Identification and Characterization of RA-GEF-2, a Rap Guanine Nucleotide Exchange Factor That Serves as a Downstream Target of M-Ras

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256 · see citing works

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., & Bos, J. L. (1998) · Nature · doi:10.1038/24884 · Cited by 1,970 · see citing works

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,632 · see citing works

A Family of cAMP-Binding Proteins That Directly Activate Rap1

Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., & Graybiel, A. M. (1998) · Science · doi:10.1126/science.282.5397.2275 · Cited by 1,360 · see citing works

FUNCTION AND REGULATION OF RAS

Lowy, D. R., & Willumsen, B. M. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.004223 · Cited by 1,164 · see citing works

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

Vossler, M. R., Yao, H. W., York, R. D., Pan, M., Rim, C. S., & Stork, P. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80184-1 · Cited by 1,044 · see citing works

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

York, R. D., Yao, H. W., Dillon, T. J., Ellig, C. L., Eckert, S. P., McCleskey, E. W., & Stork, P. A. (1998) · Nature · doi:10.1038/33451 · Cited by 858 · see citing works

Rap1 signalling: adhering to new models

Bos, J. L., de Rooij, J., & Reedquist, K. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073073 · Cited by 625 · see citing works

[16] Isolation of subcellular organelles

Storrie, B., & Amadden, E. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)82018-w · Cited by 555 · see citing works

Phospholipase Cϵ: a novel Ras effector

Kelley, G. G., Reks, S. E., Ondrako, J. M., & Smrcka, A. V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.743 · Cited by 361 · see citing works

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

Gotoh, T., Hattori, S., Nakamura, S., Kitayama, H., Noda, M., Takai, Y., Kaibuchi, K., Matsui, H., Hatase, O., Takahashi, H., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6746 · Cited by 356 · see citing works

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

Kawasaki, H., Springett, G. M., Toki, S., Canales, J. J., Harlan, P. C., Blumenstiel, J. P., Chen, E. J., Bany, I. A., Mochizuki, N., Ashbacher, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13278 · Cited by 353 · see citing works

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

Bos, J. L. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6776 · Cited by 332 · see citing works

Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras

Song, C., Hu, C., Masago, M., Kariya, K., Yamawaki‐Kataoka, Y., Shibatohge, M., Wu, D., Satoh, T., & Kataoka, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008324200 · Cited by 320 · see citing works

Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains.

Hubbard, A. L., Wall, D. A., & Ma, A. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.217 · Cited by 306 · see citing works

Signal transduction from multiple Ras effectors

Katz, M. E., & McCormick, F. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80112-8 · Cited by 299 · see citing works

A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway

López, I., Mak, E. C., Ding, J., Hamm, H. E., & Lomasney, J. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008119200 · Cited by 276 · see citing works

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

York, R. D., Molliver, D. C., Grewal, S., Stenberg, P. E., McCleskey, E. W., & Stork, P. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8069-8083.2000 · Cited by 242 · see citing works

A novel family ofras-binding domains

Ponting, C. P., & Benjamin, D. R. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30038-8 · Cited by 205 · see citing works

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

Rebhun, J. F., Castro, A. F., & Quilliam, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005327200 · Cited by 164 · see citing works

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

Hu, C., Kariya, K., Tamada, M., Akasaka, K., Shirouzu, M., Yokoyama, S., & Kataoka, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30274 · Cited by 153 · see citing works

Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling

Jin, T.-G., Satoh, T., Liao, Y., Song, C., Gao, X., Kariya, K., Hu, C., & Kataoka, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103530200 · Cited by 148 · see citing works

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

Kuroda, Y., Suzuki, N., & Kataoka, T. (1993) · Science · doi:10.1126/science.8430318 · Cited by 143 · see citing works

The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP

Pham, N., Cheglakov, I. B., Koch, C. A., de Hoog, C. L., Moran, M. F., & Rotin, D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00473-5 · Cited by 133 · see citing works

Association of the Ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex.

Béranger, F., Goud, B., Tavitian, A., & de Gunzburg, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1606 · Cited by 128 · see citing works

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

de Rooij, J., Boenink, N. M., van Triest, M. H., Cool, R. H., Wittinghofer, A., & Bos, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.38125 · Cited by 128 · see citing works

M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6

Quilliam, L. A., Castro, A. F., Rogers-Graham, K. S., Martin, C. B., Der, C. J., & Bi, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23850 · Cited by 119 · see citing works

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus.

