Cited by 393Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effectsEicosanoids and Hypertension Pharmacology

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Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2

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Kozak, Kevin R., Rowlinson, Scott W., Marnett, Lawrence J.·2000·Journal of Biological Chemistry

DOI 10.1074/jbc.m007088200

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Abstract

Cyclooxygenases (COX) play an important role in lipid signaling by oxygenating arachidonic acid to endoperoxide precursors of prostaglandins and thromboxane. Two cyclooxygenases exist which differ in tissue distribution and regulation but otherwise carry out identical chemical functions. The neutral arachidonate derivative, 2-arachidonylglycerol (2-AG), is one of two described endocannabinoids and appears to be a ligand for both the central (CB1) and peripheral (CB2) cannabinoid receptors. Here we report that 2-AG is a substrate for COX-2 and that it is metabolized as effectively as arachidonic acid. COX-2-mediated 2-AG oxygenation provides the novel lipid, prostaglandin H(2) glycerol ester (PGH(2)-G), in vitro and in cultured macrophages. PGH(2)-G produced by macrophages is a substrate for cellular PGD synthase, affording PGD(2)-G. Pharmacological studies reveal that macrophage production of PGD(2)-G from endogenous sources of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2. These results identify a distinct function for COX-2 in endocannabinoid metabolism and in the generation of a new family of prostaglandins derived from diacylglycerol and 2-AG.

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Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
CYCLOOXYGENASES 1 AND 2
Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,763
Cyclooxygenase in biology and disease
Dubois, R. N., Abramson, S. B., Crofford, L., Gupta, R., Simon, L. S., Putte, L., & Lipsky, P. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1063 · Cited by 2,606
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Kurumbail, R. G., Stevens, A. M., Gierse, J. K., McDonald, J. J., Stegeman, R. A., Pak, J. Y., Gildehaus, D., iyashiro, J. M., Penning, T. D., Seibert, K., et al. (1996) · Nature · doi:10.1038/384644a0 · Cited by 1,922
A second endogenous cannabinoid that modulates long-term potentiation
Stella, N., Schweitzer, P., & Piomelli, D. (1997) · Nature · doi:10.1038/42015 · Cited by 1,496
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C., & Seibert, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3228 · Cited by 1,310
Prostaglandin synthase 2
Herschman, H. R. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00194-8 · Cited by 1,200
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
Vane, J. R., Mitchell, J. A., Appleton, I., Tomlinson, A., Bishop‐Bailey, D., Croxtall, J. D., & Willoughby, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2046 · Cited by 1,035

Flagged first, then by citations

Show all 44 references

Research works printed but not linked: 7

Needleman, 1997, J. Rheumatol., 24 Suppl. 49, 6
Kennedy, 1993, Biochem. Cell Biol., 197, 494
Bisogno, 1999, Biochem. Cell Biol., 256, 377
Marnett, 1984, Mol. Pharmacol., 26, 328
Jeon, 1996, Mol. Pharmacol., 50, 334
Bleasdale, 1990, J. Pharmacol. Exp. Ther., 255, 756
Pinto, 1994, Mol. Pharmacol., 46, 516

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BindingDB (2012) · UC San Diego · doi:10.7270/q2j96753
BindingDB Entry 6181: Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System.
BindingDB (2014) · UC San Diego · doi:10.7270/q2t15295
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Authors: Kozak, K. R., Rowlinson, S. W., & Marnett, L. J.
Affiliations: Vanderbilt University (US)
Corresponding author: Marnett, Lawrence J.
ORCID: Kozak, Kevin R.
Marnett, Lawrence J.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2000-10
Volume: 275
Issue: 43
Pages: 33744-33749
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m007088200
OpenAlex: W2086458197
Cited by: 390
References: 44
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 18 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 17 · 2016: 18 · 2015: 15 · 2014: 16 · 2013: 19 · 2012: 18
FWCI: 8.84
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7306 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ca047479-10)
National Cancer Institute (CA-47479, CA 68484, P01CA068484)
National Institute of Environmental Health Sciences (ES00267)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: 2-arachidonoylglycerol, endocannabinoids, cyclooxygenase-2, endocannabinoid metabolism, macrophages, diacylglycerol lipase, lipid signaling, arachidonic acid oxygenation
MeSH terms: Animals, Arachidonic Acids, Binding Sites, Cell Line, Glycerides, Humans, Isoenzymes, Male, Membrane Proteins, Prostaglandin-Endoperoxide Synthases, Sheep, Prostaglandin D2, Mice, Cyclooxygenase 1, Cyclooxygenase 2, Cannabinoid Receptor Modulators, Endocannabinoids

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Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2

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