Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia

Lysine acetylation targets protein complexes and co-regulates major cellular functions

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Regulation of cellular metabolism by protein lysine acetylation

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Programmed Anuclear Cell Death Delimits Platelet Life Span

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Histone deacetylase inhibitors: Potential in cancer therapy

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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells

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Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

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Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

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Ex-527 inhibits Sirtuins by exploiting their unique NAD + -dependent deacetylation mechanism

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Platelets increase the proliferation of ovarian cancer cells

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From Sirtuin Biology to Human Diseases: An Update

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Ionomycin-activated Calpain Triggers Apoptosis

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Resveratrol Induces Apoptosis through ROS-Dependent Mitochondria Pathway in HT-29 Human Colorectal Carcinoma Cells

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Constitutive Death of Platelets Leading to Scavenger Receptor-mediated Phagocytosis

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Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

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Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia

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The Tale of Protein Lysine Acetylation in the Cytoplasm

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NAD+, Sirtuins, and Cardiovascular Disease

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p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions

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Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.

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Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways

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Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets

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Mechanisms of resveratrol-induced platelet apoptosis

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Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

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High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells

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Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy

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BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

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Chapter 5 Sirtuins and p53

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Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

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HDAC6 controls the kinetics of platelet activation

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Regulatory Role of Proteasome in Determination of Platelet Life Span

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Therapeutic potential of activators and inhibitors of sirtuins

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Platelet storage under in vitro condition is associated with calcium-dependent apoptosis-like lesions and novel reorganization in platelet cytoskeleton

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Platelet Aging In Vivo Is Associated with Loss of Membrane Phospholipid Asymmetry

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Melatonin elevates intracellular free calcium in human platelets by inositol 1,4,5-trisphosphate independent mechanism

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Proteasome inhibitor prevents experimental arterial thrombosis in renovascular hypertensive rats

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A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase

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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

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Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

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Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

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Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations

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Sirt1: Role Under the Condition of Ischemia/Hypoxia

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Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

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Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)

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Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation

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Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity

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Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

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Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections

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Rare coding variants pinpoint genes that control human hematological traits

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Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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Platelets at the crossroads of thrombosis, inflammation and haemolysis

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Uptake of platelets by cancer cells and recycling of the platelet protein CD42a

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Modulators of platelet function in aging

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From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1

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Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system

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Regulation of Adaptive Immune Cells by Sirtuins

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Leptin Maintained Zinc Homeostasis Against Glutamate-Induced Excitotoxicity by Preventing Mitophagy-Mediated Mitochondrial Activation in HT22 Hippocampal Neuronal Cells

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Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax

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Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction

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Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction

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Proteomic analysis and microRNA expression profiling of plasma‐derived exosomes in primary immune thrombocytopenia

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Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

Chaurasia, S. N., Ekhlak, M., Kushwaha, G., Singh, V., Mallick, R. L., & Dash, D. (2022) · eLife · doi:10.7554/elife.79590 · Cited by 19 · see citing works

Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase

NaveenKumar, S. K., Hemshekhar, M., Sundaram, M. S., Kemparaju, K., & Girish, K. S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.073 · Cited by 19 · see citing works

IL-17 Induces MPTP opening through ERK2 and P53 signaling pathway in human platelets

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Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia

Rahman, S., Alhallaj, A., Nedhi, A., Gmati, G., Abuelgasim, K. A., Jama, H. A., Trivilegio, T., Mashour, A., Alaskar, A., & Boudjelal, M. (2017) · Journal of Circadian Rhythms · doi:10.5334/jcr.147 · Cited by 17 · see citing works

Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice

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Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order

Ekhlak, M., Kulkarni, P. P., Singh, V., Chaurasia, S. N., Mohapatra, S. K., Chaurasia, R. N., & Dash, D. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01181-6 · Cited by 17 · see citing works

Platelet Activation in Heparin-Induced Thrombocytopenia is Followed by Platelet Death via Complex Apoptotic and Non-Apoptotic Pathways

Mordakhanova, E. R., Nevzorova, T. A., Synbulatova, G. E., Rauova, L., Weisel, J. W., & Игоревич, Л. Р. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072556 · Cited by 14 · see citing works

Gut Microbiome and Circadian Interactions with Platelets Across Human Diseases, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Cancer

Anderson, G. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266253465230920114223 · Cited by 12 · see citing works

R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy

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Molecular and functional characteristics of megakaryocytes and platelets in aging

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HDAC Inhibitors: Novel Immunosuppressants for Allo‐ and Xeno‐ Transplantation

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Platelet protein synthesis, regulation, and post-translational modifications: mechanics and function

Soslau, G. (2023) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2023.2224532 · Cited by 9 · see citing works

SIRT1 and thrombosis

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NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria

Li, Z., Liu, Y., Wang, Y., Li, X., Han, Z.-N., Hong, L., Li, Y.-S., & Cui, X. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12600 · Cited by 6 · see citing works

Protective effect of sulfated polysaccharide isolated fromUlva fasciataagainst galactosamine-induced liver injury in rats

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Aberrant Caspase Activation in Laminin-α2-Deficient Human Myogenic Cells is Mediated by p53 and Sirtuin Activity

Yoon, S., Beermann, M. L., Yu, B., Shao, D., Bachschmid, M. M., & Miller, J. B. (2017) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-170262 · Cited by 4 · see citing works

Sirtuins in hematopoiesis and blood malignancies

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Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic

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Only the Truth Would Enlighten Us — The Advantages and Disadvantages of Flow Cytometry as a Method of Choice in the Study of Mouse and Rat Platelets

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Combining the P2Y12 antagonist cangrelor with energy metabolism inhibitors has a synergistic antiaggregatory effect

Kurpińska, A., Lytvynenko, O., Kij, A., Przyborowski, K., Berkowicz, P., Rafa–Zabłocka, K., Chłopicki, S., & Kaczara, P. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117056 · Cited by 2 · see citing works

Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s DiseasePreprint

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Study of the association between silent information regulator 1 single-nucleotide gene variant and corticosteroid response in Egyptian pediatric patients with primary immune thrombocytopenia

Salah, D. M., Fouad, N. B., Elhady, M. A., Attia, O., Aly, N. A. R., & Hafez, A. A. (2025) · The Egyptian Journal of Haematology · doi:10.4103/ejh.ejh_15_25 · Cited by 1 · see citing works

CO as an Antiplatelet Agent

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Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53- dependent pathway of apoptosisPreprint

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