CoChat
Sign Up
Cited by 366Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Nuclear receptor corepressor RIP140 regulates fat accumulation

Open access
Leonardsson, Göran, Steel, Jenny H., Christian, Mark, Pocock, Victoria, Milligan, Stuart, Bell, Jimmy, So, Po-Wah, Medina-Gomez, Gema +3 more·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0401013101PMC PMC420412
Open this paper in CoChat — free account

Abstract

Nuclear receptors and their coactivators have been shown to function as key regulators of adipose tissue biology. Here we show that a ligand-dependent transcriptional repressor for nuclear receptors plays a crucial role in regulating the balance between energy storage and energy expenditure. Mice devoid of the corepressor protein RIP140 are lean, show resistance to high-fat diet-induced obesity and hepatic steatosis, and have increased oxygen consumption. Although the process of adipogenesis is unaffected, expression of certain lipogenic enzymes is reduced. In contrast, genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1, are markedly increased. Therefore, the maintenance of energy homeostasis requires the action of a transcriptional repressor in white adipose tissue, and ligand-dependent recruitment of RIP140 to nuclear receptors may provide a therapeutic target in the treatment of obesity and related disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.0401013101

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Transgenic mice with UCP1 expression in white fat display a lean phenotype.

    “Conversely, transgenic mice with UCP1 expression in white fat display lean phenotype 34,35.”

    From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [35]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 56