Wienecke, R., Maize, J. C., Shoarinejad, F., Vass, W. C., Reed, J., Bonifacino, J. S., Resau, J., de Gunzburg, J., Yeung, R. S. W., & DeClue, J. E. (1996) · PubMed · Cited by 107 · see citing works

nRap GEP: A Novel Neural GDP/GTP Exchange Protein for Rap1 Small G Protein That Interacts with Synaptic Scaffolding Molecule (S-SCAM)

Ohtsuka, T., Hata, Y., Ide, N., Yasuda, T., Inoue, E., Inoue, T., Mizoguchi, A., & Takai, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1619 · Cited by 103 · see citing works

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

Hu, C., Kariya, K., Kotani, G., Shirouzu, M., Yokoyama, S., & Kataoka, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.11702 · Cited by 99 · see citing works

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

Matsubara, K., Kishida, S., Matsuura, Y., Kitayama, H., Noda, M., & Kikuchi, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202425 · Cited by 93 · see citing works

Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution

Kimmelman, A. C., Tolkacheva, T., Lorenzi, M. V., Osada, M., & Chan, A. M.-L. (1997) · Oncogene · doi:10.1038/sj.onc.1201674 · Cited by 91 · see citing works

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

Liao, Y., Kariya, K., Hu, C., Shibatohge, M., Goshima, M., Okada, T., Watari, Y., Gao, X., Jin, T. J., Yamawaki‐Kataoka, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37815 · Cited by 87 · see citing works

The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

Okada, T., Hu, C., Jin, T. J., Kariya, K., Yamawaki‐Kataoka, Y., & Kataoka, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6057 · Cited by 81 · see citing works

Association of Yeast Adenylyl Cyclase with Cyclase-Associated Protein CAP Forms a Second Ras-Binding Site Which Mediates Its Ras-Dependent Activation

Shima, F., Okada, T., Kido, M., Sen, H., Tanaka, Y. R., Tamada, M., Hu, C., Yamawaki‐Kataoka, Y., Kariya, K., & Kataoka, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.26-33.2000 · Cited by 69 · see citing works

RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation

Liao, Y., Satoh, T., Gao, X., Jin, T. J., Hu, C., & Kataoka, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101737200 · Cited by 63 · see citing works

Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1

Ichiba, T., Hoshi, Y., Eto, Y., Tajima, N., & Kuraishi, Y. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01012-1 · Cited by 44 · see citing works

Human RAS Superfamily Proteins and Related GTPases

Colicelli, J. (2004) · Science s STKE · doi:10.1126/stke.2502004re13 · Cited by 828 · see citing works

PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis

Seino, S., & Shibasaki, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00001.2005 · Cited by 558 · see citing works

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

Rodriguez-Viciana, P., Sabatier, C., & McCormick, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4943-4954.2004 · Cited by 327 · see citing works

Differential Signaling of Cyclic AMP

Mei, F. C., Qiao, J., Tsygankova, O. M., Meinkoth, J. L., Quilliam, L. A., & Cheng, X. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110856200 · Cited by 292 · see citing works

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

Quilliam, L. A., Rebhun, J. F., & Castro, A. F. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)71047-7 · Cited by 276 · see citing works

Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory

Morozov, A., Muzzio, I. A., Bourtchouladze, R., Van-Strien, N., Lapidus, K. A. B., Yin, D., Winder, D. G., Adams, J. P., Sweatt, J. D., & Kandel, E. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00404-5 · Cited by 237 · see citing works

Ras GTPases: integrins' friends or foes?

Kinbara, K., Goldfinger, L. E., Hansen, M. B., Chou, F.-L., & Ginsberg, M. H. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1229 · Cited by 228 · see citing works

Identification of protein‐protein interactions using in vivo cross‐linking and mass spectrometry

Vasilescu, J., Guo, X., & Kast, J. (2004) · PROTEOMICS · doi:10.1002/pmic.200400856 · Cited by 226 · see citing works

Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

Caron, E. (2002) · Journal of Cell Science · doi:10.1242/jcs.00238 · Cited by 214 · see citing works

Does Rap1 deserve a bad Rap?

