Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

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Free Radicals in the Physiological Control of Cell Function

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Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

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Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

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Management of cellular energy by the AMP‐activated protein kinase system

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Multifunctional antitumor molecule 5′-triphosphate siRNA combining glutaminase silencing and RIG-I activation

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Modelling ROS formation in boreal lakes from interactions between dissolved organic matter and absorbed solar photon flux

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Impairment of starch biosynthesis results in elevated oxidative stress and autophagy activity in Chlamydomonas reinhardtii

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Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation

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Are Hydroethidine-Based Probes Reliable for Reactive Oxygen Species Detection?

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Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase

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Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR

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AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

Zhao, Q., Song, P., & Zou, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.691585 · Cited by 37

Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway

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Cellular toxicity driven by high-dose vitamin C on normal and cancer stem cells

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Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

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Effects of fluoride exposure on mitochondrial function: Energy metabolism, dynamics, biogenesis and mitophagy

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Tunable pH and redox-responsive drug release from curcumin conjugated γ-polyglutamic acid nanoparticles in cancer microenvironment

Pillarisetti, S., Maya, S., Sankaran, S., & Jayakumar, R. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.08.057 · Cited by 35

Reactive Oxygen Species (ROS) in Metabolic Disease—Don’t Shoot the Metabolic Messenger

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Redox-Inactive Peptide Disrupting Trx1–Ask1 Interaction for Selective Activation of Stress Signaling

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Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

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Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss

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Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer

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A transition to degeneration triggered by oxidative stress in degenerative disorders

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How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems

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Prooxidant activity-based guideline for a beneficial combination of (−)-epigallocatechin-3-gallate and chlorogenic acid

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Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function

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Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus

Liu, Y., Wang, D., & Yang, L. (2022) · Current Drug Targets · doi:10.2174/1389450123666220429082702 · Cited by 35

Cysteine Modifications in the Pathogenesis of ALS

Valle, C., & Carrì, M. T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00005 · Cited by 32

Oxidative stress sensing and response in neural stem cell fate

Hwang, I., Tang, D., & Paik, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.043 · Cited by 33

The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness

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The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?

Li, H., Lismont, C., Revenco, I., Hussein, M. A. F., Costa, C. F., & Fransen, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.814047 · Cited by 37

Mitochondrial adaptations throughout the Trypanosoma brucei life cycle

Zı́ková, A. (2022) · Journal of Eukaryotic Microbiology · doi:10.1111/jeu.12911 · Cited by 29

Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases

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Glutamine, Glucose and other Fuels for Cancer

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The Peroxide Dilemma: Opposing and Mediating Insulin Action

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Nitrite augments glucose uptake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion

Khoo, N. K. H., Mo, L., Zharikov, S. I., Kamga, C., Quesnelle, K. M., Golin-Bisello, F., Li, L., Wang, Y., & Shiva, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.009 · Cited by 32

Autophagy and modular restructuring of metabolism control germline tumor differentiation and proliferation inC. elegans

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CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

Deleye, Y., Cotte, A. K., Hannou, S. A., Hennuyer, N., Bernard, L., Derudas, B., Caron, S., Legry, V., Vallez, E., Dorchies, E., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012543 · Cited by 30

Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess

Luk, C., Haywood, N. J., Bridge, K., & Kearney, M. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882923 · Cited by 30

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension

Flores, K., Siqués, P., Brito, J., & Arribas, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116205 · Cited by 30

Ketone body 3-hydroxybutyrate enhances adipocyte function

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Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control

Wu, M., Zhao, A., Yan, X., Gao, H., Zhang, C., Liu, X., Luo, Q., Xie, F., Liu, S., & Shi, D. (2022) · eLife · doi:10.7554/elife.79939 · Cited by 30

Apoptotic Cells Activate AMP-activated Protein Kinase (AMPK) and Inhibit Epithelial Cell Growth without Change in Intracellular Energy Stores

Patel, V. A., Massenburg, D., Vujicic, S., Feng, L., Tang, M., Litbarg, N. O., Antoni, A., Rauch, J., Lieberthal, W., & Levine, J. S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.667345 · Cited by 32

Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration

Park, H., Kim, J., Shin, C., & Lee, S. (2021) · Antioxidants · doi:10.3390/antiox10050694 · Cited by 32

NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers

Liu, Y., Hernández‐Ochoa, E. O., Randall, W. R., & Schneider, M. F. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2012 · Cited by 29

Modulators of Redox Metabolism in Head and Neck Cancer

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Thiol‐based redox proteomics in cancer research

