi:10.2217/epi.11.72 · Cited by 37 · see citing works
Negative Feedback at the Level of Nuclear Receptor Coregulation
White, K. A., Yore, M. M., Warburton, S. L., Vaseva, A. V., Rieder, E., Freemantle, S. J., & Spinella, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300374200 · Cited by 35 · see citing works
Nuclear and Extra-Nuclear Effects of Retinoid Acid Receptors: How They Are Interconnected
Piskunov, A., Tanoury, Z. A., & Rochette‐Egly, C. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9050-5_6 · Cited by 34 · see citing works
Spinella, M. J., Kerley-Hamilton, J. S., White, K. A., & Curtin, J. C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.273s · Cited by 34 · see citing works
Marshall, P. A., Hernandez, Z., Kaneko, I., Widener, T., Tabacaru, C., Aguayo, I., & Jurutka, P. W. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.05.001 · Cited by 33 · see citing works
Hu, X., Chen, Y., Farooqui, M., Thomas, M. C., Chiang, C., & Wei, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307621200 · Cited by 33 · see citing works
Self-citationPark, S. W., Huang, W.-H., Persaud, S. D., & Wei, L. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp780 · Cited by 33 · see citing works
Self-citationLeonardsson, G., Jacobs, M. A., White, R., Jeffery, R. E., Poulsom, R., Milligan, S. R., & Parker, M. G. (2002) · Endocrinology · doi:10.1210/en.143.2.700 · Cited by 33 · see citing works
Limiting Effects of RIP140 in Estrogen Signaling
White, K. A., Yore, M. M., Deng, D., & Spinella, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412707200 · Cited by 32 · see citing works
Lysine Methylation of Nuclear Co-Repressor Receptor Interacting Protein 140
Huq, M. D. M., Ha, S. G., Barcelona, H., & Wei, L. (2009) · Journal of Proteome Research · doi:10.1021/pr800569c · Cited by 30 · see citing works
Self-citationHeim, K. C., White, K. A., Deng, D., Tomlinson, C. R., Moore, J. H., Freemantle, S. J., & Spinella, M. J. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-57 · Cited by 30 · see citing works
Gupta, P. K., Park, S. W., Farooqui, M., & Wei, L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1147 · Cited by 29 · see citing works
Self-citationSuppression of Hepatitis B Virus Core Promoter by the Nuclear Orphan Receptor TR4
Lin, W., Li, J., Lee, Y.-F., Yeh, S.-D., Altuwaijri, S., Ou, J. J., & Chang, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205944200 · Cited by 29 · see citing works
Franco, P. J., Farooqui, M., Seto, E., & Wei, L. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.8.0682 · Cited by 29 · see citing works
Self-citationWu, C., Feng, X., & Wei, L. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku092 · Cited by 28 · see citing works
Self-citationTranscriptional coregulator RIP140: an essential regulator of physiology
Nautiyal, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0156 · Cited by 26 · see citing works
Huq, M. D. M., Khan, S. A., Park, S. W., & Wei, L. (2005) · PROTEOMICS · doi:10.1002/pmic.200401090 · Cited by 26 · see citing works
Self-citationRIF‐1, a novel nuclear receptor corepressor that associates with the nuclear matrix
Li, H. J., Haque, Z. K., Chen, A. Y.-C., & Mendelsohn, M. E. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21340 · Cited by 25 · see citing works
Mellgren, G., Børud, B., Hoang, T., Yri, O. E., Fladeby, C., Lien, E. A., & Lund, J. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00097-2 · Cited by 25 · see citing works
Novel genes differentially expressed in cortical regions during late neurogenesis
Mühlfriedel, S., Kirsch, F., Gruß, P., Chowdhury, K., & Stoykova, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05639.x · Cited by 25 · see citing works
Merrell, K. W., Crofts, J. D., Smith, R. L., Sin, J. H., Kmetzsch, K. E., Merrell, A. J., Miguel, R. O., Candelaria, N. R., & Lin, C.-Y. (2010) · Oncogene · doi:10.1038/onc.2010.528 · Cited by 24 · see citing works
Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140
Chen, Y., Hu, X., & Wei, L. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.07.001 · Cited by 23 · see citing works
Self-citationThe nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks
Parker, M. G., Christian, M., & White, R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341103 · Cited by 21 · see citing works
Wu, C., Persaud, S. D., & Wei, L. (2015) · Stem Cells · doi:10.1002/stem.2190 · Cited by 20 · see citing works
Self-citationGupta, P. K., Ho, P., Ha, S. G., Lin, Y.-W., & Wei, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004363 · Cited by 20 · see citing works
Self-citation
- Authors
- Wei, L.-N., Hu, X., Chandra, D., Seto, E., & Farooqui, M.
- Affiliations
- University of Minnesota (US)
- University of South Florida (US)
- Corresponding author
- Wei, Li-Na
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 275
- Issue
- 52
- Pages
- 40782-40787
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1969973975
- Cited by
- 150
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases ([DK54733, R01DK054733)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- RIP140, histone deacetylase, HDAC1, HDAC3, gene silencing, histone deacetylation, protein-protein interaction, chromatin
- MeSH terms
- Nuclear Receptor Interacting Protein 1, Animals, Binding Sites, Chromatin, Histone Deacetylases, Histones, Hydroxamic Acids, Nuclear Proteins, Tretinoin, Receptors, Tumor Necrosis Factor, COS Cells, Gene Silencing, Adaptor Proteins, Signal Transducing, Receptors, TNF-Related Apoptosis-Inducing Ligand
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review