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Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs
Open accessAbstract
Arsenic inhibits DNA repair and enhances the genotoxicity of DNA-damaging agents such as benzo[a]pyrene and ultraviolet radiation. Arsenic interaction with DNA repair proteins containing functional zinc finger motifs is one proposed mechanism to account for these observations. Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1). Furthermore, trivalent arsenite coordinated with all three cysteine residues as demonstrated by MS/MS. MALDI-TOF-MS analysis of peptides harboring site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger revealed that arsenite bound to peptides containing three or four cysteine residues, but not to peptides with two cysteines, demonstrating arsenite binding selectivity. This finding was not unique to PARP-1; arsenite did not bind to a peptide representing the CCHH zinc finger of the DNA repair protein aprataxin, but did bind to an aprataxin peptide mutated to a CCHC zinc finger. To investigate the impact of arsenite on PARP-1 zinc finger function, we measured the zinc content and DNA-binding capacity of PARP-1 immunoprecipitated from arsenite-exposed cells. PARP-1 zinc content and DNA binding were decreased by 76 and 80%, respectively, compared with protein isolated from untreated cells. We observed comparable decreases in zinc content for XPA (xeroderma pigmentosum group A) protein (CCCC zinc finger), but not SP-1 (specificity protein-1) or aprataxin (CCHH zinc finger). These findings demonstrate that PARP-1 is a direct molecular target of arsenite and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine residues.
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“Genotoxicity occurs since ROS reacts with both deoxyribose and bases in DNA, causing base lesions and strand breaks.”
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Cites
Poly(ADP-ribose): novel functions for an old molecule
Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,975
PARP inhibition: PARP1 and beyond
Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., & Poirier, G. G. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2812 · Cited by 1,298
Toxicological profile for arsenic
Chou, C.-H. S. J. (.-H. S. J. )., & Harper, C. (2007) · doi:10.15620/cdc:11481 · Cited by 1,185
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 719
YOSHIDA, T. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.10.022 · Cited by 582
Zinc deficiency, DNA damage and cancer risk
Ho, E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.07.005 · Cited by 518
Health Effects of Arsenic and Chromium in Drinking Water: Recent Human Findings
Smith, A. H., & Steinmaus, C. (2008) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.031308.100143 · Cited by 370
Arsenic Toxicology: Five Questions
Aposhian, H. V., & Aposhian, M. M. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050106d · Cited by 319
Arsenic carcinogenesis in the skin
Yu, H.-S., Liao, W.-T., & Chai, C.-Y. (2006) · Journal of Biomedical Science · doi:10.1007/s11373-006-9092-8 · Cited by 318
The role of poly(ADP-ribose) in the DNA damage signaling network
Malanga, M., & Althaus, F. R. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-038 · Cited by 274
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Xu, H. (2017) · UNM’s Digital Repository (University of New Mexico)
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_54-1
Kim, C., & Ceresa, B. P. (2021) · Applied In Vitro Toxicology · doi:10.1089/aivt.2020.0026
Barchowsky, A. (2020) · Wiley eBooks · doi:10.1002/9781119438922.ch10
States, J. C. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-55448-8_5
Maiti, B. K., Moura, I., & Moura, J. J. G. (2026) · Chemistry - A European Journal · doi:10.1002/chem.70993
Williams, A. J., & Michel, S. L. J. (2026) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-026-02134-3
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Nail, A. N., Banerjee, M., Xu, M., Reynolds, C. H., Stýblo, M., Cable, P. H., Wilkey, D. W., Merchant, M. L., Cardoso, A. P. F., Thomas, S. D., et al. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04478-w
Huang, T. (2015) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- Zhou, X., Sun, X., Cooper, K. L., Wang, F., Liu, K. J., & Hudson, L. G.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- Liu, Ke Jian
- Hudson, Laurie G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 286
- Issue
- 26
- Pages
- 22855-22863
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3123053
- OpenAlex
- W1986093310
- Cited by
- 177
- References
- 43
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 12 · 2021: 7 · 2020: 17 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 14 · 2015: 22 · 2014: 14 · 2013: 13 · 2012: 12
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA118100)
- National Cancer Institute (P30CA118100)
- National Institute of Environmental Health Sciences (R01ES15826-03S1, R01ES15826, R01ES015826)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Keywords
- arsenite, zinc finger proteins, PARP1, CCHC zinc finger, aprataxin, XPA, Sp1, cysteine residues, DNA repair proteins, genotoxicity
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Cell Line, DNA-Binding Proteins, Humans, Mutation, Nuclear Proteins, Peptides, Poly(ADP-ribose) Polymerases, Protein Binding, Teratogens, Zinc Fingers, Arsenites
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