  1. [1]Spiegelman, B. M. & Flier, J. S. (2001) Cell 104, 531-543. [DOI] [PubMed] [Google Scholar]
  2. [2]Ahima, R. S. & Flier, J. S. (2000) Trends Endocrinol. Metab. 11, 327-332. [DOI] [PubMed] [Google Scholar]
  3. [3]Rajala, M. W. & Scherer, P. E. (2003) Endocrinology 144, 3765-3773. [DOI] [PubMed] [Google Scholar]
  4. [4]Lowell, B. B. & Spiegelman, B. M. (2000) Nature 404, 652-660. [DOI] [PubMed] [Google Scholar]
  5. [5]Francis, G. A., Fayard, E., Picard, F. & Auwerx, J. (2003) Annu. Rev. Physiol. 65, 261-311. [DOI] [PubMed] [Google Scholar]
  6. [6]Desvergne, B. & Wahli, W. (1999) Endocr. Rev. 20, 649-688. [DOI] [PubMed] [Google Scholar]
  7. [7]Lee, C. H., Olson, P. & Evans, R. M. (2003) Endocrinology 144, 2201-2207. [DOI] [PubMed] [Google Scholar]
  8. [8]Ribeiro, M. O., Carvalho, S. D., Schultz, J. J., Chiellini, G., Scanlan, T. S., Bianco, A. C. & Brent, G. A. (2001) J. Clin. Invest. 108, 97-105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. [9]Viguerie, N., Millet, L., Avizou, S., Vidal, H., Larrouy, D. & Langin, D. (2002) J. Clin. Endocrinol. Metab. 87, 630-634. [DOI] [PubMed] [Google Scholar]
  10. [10]Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B. & Cooke, P. S. (2000) Proc. Natl. Acad. Sci. USA 97, 12729-12734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. [11]Ohlsson, C., Hellberg, N., Parini, P., Vidal, O., Bohlooly, M., Rudling, M., Lindberg, M. K., Warner, M., Angelin, B. & Gustafsson, J. A. (2000) Biochem. Biophys. Res. Commun. 278, 640-645. [DOI] [PubMed] [Google Scholar]
  12. [12]Luo, J., Sladek, R., Carrier, J., Bader, J. A., Richard, D. & Giguere, V. (2003) Mol. Cell. Biol. 23, 7947-7956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. [13]Lazar, M. A. (2002) Genes Dev. 16, 1-5. [DOI] [PubMed] [Google Scholar]
  14. [14]Mueller, E., Drori, S., Aiyer, A., Yie, J., Sarraf, P., Chen, H., Hauser, S., Rosen, E. D., Ge, K., Roeder, R. G. & Spiegelman, B. M. (2002) J. Biol. Chem. 277, 41925-41930. [DOI] [PubMed] [Google Scholar]
  15. [15]Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P. & Camp, H. S. (2002) Genes Dev. 16, 27-32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. [16]Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y. Z., Ruiz-Lozano, P., Chien, K. R., Koder, A. & Evans, R. M. (1999) Mol. Cell 4, 585-595. [DOI] [PubMed] [Google Scholar]
  17. [17]Kelly, D. P. (2003) Circ. Res. 92, 482-484. [DOI] [PubMed] [Google Scholar]
  18. [18]Peters, J. M., Hennuyer, N., Staels, B., Fruchart, J. C., Fievet, C., Gonzalez, F. J. & Auwerx, J. (1997) J. Biol. Chem. 272, 27307-27312. [DOI] [PubMed] [Google Scholar]
  19. [19]Barbera, M. J., Schluter, A., Pedraza, N., Iglesias, R., Villarroya, F. & Giralt, M. (2001) J. Biol. Chem. 276, 1486-1493. [DOI] [PubMed] [Google Scholar]
  20. [20]Wang, Y. X., Lee, C. H., Tiep, S., Yu, R. T., Ham, J., Kang, H. & Evans, R. M. (2003) Cell 113, 159-170. [DOI] [PubMed] [Google Scholar]
  21. [21]McKenna, N. J. & O'Malley, B. W. (2002) Cell 108, 465-474. [DOI] [PubMed] [Google Scholar]
  22. [22]Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M. & Spiegelman, B. M. (1998) Cell 92, 829-839. [DOI] [PubMed] [Google Scholar]
  23. [23]Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C. & Spiegelman, B. M. (1999) Cell 98, 115-124. [DOI] [PubMed] [Google Scholar]
  24. [24]Puigserver, P. & Spiegelman, B. M. (2003) Endocr. Rev. 24, 78-90. [DOI] [PubMed] [Google Scholar]
  25. [25]Vega, R. B., Huss, J. M. & Kelly, D. P. (2000) Mol. Cell. Biol. 20, 1868-1876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. [26]Lin, J., Puigserver, P., Donovan, J., Tarr, P. & Spiegelman, B. M. (2002) J. Biol. Chem. 277, 1645-1648. [DOI] [PubMed] [Google Scholar]
  27. [27]Meirhaeghe, A., Crowley, V., Lenaghan, C., Lelliott, C., Green, K., Stewart, A., Hart, K., Schinner, S., Sethi, J. K., Yeo, G., et al. (2003) Biochem. J. 373, 155-165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. [28]Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O. & Kakizuka, A. (2003) Proc. Natl. Acad. Sci. USA 100, 12378-12383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. [29]Picard, F., Gehin, M., Annicotte, J., Rocchi, S., Champy, M. F., O'Malley, B. W., Chambon, P. & Auwerx, J. (2002) Cell 111, 931-941. [DOI] [PubMed] [Google Scholar]
  30. [30]Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A. S., Lunyak, V., McEvilly, R. J., Kurokawa, R., Kumar, V., Liu, F., Seto, E., et al. (2000) Cell 102, 753-763. [DOI] [PubMed] [Google Scholar]
  31. [31]Nagy, L., Kao, H. Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L. & Evans, R. M. (1997) Cell 89, 373-380. [DOI] [PubMed] [Google Scholar]
  32. [32]Gurnell, M., Wentworth, J. M., Agostini, M., Adams, M., Collingwood, T. N., Provenzano, C., Browne, P. O., Rajanayagam, O., Burris, T. P., Schwabe, J. W., et al. (2000) J. Biol. Chem. 275, 5754-5759. [DOI] [PubMed] [Google Scholar]
