The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein
Open accessAbstract
The presynaptic alpha-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease. Here we examined the pathogenic mechanism of neuronal cell death induced by alpha-synuclein. The exogenous addition of alpha-synuclein caused a marked decrease of cell viability in primary and immortalized neuronal cells. The neuronal cell death appeared to be correlated with the Rab5A-specific endocytosis of alpha-synuclein that subsequently caused the formation of Lewy body-like intracytoplasmic inclusions. This was further supported by the fact that the expression of GTPase-deficient Rab5A resulted in a significant decrease of its cytotoxicity as a result of incomplete endocytosis of alpha-synuclein.
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Neuropathology of preclinical and clinical lateonset Alzheimer's disease
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Cited by
Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115
“…in the CM. Extracellular -synuclein is internalized by proliferating SH-SY5Y cells but not differentiated SH-SY5Y cells or cortical neurons It has been reported that recombinant -synuclein can be internalized by cells via endocytosis (Sung et al., 2001; Zhang et al., 2005; Ahn et al., 2006).”
BackgroundInfluentialExosomal cell-to-cell transmission of alpha synuclein oligomers
Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal-Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., & McLean, P. J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-42 · Cited by 853
α-Synuclein misfolding and Parkinson's disease
Breydo, L., Wu, J. W., & Uversky, V. N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.002 · Cited by 657
Cell Biology and Pathophysiology of α-Synuclein
Burré, J., Sharma, M., & Südhof, T. C. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a024091 · Cited by 579
Assembly-dependent endocytosis and clearance of extracellular a-synuclein
Lee, H.-J., Suk, J.-E., Bae, E.-J., Lee, J.-H., Paik, S. R., & Lee, S.-J. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.01.017 · Cited by 470
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Metadata
- Authors
- Sung, J. Y., Kim, J., Paik, S. R., Park, J. H., Ahn, Y. S., & Chung, K. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 276
- Issue
- 29
- Pages
- 27441-27448
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2147461093
- Cited by
- 200
- References
- 7
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sung, J. Y., Kim, J., Paik, S. R., Park, J. H., Ahn, Y. S., & Chung, K. C. (2001). Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m101318200
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