Yuan, K., Liu, Y., Chen, H., Zhang, L., Lan, J., Gao, W. Q., Dou, Q., Nice, E. C., & Huang, C. (2014) · PROTEOMICS · doi:10.1002/pmic.201400164 · Cited by 30

Direct Binding of Arsenic Trioxide to AMPK and Generation of Inhibitory Effects on Acute Myeloid Leukemia Precursors

Beauchamp, E. M., Kościuczuk, E. M., Serrano, R. M. T., Nanavati, D. M., Swindell, E. P., Viollet, B., O’Halloran, T. V., Altman, J. K., & Platanias, L. C. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0665-t · Cited by 28

Interplay of ROS, mitochondrial quality, and exercise in aging: Potential role of spatially discrete signaling

Craige, S. M., Mammel, R., Amiri, N., Willoughby, O. S., & Drake, J. C. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103371 · Cited by 30

Acute Kidney Injury Induces Oxidative Stress and Hepatic Lipid Accumulation through AMPK Signaling Pathway

Au-Yeung, K. K. W., Shang, Y., Wijerathne, C. U. B., Hewage, S. M., Siow, Y. L., & Karmin, O. (2023) · Antioxidants · doi:10.3390/antiox12040883 · Cited by 27

The Interplay of Autophagy and Oxidative Stress in the Kidney: What Do We Know?

Guo, H., & Bechtel‐Walz, W. (2023) · The Nephron journals/Nephron journals · doi:10.1159/000531290 · Cited by 31

Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway

Ma, L., Zhang, B., Liu, J., Qiao, C., Liu, Y., Li, S., & Lv, H. (2020) · Food & Function · doi:10.1039/d0fo02165b · Cited by 26

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces liver lipid metabolism disorder via the ROS/AMPK/CD36 signaling pathway

Cong, Y., Hong, Y., Wang, D., Pei, C., Wang, Z., Xing, C., Sun, W., & Xu, G. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac133 · Cited by 25

AMPK S-sulfuration contributes to H2S donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells

Hou, X., Tu, H., Qian, H.-C., Li, Q., Yang, Y., Xu, G., Wang, F., Liu, C., Wang, Y.-L., & Hu, L. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105187 · Cited by 25

Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy

He, J., Dong, L., Luo, L., & Wang, K. (2022) · Life · doi:10.3390/life13010098 · Cited by 26

Oxidative damage induced by cigarette smoke exposure in mice: impact on lung tissue and diaphragm muscle,

de Carlos, S. P., Dias, A. S., Forgiarini, L. A., Patricio, P. D., Graciano, T., Nesi, R. T., Valença, S. S., Chiappa, A. M. G., Cipriano, G., de Souza, C. T., et al. (2014) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37132014000400009 · Cited by 25

Inflammatory Role of AMP-Activated Protein Kinase Signaling in an Experimental Model of Toxic Smoke Inhalation Injury*

Perng, D., Chang, T., Wang, J.-Y., Lee, C.-C., Lu, S.-H., Shyue, S., Lee, T., & Kou, Y. R. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318265f653 · Cited by 25

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Thiriveedi, V., Mattam, U., Pattabhi, P., Bisoyi, V., Talari, N. K., Krishnamoorthy, T., & Sepuri, N. B. V. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101725 · Cited by 24

Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design: Miniperspective

Miglianico, M., Nicolaes, G. A. F., & Neumann, D. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01201 · Cited by 24

Oxidative Cysteine Post Translational Modifications Drive the Redox Code Underlying Neurodegeneration and Amyotrophic Lateral Sclerosis

Percio, A., Cicchinelli, M., Masci, D., Summo, M., Urbani, A., & Greco, V. (2024) · Antioxidants · doi:10.3390/antiox13080883 · Cited by 24

The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG

Prescher, N., Hänsch, S., Knobbe-Thomsen, C. B., Stühler, K., & Poschmann, G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.038 · Cited by 24

Toward an Integrated Understanding of Retrograde Control of Photosynthesis

Dietz, K., Wesemann, C., Wegener, M., & Seidel, T. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7519 · Cited by 24

Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum

Hu, Y., Xu, W., Hu, S., Lian, L., Zhu, J. K., Ren, A., Shi, L., & Zhao, M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.041 · Cited by 25

AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170

Yashirogi, S., Nagao, T., Nishida, Y., Takahashi, Y., Qaqorh, T., Yazawa, I., Katayama, T., Kioka, H., Matsui, T. S., Saito, S., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050949 · Cited by 21

New insights into transduction pathways that regulate boar sperm function

de Llera, A. H., Martín‐Hidalgo, D., Gil, M. C., Garcı́a, L. J., & Bragado, M. J. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.05.008 · Cited by 23

