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Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria
Open accessAbstract
Rapid entry of Ca(2+) or Zn(2+) kills neurons. Mitochondria are major sites of Ca(2+)-dependent toxicity. This study examines Zn(2+)-initiated mitochondrial cell death signaling. 10 nm Zn(2+) induced acute swelling of isolated mitochondria, which was much greater than that induced by higher Ca(2+) levels. Zn(2+) entry into mitochondria was dependent upon the Ca(2+) uniporter, and the consequent swelling resulted from opening of the mitochondrial permeability transition pore. Confocal imaging of intact neurons revealed entry of Zn(2+) (with Ca(2+)) to cause pronounced mitochondrial swelling, which was far greater than that induced by Ca(2+) entry alone. Further experiments compared the abilities of Zn(2+) and Ca(2+) to induce mitochondrial release of cytochrome c (Cyt-c) or apoptosis-inducing factor. In isolated mitochondria, 10 nm Zn(2+) exposures induced Cyt-c release. Induction of Zn(2+) entry into cortical neurons resulted in distinct increases in cytosolic Cyt-c immunolabeling and in cytosolic and nuclear apoptosis-inducing factor labeling within 60 min. In comparison, higher absolute [Ca(2+)](i) rises were less effective in inducing release of these factors. Addition of the mitochondrial permeability transition pore inhibitors cyclosporin A and bongkrekic acid decreased Zn(2+)-dependent release of the factors and attenuated neuronal cell death as assessed by trypan blue staining 5-6 h after the exposures.
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“At equivalent concentrations, zinc induces a larger increase in cytochrome c and AIF than Ca 2+ [115].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [115]
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Citations
Cites
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,188
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron
Frederickson, C. J., Suh, S. W., Silva, D., Frederickson, C. J., & Thompson Richard, B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1471s · Cited by 866
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
Schinder, A. F., Olson, E. C., Spitzer, N. C., & Montal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06125.1996 · Cited by 770
A mitochondrial perspective on cell death
Bernardi, P., Petronilli, V., Lisa, F. D., & Forte, M. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01745-x · Cited by 418
Sensi, S. L., Yin, H. Z., Carriedo, S. G., Rao, S. S., & Weiss, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2414 · Cited by 408
Self-citation
Research works printed but not linked: 1
- Lobner, 2000, Cell. Mol. Biol., 46, 797
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Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,077
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Kozłowski, H., Janicka-Kłos, A., Brasuń, J., Gaggelli, E., Valensin, D., & Valensin, G. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.05.011 · Cited by 481
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Singh, I. N., Sullivan, P. G., Deng, Y., Mbye, L. H., & Hall, E. D. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600297 · Cited by 367
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Disparate roles of zinc in chemical hypoxia-induced neuronal death
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Berardis, B. D., Civitelli, G., Condello, M., Lista, P., Pozzi, R., Arancia, G., & Meschini, S. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.04.012 · Cited by 308
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Bozym, R. A., Thompson, R. B., Stoddard, A. K., & Fierke, C. A. (2006) · ACS Chemical Biology · doi:10.1021/cb500043a · Cited by 240
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Brown, M. R., Sullivan, P. G., Dorenbos, K., Modafferi, E. F., Geddes, J. W., & Steward, O. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.02.028 · Cited by 114
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Self-citationZhao, H., Yenari, M. A., Cheng, D., Chang, O. L. B., Sapolsky, R. M., & Steinberg, G. K. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000127161.89708.a5 · Cited by 99
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Liu, Z., Zhang, C., Chen, Y., He, W., & Guo, Z. (2012) · Chemical Communications · doi:10.1039/c2cc33648k · Cited by 83
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Metadata
- Authors
- Jiang, D., Sullivan, P. G., Sensi, S. L., Steward, O., & Weiss, J. H.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Weiss, John H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 276
- Issue
- 50
- Pages
- 47524-47529
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2057520074
- Cited by
- 265
- References
- 34
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 9 · 2016: 6 · 2015: 14 · 2014: 5 · 2013: 9 · 2012: 19
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- National Institutes of Health (5k02ag000836-05, 5r01ns032280-07, 5r01ns030884-11, NS30884)
- National Institute on Aging (AG00836, AG 00919, 2T32 AG 00096, T32AG000096)
- National Institute of Neurological Disorders and Stroke (NS 30884, NS-32280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- zinc, mitochondrial permeability transition pore, mitochondrial swelling, cytochrome c release, apoptosis-inducing factor, neuronal cell death, calcium uniporter, cyclosporine, bongkrekic acid, cortical neurons
- MeSH terms
- Animals, Anti-Bacterial Agents, Bongkrekic Acid, Brain, Calcium, Cations, Cytochrome c Group, Cytoplasm, Cytosol, Dose-Response Relationship, Drug, Enzyme Inhibitors, Flavoproteins, Humans, Immunohistochemistry, Male, Membrane Proteins, Mitochondria, Necrosis, Neurons, Time Factors, Trypan Blue, Zinc, Cyclosporine, Rats, Sprague-Dawley, Apoptosis, Microscopy, Confocal, Apoptosis Inducing Factor, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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