Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works

A decade of molecular biology of retinoic acid receptors

Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889 · see citing works

A transgenic model of visceral obesity and the metabolic syndrome

Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766 · see citing works

Hyperinsulinemia as an independent risk factor for ischemic heart disease

Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295 · see citing works

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891 · see citing works

The Framingham Offspring Study

Allhoff, P., Laaser, U., & Heinrich, J. (1991) · Springer eBooks · doi:10.1007/978-3-642-95642-3_25 · Cited by 832 · see citing works

Nutrient Requirements of Laboratory Animals,

National Research Council (1995) · National Academies Press eBooks · doi:10.17226/4758 · Cited by 735 · see citing works

Untitled work

(1997) · Diabetes reviews · Cited by 671 · see citing works

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520 · see citing works

Impaired retinal function and vitamin A availability in mice lacking retinol‐binding protein

Quadro, L., Blaner, W. S., Salchow, D. J., Vogel, S., Piantedosi, R., Gouras, P., Freeman, S., Cosma, M. P., Colantuoni, V., & Gottesman, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4633 · Cited by 506 · see citing works

Peroxisome Proliferator-Activated Receptors: From Genes to Physiology

Kliewer, S. A. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.239 · Cited by 426 · see citing works

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Nikoulina, S. E., Ciaraldi, T. P., Mudaliar, S., Mohideen, P., Carter, L., & Henry, R. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.263 · Cited by 357 · see citing works

Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

Duggirala, R., Blangero, J., Almasy, L., Dyer, T. D., Williams, K. L., Leach, R. J., O'Connell, P., & Stern, M. P. (1999) · The American Journal of Human Genetics · doi:10.1086/302316 · Cited by 337 · see citing works

Retinoids and retinoid-binding protein expression in rat adipocytes.

Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46017-6 · Cited by 317 · see citing works

Retinol-Binding Protein: The Serum Transport Protein for Vitamin A*

Blaner, W. S. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-308 · Cited by 316 · see citing works

Insulin Receptor Knockout Mice

Kitamura, T., Kahn, C. R., & Accili, D. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142540 · Cited by 259 · see citing works

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

Mothe‐Satney, I., & OBBERGHEN, E. V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11222 · Cited by 255 · see citing works

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol

Christensen, E., Moskaug, J. Ø., Vorum, H., Jacobsen, C. B., Gundersen, T. E., Nykjær, A., Blomhoff, R., Willnow, T. E., & Moestrup, S. K. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v104685 · Cited by 244 · see citing works

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Carvalho, E., Kotani, K., Peroni, O. D., & Kahn, B. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00116.2005 · Cited by 237 · see citing works

Tissue-specific Ablation of the GLUT4 Glucose Transporter or the Insulin Receptor Challenges Assumptions about Insulin Action and Glucose Homeostasis

Minokoshi, Y., Kahn, C. R., & Kahn, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300019200 · Cited by 219 · see citing works

The Structure of Human Retinol-Binding Protein (RBP) with Its Carrier Protein Transthyretin Reveals an Interaction with the Carboxy Terminus of RBP^,

Naylor, H. M., & Newcomer, M. E. (1999) · Biochemistry · doi:10.1021/bi982291i · Cited by 188 · see citing works

A Genome-Wide Scan for Loci Linked to Plasma Levels of Glucose and HbA1c in a Community-Based Sample of Caucasian Pedigrees

Meigs, J. B., Panhuysen, C. I. M., Myers, R. H., Wilson, P. W. F., & Cupples, L. A. (2002) · Diabetes · doi:10.2337/diabetes.51.3.833 · Cited by 185 · see citing works

The transthyretin-retinol-binding protein complex

Monaco, H. L. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00140-0 · Cited by 169 · see citing works

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization

Kotani, K., Peroni, O. D., Minokoshi, Y., Boss, O., & Kahn, B. B. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21341 · Cited by 139 · see citing works

N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma

Sheikh, M. S., Shao, Z., Li, X.-S., Ordóñez, J. V., Conley, B. A., Wu, S., Dawson, M. I., Han, Q., Chao, W.-R., Quick, T. C., et al. (1995) · Carcinogenesis · doi:10.1093/carcin/16.10.2477 · Cited by 126 · see citing works

Retinol, α-tocopherol and carotenoids in diabetes

Abahusain, M., Wright, J. L., Dickerson, J., & Vol, E. B. D. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600825 · Cited by 122 · see citing works

The interaction of retinol-binding protein with its plasma-membrane receptor.

