Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

Swardfager, Walter; Herrmann, Nathan; McIntyre, Roger S.; Mazereeuw, Graham; Goldberger, Kyle; Cha, Danielle S.; Schwartz, Yael; Lanctôt, Krista L.

doi:10.1016/j.neubiorev.2013.03.018

Cited by 116Treatment of Major DepressionTrace Elements in HealthTryptophan and brain disorders

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

Swardfager, Walter, Herrmann, Nathan, McIntyre, Roger S., Mazereeuw, Graham, Goldberger, Kyle, Cha, Danielle S., Schwartz, Yael, Lanctôt, Krista L.·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2013.03.018

Open this paper in CoChat — free account

Abstract

Incomplete response to monoaminergic antidepressants in major depressive disorder (MDD), and the phenomenon of neuroprogression, suggests a need for additional pathophysiological markers and pharmacological targets. Neuronal zinc is concentrated exclusively within glutamatergic neurons, acting as an allosteric modulator of the N-methyl D-aspartate and other receptors that regulate excitatory neurotransmission and neuroplasticity. Zinc-containing neurons form extensive associational circuitry throughout the cortex, amygdala and hippocampus, which subserve mood regulation and cognitive functions. In animal models of depression, zinc is reduced in these circuits, zinc treatment has antidepressant-like effects and dietary zinc insufficiency induces depressive behaviors. Clinically, serum zinc is lower in MDD, which may constitute a state-marker of illness and a risk factor for treatment-resistance. Marginal zinc deficiency in MDD may relate to multiple putative mechanisms underlying core symptomatology and neuroprogression (e.g. immune dysfunction, monoamine metabolism, stress response dysregulation, oxidative/nitrosative stress, neurotrophic deficits, transcriptional/epigenetic regulation of neural networks). Initial randomized trials suggest a benefit of zinc supplementation. In summary, molecular and animal behavioral data support the clinical significance of zinc in the setting of MDD.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2013.03.018

Cites

316 of 316 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In a double-blinded, placebo controlled prospective trial, involving 489 postmenopausal elderly women, there was no effect of hormone therapy and calcitriol, either individually or in combination, on depression.
“In a double-blinded, placebo controlled prospective trial, involving 489 postmenopausal elderly women, there was no effect of hormone therapy and calcitriol, either individually or in combination, on depression (55).”
From Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial (2020) · cites this paper as [55]
Observational studies show an association between low zinc dietary intake or low zinc status and depression in adults or elderly subjects.
“Observational studies show an association between low zinc dietary intake or low zinc status and depression in adults or elderly subjects [189,190,191].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [189]
Although the proof of copper implications in the oxidative mechanisms is pretty solid, some animal models studies contradicted the clinical findings, and there is still a need for the determination of the real benefits for copper therapy in patients with depression.
“Moreover, although the proof of its implications in the oxidative mechanisms is pretty solid, some animal models studies contradicted the clinical findings [285] and therefore, there is still a need for the determination of the real benefits for the copper therapy in patients with depression [288].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [288]

IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Self-citation
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90210-0 · Cited by 2,989 · see citing works
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs
Kaplan, M., & Hinds, J. W. (1977) · Science · doi:10.1126/science.887941 · Cited by 1,478 · see citing works
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,365 · see citing works
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., et al. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3628 · Cited by 1,292 · see citing works
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions
Blood, A. J., Zatorre, R. J., Bermudez, P., & Evans, A. C. (1999) · Nature Neuroscience · doi:10.1038/7299 · Cited by 1,097 · see citing works
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070 · see citing works
Trk receptors: mediators of neurotrophin action
Patapoutian, A., & Reichardt, L. F. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00208-7 · Cited by 1,070 · see citing works
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.
Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Mizuno, N., & Masu, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53849-7 · Cited by 982 · see citing works
Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 879 · see citing works
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo
Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works
Stimulation-induced uptake and release of zinc in hippocampal slices
Howell, G. A., Welch, M. G., & Frederickson, C. (1984) · Nature · doi:10.1038/308736a0 · Cited by 820 · see citing works
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
Zinc in the physiology and pathology of the CNS
Sensi, S. L., Paoletti, P., Bush, A. I., & Sekler, I. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2734 · Cited by 759 · see citing works
ZINC AND BRAIN INJURY
Choi, D. W., & Koh, J. Y. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.347 · Cited by 754 · see citing works
INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
Contextual fear, gestalt memories, and the hippocampus.
Fanselow, M. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00186-2 · Cited by 724 · see citing works
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
ZnT-3, a putative transporter of zinc into synaptic vesicles
Palmiter, R. D., Cole, T. B., Quaife, C. J., & Findley, S. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14934 · Cited by 708 · see citing works
The olfactory bulbectomized rat as a model of depression: An update
Kelly, J. P., Wrynn, A. S., & Leonard, B. E. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00004-1 · Cited by 662 · see citing works
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633 · see citing works
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 630 · see citing works
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
Liuzzi, J. P., Lichten, L. A., Rivera, S., Blanchard, R. K., Aydemir, T. B., Knutson, M. D., Ganz, T., & Cousins, R. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502257102 · Cited by 594 · see citing works
Elevated Monoamine Oxidase A Levels in the Brain: An Explanation for the Monoamine Imbalance of Major Depression
Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585 · see citing works
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Schwarcz, R. M., & Pellicciari, R. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034439 · Cited by 556 · see citing works
Zinc: role in immunity, oxidative stress and chronic inflammation
Prasad, A. S. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283312956 · Cited by 553 · see citing works
Neurotrophins and depression
Altar, C. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01309-7 · Cited by 535 · see citing works
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity
Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524 · see citing works
Altered Expression of Genes Involved in Inflammation and Apoptosis in Frontal Cortex in Major Depression
Shelton, R. C., Claiborne, J., Sidoryk-Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A., & Mirnics, K. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.52 · Cited by 511 · see citing works
Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin
O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works
The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses
Vogt, K. E., Mellor, J. R., Tong, G., & Nicoll, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81149-6 · Cited by 491 · see citing works
NMDA receptor pathways as drug targets
Kemp, J. A., & McKernan, R. M. (2002) · Nature Neuroscience · doi:10.1038/nn936 · Cited by 479 · see citing works
Reversible neural inactivation reveals hippocampal participation in several memory processes
Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V. L., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. (1999) · Nature Neuroscience · doi:10.1038/13202 · Cited by 478 · see citing works
Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients
Maes, M. H. J., Christophe, A. B., Delanghe, J., Altamura, C. A., Neels, H. M., & Meltzer, H. Y. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00014-1 · Cited by 452 · see citing works
In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.026 · Cited by 443 · see citing works
Increased Depressive Ratings in Patients With Hepatitis C Receiving Interferon-α–Based Immunotherapy Are Related to Interferon-α–Induced Changes in the Serotonergic System
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437 · see citing works
GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin
Holst, B., Egerod, K. L., Schild, E., Vickers, S. P., Cheetham, S. C., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck‐Sickinger, A. G., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0933 · Cited by 429 · see citing works
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders
Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works
Altered Lipid Metabolism in Brain Injury and Disorders
Rao, A. M., & Hatcher, J. F. (2008) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-8831-5_9 · Cited by 407 · see citing works
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
Mony, L., Kew, J. N. C., Gunthorpe, M. J., & Paoletti, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00304.x · Cited by 404 · see citing works
Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
Esslinger, C., Walter, H., Kirsch, P., Erk, S., Schnell, K., Arnold, C., Haddad, L., Mier, D., Opitz von Boberfeld, C., Raab, K., et al. (2009) · Science · doi:10.1126/science.1167768 · Cited by 400 · see citing works
Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure
Haug, F. Š. (1967) · Histochemistry and Cell Biology · doi:10.1007/bf00401978 · Cited by 393 · see citing works
Glycogen Synthase Kinase-3 (GSK3) in Psychiatric Diseases and Therapeutic Interventions
Jope, R. S., & Roh, M. (2006) · Current Drug Targets · doi:10.2174/1389450110607011421 · Cited by 382 · see citing works
Glutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 382 · see citing works
Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration
Capuron, L., Pagnoni, G., Drake, D. F., Woolwine, B. J., Spivey, J. R., Crowe, R. J., Votaw, J. R., Goodman, M. M., & Miller, A. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2094 · Cited by 382 · see citing works
Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy
Adachi, M., Barrot, M., Autry, A. E., Theobald, D., & Monteggia, L. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.019 · Cited by 380 · see citing works
Induction of Neuronal Apoptosis by Thiol Oxidation
Aizenman, E., Stout, A. K., Hartnett, K. A., Dineley, K. E., McLaughlin, B., & Reynolds, I. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751878.x · Cited by 375 · see citing works
Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works
Lower serum high‐density lipoprotein cholesterol (HDL‐C) in major depression and in depressed men with serious suicidal attempts: relationship with immune‐inflammatory markers
Maes, M. H. J., Smith, R., Christophe, A., Vandoolaeghe, E., Gastel, A. V., Neels, H. M., Demedts, P., Wauters, A., & Meltzer, H. Y. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09622.x · Cited by 356 · see citing works
Selective Zinc Sensor Molecules with Various Affinities for Zn2+, Revealing Dynamics and Regional Distribution of Synaptically Released Zn2+ in Hippocampal Slices
Komatsu, K., Kikuchi, K., Kojima, H., Urano, Y., & Nagano, T. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050301e · Cited by 352 · see citing works
Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat
Frederickson, C. J., Klitenick, M. A., Manton, W. I., & Kirkpatrick, J. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90858-2 · Cited by 346 · see citing works
Changes in cytokine production and T cell subpopulations in experimentally induced zinc deficient humans
Beck, F. W., Prasad, A. S., Kaplan, J., Fitzgerald, J. T., & Brewer, G. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1002 · Cited by 345 · see citing works
Roles of NMDA receptor activity and nitric oxide production in brain development
Contestabile, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00018-7 · Cited by 338 · see citing works
Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes
Noh, K., & Koh, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-j0001.2000 · Cited by 335 · see citing works
Reduced activation and expression of ERK1/2 MAP kinase in the post‐mortem brain of depressed suicide subjects
Dwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333 · see citing works
Cellular zinc sensors: MTF-1 regulation of gene expression
Andrews, G. K. (2001) · BioMetals · doi:10.1023/a:1012932712483 · Cited by 325 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Tissue‐specific regulation of zinc metabolism and metallothionein genes by interleukin 1
