The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation
Open accessAbstract
The zinc finger transcription factor GLI1, which mediates Sonic hedgehog signaling during development, is expressed in several human cancers, including basal cell carcinoma, medulloblastoma, and sarcomas. We identified 147 genes whose levels of expression were significantly altered in RNA obtained from cells demonstrating a transformed phenotype with stable GLI1 expression or stable Ha-ras expression. Comparison of expression profiles from GLI1- and Ha-ras-expressing cells established a set of genes unique to GLI1-induced cell transformation. Thirty genes were altered by stable GLI1 expression, and 124 genes were changed by stable Ha-ras expression. Seven genes had altered expression levels in both GLI1- and Ha-ras-expressing cells. Genes whose expression was altered by GLI1 included cell cycle genes, cell adhesion genes, signal transduction genes, and genes regulating apoptosis. GLI1 consensus DNA-binding sequences were identified in the 5' regions of cyclin D2, IGFBP-6, osteopontin, and plakoglobin, suggesting that these genes represent immediate downstream targets. Gel shift analysis confirmed the ability of the GLI1 protein to bind these sequences. Up-regulation of cyclin D2 and down-regulation of plakoglobin were demonstrated in GLI1-amplified compared with non-amplified human rhabdomyosarcoma cells. Many of the GLI1 targets with known function identified in this study increase cell proliferation, indicating that GLI1-induced cell transformation occurs through multiple downstream pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Parental imprinting of the mouse H19 gene
Bartolomei, M. S., Zemel, S., & Tilghman, S. M. (1991) · Nature · doi:10.1038/351153a0 · Cited by 1,224
Sonic hedgehog regulates the growth and patterning of the cerebellum
Dahmane, N., & Altaba, A. R. I. (1999) · Development · doi:10.1242/dev.126.14.3089 · Cited by 907
Roberts, C. J., Nelson, B., Marton, M. J., Stoughton, R., Meyer, M. R., Bennett, H. A., He, Y. D., Dai, H., Walker, W. L., Hughes, T. R., et al. (2000) · Science · doi:10.1126/science.287.5454.873 · Cited by 855
Sasaki, H., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1997) · Development · doi:10.1242/dev.124.7.1313 · Cited by 674
Drug target validation and identification of secondary drug target effects using DNA microarrays
Marton, M. J., DeRisi, J. L., Bennett, H. A., Iyer, V. R., Meyer, M. R., Roberts, C. J., Stoughton, R., Burchard, J., Slade, D., Dai, H., et al. (1998) · Nature Medicine · doi:10.1038/3282 · Cited by 643
Dahmane, N., Lee, J., Robins, P., Heller, P., & Altaba, A. R. I. (1997) · Nature · doi:10.1038/39918 · Cited by 639
Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H.-Q., Chik, K. W., Shi, X.-M., Tsui, L.-C., Cheng, S. H., et al. (1997) · Development · doi:10.1242/dev.124.1.113 · Cited by 605
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families
Vortkamp, A., Gessler, M., & Grzeschik, K.-H. (1991) · Nature · doi:10.1038/352539a0 · Cited by 545
Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A., & Joyner, A. L. (1998) · Development · doi:10.1242/dev.125.15.2759 · Cited by 489
Makałowski, W., & Boguski, M. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9407 · Cited by 460
Cited by
Basal cell carcinomas: attack of the hedgehog
Epstein, E. H. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2503 · Cited by 834
Structural basis for the recognition of Sonic Hedgehog by human Patched1
Gong, X., Qian, H., Cao, P., Zhao, X., Zhou, Q., Lei, J., & Yan, N. (2018) · Science · doi:10.1126/science.aas8935 · Cited by 216
REN KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
Di Marcotullio, L., Ferretti, E., De Smaele, E., Argenti, B., Mincione, C., Zazzeroni, F., Gallo, R., Masuelli, L., Napolitano, M., Maroder, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400690101 · Cited by 179
Argenti, B., Gallo, R., Di Marcotullio, L., Ferretti, E., Napolitano, M., Canterini, S., De Smaele, E., Greco, A., Fiorenza, M. T., Maroder, M., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2438-05.2005 · Cited by 73
Metadata
- Authors
- Yoon, J. W., Kita, Y., Frank, D. J., Majewski, R. R., Konicek, B. A., Nobrega, M. A., Jacob, H., Walterhouse, D., & Iannaccone, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 277
- Issue
- 7
- Pages
- 5548-5555
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2120954784
- Cited by
- 334
- References
- 37
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation. https://app.cochat.ai/papers/10.1074/jbc.m105708200
- The paper
- Yoon, J. W., Kita, Y., Frank, D. J., Majewski, R. R., Konicek, B. A., Nobrega, M. A., Jacob, H., Walterhouse, D., & Iannaccone, P. (2002). Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m105708200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
