The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease
Open accessAbstract
Aberrant microglial activation has been proposed to contribute to the cognitive decline in Alzheimer disease (AD), but the underlying molecular mechanisms remain enigmatic. Fractalkine signaling, a pathway mediating the communication between microglia and neurons, is deficient in AD brains and down-regulated by amyloid-β. Although fractalkine receptor (CX3CR1) on microglia was found to regulate plaque load, no functional effects have been reported. Our study demonstrates that CX3CR1 deficiency worsens the AD-related neuronal and behavioral deficits. The effects were associated with cytokine production but not with plaque deposition. Ablation of CX3CR1 in mice overexpressing human amyloid precursor protein enhanced Tau pathology and exacerbated the depletion of calbindin in the dentate gyrus. The levels of calbindin in the dentate gyrus correlated negatively with those of tumor necrosis factor α and interleukin 6, suggesting neurotoxic effects of inflammatory factors. Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6. Our findings identify CX3CR1 as a key microglial pathway in protecting against AD-related cognitive deficits that are associated with aberrant microglial activation and elevated inflammatory cytokines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“However, such complete deletion has also been associated with worsening memory deficits and tau pathology (28–31).”
From Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice (2019) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
Self-citationMucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,624
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531
Self-citationSoluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530
Imai, T., Hieshima, K., Haskell, C. A., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80438-9 · Cited by 1,472
Flagged first, then by citations
Research works printed but not linked: 1
- Wyss-Coray, 2006, Nat. Med., 12, 1005
Cited by
Sorted by citations
Items 101–200 of 268
Targeting Microglia in Alzheimer’s Disease: Pathogenesis and Potential Therapeutic Strategies
Sun, Z., Zhang, X., So, K.-F., Jiang, W., & Chiu, K. (2024) · Biomolecules · doi:10.3390/biom14070833 · Cited by 71
Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia
Mathew, N. R., Vinnakota, J. M., Apostolova, P., Erny, D., Hamarsheh, S., Andrieux, G., Kim, J., Hanke, K., Goldmann, T., Chappell‐Maor, L., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130272 · Cited by 74
Hebron, M. L. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000259 · Cited by 71
Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease
Yang, S. (2019) · International Neurourology Journal · doi:10.5213/inj.1938184.092 · Cited by 72
Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives
Bivona, G., Iemmolo, M., Agnello, L., Sasso, B. L., Gambino, C. M., Giglio, R. V., Scazzone, C., Ghersi, G., & Ciaccio, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010884 · Cited by 74
Thome, A. D., Standaert, D. G., & Harms, A. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140566 · Cited by 68
The Biphasic Role of Microglia in Alzheimer's Disease
Mizuno, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/737846 · Cited by 73
Sun, H. J., Bénardais, K., Stanslowsky, N., Thau‐Habermann, N., Hensel, N., Huang, D., Claus, P., Dengler, R., Stangel, M., & Petri, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072926 · Cited by 68
CX 3 CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions
Zhao, W., Lu, H., Wang, X., Ransohoff, R. M., & Zhou, L. (2015) · The FASEB Journal · doi:10.1096/fj.14-270090 · Cited by 70
Self-citationCX3CL1/CX3CR1 in Alzheimer’s Disease: A Target for Neuroprotection
Chen, P., Zhao, W., Guo, Y., Xu, J., & Yin, M. (2016) · BioMed Research International · doi:10.1155/2016/8090918 · Cited by 67
Winter, A. N., Subbarayan, M. S., Grimmig, B. A., Weesner, J. A., Moss, L. D., Peters, M. M., Weeber, E. J., Nash, K. R., & Bickford, P. C. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01828-y · Cited by 64
The pericyte secretome: Potential impact on regeneration
Gaceb, A., Barbariga, M., Özen, Í., & Paul, G. (2018) · Biochimie · doi:10.1016/j.biochi.2018.04.015 · Cited by 65
Edison, P., & Brooks, D. J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179929 · Cited by 65
Wu, J., Bie, B., Yang, H., Xu, J. J., Brown, D. L., & Naguib, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.003 · Cited by 62
Therapeutic potential of the chemokine–receptor duo fractalkine/CX3CR1: an update
D’Haese, J. G., Friess, H., & Ceyhan, G. O. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.682574 · Cited by 63
