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Cited by 60

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Targeted Deletion of Hepatocyte ABCA1 Leads to Very Low Density Lipoprotein Triglyceride Overproduction and Low Density Lipoprotein Hypercatabolism

Chung, Soonkyu, Timmins, Jenelle M., Duong, MyNgan, Degirolamo, Chiara, Rong, Shunxing, Sawyer, Janet K., Singaraja, Roshni R., Hayden, Michael R., Maeda, Nobuyo, Rudel, Lawrence L., Shelness, Gregory S., Parks, John S.·2010·Journal of Biological Chemistry
DOI 10.1074/jbc.m109.096933
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Crossref · 10.1074/jbc.m109.096933

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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  • When HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.

    “It is thought that when HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.22–26”

    From Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome (2023) · cites this paper as [23]

    The Discussion (page unavailable) says hepatocyte ABCA1 deficiency reduces HDL formation but increases secretion of triglyceride-enriched VLDL—the opposite of VLDL secretion being reversed when ABCA1 is compromised. It reports reversal of elevated plasma VLDL triglycerides after ABCA1 expression was restored, not after it was compromised. The paper does report increased triglyceride synthesis and secretion in deficient primary hepatocytes, but does not establish the claim's stated causal sequence. (LLM, conf=0.88)

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 42

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Metadata

Authors
Chung, S., Timmins, J. M., Duong, M., Degirolamo, C., Rong, S., Sawyer, J. K., Singaraja, R. R., Hayden, M. R., Maeda, N., Rudel, L. L., Shelness, G. S., & Parks, J. S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2010-04
Volume
285
Issue
16
Pages
12197-12209
ISSN
0021-9258
DOI
10.1074/jbc.m109.096933
Cited by
60
References
3
Language
en
Licence

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