Stork, P. A. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00087-2 · Cited by 195 · see citing works

Ras and relatives—job sharing and networking keep an old family together

Ehrhardt, A., Ehrhardt, G. R. A., Guo, X., & Schrader, J. W. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00904-9 · Cited by 184 · see citing works

Recognizing and Defining True Ras Binding Domains I: Biochemical Analysis

Wohlgemuth, S., Kiel, C., Kraemer, A., Serrano, L. G., Wittinghofer, F., & Herrmann, C. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.02.048 · Cited by 178 · see citing works

Rap1-Mediated Activation of Extracellular Signal-Regulated Kinases by Cyclic AMP Is Dependent on the Mode of Rap1 Activation

Wang, Z., Dillon, T. J., Pokala, V., Mishra, S., Labudda, K., Hunter, B. N., & Stork, P. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2130-2145.2006 · Cited by 170 · see citing works

Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion

Bivona, T. G., Wiener, H. H., Ahearn, I. M., Silletti, J., Chiu, V. K., & Philips, M. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311093 · Cited by 170 · see citing works

The Traf2- and Nck-interacting Kinase as a Putative Effector of Rap2 to Regulate Actin Cytoskeleton

TAIRA, K., Umikawa, M., Takei, K., Myagmar, B., Shinzato, M., 町田, 典., Uezato, H., Nonaka, S., & Kariya, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406370200 · Cited by 165 · see citing works

Regulating Rap small G-proteins in time and space

Gloerich, M., & Bos, J. L. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.001 · Cited by 163 · see citing works

Ras pathway signaling on endomembranes

Bivona, T. G., & Philips, M. R. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00016-4 · Cited by 134 · see citing works

Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins

Li, Y., Yan, J., De, P. K. R., Chang, H., 山内, 明., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8322 · Cited by 124 · see citing works

Functional coordination of alternative splicing in the mammalian central nervous system

Fagnani, M., Barash, Y., Ip, J. Y., Misquitta, C., Pan, Q., Saltzman, A. L., Shai, O., Lee, L., Rozenhek, A., Mohammad, N., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-6-r108 · Cited by 120 · see citing works

The RAP1 Guanine Nucleotide Exchange Factor Epac2 Couples Cyclic AMP and Ras Signals at the Plasma Membrane

Li, Y., Asuri, S., Rebhun, J. F., Castro, A. F., Paranavitana, N. C., & Quilliam, L. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508165200 · Cited by 119 · see citing works

Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε

Song, C., Satoh, T., Edamatsu, H., Wu, D., Tadano, M., Gao, X., & Kataoka, T. (2002) · Oncogene · doi:10.1038/sj.onc.1206003 · Cited by 103 · see citing works

Demonstration of Long-Range Interactions in a PDZ Domain by NMR, Kinetics, and Protein Engineering

Gianni, S., Walma, T., Arcovito, A., Calosci, N., Bellelli, A., Engström, Å., Travaglini‐Allocatelli, C., Brunori, M., Jemth, P., & Vuister, G. W. (2006) · Structure · doi:10.1016/j.str.2006.10.010 · Cited by 98 · see citing works

The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism

Gianni, S., Engström, Å., Larsson, M., Calosci, N., Malatesta, F., Eklund, L., Celestine, N., Travaglini‐Allocatelli, C., & Jemth, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506017200 · Cited by 91 · see citing works

Protein Kinase D1 and the β1 Integrin Cytoplasmic Domain Control β1 Integrin Function via Regulation of Rap1 Activation

Medeiros, R. B., Dickey, D. M., Chung, H., Quale, A. C., Nagarajan, L. R., Billadeau, D. D., & Shimizu, Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.07.006 · Cited by 89 · see citing works

Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2

Kuiperij, H. B., de Rooij, J., Rehmann, H., van Triest, M. H., Wittinghofer, A., Bos, J. L., & Zwartkruis, F. J. T. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00365-8 · Cited by 86 · see citing works

Crucial Role of Phospholipase Cε in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester

Ikuta, S., Edamatsu, H., Li, M., Hu, L., & Kataoka, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3245 · Cited by 85 · see citing works