Cousins, R. J., & Leinart, A. S. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.13.2458983 · Cited by 312 · see citing works
Signaling Pathways Regulating Gene Expression, Neuroplasticity, and Neurotrophic Mechanisms in the Action of Antidepressants: A Critical Overview
Tardito, D., Perez, J., Tiraboschi, E., Musazzi, L., Racagni, G., & Popoli, M. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.7 · Cited by 303 · see citing works
Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: Involvement in depression
You, Z., Luo, C., Zhang, W., Chen, Y., He, J., Zhao, Q., Zuo, R. M., & Wu, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.006 · Cited by 301 · see citing works
Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons
Thomas, C. G., Miller, A., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00771.2005 · Cited by 286 · see citing works
Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels
HARRISON, N., & Gibbons, S. J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90152-x · Cited by 282 · see citing works
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
Williams, H. J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L. S., Georgieva, L., Williams, N. M., Morris, D. W., Quinn, E. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.36 · Cited by 279 · see citing works
Postsynaptic Decoding of Neural Activity: eEF2 as a Biochemical Sensor Coupling Miniature Synaptic Transmission to Local Protein Synthesis
Sutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274 · see citing works
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression
Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272 · see citing works
Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness
Maes, M., Vandoolaeghe, E., Neels, H., Demedts, P., Wauters, A., Meltzer, H. Y., Altamura, C., & Desnyder, R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00365-4 · Cited by 272 · see citing works
Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.
Mayer, M. L., Vyklický, L., & Westbrook, G. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017724 · Cited by 272 · see citing works
Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria
Jiang, D., Sullivan, P. G., Sensi, S. L., Steward, O., & Weiss, J. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108834200 · Cited by 265 · see citing works
Memantine for Agitation/Aggression and Psychosis in Moderately Severe to Severe Alzheimer's Disease: A Pooled Analysis of 3 Studies
Wilcock, G. K., Ballard, C. G., Cooper, J. A., & Loft, H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0302 · Cited by 253 · see citing works
A zinc-sensing receptor triggers the release of intracellular Ca 2+ and regulates ion transport
Hershfinkel, M., Moran, A., Grossman, N., & Sekler, I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201193398 · Cited by 253 · see citing works
Stress, Depression and Hippocampal Apoptosis
Lucassen, P. J., Heine, V. M., Müller, M. B., van der Beek, E. M., Wiegant, V. M., de Kloet, E. R., Joëls, M., Fuchs, E., Swaab, D. F., & Czéh, B. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559273 · Cited by 253 · see citing works
Remission in Major Depressive Disorder: A Comparison of Pharmacotherapy, Psychotherapy, and Control Conditions
Casacalenda, N., Perry, J. C., & Looper, K. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1354 · Cited by 247 · see citing works
Chapter 6 Zinc-containing neurons in hippocampus and related CNS structures
Frederickson, C. J., & Danscher, G. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61242-x · Cited by 239 · see citing works
The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B
Rachline, J., Perin-Dureau, F., Goff, A. L., Neyton, J., & Paoletti, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3967-04.2005 · Cited by 238 · see citing works
Seizures and neuronal damage in mice lacking vesicular zinc
Cole, T. B., Robbins, C. A., Wenzel, H. J., Schwartzkroin, P. A., & Palmiter, R. D. (2000) · Epilepsy Research · doi:10.1016/s0920-1211(99)00121-7 · Cited by 237 · see citing works
Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study.
(2003) · PubMed · Cited by 236 · see citing works
Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain
Eren, İ., Nazıroğlu, M., & Demirdaş, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9289-x · Cited by 234 · see citing works
Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus
Besser, L., Chorin, E., Sekler, I., Silverman, W. F., Atkin, S. D., Russell, J. T., & Hershfinkel, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5093-08.2009 · Cited by 228 · see citing works
Inflammation: A new candidate in modulating adult neurogenesis
Das, S., & Basu, A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21585 · Cited by 226 · see citing works
Accumulation of Zinc in Degenerating Hippocampal Neurons of ZnT3-Null Mice after Seizures: Evidence against Synaptic Vesicle Origin
Lee, J. Y., Cole, T. B., Palmiter, R. D., & Koh, J.-Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-j0003.2000 · Cited by 224 · see citing works
Hypozincemia in depression
Maes, M. H. J., D’Haese, P. C., Scharpé, S., D'Hondt, P., Cosyns, P. R., & Broe, M. E. D. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90117-1 · Cited by 218 · see citing works
History of Zinc as Related to Brain Function
Sandstead, H. H., Frederickson, C. J., & Penland, J. G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.496s · Cited by 214 · see citing works
Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study
Siwek, M., Dudek, D., Paul, I. A., Sowa-Kućma, M., Zięba, A., Popik, P., Pilc, A., & Nowak, G. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.014 · Cited by 210 · see citing works
Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells
Chen, Y., Jiang, T., Chen, P., Ouyang, J., Xu, G., Zeng, Z., & Sun, Y. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.10.029 · Cited by 209 · see citing works
Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.07.001 · Cited by 206 · see citing works
Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse
Qian, J., & Noebels, J. L. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089276 · Cited by 201 · see citing works
Metallothioneins in Brain—The Role in Physiology and Pathology
Aschner, M., Cherian, M. G., Klaassen, C. D., Palmiter, R. D., Erickson, J. C., & Bush, A. I. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.8054 · Cited by 199 · see citing works
Insight into zinc signaling from dietary zinc deficiency
Takeda, A., & Tamano, H. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.003 · Cited by 195 · see citing works
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 190 · see citing works
Self-citation
Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice
Rosa, A. O., Lin, J. H. X., Calixto, J. Β., Santos, A. R. S., & Rodrigues, A. L. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00069-x · Cited by 183 · see citing works
Zinc suppresses Th17 development via inhibition of STAT3 activation
Kitabayashi, C., Fukada, T., Kanamoto, M., Ohashi, W., Hojyo, S., Atsumi, T., Ueda, N., Azuma, I., Hirota, H., Murakami, M., et al. (2010) · International Immunology · doi:10.1093/intimm/dxq017 · Cited by 176 · see citing works
Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators
Hyrc, K. L., Handran, S. D., Rothman, S., & Goldberg, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06669.1997 · Cited by 175 · see citing works
Enhanced Long-Term Synaptic Depression in an Animal Model of Depression
Holderbach, R., Clark, K., Moreau, J., Bischofberger, J., & Normann, C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.007 · Cited by 174 · see citing works
Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory
Pocivavsek, A., Wu, H., Potter, M., Elmer, G., Pellicciari, R., & Schwarcz, R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.127 · Cited by 171 · see citing works
Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
Nowak, G., Szewczyk, B., Wierońska, J. M., Brański, P., Pałucha-Poniewiera, A., Pilc, A., Sadlik, K., & Piekoszewski, W. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00104-7 · Cited by 171 · see citing works
Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: A review
Chai, F., Truong-Tran, A. Q., Ho, L. H., & Zalewski, P. D. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00825.x · Cited by 171 · see citing works
Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease
Molina, J. A., Jiménez-Jiménez, F. J., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González-Muñoz, M. J., de Bustos, F., Porta, J., Ortí-Pareja, M., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050071 · Cited by 167 · see citing works
Zinc has opposite effects on NMDA and Non-NMDA receptors expressed in xenopus oocytes
Rassendren, F.-A., Lory, P., Pin, J., & Nargeot, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90199-p · Cited by 167 · see citing works
Zinc status and serum testosterone levels of healthy adults
Prasad, A. S., Mantzoros, C. S., Beck, F. W. J., Hess, J. W., & Brewer, G. J. (1996) · Nutrition · doi:10.1016/s0899-9007(96)80058-x · Cited by 166 · see citing works
The efficacy of zinc supplementation in depression: Systematic review of randomised controlled trials
Lai, J. S., Moxey, A. J., Nowak, G., Vashum, K. P., Bailey, K. A., & McEvoy, M. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.022 · Cited by 166 · see citing works
Repeated Unpredictable Stress and Antidepressants Differentially Regulate Expression of the Bcl-2 Family of Apoptotic Genes in Rat Cortical, Hippocampal, and Limbic Brain Structures
Kosten, T. A., Galloway, M. P., Duman, R. S., Russell, D. S., & D'Sa, C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301527 · Cited by 165 · see citing works
