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Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis
Open accessAbstract
Skeletal muscle plays important roles in whole-body glucose and fatty acid metabolism. However, muscle also secretes cytokines and growth factors (collectively termed myokines) that can potentially act in an autocrine, a paracrine, and/or an endocrine manner to modulate metabolic, inflammatory, and other processes. Here, we report the identification and characterization of myonectin, a novel myokine belonging to the C1q/TNF-related protein (CTRP) family. Myonectin transcript was highly induced in differentiated myotubes and predominantly expressed by skeletal muscle. Circulating levels of myonectin were tightly regulated by the metabolic state; fasting suppressed, but refeeding dramatically increased, its mRNA and serum levels. Although mRNA and circulating levels of myonectin were reduced in a diet-induced obese state, voluntary exercise increased its expression and circulating levels. Accordingly, myonectin transcript was up-regulated by compounds (forskolin, epinephrine, ionomycin) that raise cellular cAMP or calcium levels. In vitro, secreted myonectin forms disulfide-linked oligomers, and when co-expressed, forms heteromeric complexes with other members of the C1q/TNF-related protein family. In mice, recombinant myonectin administration reduced circulating levels of free fatty acids without altering adipose tissue lipolysis. Consistent with this, myonectin promoted fatty acid uptake in cultured adipocytes and hepatocytes, in part by up-regulating the expression of genes (CD36, FATP1, Fabp1, and Fabp4) that promote lipid uptake. Collectively, these results suggest that myonectin links skeletal muscle to lipid homeostasis in liver and adipose tissue in response to alterations in energy state, revealing a novel myonectin-mediated metabolic circuit.
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In the citing paper
“It was also shown that in the presence of carbohydrates or lipids in the gastrointestinal tract there was potent stimulation of myonectin expression in the assessed muscles (Seldin et al., 2012)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Seldin et al., 2012
In the citing paper
“The study by Seldin et al., which made a general characterization of this myokine, showed that it is widely expressed in SkM, more precisely in myotubes (Seldin et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Seldin et al., 2012
In the citing paper
“Myonectin, also known as C1q/TNF-related protein 15 (CTRP15), is a new myokine recently found as a protein typical of fatty acid metabolism in response to exercise (Seldin et al., 2012; Toloza et al., 2018)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Seldin et al., 2012
In the citing paper
“In addition, it is described as a potent inducer of cell differentiation in C2C12 cells, which, according to the authors, indicates that this protein is produced in muscle fibers, not in satellite cells (Seldin et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Seldin et al., 2012
In the citing paper
“A test performed in vivo using the soleus and plantaris muscles showed increased gene expression and circulating levels of myonectin in animals that had been fed (compared to animals that had not).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Seldin et al., 2012
Citations
Cites
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells
Wigler, M. H., Silverstein, S. J., Lee, L., Pellicer, À., Cheng, Y., & Axel, R. (1977) · Cell · doi:10.1016/0092-8674(77)90333-6 · Cited by 1,352
Coburn, C. T., Knapp, F. F., Febbraio, M., Beets, A. L., Silverstein, R. L., & Abumrad, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003826200 · Cited by 726
Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488
C1q and tumor necrosis factor superfamily: modularity and versatility
