Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects

Borghi, Roberta; Marchese, Roberta; Negro, Alessandro; Marinelli, Lucio; Forloni, Gianluigi; Zaccheo, Damiano; Abbruzzese, Giovanni; Tabaton, Massimo

doi:10.1016/s0304-3940(00)01153-8

Full length α-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects

Several clues suggest that alpha-synuclein, a presynaptic protein, plays a central role in the pathogenesis of idiopathic Parkinson's disease (PD). To search a peripheral marker of PD, we analyzed presence and amount of alpha-synuclein in CSF from 12 PD patients and 10 neurologically normal subje…