Inhibition of glycogen synthase kinase-3β by bivalent zinc ions: insight into the insulin-mimetic action of zinc
Ilouz, R., Kaidanovich‐Beilin, O., Gurwitz, D., & Eldar-Finkelman, H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00636-8 · Cited by 161 · see citing works
Antidepressant-like properties of zinc in rodent forced swim test
Kroczka, B., Brański, P., Pałucha-Poniewiera, A., Pilc, A., & Nowak, G. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00473-7 · Cited by 161 · see citing works
Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain
Wenzel, A., Scheurer, L., Künzi, R., Fritschy, J., Möhler, H., & Benke, D. (1995) · Neuroreport · doi:10.1097/00001756-199512000-00010 · Cited by 159 · see citing works
Functional implications of decreases in neurogenesis following chronic mild stress in mice
Mineur, Y. S., Belzung, C., & Crusio, W. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.045 · Cited by 159 · see citing works
Zinc in depressive disorder
McLoughlin, I. J., & Hodge, J. S. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb03077.x · Cited by 159 · see citing works
Zinc and depression. An update.
Nowak, G., Szewczyk, B., & Pilc, A. (2005) · PubMed · Cited by 158 · see citing works
Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
Park, S.-E., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-12 · Cited by 157 · see citing works
Biological half-lives of zinc and manganese in rat brain
Takeda, A., Sawashita, J., & Okada, S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00916-e · Cited by 154 · see citing works
Clusterin (SGP‐2): A multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain
Pasinetti, G. M., Johnson, S. A., Oda, T., Rozovsky, I., & Finch, C. E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390307 · Cited by 154 · see citing works
Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA Receptors
Izumi, Y., Auberson, Y. P., & Zorumski, C. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1258-06.2006 · Cited by 152 · see citing works
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease
Jiménez‐Jiménez, F. J., Molina, J. A., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González‐Muñoz, M. J., de Bustos, F., Martínez‐Salio, A., Pareja, M. O., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050073 · Cited by 151 · see citing works
Nutrient intakes and the common mental disorders in women
Jacka, F. N., Maes, M., Pasco, J. A., Williams, L. J., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.018 · Cited by 149 · see citing works
Zinc in Attention-Deficit/Hyperactivity Disorder
Arnold, L. E., & DiSilvestro, R. A. (2005) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2005.15.619 · Cited by 149 · see citing works
Memantine reduces oxidative damage and enhances long-term recognition memory in aged rats
Dias, C. P., de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Garcia, V. A., Scalco, F. S., Guimarães, M. R., Constantino, L. D. S., Budni, P., Dal‐Pizzol, F., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.018 · Cited by 148 · see citing works
The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders
Nudmamud‐Thanoi, S., & Reynolds, G. P. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.09.035 · Cited by 147 · see citing works
Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor α
Meerarani, P., Ramadass, P., Toborek, M. J., Bauer, H., Bauer, H., & Hennig, B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.81 · Cited by 146 · see citing works
Zinc fluxes and zinc transporter genes in chronic diseases
Devirgiliis, C., Zalewski, P. D., Perozzi, G., & Murgia, C. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.01.013 · Cited by 144 · see citing works
Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.014 · Cited by 144 · see citing works
Light microscopical mapping of the hippocampal region, the pyriform cortex and the corticomedial amygdaloid nuclei of the rat with Timm's sulphide silver method
Haug, F. Š. (1974) · Anatomy and Embryology · doi:10.1007/bf00519123 · Cited by 144 · see citing works
Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine
Alexander, K., Wu, H., Schwarcz, R. M., & Bruno, J. P. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2539-2 · Cited by 143 · see citing works
Zinc deficiency induces depression-like symptoms in adult rats
Tassabehji, N. M., Corniola, R. S., Alshingiti, A., & Levenson, C. W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.06.017 · Cited by 138 · see citing works
Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 137 · see citing works
Chronic Zinc Deficiency Alters Neuronal Function of Hippocampal Mossy Fibers
Hesse, G. W. (1979) · Science · doi:10.1126/science.224456 · Cited by 136 · see citing works
Effects of memantine and MK‐801 on NMDA‐induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices
Frankiewicz, T., Potier, B., Bashir, Z. I., Collingridge, G. L., & Parsons, C. G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15245.x · Cited by 135 · see citing works
Interaction of zinc with antidepressants in the tail suspension test
Cunha, M. P., Machado, D. G., Bettio, L. E. B., Capra, J. C., & Rodrigues, A. L. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.09.006 · Cited by 134 · see citing works
Antidepressant drug treatments induce glial cell line‐derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells
Hisaoka, K., Nishida, A., Koda, T., Miyata, M., Zensho, H., Morinobu, S., Ohta, M., & Yamawaki, S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00531.x · Cited by 133 · see citing works
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment
Siwek, M., Dudek, D., Schlegel-Zawadzka, M., Morawska, A., Piekoszewski, W., Opoka, W., Zięba, A., Pilc, A., Popik, P., & Nowak, G. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.024 · Cited by 132 · see citing works
The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test
Szewczyk, B., Poleszak, E., Właź, P., Wróbel, A., Blicharska, E., Cichy, A., Dybała, M., Siwek, A., Pomierny-Chamioło, L., Piotrowska, A., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.011 · Cited by 131 · see citing works
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress
Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 130 · see citing works
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso
Buck-Koehntop, B. A., Stanfield, R. L., Ekiert, D. C., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., & Wright, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213726109 · Cited by 128 · see citing works
Antidepressant-like activity of zinc: further behavioral and molecular evidence
Sowa-Kućma, M., Legutko, B., Szewczyk, B., Novák, K., Znojek, P., Poleszak, E., Papp, M., Pilc, A., & Nowak, G. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0115-7 · Cited by 125 · see citing works
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines
Koponen, E., Rantamäki, T., Voikar, V., Saarelainen, T., MacDonald, E., & Castrén, E. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-8468-z · Cited by 125 · see citing works
Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis
Ryu, M., Langkamp‐Henken, B., Chang, S.-M., Shankar, M. N., & Cousins, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117207108 · Cited by 124 · see citing works
Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice
Whittle, N., Lübec, G., & Singewald, N. (2008) · Amino Acids · doi:10.1007/s00726-008-0195-6 · Cited by 124 · see citing works
Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice
da Silva, G. D. L., Matteussi, A. S., Santos, A. R. S., Calixto, J. Β., & Rodrigues, A. L. S. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00022 · Cited by 122 · see citing works
Correlation Between Dietary Zinc Intakes and Its Serum Levels with Depression Scales in Young Female Students
Amani, R., Saeidi, S., Nazari, Z., & Nematpour, S. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8572-x · Cited by 122 · see citing works
Astrocyte‐derived kynurenic acid modulates basal and evoked cortical acetylcholine release
Zmarowski, A., Wu, H., Brooks, J. M., Potter, M. C., Pellicciari, R., Schwarcz, R. M., & Bruno, J. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06594.x · Cited by 121 · see citing works
Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus
Yamawaki, Y., Fuchikami, M., Morinobu, S., Segawa, M., Matsumoto, T., & Yamawaki, S. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.585663 · Cited by 117 · see citing works
Targeting Glutamatergic Signaling for the Development of Novel Therapeutics for Mood Disorders
Machado‐Vieira, R., Salvadore, G., Ibrahim, L. A., Diazgranados, N., & Zarate, C. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168010 · Cited by 117 · see citing works
Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration
Frederickson, C. J., Giblin, L. J., Rengarajan, B., Masalha, R., Frederickson, C. J., Zeng, Y., Varea, E., Koh, J., Chorin, U., Besser, L., et al. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.11.014 · Cited by 117 · see citing works
Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort
Alasaari, J., Lagus, M., Ollila, H. M., Toivola, A., Mika Kivimaki, B., Vahtera, J., Kronholm, E., Härmä, M., Puttonen, S., & Paunio, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045813 · Cited by 113 · see citing works
Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects.
Prasad, A. S., Beck, F. W., Grabowski, S. M., Kaplan, J., & Mathog, R. H. (1997) · PubMed · Cited by 112 · see citing works
Chronic fluoxetine administration inhibits extracellular signal‐regulated kinase 1/2 phosphorylation in rat brain
Fumagalli, F., Molteni, R., Calabrese, F., Frasca, A., Racagni, G., & Riva, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03149.x · Cited by 111 · see citing works
