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Human Papillomavirus Type 16 E7 Binds to E2F1 and Activates E2F1-driven Transcription in a Retinoblastoma Protein-independent Manner

Hwang, Sun Gwan, Lee, Daeyoup, Kim, Jiyun, Seo, Taegun, Choe, Joonho·2002·Journal of Biological Chemistry
DOI 10.1074/jbc.m109113200
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Abstract

The human papillomavirus (HPV) E7 oncoprotein can immortalize primary human cells and induce tumor formation. These properties of E7 depend on its ability to inhibit the activity of retinoblastoma protein (pRB), which in turn affects E2F function. E2F proteins control the expression of genes involved in differentiation, development, cell proliferation, and apoptosis. By using genetic and biochemical approaches, the present study shows that E7 binds to E2F1 in vivo and in vitro and that both proteins co-localize in the nucleus. Importantly, the binding of the high risk group HPV E7 to E2F1 is tighter than the binding of the low risk group HPV E7 to E2F1. Although E7 of the high risk group HPVs activates E2F1-dependent transcription strongly in C33A or 293T cells, E7 of the low risk group HPVs activates transcription only weakly. By using electrophoretic mobility shift assay, we also showed that E7 binds to E2F1-DNA complexes. Furthermore, we show that these activities of E7 are independent of pRB by using E7 and E2F1 mutants that cannot bind to pRB. Taken together, these data suggest that E7 contributes to the deregulation of pRB-dependent E2F1 repression and to the further activation of E2F1 independently of pRB.

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Metadata

Authors
Hwang, S. G., Lee, D., Kim, J., Seo, T., & Choe, J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2002-01
Volume
277
Issue
4
Pages
2923-2930
ISSN
0021-9258
DOI
10.1074/jbc.m109113200
Cited by
111
References
4
Language
en
Licence

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CoChat. (2026). Citation check: Human Papillomavirus Type 16 E7 Binds to E2F1 and Activates E2F1-driven Transcription in a Retinoblastoma Protein-independent Manner. https://app.cochat.ai/papers/10.1074/jbc.m109113200
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Hwang, S. G., Lee, D., Kim, J., Seo, T., & Choe, J. (2002). Human Papillomavirus Type 16 E7 Binds to E2F1 and Activates E2F1-driven Transcription in a Retinoblastoma Protein-independent Manner. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109113200