Sivaprasadarao, A., & Findlay, J. B. C. (1988) · PubMed Central · Cited by 118 · see citing works

High Risk for Hyperlipidemia and the Metabolic Syndrome after an Episode of Hypertriglyceridemia during 13-cis Retinoic Acid Therapy for Acne: A Pharmacogenetic Study

Rodondi, N., Darioli, R., Ramelet, A., Hohl, D., Lenain, V., Perdrix, J., Wietlisbach, V., Riesen, W. F., Walther, T., Medinger, L., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-8-200204160-00007 · Cited by 111 · see citing works

Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

Anai, M., Funaki, M., Ogihara, T., Kanda, A., Onishi, Y., Sakoda, H., Inukai, K., Nawano, M., Fukushima, Y., Yazaki, Y., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.1.158 · Cited by 99 · see citing works

Amelioration of Insulin Resistance in Streptozotocin Diabetic Mice by Transgenic Overexpression of GLUT4 Driven by an Adipose-Specific Promoter1

Tozzo, E., Gnudi, L., & Kahn, B. B. (1997) · Endocrinology · doi:10.1210/endo.138.4.5043 · Cited by 90 · see citing works

Vitamin A (retinol) status of first nation adults with non-insulin-dependent diabetes mellitus.

Basualdo, C., Wein, E. E., & Basu, T. K. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718647 · Cited by 79 · see citing works

Differentiation-dependent expression of retinoid-binding proteins in BFC-1 beta adipocytes.

Zovich, D., Orologa, A., Okuno, M., Kong, L. W., Talmage, D. A., Piantedosi, R., Goodman, D. S., & Blaner, W. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49651-8 · Cited by 76 · see citing works

Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats.

Pedersen, O. B., Kahn, C. R., & Kahn, B. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115804 · Cited by 76 · see citing works

Retinoid binding to retinol-binding protein and the interference with the interaction with transthyretin

Malpeli, G., Folli, C., & Berni, R. (1996) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00264-2 · Cited by 72 · see citing works

Retinoids: in vitro interaction with retinol‐binding protein and influence on plasma retinol

Berni, R., Clerici, M., Malpeli, G., Cleris, L., & Formelli, F. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.12.8375617 · Cited by 61 · see citing works

The Molecular Physiology of Hepatic Nuclear Factor 3 in the Regulation of Gluconeogenesis

Wang, J.-C., Stafford, J. M., Scott, D. K., Sutherland, C. D., & Granner, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14717 · Cited by 59 · see citing works

Acute and Chronic Regulation of Phosphoenolpyruvate Carboxykinase mRNA by Insulin and Glucose

Kahn, C. R., Lauris, V., Koch, S. R., Crettaz, M., & Granner, D. K. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-5-840 · Cited by 58 · see citing works

Plasma and cellular retinoid-binding proteins and transthyretin (prealbumin) are all localized in the islets of Langerhans in the rat.

Kato, M., Kato, K., Blaner, W. S., Chertow, B. S., & Goodman, D. S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.8.2488 · Cited by 58 · see citing works

Muscle Expression of Human Retinol-binding Protein (RBP)

Quadro, L., Blaner, W. S., Hamberger, L., Gelder, R. N. V., Vogel, S., Piantedosi, R., Gouras, P., Colantuoni, V., & Gottesman, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205046200 · Cited by 58 · see citing works

Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice

Shen, Q., Cline, G. W., Shulman, G. I., Leibowitz, M. D., & Davies, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311729200 · Cited by 53 · see citing works

Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13‐cis‐retinoic acid

Koistinen, H. A., Remitz, A., Gylling, H., Miettinen, T. A., Koivisto, V. A., & Ebeling, P. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.222 · Cited by 53 · see citing works

Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance

Pagliassotti, M. J., Kang, J., Thresher, J. S., Sung, C. K., & Bizeau, M. E. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e170 · Cited by 52 · see citing works

Antiproliferative mechanism of retinoid derivatives in ovarian cancer cells

Um, S. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00697-8 · Cited by 39 · see citing works

Recombinant Human Retinol-Binding Protein Refolding, Native Disulfide Formation, and Characterization

Xie, Y., Lashuel, H. A., Miroy, G. J., Dikler, S., & Kelly, J. W. (1998) · Protein Expression and Purification · doi:10.1006/prep.1998.0944 · Cited by 35 · see citing works

Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver

Shin, D., Odom, D. P., Scribner, K. B., Ghoshal, S., & McGrane, M. M. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00215-0 · Cited by 31 · see citing works

Specific uptake of retinol-binding protein by variant F9 cell lines.