Lynch, M. A. (2013) · Immunology · doi:10.1111/imm.12156 · Cited by 64
Chemokines in Alzheimer’s Disease: New Insights Into Prokineticins, Chemokine-Like Proteins
Zuena, A. R., Casolini, P., Lattanzi, R., & Maftei, D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00622 · Cited by 61
The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity
Obst, J., Simon, E., Mancuso, R., & Gómez‐Nicola, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00207 · Cited by 61
Fan, Q., He, W., Gayen, M., Benoit, M. R., Luo, X., Hu, X., & Yan, R. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-19.2019 · Cited by 58
Montgomery, S. L., Narrow, W. C., Mastrangelo, M. A., Olschowka, J. A., O'Banion, M. K., & Bowers, W. J. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.02.030 · Cited by 58
Genetic manipulation of microglia during brain development and disease
Wieghofer, P., & Prinz, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.09.019 · Cited by 60
CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis
Szukiewicz, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094679 · Cited by 59
Velikic, G. S., Maric, D. M., Marić, D., Šupić, G., Puletić, M., Dulić, O., & Vojvodić, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020993 · Cited by 63
Zhu, C., Xu, B., Sun, X., Zhu, Q., & Sui, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0269-5 · Cited by 59
Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids
Gualtierotti, R., Guarnaccia, L., Beretta, M., Navone, S. E., Campanella, R., Riboni, L., Rampini, P. M., & Marfia, G. (2017) · Advances in Therapy · doi:10.1007/s12325-016-0474-7 · Cited by 58
Higher Plasma Fractalkine Is Associated With Better 6-Month Outcome From Ischemic Stroke
Donohue, M. M., Cain, K., Zierath, D., Shibata, D., Tanzi, P. M., & Becker, K. J. (2012) · Stroke · doi:10.1161/strokeaha.112.657411 · Cited by 53
Jiang, M., Xie, H., Zhang, C., Wang, T., Tian, H., Lü, L., Xu, J., Xu, G., Liu, L., & Zhang, J. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17179 · Cited by 51
Synergistic Actions of Microglia and Astrocytes in the Progression of Alzheimer's Disease
Bouvier, D. S., & Murai, K. K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143156 · Cited by 52
Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease
Camacho-Hernández, N. P., & Peña‐Ortega, F. (2023) · Neural Plasticity · doi:10.1155/2023/4637073 · Cited by 52
Acosta, S., Tajiri, N., Sanberg, P., Kaneko, Y., & Borlongan, C. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25629 · Cited by 49
Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
Pak, V. M., Onen, S. ‐., Bliwise, D. L., Kutner, N. G., Russell, K. L., & Onen, F. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00069 · Cited by 53
Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
de Groot, N. S., & Torrent, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2038-4 · Cited by 45
Gaceb, A., & Paul, G. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-02601-1_11 · Cited by 48
Ariga, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9641-0 · Cited by 43
Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
González‐Prieto, M., Gutiérrez, I. L., García‐Bueno, B., Caso, J. R., Leza, J. C., Ortega‐Hernández, A., Gómez‐Garré, D., & Madrigal, J. L. M. (2020) · Glia · doi:10.1002/glia.23885 · Cited by 42
The innate and adaptive immunological aspects in neurodegenerative diseases
Rodrigues, M. C. O., Sanberg, P. R., Cruz, L. E. G., & Garbuzova-Davis, S. N. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.09.020 · Cited by 42
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41
Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer
Lu, X. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629140540 · Cited by 41
Critical Molecular and Cellular Contributors to Tau Pathology
Song, L., Wells, E. A., & Robinson, A. S. (2021) · Biomedicines · doi:10.3390/biomedicines9020190 · Cited by 40
Xie, W.-L., Shi, Q., Zhang, J., Zhang, B., Gong, H.-S., Guo, Y., Wang, S.-B., Xu, Y., Wang, K., Chen, C., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0002-z · Cited by 38
Caruso, G., Benatti, C., Musso, N., Fresta, C. G., Fidilio, A., Spampinato, G., Brunello, N., Bucolo, C., Drago, F., Lunte, S. M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9050477 · Cited by 40
McKee, C., Hoffos, M., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1125982 · Cited by 38
Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer’s Disease
Nanjundaiah, S., Chidambaram, H., Chandrashekar, M., & Chinnathambi, S. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00883-6 · Cited by 36
Central Nervous System: (Immunological) Ivory Tower or Not?
