The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion
Open accessAbstract
Reperfusion after myocardial ischemia is associated with a rapid influx of calcium, leading to activation of various enzymes including calpain. Isolated perfused adult rabbit hearts subjected to global ischemia and reperfusion were studied. Calpain or a calpain-like activity was activated within 15 min after reperfusion, and preconditioning suppressed calpain activation. In contrast, caspase activation was not detected although cytochrome c was released after ischemia and reperfusion. The pro-apoptotic BH3-only Bcl-2 family member, Bid, was cleaved during ischemia/reperfusion in the adult rabbit heart. Recombinant Bid was cleaved by calpain to a fragment that was able to mediate cytochrome c release. The calpain cleavage site was mapped to a region within Bid that is extremely susceptible to proteolysis. These findings suggest that there is cross-talk between apoptotic and necrotic pathways in myocardial ischemia/reperfusion injury.
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Cites
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Self-citationCross-Talk between Two Cysteine Protease Families
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Cited by
Cell death by necrosis: towards a molecular definition
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Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
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Age-related differences in apoptosis with disuse atrophy in soleus muscle
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Metadata
- Authors
- Chen, M., He, H., Zhan, S., Krajewski, S., Reed, J. C., & Gottlieb, R. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 276
- Issue
- 33
- Pages
- 30724-30728
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2087261949
- Cited by
- 396
- References
- 32
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion. https://app.cochat.ai/papers/10.1074/jbc.m103701200
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- Chen, M., He, H., Zhan, S., Krajewski, S., Reed, J. C., & Gottlieb, R. A. (2001). Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m103701200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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