Solution Structure of the PDZ2 Domain from Cytosolic Human Phosphatase hPTP1E Complexed with a Peptide Reveals Contribution of the β2–β3 Loop to PDZ Domain–Ligand Interactions

Kozlov, G., Banville, D., Gehring, K., & Ekiel, I. H. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00544-2 · Cited by 79 · see citing works

BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion

Iwasaki, M., Tanaka, R., Hishiya, A., Homma, S. T., Reed, J. C., & Takayama, S.-I. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.092 · Cited by 75 · see citing works

Crystal Structure of M-Ras Reveals a GTP-bound “Off” State Conformation of Ras Family Small GTPases

Ye, M., Shima, F., Muraoka, S., Liao, J., Okamoto, H., Yamamoto, M., Tamura, A., Yagi, N., Ueki, T., & Kataoka, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505503200 · Cited by 73 · see citing works

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

Zhang, J., Sapienza, P. J., Ke, H., Chang, A., Hengel, S. R., Wang, H., Phillips, G. N., & Lee, A. L. (2010) · Biochemistry · doi:10.1021/bi101131f · Cited by 69 · see citing works

Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics

Liao, J., Shima, F., Araki, M., Ye, M., Muraoka, S., Sugimoto, T., Kawamura, M., Yamamoto, N., Tamura, A., & Kataoka, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.169 · Cited by 68 · see citing works

Non‐kinase second‐messenger signaling: new pathways with new promise

Springett, G. M., Kawasaki, H., & Spriggs, D. R. (2004) · BioEssays · doi:10.1002/bies.20057 · Cited by 68 · see citing works

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

Thatikonda, V., Lyu, H., Jurado, S., Kostyrko, K., Bristow, C. A., Albrecht, C., Alpar, D., Arnhof, H., Bergner, O., Bosch, K., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00800-6 · Cited by 76 · see citing works

The PDZ-GEF Dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in theDrosophilaembryo

Huelsmann, S., Hepper, C., Marchese, D., Knöll, C., & Reuter, R. (2006) · Development · doi:10.1242/dev.02449 · Cited by 60 · see citing works

The M-Ras-RA-GEF-2-Rap1 Pathway Mediates Tumor Necrosis Factor-α–dependent Regulation of Integrin Activation in Splenocytes

Yoshikawa, Y., Satoh, T., Tamura, T., Wei, P., Bilasy, S. E., Edamatsu, H., Aiba, A., Katagiri, K., Kinashi, T., Nakao, K., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0250 · Cited by 60 · see citing works

MRAS: A Close but Understudied Member of the RAS Family

Young, L. C., & Rodriguez-Viciana, P. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a033621 · Cited by 53 · see citing works

Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia

Chen, X., Wang, X., Hossain, S., O’Neill, F. A., Walsh, D., Pless, L., Chowdari, K. V., Nimgaonkar, V. L., Schwab, S. G., Wildenauer, D. B., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl409 · Cited by 52 · see citing works

R-Ras3/M-Ras Induces Neuronal Differentiation of PC12 Cells through Cell-Type-Specific Activation of the Mitogen-Activated Protein Kinase Cascade

Kimmelman, A. C., Rodriguez, N. J. N., & Chan, A. M.-L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5946-5961.2002 · Cited by 52 · see citing works

The RapGEF PDZ-GEF2 is required for maturation of cell–cell junctions

Dubé, N., Kooistra, M. R. H., Pannekoek, W., Vliem, M. J., Oorschot, V. M. J., Klumperman, J., Rehmann, H., & Bos, J. L. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.006 · Cited by 50 · see citing works

Aggregation of Lipid-Anchored Full-Length H-Ras in Lipid Bilayers: Simulations with the MARTINI Force Field

Li, H., & Gorfe, A. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071018 · Cited by 47 · see citing works

MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1

Nonaka, H., Takei, K., Umikawa, M., Oshiro, M., Kuninaka, K., Bayarjargal, M., Asato, T., Yamashiro, Y., Uechi, Y., Endo, S., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.038 · Cited by 46 · see citing works

Side-Chain Interactions Form Late and Cooperatively in the Binding Reaction between Disordered Peptides and PDZ Domains