Matarese, V., & Lodish, H. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46706-8 · Cited by 24 · see citing works

Production of human plasma retinol-binding protein in Escherichia coll

Wang, T. T. Y., Lewis, K. C., & Phang, J. M. (1993) · Gene · doi:10.1016/0378-1119(93)90654-l · Cited by 9 · see citing works

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448 · see citing works

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,195 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works

Adipocytes as regulators of energy balance and glucose homeostasis

Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · see citing works

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

Jung, U. J., & Choi, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,898 · see citing works

Adipose tissue as an endocrine organ

Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,597 · see citing works

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works

The GLUT4 Glucose Transporter

Huang, S., & Czech, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.006 · Cited by 1,399 · see citing works

Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319 · see citing works

A Single-Cell Transcriptome Atlas of the Human Pancreas

Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,288 · see citing works

Homeostasis, Inflammation, and Disease Susceptibility

Kotas, M. E., & Medzhitov, R. (2015) · Cell · doi:10.1016/j.cell.2015.02.010 · Cited by 1,213 · see citing works

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206 · see citing works

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works

Adipose Tissue

Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,062 · see citing works

Gut Microbiota and Immune System Interactions

Yoo, J. Y., Groer, M. E., Dutra, S. V. O., Sarkar, A., & McSkimming, D. I. (2020) · Microorganisms · doi:10.3390/microorganisms8101587 · Cited by 1,062 · see citing works

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026 · see citing works

Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body

Cristofori, F., Dargenio, V. N., Dargenio, C., Miniello, V. L., Barone, M., & Francavilla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.578386 · Cited by 958 · see citing works

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works

Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome

Bozaoglu, K., Bolton, K. A., McMillan, J. S., Zimmet, P., Jowett, J. B. M., Collier, G. R., Walder, K. R., & Segal, D. (2007) · Endocrinology · doi:10.1210/en.2007-0175 · Cited by 859 · see citing works

A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A

Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836 · see citing works

PPAR and human metabolic disease

Semple, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28003 · Cited by 823 · see citing works

Adipokines and Insulin Resistance

Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 814 · see citing works

Gluteofemoral body fat as a determinant of metabolic health

Manolopoulos, K. N., Karpe, F., & Frayn, K. N. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.286 · Cited by 811 · see citing works

Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

Lee, M., Wu, Y., & Fried, S. K. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.001 · Cited by 804 · see citing works

Mechanisms of obesity-associated insulin resistance: many choices on the menuPreprint

Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works

Inflammatory mechanisms in the regulation of insulin resistance

Tilg, H., & Moschen, A. R. (2008) · Molecular Medicine · doi:10.2119/2007-00119.tilg · Cited by 779 · see citing works

Adipocytokines and the Metabolic Complications of Obesity

Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 739 · see citing works

Adipokines: The missing link between insulin resistance and obesity

Antuna-Puente, B., Fève, B., Fellahi, S., & Bastard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.09.004 · Cited by 738 · see citing works

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

de Ferranti, S. D., & Mozaffarian, D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.100156 · Cited by 732 · see citing works

Adipocytokines in Obesity and Metabolic Disease

Cao, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0339 · Cited by 705 · see citing works

Impact of Obesity and Metabolic Syndrome on Immunity

Andersen, C. J., Murphy, K. E., & Fernandez, M. L. (2016) · Advances in Nutrition · doi:10.3945/an.115.010207 · Cited by 701 · see citing works

Adipokines Mediate Inflammation and Insulin Resistance

Kwon, H., & Pessin, J. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00071 · Cited by 695 · see citing works

Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?