Kishore, U., Gaboriaud, C., Waters, P. J., Shrive, A. K., Greenhough, T. J., Reid, K. B. M., Sim, R. B., & Arlaud, G. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.08.006 · Cited by 437
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Tan, S. Y., Little, H. C., Sarver, D. C., Watkins, P. A., & Wong, G. W. (2020) · FEBS Letters · doi:10.1002/1873-3468.13895 · Cited by 16
Rajna, A., Gibling, H., Sarr, O., Matravadia, S., Holloway, G. P., & Mutch, D. M. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00038.2018 · Cited by 16
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Timofte, D. V., Tudor, R. C., Mocanu, V., & Labusca, L. S. (2024) · Nutrients · doi:10.3390/nu16234231 · Cited by 16
Serum myonectin is increased after laparoscopic sleeve gastrectomy
Li, L., Wang, Q., & Qin, C. (2020) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563220942263 · Cited by 15
Grootendorst, S. T., de Wilde, J. R. A., van Dooijeweert, B., van Vuren, A. J., van Solinge, W. W., Schutgens, R. E. G., van Wijk, R., & Bartels, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042204 · Cited by 16
Weber‐Rajek, M., Radzimińska, A., Strączyńska, A., Strojek, K., Piekorz, Z., Kozakiewicz, M., & Styczyńska, H. (2019) · BioMed Research International · doi:10.1155/2019/7356187 · Cited by 15
Late‐onset renal hypertrophy and dysfunction in mice lacking CTRP1
Rodriguez, S., Little, H. C., Daneshpajouhnejad, P., Shepard, B. D., Tan, S. Y., Wolfe, A., Cheema, M. U., Jandu, S., Woodward, O. M., Talbot, C. C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900558rr · Cited by 14
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Song, Y., Wei, D., Raza, S. H. A., Zhao, Y., Jiang, C. Q., Song, X., Wu, H., Wang, X., Luoreng, Z., & Ma, Y. (2022) · Animal Biotechnology · doi:10.1080/10495398.2022.2127410 · Cited by 14
Petro, J. L., Fragozo-Ramos, M. C., Milán, A. F., Aristizábal, J. C., Calderón, J. C., & Gallo‐Villegas, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307256 · Cited by 14
C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19
Xie, Y., Meng, Z., Gao, J., Liu, C., Wang, J., Guo, R., Zhao, J., Lopez, B., Christopher, T. A., Lee, D., et al. (2021) · Proteomes · doi:10.3390/proteomes9010012 · Cited by 14
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Sarver, D. C., Xu, C., Aja, S. M., & Wong, G. W. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00002.2022 · Cited by 14
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Wang, Y., Zhao, J., Lau, W. B., Liu, J., Guo, R., & Ma, X. (2017) · Vessel Plus · doi:10.20517/2574-1209.2017.29 · Cited by 14
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Gauze-Gnagne, C., Raynaud, F., Djohan, Y. F., Lauret, C., Feillet‐Coudray, C., Coudray, C., Monde, A., Koffi, G., Morena-Carrere, M., Camara-Cissé, M., et al. (2020) · Food & Function · doi:10.1039/d0fo01269f · Cited by 13
Orioli, L., & Thissen, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1554617 · Cited by 17
Meng, G., Liu, F., Fang, L., Li, C., Zhang, Q., Liu, L., Wu, H., Du, H., Shi, H., Xia, Y., et al. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1219454 · Cited by 13
C1q/Tumor Necrosis Factor-Related Protein 9: Basics and Therapeutic Potentials
Guan, H., Wang, Y., Li, X., Xiang, A., Guo, F., Fan, J., & Yu, Q. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.816218 · Cited by 14
Decreased serum myonectin concentrations in diabetic nephropathy patients
Zhang, J., Hu, W., Lin, P., & Wang, R. (2020) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00654-z · Cited by 13
Skeletal muscle: a novel and intriguing characteristics as a secretory organ
Aoi, W., & Sakuma, K. (2013) · Biodiscovery · doi:10.7750/biodiscovery.2013.7.2 · Cited by 13
Saleh, J., Al‐Maqbali, M., & Abdel‐Hadi, D. (2019) · Comprehensive physiology · doi:10.1002/cphy.c170037 · Cited by 15
Hekmatikar, A. H. A., Nelson, A. R., & Petersen, A. C. (2023) · BMC Cancer · doi:10.1186/s12885-023-11391-3 · Cited by 13
FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
Mina, E., Wyart, E., Sartori, R., Angelino, E., Zaggia, I., Rausch, V., Maldotti, M., Pagani, A., Hsu, M. Y., Friziero, A., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101306 · Cited by 13
Tan, W., Peng, Z., You, T., & Sun, Z. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00885-6 · Cited by 12
RetractedSeldin, M. M., Byerly, M. S., Petersen, P. S., Swanson, R. D., Balkema‐Buschmann, A., Groschup, M. H., & Wong, G. W. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.095976 · Cited by 11
Bonnet, M., Tournayre, J., & Cassar‐Malek, I. (2016) · Molecular BioSystems · doi:10.1039/c6mb00224b · Cited by 12
Guennec, D. L., & Rossary, A. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.02.001 · Cited by 12
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Katz, D. H., Lindholm, M. E., & Ashley, E. A. (2024) · Physiology · doi:10.1152/physiol.00024.2024 · Cited by 12
Gurieva, I., Frýdlová, J., Rychtarčíková, Z., Vokurka, M., Truksa, J., & Krijt, J. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.02.007 · Cited by 11
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Crespo‐Piazuelo, D., Criado‐Mesas, L., Revilla, M., Castelló, A., Fernández, A. I., Folch, J. M., & Ballester, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218862 · Cited by 12
Ishiuchi-Sato, Y., & Nedachi, T. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej21-0275 · Cited by 11
Skeletal muscle as a protagonist in the pregnancy metabolic syndrome
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Drasites, K. P., Shams, R., Zaman, V., Matzelle, D. D., Shields, D. C., Garner, D. P., Sole, C. J., Haque, A., & Banik, N. L. (2020) · Brain Sciences · doi:10.3390/brainsci10120933 · Cited by 12
Riabov, V., Mossner, M., Stöhr, A., Jann, J.-C., Streuer, A., Schmitt, N., Knaflic, A., Nowak, V., Weimer, N., Obländer, J., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17314 · Cited by 11
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Lawen, A. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i3.78 · Cited by 11
Onat, T., İnandıklıoğlu, N., Kara, M., Yalvaç, S., Türkler, C., Çıplak, B., & Altindag, M. M. (2021) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2021.1980516 · Cited by 10
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Exercise-mediated circulating metabolites for brain health
Wang, M., Nasb, M., Wu, T., Jia, M., & So, K. (2024) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2024.11.001 · Cited by 11
Myonectin and metabolic health: a systematic review
Petro, J. L., Gallo‐Villegas, J., & Calderón, J. C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1557142 · Cited by 11
Sabouri, M., Taghibeikzadehbadr, P., Shabkhiz, F., Izanloo, Z., & Shaghaghi, F. A. (2022) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-021-09613-x · Cited by 12
Jiang, W., Huang, S., Ma, S., Gong, Y., Fu, Z., Zhou, L. Q., Hu, W., Mao, G., Ma, Z., Yang, L., et al. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-020-00511-6 · Cited by 10
Zhang, J., Chen, L., & Ye, J. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-458 · Cited by 10
Frýdlová, J., Rychtarčíková, Z., Gurieva, I., Vokurka, M., Truksa, J., & Krijt, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186844 · Cited by 10
Inomata, S., Morihara, D., Anan, A., Yamauchi, E., Yamauchi, R., Takata, K., Tanaka, T., Yokoyama, K., Takeyama, Y., Irie, M., et al. (2021) · Internal Medicine · doi:10.2169/internalmedicine.7172-21 · Cited by 9
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Li, A., Zhou, Z., Li, D., Sha, P.-R., Hu, H., Lin, Y.-Q., Yue, B.-L., Li, J., & Xiong, Y. (2025) · Cells · doi:10.3390/cells14241954 · Cited by 10
Chen, J., Zhou, Y., Pan, X., Li, X., Long, J., Zhang, H., & Zhang, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239031 · Cited by 11
