Cited by 187Sirtuins and Resveratrol in MedicineLiver Disease Diagnosis and TreatmentNuclear Receptors and Signaling

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Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

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Gao, Zhanguo, Zhang, Jin, Kheterpal, Indu, Kennedy, Norm, Davis, Roger J., Ye, Jianping·2011·Journal of Biological Chemistry

DOI 10.1074/jbc.m111.228874PMC PMC3121368

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Abstract

SIRT1 is involved in the pathogenesis of obesity, diabetes, and aging. However, it is not clear how SIRT1 activity is regulated by intracellular kinases in cells. In this study, we investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation in obese mice. Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1), which is one of the four potential residues targeted by JNK1. The phosphorylation induces a brief activation of SIRT1 function and degradation of SIRT1 thereafter by the proteasome. Ubiquitination occurs in SIRT1 protein after the phosphorylation. Mutation of Ser-46 to alanine prevents the phosphorylation, ubiquitination, and degradation. In vivo, SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1. The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. The degradation disappears in obesity when JNK1 is inactivated in mice. JNK2 exhibits an opposite activity in the regulation of SIRT1 degradation. The JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity.

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Authors: Gao, Z., Zhang, J., Kheterpal, I., Kennedy, N., Davis, R. J., & Ye, J.
Affiliations: Pennington Biomedical Research Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Ye, Jianping
ORCID: Zhang, Jin
Davis, Roger J.
Ye, Jianping
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2011-06
Volume: 286
Issue: 25
Pages: 22227-22234
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m111.228874
PMC: PMC3121368
OpenAlex: W2001428385
Cited by: 187
References: 46
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 16 · 2017: 16 · 2016: 17 · 2015: 20 · 2014: 13 · 2013: 21 · 2012: 13
FWCI: 7.31
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 3438 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health (DK085495)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-085495, R56DK068036, R01DK085495, R01DK068036, DK068036, P30DK072476)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: SIRT1, JNK1, JNK2, protein degradation, ubiquitination, proteasome, hepatic steatosis, obesity, hepatocytes
MeSH terms: Animals, Cell Line, Dietary Fats, Enzyme Activation, Fatty Liver, Histone Deacetylases, Humans, Male, Mice, Inbred C57BL, Obesity, Phosphorylation, Mitogen-Activated Protein Kinase 8, Mice, Rats, Ubiquitination, Gene Knockout Techniques, Sirtuin 1

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Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

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