Haq, S. R., Celestine, N., Bach, A., Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, K., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja209341w · Cited by 46 · see citing works

Peptide Binding to a PDZ Domain by Electrostatic Steering via Nonnative Salt Bridges

Blöchliger, N., Xu, M., & Caflisch, A. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.03.038 · Cited by 40 · see citing works

PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector

Myagmar, B., Umikawa, M., Asato, T., TAIRA, K., Oshiro, M., Hino, A., Takei, K., Uezato, H., & Kariya, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.069 · Cited by 39 · see citing works

Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial–mesenchymal transition and tumorigenesis

Ward, K. R., Zhang, K.-X., Somasiri, A. M., Roskelley, C. D., & Schrader, J. W. (2004) · Oncogene · doi:10.1038/sj.onc.1207226 · Cited by 40 · see citing works

M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation

Watanabe‐Takano, H., Takano, K., Keduka, E., & Endo, T. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.09.028 · Cited by 37 · see citing works

Insight into Catalysis of a Unique GTPase Reaction by a Combined Biochemical and FTIR Approach

Chakrabarti, P., Daumke, O., Suveyzdis, Y., Kötting, C., Gerwert, K. B., & Wittinghofer, A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.022 · Cited by 37 · see citing works

M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration

Kota, P. B., Terrell, E. M., Ritt, D. A., Insinna, C., Westlake, C. J., & Morrison, D. K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805919116 · Cited by 36 · see citing works

Critical Function of the Ras-associating Domain as a Primary Ras-binding Site for Regulation of Saccharomyces cerevisiaeAdenylyl Cyclase

Kido, M., Shima, F., Satoh, T., Asato, T., Kariya, K., & Kataoka, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109526200 · Cited by 36 · see citing works

Requirement of theCaenorhabditis elegansRapGEFpxf-1andrap-1for Epithelial Integrity

Berkel, W. P.-V., Verheijen, M. H. G., Cuppen, E. P. J. G., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R. H. A., Bos, J. L., & Zwartkruis, F. J. T. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-06-0492 · Cited by 35 · see citing works

Screening of hibernation-related genes in the brain of Rhinolophus ferrumequinum during hibernation

Chen, J., Yuan, L., Sun, M., Zhang, L., & Zhang, S. Y. (2007) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2007.10.011 · Cited by 30 · see citing works

Identification of a Novel Domain of Ras and Rap1 That Directs Their Differential Subcellular Localizations

Nomura, K., Kanemura, H., Satoh, T., & Kataoka, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314169200 · Cited by 30 · see citing works

Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex

Maeta, K., Edamatsu, H., Nishihara, K., Ikutomo, J., Bilasy, S. E., & Kataoka, T. (2016) · eNeuro · doi:10.1523/eneuro.0142-16.2016 · Cited by 29 · see citing works

Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese

Luo, X.-J., Diao, H.-B., Wang, J.-K., Zhang, H., Zhao, Z. W., & Su, B. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.060657 · Cited by 29 · see citing works

Long-Range Conformational Response of a PDZ Domain to Ligand Binding and Release: A Molecular Dynamics Study

Lu, C., Knecht, V., & Stock, G. (2015) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.5b01009 · Cited by 29 · see citing works

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1

Wei, P., Satoh, T., Edamatsu, H., Aiba, A., Setsu, T., Terashima, T., Kitazawa, S., Nakao, K., Yoshikawa, Y., Tamada, M., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.149 · Cited by 27 · see citing works

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac

Dupuy, A. G., L'Hoste, S., Cherfils, J., Camonis, J., Gaudriault, G., & de Gunzburg, J. (2005) · Oncogene · doi:10.1038/sj.onc.1208647 · Cited by 26 · see citing works

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Maeta, K., Hattori, S., Ikutomo, J., Edamatsu, H., Bilasy, S. E., Miyakawa, T., & Kataoka, T. (2018) · Molecular Brain · doi:10.1186/s13041-018-0370-y · Cited by 24 · see citing works

RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures

Bilasy, S. E., Satoh, T., Terashima, T., & Kataoka, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.08.004 · Cited by 23 · see citing works