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Chen, F., Sarver, D. C., Saqib, M., Zhou, M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101824 · Cited by 9
Weng, H., Pei, Q., Yang, M., Zhang, J., Cheng, Z., & Yi, Q. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.02.002 · Cited by 9
Jawkar, S., & Nongthomba, U. (2020) · The International Journal of Developmental Biology · doi:10.1387/ijdb.190333un · Cited by 9
FABP4gene has a very large effect on feed efficiency in lactating Israeli Holstein cows
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Vatannejad, A., Fadaei, R., Salimi, F., Fouani, F. Z., Habibi, B., Shapourizadeh, S., Eivazi, S., Eivazi, S., Sadeghi, A., & Moradi, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263658 · Cited by 8
The role of new adipokines in gestational diabetes mellitus pathogenesis
Mierzyński, R., Poniedziałek‐Czajkowska, E., Dłuski, D. F., & Leszczyńska‐Gorzelak, B. (2018) · Ginekologia Polska · doi:10.5603/gp.a2018.0038 · Cited by 8
Youssef, S. R., Hassan, E. H., Morad, C. S., Elged, A. A. E., & El‐Gamal, R. A. E. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s327465 · Cited by 8
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Mińko, A., Turoń-Skrzypińska, A., Rył, A., Mańkowska, K., Cymbaluk‐Płoska, A., & Rotter, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040836 · Cited by 8
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Zhao, X.-Z., Li, Y., Yan, Y., Ma, X., & Guo, C. (2020) · Genes & Genomics · doi:10.1007/s13258-020-00936-6 · Cited by 7
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Adigozalpour, M., & Safarzade, A. (2017) · Annals of Applied Sport Science · doi:10.18869/acadpub.aassjournal.5.2.11 · Cited by 6
Neves, J. V., Barroso, C., Carvalho, P., Nunes, M., Gonçalves, G. S., & Rodrigues, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867630 · Cited by 6
Sini, Z. K., Afzalpour, M. E., Ahmadi, M. M., Sardar, M. A., Khaleghzadeh, H., Gorgani‐Firuzjaee, S., Hofmeister, M., Akaras, E., & Azimkhani, A. (2022) · Egyptian Liver Journal · doi:10.1186/s43066-022-00229-5 · Cited by 6
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Takada, S., Fumoto, Y., & Kinugawa, S. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.969623 · Cited by 6
Sarcopenia and non-alcoholic fatty liver disease
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Qin, H., Chen, J.-M., Xu, Z.-Y., Chen, J.-F., Fu, Y., Wang, Z., Liu, X., & Zheng, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70014 · Cited by 5
Melchert, J., Henningfeld, K. A., Richts, S., Lingner, T., Jonigk, D. D., & Pieler, T. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.12.007 · Cited by 5
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Aoi, W. (2017) · Springer eBooks · doi:10.1007/978-981-10-3292-9_9 · Cited by 5
Skeletal muscle hormone activity and non-alcoholic fatty liver disease
Sas, E. I., & Barnakova, V. A. (2020) · Medical alphabet · doi:10.33667/2078-5631-2020-17-31-34 · Cited by 5
Yang, G., Liang, X., Jiang, Y., Li, C., Hu, J., Zhang, Y., Zhang, X., Chang, X., Hu, W., Li, K., et al. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101306 · Cited by 6
Muthukrishnan, R., Alzaabi, A. M. M. A., Ismail, M., Kandakurthi, P. K., Durairaj, S., Sukumar, S., & Gopal, K. (2025) · Journal of Medicine and Life · doi:10.25122/jml-2024-0277 · Cited by 5
Qi, D. E. N. G., Huang, J., Wang, C., & Liang, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062746 · Cited by 4
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Avcu, E. Ç., Çınar, V., Yasul, Y., Akbulut, T., Pancar, Z., Aydemir, İ., Aydın, S., Yalçın, M. H., & Aydın, S. (2024) · Biotechnic & Histochemistry · doi:10.1080/10520295.2024.2305113 · Cited by 4
Vasodilator Dysfunction in Human Obesity: Established and Emerging Mechanisms
Schinzari, F., Tesauro, M., & Cardillo, C. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001108 · Cited by 5
Xue, S., Ling, J., Tian, M., Li, K., Li, S., Liu, D., Li, L., Yang, M., & Yang, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30029 · Cited by 4