Marin, I. A., & Kipnis, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.122 · Cited by 36
CNS-Wide over Expression of Fractalkine Improves Cognitive Functioning in a Tauopathy Model
Finneran, D. J., Morgan, D., Gordon, M. N., & Nash, K. R. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9822-5 · Cited by 34
Complex role of chemokine mediators in animal models of Alzheimer's Disease
Martin, E., & Delarasse, C. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.002 · Cited by 40
CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer’s Disease
Bivona, G., Iemmolo, M., & Ghersi, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098230 · Cited by 35
High‐resolution in vivo imaging of microglia using a versatile nongenetically encoded marker
Schwendele, B., Brawek, B., Hermes, M., & Garaschuk, O. (2012) · European Journal of Immunology · doi:10.1002/eji.201242436 · Cited by 35
Desforges, N. M., Hebron, M. L., Algarzae, N. K., Lonskaya, I., & Moussa, C. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/345472 · Cited by 36
HIV-1 Tat Disrupts CX3CL1-CX3CR1 Axis in Microglia via the NF-κBYY1 Pathway
Duan, M., Yao, H., Cai, Y. C., Liao, K., Seth, P., & Buch, S. J. (2014) · Current HIV Research · doi:10.2174/1570162x12666140526123119 · Cited by 34
Briones, T. L., Woods, J., & Wadowska, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-13 · Cited by 35
RetractedAlthafar, Z. M. (2022) · Molecules · doi:10.3390/molecules27134124 · Cited by 36
The Fine Balance of Chemokines During Disease: Trafficking, Inflammation, and Homeostasis
Cardona, S. M., Garcia, J. A., & Cardona, A. E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-426-5_1 · Cited by 34
Vinnakota, J. M., Adams, R. C., Athanassopoulos, D., Schmidt, D., Biavasco, F., Zähringer, A., Erny, D., Schwabenland, M., Langenbach, M., Wenger, V., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj9672 · Cited by 35
The emerging role of brain neuroinflammatory responses in Alzheimer’s disease
AmeliMojarad, M., AmeliMojarad, M., & Cui, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1391517 · Cited by 34
Maresin 1 attenuates pro‐inflammatory activation induced by β‐amyloid and stimulates its uptake
Wang, Y., Leppert, A., Tan, S., van der Gaag, B., Li, N., Schultzberg, M., & Hjorth, E. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16098 · Cited by 33
Blon, D. L., Hoornaert, C., Daans, J., Santermans, E., Hens, N., Goossens, H., Berneman, Z. N., & Ponsaerts, P. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.49 · Cited by 31
Huang, X., Wang, Y., & Xiang, Y. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104263 · Cited by 32
Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity
Dworzak, J., Renvoisé, B., Habchi, J., Yates, E. V., Combadière, C., Knowles, T. P., Dobson, C. M., Blackstone, C., Paulsen, O., & Murphy, P. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0127730 · Cited by 30
Jiang, S., & Bhaskar, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161123 · Cited by 31
Vocht, N. D., Praet, J., Reekmans, K., Blon, D. L., Hoornaert, C., Daans, J., Berneman, Z. N., der Linden, A. V., & Ponsaerts, P. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt312 · Cited by 29
Li, A., Zhao, J., Fan, C., Zhu, L., Huang, C., Li, Q., Gan, D., Wen, C., Chen, M., & Lu, D. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.012 · Cited by 32
Kulczyńska‐Przybik, A., Słowik, A., Mroczko, P., Borawski, B., Groblewska, M., Borawska, R., & Mroczko, B. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666201109095657 · Cited by 29
Kiely, A. P., Murray, C. E., Foti, S. C., Benson, B. C., Courtney, R. J., Strand, C., Lashley, T., & Holton, J. L. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly035 · Cited by 27
The Microglial Response to Neurodegenerative Disease
Song, W. M., & Colonna, M. (2018) · Advances in immunology · doi:10.1016/bs.ai.2018.04.002 · Cited by 30
Neuroimmune nexus of depression and dementia: Shared mechanisms and therapeutic targets
