The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Peroxynitrite Is the Major Species Formed from Different Flux Ratios of Co-generated Nitric Oxide and Superoxide
Open accessAbstract
There is much interest in the nitration and oxidation reaction mechanisms initiated by superoxide radical anion (O(2)()) and nitric oxide ((*)NO). It is well known that O(2) and (*)NO rapidly react to form a potent oxidant, peroxynitrite anion (ONOO(-)). However, indirect measurements with the existing probes (e.g. dihydrorhodamine) previously revealed a bell-shaped response to co-generated (*)NO and O(2) fluxes, with the maximal yield of the oxidation or nitration product occurring at a 1:1 ratio. These results raised doubts on the formation of ONOO(-) per se at various fluxes of (*)NO and O(2). Using a novel fluorogenic probe, coumarin-7-boronic acid, that reacts stoichiometrically and rapidly with ONOO(-) (k = 1.1 x 10(6) m(-1)s(-1)), we report that ONOO(-) formation increased linearly and began to plateau after reaching a 1:1 ratio of co-generated (*)NO and O(2) fluxes. We conclude that ONOO(-) is formed as the primary intermediate during the reaction between (*)NO and O(2) co-generated at different fluxes.
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Cites
Chemical biology of peroxynitrite: Kinetics, diffusion, and radicals
Ferrer-Sueta, G., & Radi, R. (2009) · ACS Chemical Biology · doi:10.1021/cb800279q · Cited by 776
Superoxide fluxes limit nitric oxide-induced signaling
Thomas, D. D., Ridnour, L. A., Espey, M. G., Donzelli, S., Ambs, S., Hussain, S. P., Harris, C. C., DeGraff, W., Roberts, D. D., Mitchell, J. B., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602242200 · Cited by 121
Thomas, D. D., Miranda, K. M., Graham Espey, M., Citrin, D., Jourd'heuil, D., Paolocci, N., Hewett, S. J., Colton, C. A., Grisham, M. B., Feelisch, M., et al. (2002) · Methods in Enzymology · doi:10.1016/s0076-6879(02)59174-6 · Cited by 76
Cited by
Peroxynitrite, a Stealthy Biological Oxidant
Radi, R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.472936 · Cited by 888
Unraveling the biological roles of reactive oxygen species
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836
Self-citationBiochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer-Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Alvarez, B., & Radi, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 640
Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species
Dikalov, S. I., & Harrison, D. G. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4886 · Cited by 630
Yu, F., Li, P., Wang, B., & Han, K. (2013) · Journal of the American Chemical Society · doi:10.1021/ja401360a · Cited by 621
Metadata
- Authors
- Zielonka, J., Sikora, A., Joseph, J., & Kalyanaraman, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 285
- Issue
- 19
- Pages
- 14210-14216
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1993272766
- Cited by
- 222
- References
- 3
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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