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Cited by 426

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

ENZYMATIC METHYLATION OF ARSENIC SPECIES AND OTHER NEW APPROACHES TO ARSENIC TOXICITY

Aposhian, H. Vasken·1997·Annual Review of Pharmacology and Toxicology
DOI 10.1146/annurev.pharmtox.37.1.397
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Abstract

▪ Abstract Arsenic metabolism has typically been studied by administering arsenate or arsenite into animals and humans and then studying the metabolites excreted in the urine. Although such studies have yielded information about the beginning and the end of the metabolic pathways for the metabolism of inorganic arsenic compounds, any statements as to the molecular mechnisms of these reactions have had to be highly speculative. Now that the rabbit and the rhesus monkey liver enzymes that transfer methyl groups from S-adenosylmethionine to arsenite and monomethlyarsonic acid have been purified and the reactions characterized, meaningful investigations of species diversity and polymorphism of these enzymes have become possible. New World animals studied thus far appear to be deficient in or totally lacking these enzymes. Old World animals, with the exception of the chimpanzee, have ample amounts of arsenite and monomethylarsonic acid methyltransferases. A hypothesis that the lack of arsenite methlytransferases may have had an evolutionary advantage for certain species is proposed.

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Metadata

Authors
Aposhian, H. V.
Venue
Annual Review of Pharmacology and Toxicology
Publisher
Annual Reviews
Published
1997-04
Volume
37
Issue
1
Pages
397-419
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
DOI
10.1146/annurev.pharmtox.37.1.397
OpenAlex
W2167586301
Cited by
426
References
35
FWCI
3.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: ENZYMATIC METHYLATION OF ARSENIC SPECIES AND OTHER NEW APPROACHES TO ARSENIC TOXICITY. https://app.cochat.ai/papers/10.1146/annurev.pharmtox.37.1.397
The paper
Aposhian, H. V. (1997). ENZYMATIC METHYLATION OF ARSENIC SPECIES AND OTHER NEW APPROACHES TO ARSENIC TOXICITY. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.37.1.397

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.