ZNF804a Regulates Expression of the Schizophrenia-Associated Genes PRSS16, COMT, PDE4B, and DRD2
Girgenti, M. J., LoTurco, J. J., & Maher, B. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032404 · Cited by 110 · see citing works
Stress in early life inhibits neurogenesis in adulthood
Karten, Y. J. G., Olariu, A., & Cameron, H. A. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.009 · Cited by 108 · see citing works
Evaluating antidepressant therapies: remission as the optimal outcome.
Thase, M. E. (2003) · PubMed · Cited by 107 · see citing works
Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study
Marcellini, F., Giuli, C., Papa, R., Gagliardi, C., Dedoussis, G. V., Herbein, G., Fülöp, T., Monti, D., Rink, L., Jajte, J., et al. (2006) · Biogerontology · doi:10.1007/s10522-006-9048-4 · Cited by 107 · see citing works
Anxiety-like behavior of young rats after 2-week zinc deprivation
Takeda, A., Tamano, H., Kan, F., Itoh, H., & Oku, N. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.023 · Cited by 107 · see citing works
Synaptically released zinc gates long-term potentiation in fear conditioning pathways
Kodirov, S. A., Takizawa, S., Joseph, J., Kandel, E. R., Shumyatsky, G. P., & Bolshakov, V. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607131103 · Cited by 105 · see citing works
Noncompetitive inhibition of gamma-aminobutyric acidA channels by Zn.
Legendre, P., & Westbrook, G. L. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10881-x · Cited by 104 · see citing works
Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression
Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.032 · Cited by 103 · see citing works
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum
Amori, L., Wu, H., Marinozzi, M., Pellicciari, R., Guidetti, P., & Schwarcz, R. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.055 · Cited by 101 · see citing works
Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant
Kanoni, S., Nettleton, J. A., Hivert, M., Ye, Z., van Rooij, F. J. A., Shungin, D., Sonestedt, E., Ngwa, J. S., Wojczynski, M. K., Lemaître, R. N., et al. (2011) · Diabetes · doi:10.2337/db11-0176 · Cited by 99 · see citing works
Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation
Wong, C. P., Magnusson, K. R., & Ho, E. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.005 · Cited by 98 · see citing works
Zinc exhibits an antidepressant-like effect in the forced swimming test in mice.
Kroczka, B., Zieba, A., Dudek, D., Pilc, A., & Nowak, G. (2000) · PubMed · Cited by 97 · see citing works
Dizocilpine antagonizes the effect of chronic imipramine on learned helplessness in rats
Meloni, D., Gambarana, C., Montis, M. G. D., Pra, P. D., Taddei, I., & Tagliamonte, A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90374-3 · Cited by 96 · see citing works
One-year treatment with ethyl esters of n-3 fatty acids in patients with hypertriglyceridemia and glucose intolerance
Sirtori, C. R., Crepaldi, G., Manzato, E., Mancini, M., Rivellese, A., Paoletti, R., Pazzucconi, F., Pamparana, F., & Stragliotto, E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00298-0 · Cited by 95 · see citing works
Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression
Anttila, S., Huuhka, K., Huuhka, M., Rontu, R., Hurme, M., Leinonen, E. V. J., & Lehtimäki, T. J. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0705-9 · Cited by 95 · see citing works
Vitamin A and zinc metabolism in alcoholism
Russell, R. M. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.12.2741 · Cited by 95 · see citing works
The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
Gold, A. B., Herrmann, N., Swardfager, W., Black, S. E., Aviv, R. I., Tennen, G., Kiss, A., & Lanctôt, K. L. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-17 · Cited by 95 · see citing works
Self-citation
Neuronal Nitric Oxide Contributes to Neuroplasticity-Associated Protein Expression through cGMP, Protein Kinase G, and Extracellular Signal-Regulated Kinase
Gallo, E. F., & Iadecola, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0374-11.2011 · Cited by 94 · see citing works
Low dietary or supplemental zinc is associated with depression symptoms among women, but not men, in a population-based epidemiological survey
Maserejian, N. N., Hall, S. A., & McKinlay, J. B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.039 · Cited by 94 · see citing works
Alterations in serum and brain trace element levels after antidepressant treatment
Nowak, G., & Schlegel-Zawadzka, M. (1999) · Biological Trace Element Research · doi:10.1007/bf02784278 · Cited by 93 · see citing works
Behavioural and Neurochemical Effects of Dizocilpine in the Olfactory Bulbectomized Rat Model of Depression
Redmond, A. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00259-1 · Cited by 92 · see citing works
The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test
Szewczyk, B., Poleszak, E., Sowa-Kućma, M., Wróbel, A., Słotwiński, S., Listos, J., Właź, P., Cichy, A., Siwek, A., Dybała, M., et al. (2009) · Amino Acids · doi:10.1007/s00726-009-0412-y · Cited by 91 · see citing works
Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice
Baarendse, P. J. J., van Grootheest, G., Jansen, R. F., Pieneman, A. W., Ögren, S. O., Verhage, M., & Stiedl, O. (2007) · Hippocampus · doi:10.1002/hipo.20356 · Cited by 88 · see citing works
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
Joo, J., Kim, B., Lee, J.-S., Park, J.-Y., Kim, S., Yun, Y.-J., Lee, S.-H., Lee, S., Rhim, H., & Son, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.002154 · Cited by 87 · see citing works
Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins
Ferland‐Beckham, C., & Schrader, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.077 · Cited by 86 · see citing works
Lanthanum actions on excitatory amino acid‐gated currents and voltage‐gated calcium currents in rat dorsal horn neurons.
Reichling, D. B., & MacDermott, A. B. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018746 · Cited by 85 · see citing works
Lymphocyte subset differences in patients with chronic fatigue syndrome, multiple sclerosis and major depression
Robertson, M. J., Schacterle, R. S., Mackin, G. A., Wilson, S. N., Bloomingdale, K. L., Ritz, J., & Komaroff, A. L. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02833.x · Cited by 85 · see citing works
Antepartum/postpartum depressive symptoms and serum zinc and magnesium levels.
Wójcik, J., Dudek, D., Schlegel-Zawadzka, M., Grabowska, M., Marcinek, A., Florek, E., Piekoszewski, W., Nowak, R. J., Opoka, W., & Nowak, G. (2006) · PubMed · Cited by 85 · see citing works
Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly
Pepersack, T., Rotsaert, P., Benoit, F., Willems, D., Fuss, M., Bourdoux, P., & Duchateau, J. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00186-8 · Cited by 84 · see citing works
Zinc deficiency induces behavioral alterations in the tail suspension test in mice. Effect of antidepressants
Młyniec, K., & Nowak, G. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70762-4 · Cited by 84 · see citing works
Enhanced proliferation of progenitor cells following long-term potentiation induction in the rat dentate gyrus
Chun, S., Sun, W., Park, J., & JUNG, M. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.005 · Cited by 84 · see citing works
pH-Dependent Inhibition of Kainate Receptors by Zinc
Mott, D. D., Benveniste, M., & Dingledine, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3567-07.2008 · Cited by 82 · see citing works
Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease.
Thevandavakkam, M., Schwarcz, R., Muchowski, P., & Giorgini, F. (2010) · CNS and Neurological Disorders - Drug Targets · doi:10.2174/187152710793237430 · Cited by 80 · see citing works
Blockade of insulin‐like growth factor‐I has complex effects on structural plasticity in the hippocampus
Glasper, E. R., Llorens-Martı́n, M., Leuner, B., Gould, E., & Trejo, J. L. (2009) · Hippocampus · doi:10.1002/hipo.20672 · Cited by 79 · see citing works
Mossy fiber sprouting induced by repeated electroconvulsive shock seizures
Gombos, Z., Spiller, A. E., Cottrell, G. A., Racine, R. J., & Burnham, W. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01924-1 · Cited by 79 · see citing works
Zinc Attenuates Malathion-Induced Depressant-like Behavior and Confers Neuroprotection in the Rat Brain
Brocardo, P. S., Assini, F. L., Franco, J. L., Pandolfo, P., Müller, Y. M. R., Takahashi, R. N., Dafré, A. L., & Rodrigues, A. L. S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm024 · Cited by 79 · see citing works
Interaction of zinc with antidepressants in the forced swimming test in mice.
Szewczyk, B., Brański, P., Wierońska, J. M., Pałucha-Poniewiera, A., Pilc, A., & Nowak, G. (2002) · PubMed · Cited by 79 · see citing works
G protein-coupled receptors control NMDARs and metaplasticity in the hippocampus
MacDonald, J. F., Jackson, M. F., & Beazely, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.006 · Cited by 78 · see citing works
Serum trace elements in animal models and human depression. Part I. Zinc
Nowak, G., ba, A. Z., Dudek, D., Krośniak, M., Szymaczek, M., & Schlegel-Zawadzka, M. (1999) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(199903)14:2 · Cited by 78 · see citing works
Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats.
Cieślik, K., Klenk-Majewska, B., Danilczuk, Z., Wróbel, A., Lupina, T., & Ossowska, G. (2007) · PubMed · Cited by 78 · see citing works
Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response
Maes, M. H. J., Verkerk, R. M., Vandoolaeghe, E., Hunsel, F. V., Neels, H. M., Wauters, A., Demedts, P., & Scharpé, S. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf03033069 · Cited by 76 · see citing works