Herman, F. J., Simkovic, S. J., & Pasinetti, G. M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14569 · Cited by 29
Neural inflammation and the microglial response in diabetic retinopathy
Abcouwer, S. F. (2011) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-012-9086-x · Cited by 27
Mocchetti, I., Campbell, L. A., Harry, G. J., & Avdoshina, V. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9353-4 · Cited by 27
Banerjee, J., Dorfman, M. D., Fasnacht, R. D., Douglass, J. D., Wyse‐Jackson, A. C., Barría, A., & Thaler, J. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126380 · Cited by 26
Xie, X., Hao, J.-J., Shi, J.-Z., Zhou, Y., Liu, P., Wang, F., Zheng, X.-M., Yu, X., Wang, C., Yan, Y., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109994 · Cited by 23
Self-citationN-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer's disease
Layé, S., Madore, C., St‐Amour, I., Delpech, J.-C., Joffre, C., Nadjar, A., & Calon, F. (2015) · Nutrition and Aging · doi:10.3233/nua-150049 · Cited by 24
Ni, H., Ren, J., Wang, Q., Li, X., Wu, Y. H., Liu, D., & Wang, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16755 · Cited by 22
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
Bettinetti‐Luque, M., Trujillo‐Estrada, L., García‐Fuentes, E., Andreo‐Lopez, J., Sanchez-Varo, R. M., Garrido‐Sánchez, L., Mediavilla, A. G., López, M. G., García‐Caballero, M., Gutiérrez, A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16243 · Cited by 21
Striebel, J. F., Race, B., Carroll, J. A., Phillips, K. L., & Chesebro, B. W. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000442 · Cited by 19
Decoding the genetic landscape of autism: A comprehensive review
Al‐Beltagi, M., Saeed, N. K., Bediwy, A. S., Bediwy, E. A., & Elbeltagi, R. M. (2024) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v13.i3.98468 · Cited by 23
Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1
Finneran, D. J., Li, Q., Subbarayan, M. S., Joly‐Amado, A., Kamath, S. G., Dengler, D. G., Gordon, M. N., Jackson, M. R., Morgan, D., Bickford, P. C., et al. (2022) · Glia · doi:10.1002/glia.24269 · Cited by 18
Sirkis, D. W., Solsberg, C. W., Johnson, T. P., Bonham, L. W., Sturm, V. E., Lee, S. E., Rankin, K. P., Rosen, H. J., Boxer, A. L., Seeley, W. W., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01205-3 · Cited by 19
Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases
Eugenín, J. L., Bernhardi, L. E.-V., & Rommy von Bernhardi, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1249320 · Cited by 19
CX3CL1 Regulation of Gliosis in Neuroinflammatory and Neuroprotective Processes
Gutiérrez, I. L., Martín‐Hernández, D., MacDowell, K. S., García‐Bueno, B., Caso, J. R., Leza, J. C., & Madrigal, J. L. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030959 · Cited by 20
The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices
O’Sullivan, S. A., & Dev, K. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0932-4 · Cited by 17
Hemonnot-Girard, A.-L., Valverde, A., Hua, J., Delaygue, C., Linck, N., Maurice, T., Rassendren, F., & Hirbec, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.021 · Cited by 17
Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets
Ahremenko, E. A., Andreev, A., Apushkin, D., & Korkotian, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411995 · Cited by 20
Moon, M., Choi, J. G., Kim, S. Y., & Oh, M. S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140270 · Cited by 16
The Influence of the Gut Microbiota on Alzheimer's Disease: A Narrative Review
Yin, J.-T., Xu, X., Jin, C.-Y., Yuan, X., & Wang, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2202038 · Cited by 15
Stothert, A. R., & Kaur, T. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.694292 · Cited by 15
Kulczyńska‐Przybik, A., Dulewicz, M., Doroszkiewicz, J., Borawska, R., Słowik, A., Zetterberg, H., Hanrieder, J., Blennow, K., & Mroczko, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713166 · Cited by 14
