The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Bax and Bak Independently Promote Cytochrome cRelease from Mitochondria
Open accessAbstract
Pro-apoptotic Bax and Bak have been implicated in the regulation of p53-dependent apoptosis. We assessed the ability of primary baby mouse kidney (BMK) epithelial cells from bax(-/-), bak(-/-), and bax(-/-) bak(-/-) mice to be transformed by E1A alone or in conjunction with dominant-negative p53 (p53DD). Although E1A alone transformed BMK cells from p53-deficient mice, E1A alone did not transform BMK cells from bax(-/-), bak(-/-), or bax(-/-) bak(-/-) mice. Thus, the loss of both Bax and Bak was not sufficient to relieve p53-dependent suppression of transformation in epithelial cells. To test the requirement for Bax and Bak in other death signaling pathways, stable E1A plus p53DD-transformed BMK cell lines were derived from the bax(-/-), bak(-/-), and bax(-/-) bak(-/-) mice and characterized for their response to tumor necrosis factor-alpha (TNF-alpha)-mediated apoptosis. The loss of both Bax and Bak severely impaired TNF-alpha-mediated apoptosis, but the presence of either Bax or Bak alone was sufficient for cell death. Cytochrome c was released from mitochondria, and caspase-9 was activated in Bax- or Bak-deficient cells in response to TNF-alpha but not in cells deficient in both. Thus, either Bax or Bak is required for death signaling through mitochondria in response to TNF-alpha, but both are dispensable for p53-dependent transformation inhibition.
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Cites
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Metadata
- Authors
- Degenhardt, K., Sundararajan, R., Lindsten, T., Thompson, C., & White, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 277
- Issue
- 16
- Pages
- 14127-14134
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2000529918
- Cited by
- 195
- References
- 6
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Degenhardt, K., Sundararajan, R., Lindsten, T., Thompson, C., & White, E. (2002). Bax and Bak Independently Promote Cytochrome cRelease from Mitochondria. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109939200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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