Rehman, K., & Akash, M. S. H. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0303-y · Cited by 685 · see citing works

Metabolites as regulators of insulin sensitivity and metabolism

Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 681 · see citing works

Brown adipose tissue as a secretory organ

Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 677 · see citing works

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

Kahn, C. R., Wang, G., & Lee, K. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129187 · Cited by 656 · see citing works

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

Lass, A., Zimmermann, R., Oberer, M., & Zechner, R. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.004 · Cited by 641 · see citing works

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631 · see citing works

The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615 · see citing works

Adipose Tissue-Derived Factors: Impact on Health and Disease

Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 611 · see citing works

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603 · see citing works

Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome

Xu, A., Wang, Y., Xu, J. Y., Stejskal, D., Tam, S., Zhang, J., Wat, N. M. S., Wong, W. K., & Lam, K. S. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.062463 · Cited by 597 · see citing works

Testosterone: a metabolic hormone in health and disease

Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0455 · Cited by 586 · see citing works

Adipose Tissue: The New Endocrine Organ? A Review Article

Wozniak, S. E., Gee, L. L., Wachtel, M. S., & Frezza, E. E. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0585-3 · Cited by 585 · see citing works

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

Holland, W. L., & Summers, S. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0025 · Cited by 585 · see citing works

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583 · see citing works

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.075614 · Cited by 578 · see citing works

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Deng, Z., Poliakov, A., Hardy, R. W., Clements, R. H., Liu, C., Liu, Y., Wang, J., Xiang, X., Zhang, S., Zhuang, X., et al. (2009) · Diabetes · doi:10.2337/db09-0216 · Cited by 573 · see citing works

Toll-Like Receptor 4 Is Involved in the Development of Fructose-Induced Hepatic Steatosis in Mice†

Spruss, A., Kanuri, G., Wagnerberger, S., Haub, S., Bischoff, S. C., & Bergheim, I. (2009) · Hepatology · doi:10.1002/hep.23122 · Cited by 563 · see citing works

Vitamin A metabolism: An update

D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562 · see citing works

Adipokines as novel biomarkers and regulators of the metabolic syndrome

Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 558 · see citing works

Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation

Sethi, J. K., & Vidal‐Puig, A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700005-jlr200 · Cited by 558 · see citing works

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

Babu, P. V. A., Liu, D., & Gilbert, E. R. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.06.003 · Cited by 549 · see citing works

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works

Dietary anthocyanin‐rich plants: Biochemical basis and recent progress in health benefits studies

Tsuda, T. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100526 · Cited by 535 · see citing works

Management of type 2 diabetes: new and future developments in treatment

Tahrani, A. A., Bailey, C. J., Prato, S. D., & Barnett, A. H. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60207-9 · Cited by 532 · see citing works

Causes and Metabolic Consequences of Fatty Liver

Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 529 · see citing works

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00471-8 · Cited by 527 · see citing works

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

Hotamışlıgil, G. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.009 · Cited by 515 · see citing works

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Chadt, A., & Al-Hasani, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02417-x · Cited by 510 · see citing works

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498 · see citing works

Immune Regulation of Metabolic Homeostasis in Health and Disease

Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 498 · see citing works

Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids

Smith, U., & Kahn, B. B. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12540 · Cited by 498 · see citing works

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Kraus, D., Yang, Q., Kong, D., Banks, A. S., Zhang, L., Rodgers, J. T., Pirinen, E., Pulinilkunnil, T., Gong, F., Wang, Y.-C., et al. (2014) · Nature · doi:10.1038/nature13198 · Cited by 487 · see citing works

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D. (2007) · Diabetes · doi:10.2337/db07-0007 · Cited by 471 · see citing works

Pathogenesis of Type 2 Diabetes Mellitus

Leahy, J. L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.003 · Cited by 469 · see citing works

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462 · see citing works

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

Osei‐Hyiaman, D., Liu, J., Zhou, L., Godlewski, G., Harvey-White, J. D., Jeong, W., Bátkai, S., Marsicano, G., Lutz, B., Buettner, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34827 · Cited by 461 · see citing works

Current views on type 2 diabetes

Lin, Y., & Sun, Z. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0260 · Cited by 457 · see citing works

White Adipose Tissue as Endocrine Organ and Its Role in Obesity

Frigolet, M. E., Torres, N., & Tovar, A. R. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2008.09.005 · Cited by 457 · see citing works

Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice

Takikawa, M., Inoue, S., Horio, F., & Tsuda, T. (2010) · Journal of Nutrition · doi:10.3945/jn.109.118216 · Cited by 440 · see citing works

Inflamed Adipose Tissue

Gustafson, B., Hammarstedt, A., Andersson, C. X., & Smith, U. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147835 · Cited by 434 · see citing works

Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis

Wieckowska, A., McCullough, A. J., & Feldstein, A. E. (2007) · Hepatology · doi:10.1002/hep.21768 · Cited by 422 · see citing works

Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity

Carazo, A., Macáková, K., Matoušová, K., Krčmová, L. K., Protti, M., & Mladěnka, P. (2021) · Nutrients · doi:10.3390/nu13051703 · Cited by 418 · see citing works

Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage

Mori, K., & Nakao, K. (2007) · Kidney International · doi:10.1038/sj.ki.5002165 · Cited by 415 · see citing works

Inflammation, a Link between Obesity and Cardiovascular Disease

Wang, Z., & Nakayama, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/535918 · Cited by 413 · see citing works

Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis

Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406 · see citing works

Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass

Klöting, N., Graham, T. E., Berndt, J., Kralisch, S., Kovacs, P. L., Wason, C. J., Faßhauer, M., Schön, M. R., Stümvoll, M., Blüher, M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.002 · Cited by 404 · see citing works

Obesity, Inflammation, and Periodontal Disease

Pischon, N., Heng, N., Bernimoulin, J. ‐., Kleber, B. M., Willich, S. N., & Pischon, T. (2007) · Journal of Dental Research · doi:10.1177/154405910708600503 · Cited by 403 · see citing works

Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes

Cho, Y. M., Youn, B., Lee, H., Lee, N., Min, S.-S., Kwak, S. H., Lee, H. K., & Park, K. S. (2006) · Diabetes Care · doi:10.2337/dc06-0360 · Cited by 401 · see citing works

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

Tahrani, A. A., Barnett, A. H., & Bailey, C. J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.86 · Cited by 398 · see citing works

Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet

Volek, J. S., Phinney, S. D., Forsythe, C. E., Quann, E. E., Wood, R. J., Puglisi, M. J., Kraemer, W. J., Bibus, D. M., Fernandez, M. L., & Feinman, R. D. (2009) · Lipids · doi:10.1007/s11745-008-3274-2 · Cited by 397 · see citing works

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

Herman, M. A., She, P., Peroni, O. D., Lynch, C. J., & Kahn, B. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075184 · Cited by 395 · see citing works

The role of adipokines in chronic inflammation

Mancuso, P. (2016) · ImmunoTargets and Therapy · doi:10.2147/itt.s73223 · Cited by 391 · see citing works

Retinaldehyde represses adipogenesis and diet-induced obesity

Ziouzenkova, O., Orasanu, G., Sharlach, M., Akiyama, T. E., Berger, J. P., Viereck, J. C., Hamilton, J. A., Tang, G., Dolnikowski, G. G., Vogel, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1587 · Cited by 380 · see citing works

Plasma fetuin-A levels and the risk of type 2 diabetes

Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., & Schulze, M. B. (2008) · Diabetes · doi:10.2337/db08-0538 · Cited by 379 · see citing works

Retinol and retinyl esters: biochemistry and physiology

O'Byrne, S. M., & Blaner, W. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037648 · Cited by 378 · see citing works

Roles of diacylglycerols and ceramides in hepatic insulin resistance

Petersen, M. C., & Shulman, G. I. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.004 · Cited by 373 · see citing works

Retinoid pathway and cancer therapeutics

Bushue, N., & Wan, Y. Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.003 · Cited by 373 · see citing works

A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

Gheibi, S., Kashfi, K., & Ghasemi, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.098 · Cited by 365 · see citing works

Role of retinol-binding protein 4 in the pathogenesis of Type 2 diabetes

Takebayashi, K., Aso, Y., & Inukai, T. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.2.161 · Cited by 9 · see citing works

Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Graham, T. E., Yang, Q., Blüher, M., Hammarstedt, A., Ciaraldi, T. P., Henry, R. R., Wason, C. J., Oberbach, A., Jansson, P.-A., Smith, U., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054862 · Cited by 1,319 · see citing works

Serum Retinol-Binding Protein: A Link Between Obesity, Insulin Resistance, and Type 2 Diabetes

Wolf, G. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00302.x · Cited by 131 · see citing works

Retinol‐binding protein‐4 attenuates insulin‐induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes

Öst, A., Danielsson, A., Lidén, M., Eriksson, U., Nyström, F. H., & Strålfors, P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8173com · Cited by 126 · see citing works

Retinol-Binding Protein 4 in Twins

Ribel‐Madsen, R., Friedrichsen, M. H., Vaag, A. A., & Poulsen, P. (2008) · Diabetes · doi:10.2337/db08-1019 · Cited by 62 · see citing works