The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Coregulation of Neurite Outgrowth and Cell Survival by Amphoterin and S100 Proteins through Receptor for Advanced Glycation End Products (RAGE) Activation
Open accessAbstract
Amphoterin is a protein enhancing process extension and migration in embryonic neurons and in tumor cells through binding to receptor for advanced glycation end products (RAGE), a multiligand transmembrane receptor. S100 proteins, especially S100B, are abundantly expressed in the nervous system and are suggested to function as cytokines with both neurotrophic and neurotoxic effects. However, the cell surface receptor for the cytokine function of S100B has not been identified. Here we show that two S100 family proteins, S100B and S100A1, activate RAGE in concert with amphoterin inducing neurite outgrowth and activation of transcription factor NF-kappaB. Furthermore, activation of RAGE by amphoterin and S100B promotes cell survival through increased expression of the anti-apoptotic protein Bcl-2. However, whereas nanomolar concentrations of S100B induce trophic effects in RAGE-expressing cells, micromolar concentrations of S100B induce apoptosis in an oxidant-dependent manner. Both trophic and toxic effects are specific for cells expressing full-length RAGE since cells expressing a cytoplasmic domain deletion mutant of RAGE are unresponsive to these stimuli. These findings suggest that activation of RAGE by multiple ligands is able to promote trophic effects whereas hyperactivation of RAGE signaling pathways promotes apoptosis. We suggest that RAGE is a signal-transducing receptor for both trophic and toxic effects of S100B.
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Role of advanced glycation end products in cellular signaling
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“Low concentrations lead to more beneficial events (neurite outgrowth) and high concentrations, inducing more deleterious events (inflammatory signaling) [200].”
Background
Metadata
- Authors
- Huttunen, H. J., Kuja-Panula, J., Sorci, G., Agneletti, A. L., Donato, R., & Rauvala, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 275
- Issue
- 51
- Pages
- 40096-40105
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2008721781
- Cited by
- 577
- References
- 62
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Huttunen, H. J., Kuja-Panula, J., Sorci, G., Agneletti, A. L., Donato, R., & Rauvala, H. (2000). Coregulation of Neurite Outgrowth and Cell Survival by Amphoterin and S100 Proteins through Receptor for Advanced Glycation End Products (RAGE) Activation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m006993200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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