M‐Ras induces Ral and JNK activation to regulate MEK/ERK‐independent gene expression in MCF‐7 breast cancer cells

Castro, A. F., Campos, T., Babcock, J. T., Armijo, M. E., Martínez‐Conde, A., Pincheira, R., & Quilliam, L. A. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23458 · Cited by 22 · see citing works

Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras

Guo, X., Schrader, K. A., Xu, Y., & Schrader, J. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208441 · Cited by 21 · see citing works

Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice

Levy, R. J., Kvajo, M., Li, Y., Tsvetkov, E., Dong, W., Yoshikawa, Y., Kataoka, T., Bolshakov, V. Y., Karayiorgou, M., & Gogos, J. A. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.75 · Cited by 19 · see citing works

M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras

Keduka, E., Kaiho, A., Hamada, M., Watanabe‐Takano, H., Takano, K., Ogasawara, M., Satou, Y., Satoh, N., & Endo, T. (2008) · Gene · doi:10.1016/j.gene.2008.10.001 · Cited by 19 · see citing works

Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-κB activity and inflammatory gene expression

Carvalho, B. C., de Oliveira, L. C., Rocha, C. D., Fernandes, H. D. B., de Oliveira, I. M., Leão, F. B., Valverde, T. M., Rego, I. M. G., Ghosh, S., & Silva, A. M. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.02.015 · Cited by 18 · see citing works

Rapid Protein–Ligand Affinity Determination by Photoinduced Hyperpolarized NMR

Bütikofer, M., Stadler, G. R., Kadavath, H., Cadalbert, R., Torres, F., & Riek, R. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c04000 · Cited by 17 · see citing works

Multiple Aspects of the Phenotype of Mammary Epithelial Cells Transformed by Expression of Activated M-Ras Depend on an Autocrine Mechanism Mediated by Hepatocyte Growth Factor/Scatter Factor

Zhang, K., Ward, K. R., & Schrader, J. W. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.242.2.4 · Cited by 16 · see citing works

M-RAS Regulate CDH1 Function in Blastomere Compaction during Porcine Embryonic Development

Zhou, D., Niu, Y., & Cui, X. (2020) · Journal of Animal Reproduciton and Biotechnology · doi:10.12750/jarb.35.1.12 · Cited by 14 · see citing works

Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes

López‐Menéndez, C., Simón‐García, A., Gamir-Morralla, A., Pose‐Utrilla, J., Luján, R., Mochizuki, N., Díaz‐Guerra, M., & Iglesias, T. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1766-z · Cited by 15 · see citing works

M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras

Endo, T. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112342 · Cited by 14 · see citing works

Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis

Okada, K., Miyake, H., Yamaguchi, K., Chiba, K., Maeta, K., Bilasy, S. E., Edamatsu, H., Kataoka, T., & Fujisawa, M. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.149 · Cited by 14 · see citing works

Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1

Kanemura, H., Satoh, T., Bilasy, S. E., Ueda, S., Hirashima, M., & Kataoka, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.108 · Cited by 14 · see citing works

A RAPGEF6 variant constitutes a major risk factor for laryngeal paralysis in dogs

Rasouliha, S. H., Barrientos, L., Anderegg, L., Klesty, C., Lorenz, J., Chevallier, L., Jagannathan, V., Rösch, S., & Leeb, T. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008416 · Cited by 13 · see citing works

Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells☆

Curry, B. J., Su, H., Law, E. G., McLaughlin, E. A., Nixon, B., & Aitken, R. J. (2004) · Genomics · doi:10.1016/j.ygeno.2004.03.004 · Cited by 13 · see citing works

Cytoplasmic Protein Serine/Threonine Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_5 · Cited by 11 · see citing works

Signaling Lipids

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_2 · Cited by 9 · see citing works

Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data

Jung, H. C., Kim, S. H., Lee, J. H., Kim, J. H., & Han, S. W. (2017) · Journal of Breast Cancer · doi:10.4048/jbc.2017.20.3.240 · Cited by 10 · see citing works

Cytoplasmic Protein Tyrosine Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_4 · Cited by 8 · see citing works

Guanosine Triphosphatases and Their Regulators

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_9 · Cited by 7 · see citing works

The influence of MRAS gene variants on ischemic stroke and serum lipid levels in Chinese Han population

Song, Y., Ma, R., & Zhang, H. (2019) · Medicine · doi:10.1097/md.0000000000018065 · Cited by 8 · see citing works

Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2.