  33. [33]Cavailles, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J. & Parker, M. G. (1995) EMBO J. 14, 3741-3751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. [34]L'Horset, F., Dauvois, S., Heery, D. M., Cavailles, V. & Parker, M. G. (1996) Mol. Cell. Biol. 16, 6029-6036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. [35]Treuter, E., Albrektsen, T., Johansson, L., Leers, J. & Gustafsson, J. A. (1998) Mol. Endocrinol. 12, 864-881. [DOI] [PubMed] [Google Scholar]
  36. [36]Fernandes, I., Bastien, Y., Wai, T., Nygard, K., Lin, R., Cormier, O., Lee, H. S., Eng, F., Bertos, N. R., Pelletier, N., et al. (2003) Mol. Cell 11, 139-150. [DOI] [PubMed] [Google Scholar]
  37. [37]Wei, L. N., Hu, X., Chandra, D., Seto, E. & Farooqui, M. (2000) J. Biol. Chem. 275, 40782-40787. [DOI] [PubMed] [Google Scholar]
  38. [38]Christian, M., Tullet, J. M. & Parker, M. G. (2004) J. Biol. Chem. 279, 15645-15651. [DOI] [PubMed] [Google Scholar]
  39. [39]Vo, N., Fjeld, C. & Goodman, R. H. (2001) Mol. Cell. Biol. 21, 6181-6188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. [40]Kumar, V., Carlson, J. E., Ohgi, K. A., Edwards, T. A., Rose, D. W., Escalante, C. R., Rosenfeld, M. G. & Aggarwal, A. K. (2002) Mol. Cell 10, 857-869. [DOI] [PubMed] [Google Scholar]
  41. [41]Kozak, L. P. & Harper, M. E. (2000) Annu. Rev. Nutr. 20, 339-363. [DOI] [PubMed] [Google Scholar]
  42. [42]White, R., Leonardsson, G., Rosewell, I., Ann Jacobs, M., Milligan, S. & Parker, M. (2000) Nat. Med. 6, 1368-1374. [DOI] [PubMed] [Google Scholar]
  43. [43]Soukas, A., Socci, N. D., Saatkamp, B. D., Novelli, S. & Friedman, J. M. (2001) J. Biol. Chem. 276, 34167-34174. [DOI] [PubMed] [Google Scholar]
  44. [44]McGarry, J. D. & Brown, N. F. (1997) Eur. J. Biochem. 244, 1-14. [DOI] [PubMed] [Google Scholar]
  45. [45]Barrero, M. J., Camarero, N., Marrero, P. F. & Haro, D. (2003) Biochem. J. 369, 721-729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. [46]Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovska, P., Horakova, M., Syrovy, I., Cinti, S. & Kopecky, J. (2002) Eur. J. Biochem. 269, 19-28. [DOI] [PubMed] [Google Scholar]
  47. [47]Walczak, R. & Tontonoz, P. (2003) Nat. Med. 9, 1348-1349. [DOI] [PubMed] [Google Scholar]
  48. [48]del Mar Gonzalez-Barroso, M., Pecqueur, C., Gelly, C., Sanchis, D., Alves-Guerra, M. C., Bouillaud, F., Ricquier, D. & Cassard-Doulcier, A. M. (2000) J. Biol. Chem. 275, 31722-31732. [DOI] [PubMed] [Google Scholar]
  49. [49]Alvarez, R., de Andres, J., Yubero, P., Vinas, O., Mampel, T., Iglesias, R., Giralt, M. & Villarroya, F. (1995) J. Biol. Chem. 270, 5666-5673. [DOI] [PubMed] [Google Scholar]
  50. [50]Hernandez, A. & Obregon, M. J. (2000) Am. J. Physiol. 278, E769-E777. [DOI] [PubMed] [Google Scholar]
  51. [51]Sears, I. B., MacGinnitie, M. A., Kovacs, L. G. & Graves, R. A. (1996) Mol. Cell. Biol. 16, 3410-3419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. [52]Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D. & Langin, D. (2003) J. Biol. Chem. 278, 33370-33376. [DOI] [PubMed] [Google Scholar]
  53. [53]Tazawa, H., Osman, W., Shoji, Y., Treuter, E., Gustafsson, J. A. & Zilliacus, J. (2003) Mol. Cell. Biol. 23, 4187-4198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. [54]Rosen, E. D. (2003) Curr. Biol. 13, R961-R963. [DOI] [PubMed] [Google Scholar]
  55. [55]Ge, K., Guermah, M., Yuan, C. X., Ito, M., Wallberg, A. E., Spiegelman, B. M. & Roeder, R. G. (2002) Nature 417, 563-567. [DOI] [PubMed] [Google Scholar]
  56. [56]Flier, J. S. (2004) Cell 116, 337-350. [DOI] [PubMed] [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., & Parker, M. G.
Affiliations
  • King's College London (GB)
  • Institute of Reproductive and Developmental Biology and Clinical Sciences Centre, MRI Unit, Hammersmith Campus, Imperial College London, Du Cane Road, London W12 ONN, United Kingdom; School of Biomedical Sciences, Guy's Campus, Kings College London, London SE1 1UL, United Kingdom; and Department of Medicine and Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
Corresponding author
Parker, Malcolm G.
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-05-20
Volume
101
Issue
22
Pages
8437-8442
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0401013101
PMC
PMC420412
OpenAlex
W2087236819
Cited by
366
References
57
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 14 · 2017: 18 · 2016: 19 · 2015: 20 · 2014: 21 · 2013: 25 · 2012: 23
FWCI
13.39
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Wellcome Trust (065326/Z/01/Z)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
RIP140, nuclear receptor corepressor, transcriptional repressor, fat deposition, obesity, hepatic steatosis, energy homeostasis, white adipose tissue, UCP1, mitochondrial uncoupling, energy expenditure, lipogenesis, adipogenesis, high-fat diet, oxygen consumption
MeSH terms
Nuclear Receptor Interacting Protein 1, Adipose Tissue, Animals, Body Weight, Cell Differentiation, Cells, Cultured, Dietary Fats, Energy Metabolism, Fibroblasts, Gene Expression Regulation, Liver, Magnetic Resonance Imaging, Mice, Inbred C57BL, Nuclear Proteins, Obesity, Phenotype, Repressor Proteins, Biomarkers, Adipocytes, Adaptor Proteins, Signal Transducing, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review