Adipokines protecting CKD

Miyamoto, S., & Sharma, K. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft261 · Cited by 23

Involvement of NRF2 and AMPK signaling in aging and progeria: a digest

Petsouki, E., Gerakopoulos, V., Gianniou, D. D., Heiß, E. H., & Trougakos, I. P. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103782 · Cited by 22

Reactive oxygen species in health and disease

Ren, Y., Li, J., & Dai, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00419-2 · Cited by 27

Triggering receptor expressed on myeloid cells and 5’adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target

Thankam, F. G., Dilisio, M. F., Dougherty, K. A., Dietz, N. E., & Agrawal, D. K. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1196138 · Cited by 22

Reduced metabolic capacity in fast and slow skeletal muscle via oxidative stress and the energy‐sensing of AMPK/SIRT1 in malnutrition

Hirabayashi, T., Nakanishi, R., Tanaka, M., Nisa, B. U., Maeshige, N., Kondo, H., & Fujino, H. (2021) · Physiological Reports · doi:10.14814/phy2.14763 · Cited by 22

Dynamic Regulation of Cysteine Oxidation and Phosphorylation in Myocardial Ischemia–Reperfusion Injury

Casin, K. M., & Calvert, J. W. (2021) · Cells · doi:10.3390/cells10092388 · Cited by 23

Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis

Pimková, K., Jassinskaja, M., Munita, R., Cieśla, M., Guzzi, N., Ngoc, P. C. T., Vajrychová, M., Johansson, E., Bellodi, C., & Hansson, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102343 · Cited by 22

AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?

Evans, A. M., & Hardie, D. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103518 · Cited by 21

Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues

Zaher, A., Petronek, M. S., Allen, B. G., & Mapuskar, K. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168885 · Cited by 23

The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity

Wei, Y., Ni, L., Pan, J., Li, X., Xu, B., Deng, Y. L., Yang, T., & Liu, W. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.06.026 · Cited by 20

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugasesPreprint

Opazo, C. M., Lotan, A., Xiao, Z., Zhang, B., Greenough, M. A., Lim, C. M., Trytell, H., Ramírez, A., Ukuwela, A. A., Mawal, C. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.15.431211 · Cited by 21

Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation

Hashimoto, M., Fujimoto, M., Konno, K., Lee, M., Yamada, Y., Yamashita, K., Toda, C., Tomura, M., Watanabe, M., Inanami, O., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2504-21.2022 · Cited by 20

Characterization of thermally sensitive miRNAs reveals a central role of the FoxO signaling pathway in regulating the cellular stress response of an extreme stenotherm, Trematomus bernacchii

Vasadia, D., Zippay, M. L., & Place, S. P. (2019) · Marine Genomics · doi:10.1016/j.margen.2019.100698 · Cited by 20

Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias

Vamecq, J., Papegay, B., Nuyens, V., Boogaerts, J. G., Léo, O., & Kruys, V. (2019) · Biochimie · doi:10.1016/j.biochi.2019.10.004 · Cited by 22

Stearoyl lysophosphatidylcholine enhances the phagocytic ability of macrophages through the AMP-activated protein kinase/p38 mitogen activated protein kinase pathway

Quan, H. Y., Hur, Y., Xin, C., Kim, J., Choi, J. I., Kim, M.-Y., & Bae, H. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.07.014 · Cited by 20

Antioxidants and Oxidants in Boar Spermatozoa and Their Surrounding Environment Are Associated with AMPK Activation during Liquid Storage

Li, J., Zhao, W., Zhu, J., Ju, H., Liang, M., Wang, S., Chen, S.-F., Ferreira-Dias, G. M., & Liu, Z. (2023) · Veterinary Sciences · doi:10.3390/vetsci10030214 · Cited by 21

Autophagy in Tissue Repair and Regeneration

Moreno-Blas, D., Adell, T., & González‐Estévez, C. (2025) · Cells · doi:10.3390/cells14040282 · Cited by 22

3-Aminotriazole protects from CoCl2-induced ototoxicity by inhibiting the generation of reactive oxygen species and proinflammatory cytokines in mice

Lee, J. N., Kim, S., Lim, J.-Y., Dutta, R. K., Kim, S.-J., Choe, S., So, H., & Park, R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1506-9 · Cited by 19

Hydrogen peroxide induces activation of insulin signaling pathway via AMP-dependent kinase in podocytes

Piwkowska, A., Rogacka, D., Angielski, S., & Jankowski, M. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.033 · Cited by 19

The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration

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