Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

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Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma

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HDAC10 promotes lung cancer proliferation via AKT phosphorylation

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Subcellular Localization of Class II HDAs in Arabidopsis thaliana: Nucleocytoplasmic Shuttling of HDA15 Is Driven by Light

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HDAC6 controls the kinetics of platelet activation

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New perspectives of valproic acid in clinical practice

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Class IIa histone deacetylases: conducting development and differentiation

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Chromatin remodeling and stem cell theory of relativity

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HDAC Inhibition in Lupus Models

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Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2

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Histone deacetylases and atherosclerosis

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Uropathogenic Escherichia coli Invades Host Cells via an HDAC6-modulated Microtubule-dependent Pathway

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Classical HDACs in the regulation of neuroinflammation

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The therapeutic uses of chromatin-modifying agents

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Histone Deacetylase 10 Relieves Repression on the Melanogenic Program by Maintaining the Deacetylation Status of Repressors

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SHP Represses Transcriptional Activity via Recruitment of Histone Deacetylases

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Histone deacetylase 10, a potential epigenetic target for therapy

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Intranasal curcumin and sodium butyrate modulates airway inflammation and fibrosis via HDAC inhibition in allergic asthma

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Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

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Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells

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VALPROIC ACID PREVENTS HEMORRHAGE-ASSOCIATED LETHALITY AND AFFECTS THE ACETYLATION PATTERN OF CARDIAC HISTONES

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Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases,

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HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2

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Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation

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Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors

Ediriweera, M. K., To, N. B., Lim, Y., & Cho, S. K. (2021) · Biochimie · doi:10.1016/j.biochi.2021.04.011 · Cited by 49

Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90

Meng, Q., Chen, X., Sun, L., Zhao, C., Sui, G., & Cai, L. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0651-y · Cited by 48

Regulatory Factor for X-box Family Proteins Differentially Interact with Histone Deacetylases to Repress Collagen α2(I) Gene (COL1A2) Expression

Xu, Y., Sengupta, P. K., Seto, E., & Smith, B. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511724200 · Cited by 48

Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic Cancer

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Tubulin must be acetylated in order to form a complex with membrane Na+,K+-ATPase and to inhibit its enzyme activity

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An update on the emerging approaches for histone deacetylase (HDAC) inhibitor drug discovery and future perspectives

Su, M., Gong, X.-Y., & Liu, F. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1877656 · Cited by 46

Class IIA HDACs in the regulation of neurodegeneration

Majdzadeh, N. (2007) · Frontiers in bioscience · doi:10.2741/2745 · Cited by 44

HDACi: molecular mechanisms and therapeutic implications in the innate immune system

Suliman, B. A., Xu, D., & Williams, B. R. G. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.92 · Cited by 44

Lysine acetylation of cytoskeletal proteins: Emergence of an actin code

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Histone deacetylases 1 and 2 are required for brain development

Jaworska, J., Ziemka‐Nałęcz, M., & Zalewska, T. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150071tz · Cited by 43

Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies

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Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

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Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor

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Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient Care

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Class II and IV HDACs function as inhibitors of osteoclast differentiation

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Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition

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HDAC10 upregulation contributes to interleukin 1β‐mediated inflammatory activation of synovium‐derived mesenchymal stem cells in temporomandibular joint

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Epigenetics: tools and technologies

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Signal-dependent Regulation of Transcription by Histone Deacetylase 7 Involves Recruitment to Promyelocytic Leukemia Protein Nuclear Bodies

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Submembraneous microtubule cytoskeleton: regulation of ATPases by interaction with acetylated tubulin

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Gene silencing by the thyroid hormone receptor

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Epigenetic assays for chemical biology and drug discovery

Gul, S. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0342-6 · Cited by 31

The role of histone deacetylases in cardiac energy metabolism in heart diseases

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Inhibitors selective for HDAC6 in enzymes and cells

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HDAC expression and activity is upregulated in diseased lupus-prone mice

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Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum

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An Overview of Naturally Occurring Histone Deacetylase Inhibitors

Kim, B., & Hong, J. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666141208105614 · Cited by 30

Histone Deacetylase-Dependent Establishment and Maintenance of Broad Low-Level Histone Acetylation within a Tissue-Specific Chromatin Domain

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An Overview of HDAC Inhibitors and their Synthetic Routes

Peng, X., Liao, G., Sun, P., Yu, Z., & Chen, J. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190227221507 · Cited by 28

Histone Deacetylases and Cardiometabolic Diseases

Yiew, K. H., Chatterjee, T. K., Hui, D. Y., & Weintraub, N. L. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305046 · Cited by 28

β-Carboline tethered cinnamoyl 2-aminobenzamides as class I selective HDAC inhibitors: Design, synthesis, biological activities and modelling studies

Krishna, N. H., Anchi, P., Manasa, K. L., Soni, J. P., Godugu, C., Shankaraiah, N., & Kamal, Ä. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105461 · Cited by 29

miR ‐3,178 contributes to the therapeutic action of baicalein against hepatocellular carcinoma cells via modulating HDAC10

Qi, J., Li, J., Bie, B., Shi, M., Zhu, M., Tian, J., Zhu, K., Sun, J., Mu, Y., Li, Z., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7613 · Cited by 28

Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects

Ru, J., Wang, Y., Li, Z., Wang, J., Ren, C., & Zhang, J. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115800 · Cited by 28

Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222

Terracciano, S., Micco, S. D., Bifulco, G., Gallinari, P., Riccio, R., & Bruno, I. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.03.022 · Cited by 27

Understanding Histone Deacetylases in the Cancer Development and Treatment: An Epigenetic Perspective of Cancer Chemotherapy

Ahmad, M., Hamid, A., Hussain, A., Majeed, R., Qurishi, Y., Bhat, J. A., Najar, R. A., Qazi, A. K., Zargar, M. A., Singh, S. K., et al. (2012) · DNA and Cell Biology · doi:10.1089/dna.2011.1575 · Cited by 27

Energy-optimised pharmacophore approach to identify potential hotspots during inhibition of Class II HDAC isoforms

Ganai, S. A., Shanmugam, K., & Mahadevan, V. (2014) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2013.879073 · Cited by 27

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases

Scholte, L., Mourão, M. D. M., Pais, F. S.-M., Melesina, J., Robaa, D., Volpini, Â. C., Sippl, W., Pierce, R. J., Oliveira, G., & Nahum, L. A. (2017) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2017.05.011 · Cited by 27

MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke–Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade

Yuan, S., Tan, R., Sun, M., Yuan, L., Ruiz, M., Dupuis, J., Hu, Q., & Zhu, L. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19560 · Cited by 24

Differential regulation of connective tissue growth factor in renal cells by histone deacetylase inhibitors

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The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus

Ren, J., Panther, E. J., Liao, X., Grammer, A. C., Lipsky, P. E., & Reilly, C. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124007 · Cited by 25

Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease (Review)

Liu, Y.-R., Wang, J., Huang, Z., Chen, R.-N., Cao, X., Zhu, D., Yu, H., Wang, X., Zhou, H.-Y., Xia, Q., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4964 · Cited by 23

Histone Acetylation and Deacetylation

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Histone deacetylase 10 knockout activates chaperone-mediated autophagy and accelerates the decomposition of its substrate

Obayashi, H., Nagano, Y., Takahashi, T., Seki, T., Tanaka, S., Sakai, N., Matsumoto, M., & Maruyama, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.048 · Cited by 20

An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1α/VEGF axis suppression in mice

Islam, R., Dash, D., & Singh, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-36678-0 · Cited by 24

Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update

Sultana, F., Manasa, K. L., Shaik, S. P., Bonam, S. R., & Kamal, Ä. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530094120 · Cited by 21

Aroyl‐Pyrrolyl Hydroxyamides: Influence of Pyrrole C4‐Phenylacetyl Substitution on Histone Deacetylase Inhibition

Mai, A., Massa, S., Valente, S., Simeoni, S., Ragno, R., Bottoni, P., Scatena, R., & Brosch, G. (2005) · ChemMedChem · doi:10.1002/cmdc.200500015 · Cited by 21

Epigenetic Regulation Through Histone Deacetylation: Implications and Therapeutic Potential in Hepatocellular Carcinoma

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Restoration of mutant hERG stability by inhibition of HDAC6

Li, P., Kurata, Y., Mahati, E., Ninomiya, H., Higaki, K., Taufiq, F., Morikawa, K., Shirayoshi, Y., Horie, M., & Hisatome, I. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.009 · Cited by 19

LncRNA SOX1‐OT V1 acts as a decoy of HDAC10 to promote SOX1‐dependent hESC neuronal differentiation

Xi, J., Xu, Y., Guo, Z., Li, J., Wu, Y., Sun, Q., Wang, Y., Chen, M., Zhu, S., Bian, S., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153015 · Cited by 20

Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases

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Sex Differences in Psychostimulant Abuse: Implications for Estrogen Receptors and Histone Deacetylases

Torres, O. V. (2022) · Genes · doi:10.3390/genes13050892 · Cited by 20

HDAC1 in axonal degeneration

Kim, J. Y., & Casaccia, P. (2010) · Cell Cycle · doi:10.4161/cc.9.18.12716 · Cited by 17

Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology

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Growth attenuation is associated with histone deacetylase 10-induced autophagy in the liver

Pinto, G., Shtaif, B., Phillip, M., & Gat‐Yablonski, G. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.031 · Cited by 16

Histone deacetylases and cardiovascular cell lineage commitment

Yang, J. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i5.852 · Cited by 15

The Guanine Nucleotide Exchange Factor Kalirin-7 Is a Novel Synphilin-1 Interacting Protein and Modifies Synphilin-1 Aggregate Transport and Formation

Tsai, Y.-C., Rieß, O., Soehn, A. S., & Nguyen, H. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051999 · Cited by 14

HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

Ling, H., Li, Y., Peng, C., Yang, S., & Seto, E. (2024) · NAR Cancer · doi:10.1093/narcan/zcae018 · Cited by 13

Exploring structural requirements of HDAC10 inhibitors through comparative machine learning approaches

Bhattacharya, A., Amin, S. A., Kumar, P., Jha, T., & Gayen, S. (2023) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2023.108510 · Cited by 13

5 Histone Deacetylase Inhibitors: A Novel Class of Anti-Cancer Agents on its Way to the Market

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Modulation of Splicing Events in Histone Deacetylase 3 by Various Extracellular and Signal Transduction Pathways

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Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors

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