Ambroszkiewicz, J., Chełchowska, M., Mazur, J., Rowicka, G., Klemarczyk, W., Strucińska, M., & Gajewska, J. (2025) · Nutrients · doi:10.3390/nu17050834 · Cited by 4
Stewart, A. N., Tan, S. Y., Clark, D. J., Zhang, H., & Wong, G. W. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00528 · Cited by 4
Zou, H.-L., Yang, W., & Liu, Y. (2020) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563220978680 · Cited by 4
Sini, Z. K., Afzalpour, M. E., Ahmadi, M. M., Sardar, M. A., & Gorgani‐Firuzjaee, S. (2020) · Annals of Applied Sport Science · doi:10.29252/aassjournal.855 · Cited by 4
Short-term periods of strenuous physical activity lower iron absorption
Brittenham, G. M. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa365 · Cited by 4
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Alifarsangi, A., Khaksari, M., Rajizadeh, M. A., Zadeh, N. A., & Rafie, F. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111565 · Cited by 3
Mănescu, D. C., Plastoi, C. D., Pîrvan, A., Dîrnu, R., Floroiu, E. A., & Popescu, A. (2026) · Cells · doi:10.3390/cells15141236 · Cited by 5
Fournier, C., Karagounis, L. G., Sacco, S. M., Horcajada, M.-N., Decaens, T., Offord, E., Bouzakri, K., & Ammann, P. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108952 · Cited by 3
Tymochko-Voloshyn, R. I., Hashchyshyn, V., Параняк, Н., Boretsky, V. Y., Решетило, С., & Boretsky, Y. (2023) · Visnyk of Lviv University Biological series · doi:10.30970/vlubs.2023.88.01 · Cited by 4
Myokines Produced by Cultured Bovine Satellite Cells Harvested from 3- and 11-Month-Old Angus Steers
Shira, K. A., Murdoch, B. M., Thornton, K. J., Reichhardt, C. C., Becker, G. M., Chibisa, G. E., & Murdoch, G. K. (2024) · Animals · doi:10.3390/ani14050709 · Cited by 3
Aguirre, F. S., Valero‐Breton, M., Cabrera, D., Peñailillo, L., Otero, C., Fredes, C., & Cabello‐Verrugio, C. (2025) · European Journal of Translational Myology · doi:10.4081/ejtm.2025.13365 · Cited by 4
Safarzade, A., & Safarpour, H. (2021) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms.108209 · Cited by 3
Xu, Q., Altrock, E., Schmitt, N., Streuer, A., Rapp, F., Nowak, V., Obländer, J., Weimer, N., Palme, I., Göl, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021725 · Cited by 3
Normal range and predictors of serum erythroferrone in infants
Bäckström, F., Chmielewska, A., Domellöf, M., & Berglund, S. K. (2023) · Pediatric Research · doi:10.1038/s41390-023-02594-2 · Cited by 3
Metadata
- Authors
- Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wong, G. William
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 287
- Issue
- 15
- Pages
- 11968-11980
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3320944
- OpenAlex
- W2083855314
- Cited by
- 406
- References
- 46
- Citations by year
- 2026: 27 · 2025: 27 · 2024: 33 · 2023: 30 · 2022: 34 · 2021: 32 · 2020: 44 · 2019: 35 · 2018: 31 · 2017: 22 · 2016: 24 · 2015: 20 · 2014: 22 · 2013: 19 · 2012: 5
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-084171, T32DK007751, F32DK084607, P30DK079637, R01DK084171)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myonectin, myokines, skeletal muscle, lipid homeostasis, free fatty acids, fatty acid uptake, adipocytes, hepatocytes, diet-induced obesity, fasting and refeeding, voluntary exercise, cAMP signaling, calcium signaling, heteromeric protein complexes, CD36, FATP1, FABP1, FABP4, energy metabolism
- MeSH terms
- Animals, Cells, Cultured, Fatty Acids, Female, Gene Expression Regulation, Glycosylation, Homeostasis, Humans, Male, Mice, Inbred C57BL, Molecular Sequence Data, Motor Activity, Muscle Proteins, Nutritional Status, Obesity, Protein Binding, Rabbits, Transcription, Genetic, Cytokines, Protein Structure, Tertiary, Muscle, Skeletal, Muscle Fibers, Skeletal, Lipid Metabolism, Mice, Adipokines, Protein Multimerization
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