The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
A Novel S-Adenosyl-l-methionine:Arsenic(III) Methyltransferase from Rat Liver Cytosol
Open accessAbstract
S-Adenosyl-l-methionine (AdoMet):arsenic(III) methyltransferase, purified from liver cytosol of adult male Fischer 344 rats, catalyzes transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. The kinetics of production of methylated arsenicals in reaction mixtures containing enzyme, AdoMet, dithiothreitol, glutathione (GSH), and arsenite are consistent with a scheme in which monomethylated arsenical produced from arsenite is the substrate for a second methylation reaction that yields dimethylated arsenical. The mRNA for this protein predicts a 369-amino acid residue protein (molecular mass 41056) that contains common methyltransferase sequence motifs. Its sequence is similar to Cyt19, a putative methyltransferase, expressed in human and mouse tissues. Reverse transcription-polymerase chain reaction detects S-adenosyl-l-methionine:arsenic(III) methyltransferase mRNA in rat tissues and in HepG2 cells, a human cell line that methylates arsenite and methylarsonous acid. S-Adenosyl-l-methionine:arsenic(III) methyltransferase mRNA is not detected in UROtsa cells, an immortalized human urothelial cell line that does not methylate arsenite. Because methylation of arsenic is a critical feature of its metabolism, characterization of this enzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a carcinogen.
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Styblo, M., Del Razo, L. M., Vega, L., Germolec, D. R., LeCluyse, E. L., Hamilton, G. A., Reed, W., Wang, C., Cullen, W. R., & Thomas, D. J. (2000) · Archives of Toxicology · doi:10.1007/s002040000134 · Cited by 998
Self-citationArsenic: exposure and health effects
(1998) · Choice Reviews Online · doi:10.5860/choice.35-5073 · Cited by 799
Monomethylarsonous Acid (MMAIII) Is More Toxic Than Arsenite in Chang Human Hepatocytes
Petrick, J. S., Ayala-Fierro, F., Cullen, W. R., Carter, D. E., & Vasken Aposhian, H. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8872 · Cited by 716
The Cellular Metabolism and Systemic Toxicity of Arsenic
Thomas, D. J., Styblo, M., & Lin, S. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9258 · Cited by 592
Self-citationMethylated Trivalent Arsenic Species Are Genotoxic
Mass, M. J., Tennant, A., Roop, B. C., Cullen, W. R., Styblo, M., Thomas, D. J., & Kligerman, A. D. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000251l · Cited by 525
Self-citationKagan, R. M., & Clarke, S. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1187 · Cited by 470
Reactions of arsenic(III) and arsenic(V) species with glutathione
Scott, N., Hatlelid, K. M., MacKenzie, N. E., & Carter, D. E. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00031a016 · Cited by 458
ENZYMATIC METHYLATION OF ARSENIC SPECIES AND OTHER NEW APPROACHES TO ARSENIC TOXICITY
Aposhian, H. V. (1997) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.397 · Cited by 426
Mandal, B. K., Ogra, Y., & Suzuki, K. T. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000246h · Cited by 349
Petrick, J. S., Jagadish, B., Mash, E. A., & Aposhian, H. V. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000264z · Cited by 346
Cited by
Arsenic Exposure and Toxicology: A Historical Perspective
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., & Thomas, D. J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr184 · Cited by 1,312
Self-citationArsenic Exposure and the Induction of Human Cancers
Martinez, V. D., Vucic, E. A., Becker-Santos, D. D., Gil, L., & Lam, W. L. (2011) · Journal of Toxicology · doi:10.1155/2011/431287 · Cited by 438
Molin, M., Ulven, S. M., Meltzer, H. M., & Alexander, J. (2015) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2015.01.010 · Cited by 229
Benbrahim-Tallaa, L., Waterland, R. A., Styblo, M., Achanzar, W. E., Webber, M. M., & Waalkes, M. P. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.017 · Cited by 175
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Metadata
- Authors
- Lin, S., Shi, Q., Nix, F. B., Styblo, M., Beck, M. A., Herbin-Davis, K. M., Hall, L. L., Simeonsson, J. B., & Thomas, D. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 277
- Issue
- 13
- Pages
- 10795-10803
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2065170814
- Cited by
- 344
- References
- 53
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A Novel S-Adenosyl-l-methionine:Arsenic(III) Methyltransferase from Rat Liver Cytosol. https://app.cochat.ai/papers/10.1074/jbc.m110246200
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- Lin, S., Shi, Q., Nix, F. B., Styblo, M., Beck, M. A., Herbin-Davis, K. M., Hall, L. L., Simeonsson, J. B., & Thomas, D. J. (2002). A Novel S-Adenosyl-l-methionine:Arsenic(III) Methyltransferase from Rat Liver Cytosol. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m110246200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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