Ogihara, H., Shima, F., Naito, K., Asato, T., Kariya, K., & Kataoka, T. (2004) · PubMed · Cited by 7 · see citing works

Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression

Farag, M. I., Yoshikawa, Y., Maeta, K., & Kataoka, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.062 · Cited by 5 · see citing works

Transient recruitment of M-Ras GTPase to phagocytic cups in RAW264 macrophages during FcγR-mediated phagocytosis

Egami, Y., & Araki, N. (2018) · Microscopy · doi:10.1093/jmicro/dfx131 · Cited by 5 · see citing works

A road map for happiness: The psychological factors related cell types in various parts of human body from single cell RNA-seq data analysis

Wang, Z., Zhang, Y., Li, Q., Zou, Q., & Liu, Q. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105286 · Cited by 5 · see citing works

Mitogen-Activated Protein Kinase Module

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_6 · Cited by 5 · see citing works

Biochemistry of the Rap‐Specific Guanine Nucleotide Exchange Factors PDZ‐GEF1 and ‐2

Kuiperij, H. B., Rehmann, H., & Zwartkruis, F. J. T. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07015-1 · Cited by 3 · see citing works

Role of R-Ras in Cell Growth

Repasky, G. A., Cox, A. D., Hanker, A. B., Mitin, N., & Der, C. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00214-x · Cited by 3 · see citing works

Ras Family Proteins

de Gunzburg, J. (2006) · Springer eBooks · doi:10.1007/1-4020-4708-8_13 · Cited by 2 · see citing works

Dual-Specificity Protein Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_7 · Cited by 2 · see citing works

Conclusion

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_12 · Cited by 1 · see citing works

Cotargeting of Androgen Synthesis and Androgen Receptor Expression as a Novel Treatment for Castration-Resistant Prostate Cancer

Hu, C., Deng, X., Beketova, E., Owens, J. L., & Malola, J. (2017) · Cited by 1 · see citing works

Preamble to Cytoplasmic Protein Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_3

Does Rap1 mix and match

Post, A. (2009) · Utrecht University Repository (Utrecht University)

Cytosolic Protein Phosphatases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_8

Other Major Types of Signaling Mediators

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_10

Structural Analysis of Active Site Conformations in Ras and Rap1 GTPases.

Holzapfel, G. A. (2011) · NCSU Libraries Repository (North Carolina State University Libraries)

Targeting Neuroendocrine Differentiation for Prostate Cancer Radiosensitization

Hu, C., Deng, X., & Oh, G. (2014) · doi:10.21236/ada613326

The spatial control of Rap1 and Epac proteins

Liu, C. (2010) · doi:10.6083/m42r3ppd

Role of R-Ras in Cell Growth

Murphy, G. A., Cox, A. D., & Der, C. J. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50595-7

Structure and dynamics of the MAGUK core of PSD-95

Zhang, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/wyec-7388

INTERACTOME REWIRING THROUGH CANCER-ASSOCIATED MUTATION IN GROWTH FACTOR SIGNALING PATHWAYS

Wong, C.-J. (2017) · TSpace (University of Toronto)

Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase

Rebhun, J. F., Castro, A. F., & Quilliam, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005327200 · Cited by 164 · see citing works

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

Liao, Y., Kariya, K., Hu, C., Shibatohge, M., Goshima, M., Okada, T., Watari, Y., Gao, X., Jin, T. J., Yamawaki‐Kataoka, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37815 · Cited by 87 · see citing works

RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP‐binding proteins and mediate Rap2‐specific nucleotide exchange

Yaman, E., Gasper, R., Koerner, C., Wittinghofer, A., & Tazebay, U. H. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07166.x · Cited by 42 · see citing works

RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation

Liao, Y., Satoh, T., Gao, X., Jin, T. J., Hu, C., & Kataoka, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101737200 · Cited by 63 · see citing works

PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2

de Rooij, J., Boenink, N. M., van Triest, M. H., Cool, R. H., Wittinghofer, A., & Bos, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.38125 · Cited by 128 · see citing works