The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway
Open accessAbstract
Endothelial nitric-oxide synthase (eNOS) is an important component of vascular homeostasis. During vascular disease, endothelial cells are exposed to excess reactive oxygen species that can alter cellular phenotype by inducing various signaling pathways. In the current study, we examined the implications of H(2)O(2)-induced signaling for eNOS phosphorylation status and activity in porcine aortic endothelial cells. We found that H(2)O(2) treatment enhanced eNOS activity and NO bioactivity as determined by the conversion of l-[(3)H]arginine to l-[(3)H]citrulline and cellular cGMP content. Concomitant with eNOS activation, H(2)O(2) also activated Akt, increased eNOS phosphorylation at Ser-1177, and decreased eNOS phosphorylation at Thr-495. H(2)O(2)-induced promotion of eNOS activity and modulation of the eNOS phosphorylation status at Ser-1177 and Thr-495 were significantly attenuated by selective inhibitors of Src kinase, the ErbB receptor family, and phosphoinositide 3-kinase (PI 3-K). We found that Akt activation, eNOS Ser-1177 phosphorylation, and eNOS activation by H(2)O(2) were calcium-dependent, whereas eNOS dephosphorylation at Thr-495 was not, suggesting a branch point in the signaling cascade downstream from PI 3-K. Consistent with this, overexpression of a dominant negative isoform of Akt inhibited H(2)O(2)-induced phosphorylation of eNOS at Ser-1177 but not dephosphorylation of eNOS at Thr-495. Together, these data indicate that H(2)O(2) promotes calcium-dependent eNOS activity through a coordinated change in the phosphorylation status of the enzyme mediated by Src- and ErbB receptor-dependent PI 3-K activation. In turn, PI 3-K mediates eNOS Ser-1177 phosphorylation via a calcium- and Akt-dependent pathway, whereas eNOS Thr-495 dephosphorylation does not involve calcium or Akt. This response may represent an attempt by endothelial cells to maintain NO bioactivity under conditions of enhanced oxidative stress.
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“An emerging paradigm proposes that intermediate levels (50–300 nM) can activate a range of positive and negative responses from wound healing to oncogenic pathways”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [938]
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“Higher concentrations of NO (>1 μM) can lead not only to oxidative stress but also nitrative and nitrosative stress via the generation of peroxynitrite and nitrosating species”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [938]
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Cites
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382
Research works printed but not linked: 3
- Govers, 2001, Am. J. Physiol., 280, F193
- Fleming, 2001, Circ. Res., 88, E68
- Shimizu, 1997, Res. Commun. Mol. Pathol. Pharmacol., 95, 227
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Chaudary, S., Rieger, S. B., Redl, H. R., & Dungel, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-21056-8_4-2 · Cited by 1
Han, J.-A., Seo, E. Y., Kim, H. J., Park, S. J., Yoo, H. Y., Kim, J. Y., Shin, D. M., Kim, J., Zhang, Y. H., & Kim, S. J. (2013) · Cited by 1
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Allen, K. N., & Vázquez‐Medina, J. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816196-8.00011-4 · Cited by 1
Mantzouranis, L. (2009) · doi:10.11606/t.46.2009.tde-10122009-093106 · Cited by 1
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Vegfors, J. (2014) · Linköping University Electronic Press eBooks · doi:10.3384/diss.diva-110031
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Holton, M. (2009) · Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)
Trott, D. W. (2012) · OakTrust (Texas A&M University Libraries)
Azor, M. H., dos Santos, J. C., Futata, E. A., de Brito, C. A., Maruta, C. W., Rivitti, E. A., Pontillo, A., Duarte, A. J. D. S., & Sato, M. N. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.004
RetractedWon, D. (2009) · TSpace (University of Toronto)
Chaudary, S., Rieger, S. B., Redl, H. R., & Dungel, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-21056-8_4-1
Reidinger, A. Z. (2015) · Digital WPI
Hiền, T. T., Oh, W. K., Nguyễn, P. H., Oh, S. J., Lee, M. Y., & Kang, K. W. (2011)
Mediators in cardiovascular disease: association with Raynaud’s phenomenon
Abdulle, A. E. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.194678419
Vascular Reactive Oxygen Species Biology – Insights from Transgenic and Knockout Mouse Models
Tan, S. M., & de Haan, J. B. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_22
要是通过调节血管张力和血压, 抑., 蒋建刚, 肖啸, & 汪道文 (2005) · Science in China Series C-Life Sciences (in Chinese) · doi:10.1360/052004-36
Effect of high salt intake on arteriolar responses to metabolic stimuli
Marvar, P. J. (2006) · doi:10.33915/etd.4246
Pathogenetic Predictors of Complications of the New Coronavirus Infection SARS-COV-2
Chepur, S. V., Nn, P., Chubar, O. V., Сергеевна, Б. Л., Litvinenko, I., Tjunin, M. A., Mjasnikova, I. A., & Пугач, В. А. (2025) · Biology Bulletin Reviews · doi:10.1134/s2079086425600110
Fadishei, M., Mohsenzadeh, M. S., Razavi, B. M., Imenshahidi, M., Mohajeri, S. A., Rahbardar, M. G., & Hosseinzadeh, H. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71290
Denniss, S. G. (2011) · UWSpace (University of Waterloo)
Echeverría‐Rodríguez, O., Rodríguez, S. R., Torres, S. D. H., Riveros‐Rosas, H., Ortiz, I. A. G., Molina, R. V., & Vilchis‐Landeros, M. M. (2026) · Vascular Pharmacology · doi:10.1016/j.vph.2026.107692
Boo, Y. C. (2005) · Journal of Applied Biological Chemistry
Biodisponibilidade cardiovascular do oxdo nitrico em camundongos LDLr-/-
Wanschel, A. C. B. A. (2010) · doi:10.47749/t/unicamp.2010.480714
Metadata
- Authors
- Thomas, S. R., Chen, K., & Keaney, J. F.
- Affiliations
- Boston University (US)
- Corresponding author
- Keaney, John F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 277
- Issue
- 8
- Pages
- 6017-6024
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2119043221
- Cited by
- 381
- References
- 47
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 12 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 13 · 2015: 20 · 2014: 21 · 2013: 17 · 2012: 19
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk055656-03)
- National Heart, Lung, and Blood Institute (P01HL060886, HL-60886)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-55656)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- hydrogen peroxide, endothelial nitric oxide synthase, eNOS phosphorylation, phosphatidylinositol 3-kinase, Akt signaling, Src kinase, ErbB receptors, calcium signaling, nitric oxide bioactivity, cyclic GMP, reactive oxygen species
- MeSH terms
- Animals, Aorta, Arginine, Cells, Cultured, Chromones, Citrulline, Egtazic Acid, Endothelium, Vascular, Enzyme Activation, Enzyme Inhibitors, Hydrogen Peroxide, Kinetics, Morpholines, Nitric Oxide, Phosphorylation, Phosphoserine, Phosphothreonine, Quinazolines, Swine, Signal Transduction, Nitric Oxide Synthase, Phosphatidylinositol 3-Kinases, Calcium Signaling, Tyrphostins, Nitric Oxide Synthase Type III
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