Flagged first, then by citations

2 of the 318 references couldn’t be matched to a known paper.

Sorted by citations

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436 · see citing works
Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry
Selhub, E. M., Logan, A. C., & Bested, A. C. (2014) · Journal of Physiological Anthropology · doi:10.1186/1880-6805-33-2 · Cited by 280 · see citing works
Depression in neurodegenerative diseases: Common mechanisms and current treatment options
Galts, C., Bettio, L. E. B., Jewett, D. C., Yang, C. C., Brocardo, P. S., Rodrigues, A. L. S., Thacker, J. S., & Gil‐Mohapel, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.002 · Cited by 268 · see citing works
Zinc in depression: a meta-analysis
Swardfager, W., Herrmann, N., Mazereeuw, G., Goldberger, K., Harimoto, T., & Lanctôt, K. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.008 · Cited by 246 · see citing works
Self-citation
Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment
Juszczyk, G., Mikulska, J., Kasperek, K., Pietrzak, D., Mrozek, W., & Herbet, M. (2021) · Antioxidants · doi:10.3390/antiox10091439 · Cited by 235 · see citing works
Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer’s Disease
Li, Y. H., Jiao, Q., Xu, H., Du, X., Shi, L., Jia, F., & Jiang, H. F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00339 · Cited by 169 · see citing works
Association of total zinc, iron, copper and selenium intakes with depression in the US adults
Li, Z., Wang, W., Xin, X., Song, X., & Zhang, D. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.004 · Cited by 167 · see citing works
The Important Role of Zinc in Neurological Diseases
Li, Z., Liu, Y., Wei, R., Yong, V. W., & Xue, M. (2022) · Biomolecules · doi:10.3390/biom13010028 · Cited by 163 · see citing works
Dietary zinc and iron intake and risk of depression: a meta-analysis
Li, Z., Li, B., Song, X., & Zhang, D. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.006 · Cited by 156 · see citing works
Secretory sphingomyelinase in health and disease
Kornhuber, J., Rhein, C., Müller, C. P., & Mühle, C. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0109 · Cited by 145 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125 · see citing works
Self-citation
Mechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111 · see citing works
Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
Zinc and Central Nervous System Disorders
Wang, B., Fang, T., & Chen, H. (2023) · Nutrients · doi:10.3390/nu15092140 · Cited by 93 · see citing works
GPR39 (Zinc Receptor) Knockout Mice Exhibit Depression-Like Behavior and CREB/BDNF Down-Regulation in the Hippocampus
Młyniec, K., Budziszewska, B., Holst, B., Ostachowicz, B., & Nowak, G. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu002 · Cited by 89 · see citing works
The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition
Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00136 · Cited by 86 · see citing works
Zinc in the Glutamatergic Theory of Depression
Młyniec, K. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150115220617 · Cited by 86 · see citing works
A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation
Mehdi, S., Wani, S. U. D., Krishna, K. L., Kinattingal, N., & Roohi, T. F. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101571 · Cited by 84 · see citing works
Zinc as a marker of affective disorders
Siwek, M., Szewczyk, B., Dudek, D., Styczeń, K., Sowa-Kućma, M., Młyniec, K., Siwek, A., Witkowski, L., Pochwat, B., & Nowak, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71512-3 · Cited by 77 · see citing works
Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges
Visentin, A. P. V., Colombo, R., Scotton, E., Fracasso, D. S., Rosa, A. R., Branco, C. S., & Salvador, M. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2972968 · Cited by 77 · see citing works
The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims
Młyniec, K., Doboszewska, U., Szewczyk, B., Sowa-Kućma, M., Misztak, P., Piekoszewski, W., Trela, F., Ostachowicz, B., & Nowak, G. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.001 · Cited by 76 · see citing works
Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims
Sowa-Kućma, M., Szewczyk, B., Sadlik, K., Piekoszewski, W., Trela, F., Opoka, W., Poleszak, E., Pilc, A., & Nowak, G. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.08.009 · Cited by 75 · see citing works
Cell sensitivity, non-linearity and inverse effects
Bellavite, P., Signorini, A. M., Marzotto, M., Moratti, E., Bonafini, C., & Olioso, D. (2015) · Homeopathy · doi:10.1016/j.homp.2015.02.002 · Cited by 73 · see citing works
Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence
Hoepner, C. T., McIntyre, R. S., & Papakostas, G. I. (2021) · Nutrients · doi:10.3390/nu13030767 · Cited by 69 · see citing works
Self-citation
The serum zinc concentration as a potential biological marker in patients with major depressive disorder
Styczeń, K., Sowa-Kućma, M., Siwek, M., Dudek, D., Reczyński, W., Szewczyk, B., Misztak, P., Topór‐Mądry, R., Opoka, W., & Nowak, G. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9888-9 · Cited by 68 · see citing works
Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action
Nowak, G. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.01.015 · Cited by 65 · see citing works
Zinc in schizophrenia: A meta-analysis
Joe, P., Petrilli, M., Malaspina, D., & Weissman, J. D. (2018) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2018.04.004 · Cited by 63 · see citing works
Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells
Hongxia, L., Yuxiao, T., Zhilei, S., Yan, S., Qu, Y., Jiamin, S., Xin, X., Yang, J., Mo, F., & Shen, H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.041 · Cited by 59 · see citing works
Crosstalk between zinc and free fatty acids in plasma
Coverdale, J. P. C., Khazaipoul, S., Arya, S., Stewart, A. J., & Blindauer, C. A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.09.007 · Cited by 59 · see citing works
Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia
Whitfield, D., Vallortigara, J., Alghamdi, A. A., Hortobágyi, T., Ballard, C. G., Thomas, A. J., O'Brien, J. T., Aarsland, D., & Francis, P. T. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.05.001 · Cited by 51 · see citing works
GPR39 Zn2+-sensing receptor: A new target in antidepressant development?
Młyniec, K., Singewald, N., Holst, B., & Nowak, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.033 · Cited by 49 · see citing works
Single-Micronutrient and Broad-Spectrum Micronutrient Approaches for Treating Mood Disorders in Youth and Adults
Popper, C. W. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.04.001 · Cited by 48 · see citing works
Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial
Yosaee, S., Soltani, S., Esteghamati, A., Motevalian, S. A., Tehrani-Doost, M., Clark, C. C. T., & Jazayeri, S. (2020) · Nutrition · doi:10.1016/j.nut.2019.110601 · Cited by 46 · see citing works
Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches
Baj, J., Bargieł, J., Cabaj, J., Skierkowski, B., Hunek, G., Portincasa, P., Flieger, J., & Smoleń, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015071 · Cited by 46 · see citing works
Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation
Manosso, L. M., Moretti, M., Ribeiro, C. M., Gonçalves, F. M., Leal, R. B., & Rodrigues, A. L. S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.008 · Cited by 42 · see citing works
Targeting the Inflammatory Pathway as a Therapeutic Tool for Major Depression
Noto, C. D. S., Rizzo, L. B., Mansur, R. B., McIntyre, R. S., Maes, M. H. J., & Brietzke, E. M. (2014) · NeuroImmunoModulation · doi:10.1159/000356549 · Cited by 38 · see citing works
Self-citation
Nutritional strategies for dealing with depression
Manosso, L. M., Moretti, M., & Rodrigues, A. L. S. (2013) · Food & Function · doi:10.1039/c3fo60246j · Cited by 38 · see citing works
Study of antidepressant drugs in GPR39 (zinc receptor−/−) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists
Młyniec, K., Gaweł, M., & Nowak, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.053 · Cited by 36 · see citing works
Key Nutrients for Optimal Blood Glucose Control and Mental Health in Individuals with Diabetes: A Review of the Evidence
Basiri, R., Seidu, B., & Cheskin, L. J. (2023) · Nutrients · doi:10.3390/nu15183929 · Cited by 34 · see citing works
Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008
Starowicz, G., Jarosz, M., Frąckiewicz, E., Grzechnik, N., Ostachowicz, B., Nowak, G., & Młyniec, K. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.003 · Cited by 35 · see citing works
Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation
Twayej, A. J., Al‐Hakeim, H. K., Al-Dujaili, A. H., & Maes, M. H. J. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1612090 · Cited by 33 · see citing works
Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.
Kern, J. K., Geier, D. A., Bjørklund, G., King, P. G., Homme, K. G., Haley, B. E., Sykes, L. K., & Geier, M. R. (2014) · PubMed · Cited by 31 · see citing works
Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission
Młyniec, K., Gaweł, M., Librowski, T., Reczyński, W., Bystrowska, B., & Holst, B. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.04.005 · Cited by 31 · see citing works
Up-regulation of the GPR39 Zn(2+)-sensing receptor and CREB/BDNF/TrkB pathway after chronic but not acute antidepressant treatment in the frontal cortex of zinc-deficient mice
Młyniec, K., & Nowak, G. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.04.003 · Cited by 30 · see citing works
Alterations of Hair and Nail Content of Selected Trace Elements in Nonoccupationally Exposed Patients with Chronic Depression from Different Geographical Regions
Błażewicz, A., Liao, K.-Y., Liao, H.-H., Niziński, P., Komsta, Ł., Momčilović, B., Jabłońska‐Czapla, M., Michalski, R., Prystupa, A., Sak, J. J., et al. (2017) · BioMed Research International · doi:10.1155/2017/3178784 · Cited by 29 · see citing works
Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option
Hermens, D. F., Simcock, G. P., Dutton, M., Bouças, A. P., Can, A., Lilley, C. J., & Lagopoulos, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109921 · Cited by 29 · see citing works
Associations of different types of dairy intakes with depressive symptoms in adults
Sun, J., Wang, W., & Zhang, D. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.095 · Cited by 27 · see citing works
Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
Richardson, A. C., Heath, A. M., Haszard, J. J., Polak, M., Houghton, L. A., & Conner, T. S. (2015) · Nutrients · doi:10.3390/nu7085270 · Cited by 27 · see citing works
The Role of Elements in Anxiety
Młyniec, K., Gaweł, M., Doboszewska, U., Starowicz, G., & Nowak, G. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.002 · Cited by 27 · see citing works
Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions
Satała, G., Duszyńska, B., Lenda, T., Nowak, G., & Bojarski, A. J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0536-0 · Cited by 25 · see citing works
Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice
Carlson, V. C. C., Ford, M. M., Carlson, T. L., Lomniczi, A., Grant, K. A., Ferguson, B. M., & Cervera‐Juanes, R. P. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0308-1 · Cited by 24 · see citing works
A review of nutrient treatments for paediatric depression
Lopresti, A. L. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.014 · Cited by 23 · see citing works
Potential role for selenium in the pathophysiology of crib-biting behavior in horses
Omidi, ‌., Jafari, R., Nazıfı, S., & Parker, M. O. (2017) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2017.10.003 · Cited by 21 · see citing works
An adjunctive antidepressant nutraceutical combination in treating major depression: Study protocol, and clinical considerations
