Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

Targeting HIF-1 for cancer therapy

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

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Hsp70 chaperones: Cellular functions and molecular mechanism

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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Impact of epoetin alfa on clinical end points in patients with chronic renal failure: A meta-analysis

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Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

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Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma

Raval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

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HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthPreprint

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An essential role for p300/CBP in the cellular response to hypoxia

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Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs

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Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

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CHIP Is a U-box-dependent E3 Ubiquitin Ligase

Jiang, J., Ballinger, C. A., Wu, Y., Dai, Q., Cyr, D., Höhfeld, J., & Patterson, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101968200 · Cited by 592

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

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HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.001 · Cited by 490

Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells

Uchida, T., Rossignol, F., Matthay, M. A., Mounier, R., Couette, S., Clottes, E., & Clérici, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400461200 · Cited by 452

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Xu, W., Marcu, M. G., Yuan, X., Mimnaugh, E. G., Patterson, C., & Neckers, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202365899 · Cited by 431

Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia

Nakayama, K., Frew, I. J., Hagensen, M. K., Skals, M., Habelhah, H., Bhoumik, A., Kadoya, T., Erdjument‐Bromage, H., Tempst, P., Frappell, P. B., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.001 · Cited by 406

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355

Mitochondria and cellular oxygen sensing in the HIF pathway

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Hypoxia Up-regulates Prolyl Hydroxylase Activity

D’Angelo, G., Duplan, E., Boyer, N., Vigne, P., & Frelin, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302244200 · Cited by 294

Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α

Kong, X., Lin, Z., Liang, D., Fath, D., Sang, N., & Caro, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2019-2028.2006 · Cited by 258

PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis

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Targeting hypoxia cell signaling for cancer therapy

Melillo, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9059-x · Cited by 230

Quantitative proteomics using stable isotope labeling with amino acids in cell culture

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Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Koh, M. Y., Darnay, B. G., & Powis, G. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00773-08 · Cited by 182

Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O., & Semenza, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705015200 · Cited by 154

Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells

Cui, Y. R., Golob, J. L., Kelleher, E., Ye, Z., Pardoll, D. M., & Cheng, L. (2002) · Blood · doi:10.1182/blood.v99.2.399 · Cited by 138

p24A, a Type I Transmembrane Protein, Controls ARF1-dependent Resensitization of Protease-activated Receptor-2 by Influence on Receptor Trafficking

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Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

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Transcriptional regulation by hypoxia inducible factors

Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.838205 · Cited by 816

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2

Prabhakar, N. R., & Semenza, G. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00030.2011 · Cited by 641

Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions

Wang, R., Zhang, P., Li, J., Guan, H., & Shi, G. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.005 · Cited by 11

Constitutive/Hypoxic Degradation of HIF-α Proteins by the Proteasome Is Independent of von Hippel Lindau Protein Ubiquitylation and the Transactivation Activity of the Protein

Kong, X., Alvarez‐Castelao, B., Lin, Z., Castaño, J. G., & Caro, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700704200 · Cited by 72

Analysis of HIF-1alpha degradation and function

André, H. (2005) · Figshare

HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation

Berra, E., Richard, D. E., Gothié, E., & Pouysségur, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02159-7 · Cited by 147

Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α

Baek, J. H., Liu, Y. V., McDonald, K. R., Wesley, J. B., Zhang, H., & Semenza, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705627200 · Cited by 71