Arsenic and Tau Phosphorylation: A Mechanistic Review
Abstract
Arsenic poisoning can affect the peripheral nervous system and cause peripheral neuropathy. Despite different studies on the mechanism of intoxication, the complete process is not explained yet, which can prevent further intoxication and produce effective treatment. In the following paper, we would like to consider the idea that arsenic might cause some diseases via inflammation induction, and tauopathy in neurons. Tau protein, one of the microtubule-associated proteins expressed in neurons, contributes to neuronal microtubules structure. Arsenic may be involved in cellular cascades involved in modulating tau function or hyperphosphorylation of tau protein, which ultimately leads to nerve destruction. For proof of this assumption, some investigations have been planned to measure the association between arsenic and quantities of phosphorylation of tau protein. Additionally, some researchers have investigated the association between microtubule trafficking in neurons and the levels of tau protein phosphorylation. It should be noticed that changing tau phosphorylation in arsenic toxicity may add a new feature to understanding the mechanism of poisonousness and aid in discovering novel therapeutic candidates such as tau phosphorylation inhibitors for drug development.
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Arsenic is involved in cellular signalling cascades that regulate tau protein function or hyperphosphorylation, ultimately leading to neurological damage.
“Arsenic is involved in cellular signalling cascades involved in regulating tau protein function or hyperphosphorylation, which ultimately leads to neurological damage [143].”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [143]
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MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy
Li, Y.-B., Fu, Q., Guo, M., Du, Y., Chen, Y., & Cheng, Y. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03075-8 · Cited by 123 · see citing works
“In AD, however, tau undergoes abnormal phosphorylation and aggregation, resulting in the formation of NFTs [25, 26].”
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“Arsenic is involved in cellular signalling cascades involved in regulating tau protein function or hyperphosphorylation, which ultimately leads to neurological damage [143].”
BackgroundAlzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches
Gholami, A. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137532 · Cited by 51 · see citing works
Functions of Intrinsically Disordered Regions
Xiao, L., & Xia, K. (2025) · Biology · doi:10.3390/biology14070810 · Cited by 17 · see citing works
“The modification of multiple phosphorylation sites (such as Ser262, Thr231) can alter the global conformation of TAU protein [43,44].”
Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge
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“As is a well-known environmental toxicant, and, although a growing body of evidence has reported that even low concentrations of As impair neurological and cognitive functions [119], the exact mechanism of action of As remains to be elucidated (see [105,120–122] for more details).”
BackgroundMetabolome informs about the chemical exposome and links to brain health
Orešič, M., Karu, N., Zhao, H. N., Moseley, M. A., Hankemeier, T., Wishart, D. S., Dorrestein, P. C., Fiehn, O., Hyötyläinen, T., & Kaddurah‐Daouk, R. (2025) · Environment International · doi:10.1016/j.envint.2025.109741 · Cited by 15 · see citing works
“…and neuronal apoptosis (Gauvrit et al., 2022; Babić Leko et al., 2023; Huat et al., 2019; Yu et al., 2024; Paglia et al., 2016; Breijyeh and Karaman, 2020; Colomina and Peris-Sampedro, 2017; Ariafar et al., 2023; Deng et al., 2023; Mutter et al., 2004; Rahman et al., 2020; Zheng et al., 2003).”
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Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic
Antinori, D., Lucarelli, M., & Fuso, A. (2025) · Essays in Biochemistry · doi:10.1042/ebc20253019 · Cited by 5 · see citing works
“Wisessaowapak et al. [40] exposed differentiated SH-SY5Y neuroblastoma cells to 1–10 μM of sodium arsenate, inducing increased tau hyperphosphorylation.”
Dutta, A., Phukan, B. C., Roy, R., Bhattacharya, P., Kumar, D., & Borah, A. (2025) · Current Alzheimer Research · doi:10.2174/0115672050390649250904100840 · Cited by 2 · see citing works
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“Arsenic-containing compounds, such as NaAsO 2 and As 2 O 3 , can disrupt normal neural function by interfering with neurotransmitter synthesis and nerve signal transduction 27 .”
He, H.-Y., & Hsiao, H. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.112179 · Cited by 1 · see citing works
Decoding the Involvement of miRNAs in Alzheimer’s Disease: Focus on Neuroinflammation
Yadav, S., & Wojda, U. (2025) · RNA technologies · doi:10.1007/978-3-031-91072-2_14
Najm, M. S., Hammadi, N. I., Musleh, A. H., & Shalal, M. S. (2026) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_1750_23
- Authors
- Ariafar, S., Makhdoomi, S., & Mohammadi, M.
- Affiliations
- Hamedan University of Medical Sciences (IR)
- Corresponding author
- Mohammadi, Mojdeh
- Venue
- Biological Trace Element Research
- Published
- 2023-05-22
- Volume
- 201
- Issue
- 12
- Pages
- 5708-5720
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W4377193315
- Cited by
- 13
- References
- 127
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Keywords
- arsenic toxicity, tau phosphorylation, peripheral neuropathy, tauopathy, neuroinflammation, microtubule-associated proteins, neuronal injury
- MeSH terms
- Arsenic, Microtubules, Neurons, Phosphorylation, tau Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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