Menasria, R., Canivet, C., Piret, J., Gosselin, J., & Boivin, G. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000667 · Cited by 16
CX3C chemokine: Hallmarks of fibrosis and ageing
Chen, X., Yang, Y., Sun, S., Liu, Q., Yang, Y., & Jiang, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107348 · Cited by 13
Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease
Doroszkiewicz, J., Mroczko, P., & Kulczyńska‐Przybik, A. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211202143935 · Cited by 14
Kim, B., Vasanthakumar, A., Li, Q. S., Nudelman, K. N. H., Risacher, S. L., Davis, J. W., Idler, K. B., Lee, J., Seo, S. W., Waring, J. F., et al. (2022) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12354 · Cited by 13
Hebron, M. L., Algarzae, N. K., Lonskaya, I., & Moussa, C. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.009 · Cited by 14
Kukharsky, M. S., Овчинников, Р. К., & Бачурин, С. О. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20151156103-114 · Cited by 15
Modulation of microglia activation and Alzheimer's disease
Suresh, P., Phasuk, S., & Liu, I. Y. (2021) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_144_20 · Cited by 14
Fehrenbach, M. K., Tjwa, M., Bechmann, I., & Krueger, M. (2018) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2018.03.004 · Cited by 14
Shen, Z., Yang, X., Lan, Y., & Chen, G. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231159 · Cited by 13
Zhang, X., Subbanna, S., Williams, C. R. O., Canals‐Baker, S., Smiley, J. F., Wilson, D. A., Das, B. C., & Saito, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03888-x · Cited by 12
Lv, J., Shen, X., Shen, X.-Y., Zhao, S., Xu, R., Yan, Q., Lu, J., Zhu, D., Zhao, Y., Dong, J., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7945 · Cited by 12
Huang, Z. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221042 · Cited by 12
The Role of Fractalkine in Diabetic Retinopathy: Pathophysiology and Clinical Implications
Lee, C.-Y., & Yang, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010378 · Cited by 11
Microglia in Alzheimer’s Disease: A Favorable Cellular Target to Ameliorate Alzheimer’s Pathogenesis
Sumsuzzman, D. M., Uddin, M. S., Kabir, M. T., Hasana, S., Perveen, A., Alanazi, I. S., Albadrani, G. M., Abdel‐Daim, M. M., & Ashraf, G. M. (2022) · Mediators of Inflammation · doi:10.1155/2022/6052932 · Cited by 12
Metadata
- Authors
- Cho, S.-H., Sun, B., Zhou, Y., Kauppinen, T. M., Halabisky, B., Wes, P., Ransohoff, R. M., & Gan, L.
- Affiliations
- Gladstone Institutes (US)
- University of California, San Francisco (US)
- Bristol-Myers Squibb (United States) (US)
- Cleveland Clinic (US)
- Corresponding author
- Gan, Li
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 286
- Issue
- 37
- Pages
- 32713-32722
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3173153
- OpenAlex
- W2148721608
- Cited by
- 268
- References
- 52
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 15 · 2021: 14 · 2020: 16 · 2019: 20 · 2018: 18 · 2017: 17 · 2016: 18 · 2015: 28 · 2014: 27 · 2013: 22 · 2012: 14
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1c06rr018928-01)
- University of California, San Diego
- National Institute on Aging (R01AG030207)
- National Cancer Institute (CO6 RRO18928)
- National Institute of Neurological Disorders and Stroke (P30NS065780)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- CX3CR1, microglial activation, Alzheimer's disease, cognitive impairment, amyloid precursor protein, tau pathology, calbindin, dentate gyrus, neuroinflammation, interleukin-6, TNF-α, memory impairment, novel object recognition, passive avoidance
- MeSH terms
- CX3C Chemokine Receptor 1, Alzheimer Disease, Animals, Cognition Disorders, Disease Models, Animal, Humans, Nerve Tissue Proteins, Signal Transduction, Cytokines, Amyloid beta-Protein Precursor, Microglia, Mice, Knockout, Dentate Gyrus, Receptors, Chemokine, Mice, Calbindins, S100 Calcium Binding Protein G
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
