The role of STAT3 in autophagy
Open accessAbstract
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful components and maintains cellular homeostasis in response to a series of extracellular insults. However, these insults may trigger the downstream signaling of another prominent stress responsive pathway, the STAT3 signaling pathway, which has been implicated in multiple aspects of the autophagic process. Recent reports further indicate that different subcellular localization patterns of STAT3 affect autophagy in various ways. For example, nuclear STAT3 fine-tunes autophagy via the transcriptional regulation of several autophagy-related genes such as BCL2 family members, BECN1, PIK3C3, CTSB, CTSL, PIK3R1, HIF1A, BNIP3, and microRNAs with targets of autophagy modulators. Cytoplasmic STAT3 constitutively inhibits autophagy by sequestering EIF2AK2 as well as by interacting with other autophagy-related signaling molecules such as FOXO1 and FOXO3. Additionally, the mitochondrial translocation of STAT3 suppresses autophagy induced by oxidative stress and may effectively preserve mitochondria from being degraded by mitophagy. Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via blocking STAT3 signaling, which inevitably affects the autophagy pathway. Here, we review several of the representative studies and the current understanding in this particular field.
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STAT3 is indispensable for physiologic leptin actions, and STAT3 dysfunction in any direction could cause pathophysiological alterations in mice and humans.
“Overall, STAT3 is indispensable for physiologic leptin actions, and STAT3 dysfunction in any direction could cause pathophysiological alterations in mice and humans”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as You et al., 2015
The Introduction reports that constitutive STAT3 activation is associated with malignant tumors and that disruption of the mouse Stat3 gene causes embryonic lethality. These examples support a narrower claim that altered STAT3 function can have pathological consequences, but the paper does not address whether STAT3 is indispensable for physiological leptin actions or establish the claimed effects of dysfunction in any direction across mice and humans (searched: leptin actions, leptin receptor, pathophysiological alterations). (LLM, conf=0.78)
Experimental — accuracy not yet measuredSTAT3 undergoes post-translational modifications including methylation, acetylation, ubiquitination, ISGylation, and SUMOylation.
“In addition to tyrosine phosphorylation, STAT3 also undergoes a variety of other post-translational modifications, including methylation, acetylation, ubiquitination, IFN-stimulated gene (ISG)-ylation, and small ubiquitin-related modifiers (SUMOs)-conjugation (SUMOylation) (Kojima et al., 2013; You et al., 2015; Zouein et al., 2015; Avalle and Poli, 2018; Hu et al., 2018) with various effects on”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as You et al., 2015
The sections on tyrosine and serine phosphorylation of STAT3 discuss those modifications, but do not address any of the five modifications named in the claim. Searches for methylation, acetylation, ubiquitination, ISGylation, and SUMOylation found no supporting passage in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredAt the molecular level, IL-6 increases the activity of DNMT1 with activating effects on JAK/STAT3, NF-κB and PI3K/AKT/mTOR signaling pathways, affecting regulation of autophagy-related functions required to maintain cellular homeostasis under stress such as a prenatal insult.
“At the molecular level, IL-6 increases the activity of DNA methyltransferases 1 (DNMT1) with activating effects on the JAK/STAT3, NF-κB and PI3K/AKT/mTOR signaling pathways [144–148] affecting the regulation of autophagy-related functions, that are required to maintain cellular homeostasis under stress [149], such as a prenatal insult.”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [149]
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- [83]Pratt J, Annabi B. Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. Cellular Signal 2014; 26: 917- 24; PMID:24462646; http://dx.doi.org/ 10.1016/j.cellsig.2014.01.012 24462646 · DOI
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Bharath, L. P., Agrawal, M., McCambridge, G., Nicholas, D. A., Hasturk, H., Liu, J., Jiang, K., Liu, R., Guo, Z., Deeney, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.015 · Cited by 614 · see citing works
The ASD Living Biology: from cell proliferation to clinical phenotype
Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“In addition to tyrosine phosphorylation, STAT3also undergoes a variety of other post-translational modifications, including methylation, acetylation, ubiquitination, IFN-stimulated gene (ISG)-ylation, and small ubiquitin-related modifiers (SUMOs)-conjugation (SUMOylation) (Kojima et al., 2013; You et al., 2015; Zouein…”
BackgroundIL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
Hu, F., Song, D., Yan, Y., Huang, C., Shen, C., Lan, J., Chen, Y., Liu, A., Wu, Q., Sun, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23923-1 · Cited by 235 · see citing works
The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.-A., Ben Haim, L., & Escartin, C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.043 · Cited by 185 · see citing works
Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01185-4 · Cited by 100 · see citing works
Drug resistance in colorectal cancer: An epigenetic overview
Luo, M., Yang, X., Chen, H.-N., Nice, E. C., & Huang, C. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188623 · Cited by 94 · see citing works
Wang, P., Feng, Y.-B., Wang, L., Li, Y., Fan, C., Song, Q., & Yu, S. Y. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.08.002 · Cited by 38 · see citing works
Tian, Y.-T., Ma, L.-P., Ding, C.-Y., Liu, M.-M., Wang, S.-N., Tian, M., Gao, L., & Liu, Q.-J. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2022.2055799 · Cited by 10 · see citing works
- Authors
- You, L., Wang, Z., Li, H., Shou, J., Jing, Z., Xie, J., Sui, X., Pan, H., & Han, W.
- Affiliations
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
- Corresponding author
- Pan, Hongming
- Han, Weidong
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2015-05-04
- Volume
- 11
- Issue
- 5
- Pages
- 729-739
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC4509450
- OpenAlex
- W1853894947
- Cited by
- 515
- References
- 91
- Citations by year
- 2026: 29 · 2025: 57 · 2024: 69 · 2023: 47 · 2022: 85 · 2021: 68 · 2020: 55 · 2019: 36 · 2018: 25 · 2017: 24 · 2016: 15 · 2015: 4
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Autophagy (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- STAT3, STAT3 signaling, PKR, FOXO1, FOXO3, mitophagy, oxidative stress, HIF1A, Bcl-2 family proteins, PIK3C3, Beclin-1, PIK3R1, microRNA, cancer therapy, targeted therapy
- MeSH terms
- Animals, Autophagy, Humans, Mitochondria, Models, Biological, Neoplasms, Subcellular Fractions, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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