Sarris, J. J., Stough, C. K. K., Bousman, C., Murphy, J., Savage, K. M., Smith, D. J., Menon, R., Chamoli, S., Oliver, G., Berk, M., et al. (2015) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2015.02.001 · Cited by 19 · see citing works
Association between serum zinc levels and suicidal ideation in US adults: A population-based cross-sectional study
Huang, D., Zhong, S., Yan, H., Lai, S., Lam, M., & Jia, Y. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.039 · Cited by 18 · see citing works
The level of the zinc homeostasis regulating proteins in the brain of rats subjected to olfactory bulbectomy model of depression
Rafało-Ulińska, A., Zadrożna, M., Nowak, B., Kotarska, K., Wiatrowska, K., Pochwat, B., Sowa-Kućma, M., Misztak, P., Nowak, G., & Szewczyk, B. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.08.009 · Cited by 18 · see citing works
Relationship of Dietary and Serum Zinc with Depression Score in Iranian Adolescent Girls
Gonoodi, K., Moslem, A., Ahmadnezhad, M., Darroudi, S., Khorasani, Z. M., Tayefi, M., Tabatabaeizadeh, S., Eslami, S., Shafiee, M., Khashayarmanesh, Z., et al. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1301-6 · Cited by 18 · see citing works
Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia
Kovács, G., Környei, Z., Tóth, K., Baranyi, M., Brunner, J., Neubrandt, M., Dénes, Á., & Sperlágh, B. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.07.010 · Cited by 16 · see citing works
Cellular neurobiology of hyperforin
Bouron, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.8063 · Cited by 15 · see citing works
Involvement of glutamatergic neurotransmission in the antidepressant-like effect of zinc in the chronic unpredictable stress model of depression
Manosso, L. M., Moretti, M., Colla, A. R. D. S., Ribeiro, C. M., Dal-Cim, T. A., Tasca, C. I., & Rodrigues, A. L. S. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-015-1504-3 · Cited by 15 · see citing works
Drugs with glutamate-based mechanisms of action in psychiatry
Chrobak, A. A., & Siwek, M. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00656-8 · Cited by 14 · see citing works
Oxidative stress-induced increase of intracellular zinc in astrocytes decreases their functional expression of P2X7 receptors and engulfing activity
Furuta, T., Mukai, A., Ohishi, A., Nishida, K., & Nagasawa, K. (2017) · Metallomics · doi:10.1039/c7mt00257b · Cited by 13 · see citing works
Serum zinc levels in acute psychiatric patients: A case series
Joe, P., Getz, M., Redman, S. L., Petrilli, M., Kranz, T. M., Ahmad, S., & Malaspina, D. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.082 · Cited by 13 · see citing works
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J. J., Murphy, J., Mischoulon, D., Papakostas, G. I., D, M. F. M., Berk, M., & Ng, C. H. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16304 · Cited by 13 · see citing works
Study on the comorbid mechanisms of sarcopenia and late-life depression
Wu, J., Tang, J., Huang, D., Wang, Y., Zhou, E., Ru, Q., Xu, G., Chen, L., & Wu, Y. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115538 · Cited by 12 · see citing works
Gender-related alterations of serum trace elements and neurometabolism in the anterior cingulate cortex of patients with major depressive disorder
Zhong, Q., Lai, S., He, J., Zhong, S., Song, X., Wang, Y., Zhang, Y., Chen, G., Yan, S., & Jia, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.039 · Cited by 12 · see citing works
Epigenetics and Metal Deficiencies
Weßels, I. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0091-5 · Cited by 12 · see citing works
Rare variants and biological pathways identified in treatment‐refractory depression
McClain, L. L., Shaw, P., Sabol, R. M., Chedia, A. M., Segreti, A. M., Rengasamy, M. L., Finegold, D. N., Pan, L. A., & Peters, D. G. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24609 · Cited by 12 · see citing works
The Role of Zinc in Mood Disorders
Piao, M., Cong, X., Ying, L., Feng, C., & Ge, P. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000225 · Cited by 11 · see citing works
Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk
Guevara‐Ramírez, P., Tamayo‐Trujillo, R., Cadena-Ullauri, S., Ruiz‐Pozo, V. A., Paz‐Cruz, E., Annunziata, G., Verde, L., Frías-Toral, E., Simancas‐Racines, D., & Zambrano, A. K. (2024) · Food and Agricultural Immunology · doi:10.1080/09540105.2024.2434457 · Cited by 9 · see citing works
The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications
Li, Y., Lu, Y., Lin, X., & Zhao, L. (2026) · Annals of Medicine · doi:10.1080/07853890.2025.2611191 · Cited by 10 · see citing works
Reply to: Serum Zinc and the Risk of Depression in Men: Observations from a 20-Year Follow-up Study
Swardfager, W., Herrmann, N., Mazereeuw, G., & Lanctôt, K. L. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.006 · Cited by 9 · see citing works
Self-citation
Association between oral health-related quality of life and mental health among university students in Riyadh, Saudi Arabia
AlJameel, A. H., Alsaleh, L., Bawazir, N. H., Alomair, A., & Almalki, S. A. (2025) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2025.101984 · Cited by 8 · see citing works
Leveraging machine learning and decision analytics for sustainable and resilient environmental monitoring in metal processing industries: a step towards Industry 5.0
Bamdad, S. (2025) · International Journal of Production Research · doi:10.1080/00207543.2025.2487567 · Cited by 8 · see citing works
Negative correlation between CSF zinc level and anxiety in male Chinese subjects
Song, N., Yu, D., Kang, Y., Cao, Z., Yang, X., Wang, J., Liu, Y., & Wang, F. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.067 · Cited by 8 · see citing works
Chronic but not acute antidepresant treatment alters serum zinc/copper ratio under pathological/zinc-deficient conditions in mice.
Młyniec, K., Ostachowicz, B., Krakowska, A., Reczyński, W., Opoka, W., & Nowak, G. (2014) · PubMed · Cited by 7 · see citing works
Factors associated with symptoms of depression among pregnant women with gestational diabetes mellitus in Japan
Hayashi, A., Oguchi, H., Kozawa, Y., Ban, Y., Shinoda, J., & Suganuma, N. (2020) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2020.03078 · Cited by 6 · see citing works
Serum zinc concentrations and depression in persons with Human Immunodeficiency Virus infection: The positive living with HIV (POLH) study
Poudel‐Tandukar, K., Jacelon, C. S., Bertone‐Johnson, E. R., Palmer, P. H., & Poudel, K. C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.05.021 · Cited by 6 · see citing works
Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms
Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-69277-4 · Cited by 6 · see citing works
Associations Between Serum Zinc Levels and Mental Health: Findings from the 2010 Korean National Health and Nutrition Examination Survey
Kim, N., Kim, K. W., Kim, H.-N., & Song, S.-W. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-1051-x · Cited by 6 · see citing works
The Relationship Between Zinc and Quality of Life in Patients With Upper GI Cancer on Chemotherapy
Brutcher, E., Chen, Z., Pan, A., & Barrett, T. (2017) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2017.8.4.3 · Cited by 5 · see citing works
Lowered Zinc and Copper Levels in Drug-Naïve patients with Major Depression: Effects of Antidepressants, Ketoprofen and Immune ActivationPreprint
Twayej, A. J., Al‐Hakeim, H. K., Al-Dujaili, A. H., & Maes, M. H. J. (2019) · Preprints.org · doi:10.20944/preprints201901.0135.v1 · Cited by 4 · see citing works
Orphan receptor GPR39: A potential therapeutic target for inflammatory diseases.
Ran, S., Pan, L., & Shen, Y. (2025) · Gene · doi:10.1016/j.gene.2025.149625 · Cited by 4 · see citing works
The Role of Various Types of Diets in the Treatments of Depressive Disorders
Lis, A., Maj, P., Świętek, A., & Romuk, E. B. (2025) · Medicina · doi:10.3390/medicina61101737 · Cited by 5 · see citing works
Tolerability of Artemisia absinthium in anorexia: Targeting of neuronal appetite and satiety in zinc deficiency diet rat model
El-bakry, K. A.-E. K. M., Bahnasawy, M., Deef, L. E. M., Ahmed-Farid, O. A.-H., & el-naeli, S. S. (2024) · Scientific African · doi:10.1016/j.sciaf.2024.e02162 · Cited by 4 · see citing works
Intracellular labile zinc is a determinant of vulnerability of cultured astrocytes to oxidative stress
Furuta, T., Ohishi, A., & Nagasawa, K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134315 · Cited by 3 · see citing works
Non-Pharmacological Interventions for Enhancing Brain Plasticity and Promoting Brain Recovery: A Review
Farzana, F., Ahuja, Y. R., & Vemula, S. (2013) · Research in neuroscience · Cited by 3 · see citing works
Zinc in drug-naïve patients with short-illness-duration first episode major depressive disorder: impact on psychopathological features.
Cubała, W. J., Landowski, J., Szyszko, M., & Wielgomas, B. (2014) · PubMed · Cited by 3 · see citing works
O papel do zinco no transtorno depressivo maior
Manosso, L. M. (2019) · Revista Brasileira de Nutrição Funcional · doi:10.32809/2176-4522.43.78.01 · Cited by 3 · see citing works
Dysregulated zinc homeostasis and microadenomas in the anterior pituitary: pathological insights into suicide risk
Tendilla‐Beltrán, H., Aguilar‐Alonso, P., Hernández-González, C. A., Baltazar‐Gaytán, E., Orduña, A. A., Nicolini, H., García‐Dolores, F., & Flores, G. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1446255 · Cited by 2 · see citing works
Decoding psychotropic-induced metabolic disturbances: gut-brain axis, multi-omics, and nutrition-lifestyle integration
Dhieb, D., & Bastaki, K. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778794 · Cited by 2 · see citing works
Zinc Chloride Reverse Influence on Dexamethasone Depressant Effects in Adult Male Rats
Navabi, S. P., Harooni, H. E., Moazedi, A. A., & Khajehpour, L. (2015) · Jentashapir Journal of Health Research · doi:10.17795/jjhr-24297 · Cited by 2 · see citing works
Improving Treatment of Alcoholism by Using Evidence-based Practices and Computer-assisted Game-like Programs
Reid, L. D. (2015) · Cited by 2 · see citing works
Treatments for Comorbid Anxiety and Mood Disorders
Sarris, J. J., & Mischoulon, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-42307-4_6 · Cited by 2 · see citing works
Serum copper, rubidium, selenium, strontium, and zinc and psychophysical health in adults of the Sarno river Basin: PREVES-STOP 2025 community biomonitoring results
Scafuri, L., Baio, R., Buonerba, C., Crocetto, F., Verde, A., Ferraioli, A., Riccio, V., Rizzano, S., Rizzano, S., Pisapia, A., et al. (2026) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2025-0195 · Cited by 1 · see citing works
Unlocking Stress Coping Mechanisms: Implications for Salivary Antioxidant Defense and Trace Element Homeostasis
Portnova, G. V., Proskurnina, E. V., Liaukovich, K. M., Mikheev, I. V., Chermashentsev, G. R., Alshanskaia, E. I., & Martynova, O. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02478-0 · Cited by 1 · see citing works
Mood-modulating foods: Pathways, challenges, and opportunities for mental well-being in the AI era
Ouyang, K., Jin, R., Zang, J., Zhao, G., He, J., Li, X., Lu, W., Zhao, Y., Sun, C., Fang, Y., et al. (2026) · Nexus · doi:10.1016/j.ynexs.2026.100132 · Cited by 1 · see citing works
Metals Toxicity Associated with Oxidative Stress and Altered Level of Antioxidants in the Pathogenesis of Alzheimer’s Disease
Yadav, J., Verma, A., Singla, A., & Garg, R. K. (2023) · Indian Journal of Behavioural Sciences · doi:10.55229/ijbs.v26i2.10 · Cited by 1 · see citing works
Mineral Deficiencies and Depression: Evidence-Based Research
Greenblatt, J. M., & Grossmann, K. (2015) · CRC Press eBooks · doi:10.1201/b19089-10 · Cited by 1 · see citing works

Role of zinc in the development and treatment of mood disorders
Cope, E. C., & Levenson, C. W. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833df61a · Cited by 86 · see citing works
The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications
Li, Y., Lu, Y., Lin, X., & Zhao, L. (2026) · Annals of Medicine · doi:10.1080/07853890.2025.2611191 · Cited by 10 · see citing works
Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action
Nowak, G. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.01.015 · Cited by 65 · see citing works
Zinc and depression. An update.
Nowak, G., Szewczyk, B., & Pilc, A. (2005) · PubMed · Cited by 158 · see citing works
The role of zinc in neurodegenerative inflammatory pathways in depression
Szewczyk, B., Kubera, M., & Nowak, G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.010 · Cited by 176 · see citing works

Authors: Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L.
Affiliations: Toronto Rehabilitation Institute (CA)
University of Toronto (CA)
University Health Network (CA)
Sunnybrook Research Institute (CA)
Corresponding author: Lanctôt, Krista L.
ORCID: Swardfager, Walter
Herrmann, Nathan
McIntyre, Roger S.
Mazereeuw, Graham
Lanctôt, Krista L.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-06
Volume: 37
Issue: 5
Pages: 911-929
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2013.03.018
OpenAlex: W2087435407
Cited by: 116
References: 318
Citations by year: 2026: 7 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 2 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 14 · 2015: 15 · 2014: 12 · 2013: 7
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: zinc, major depressive disorder, neuroprogression, treatment-resistant depression, NMDA receptor, glutamatergic neurons, excitatory neurotransmission, neuroplasticity, zinc supplementation, serum zinc, dietary zinc deficiency, mood regulation, oxidative stress, immune dysfunction, monoamine metabolism, stress response dysregulation, epigenetic regulation
MeSH terms: Animals, Major Depressive Disorder, Humans, Synaptic Transmission, Neurons, Zinc, Receptors, N-Methyl-D-Aspartate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks