Differential Phosphorylation of a Regulatory Subunit of Protein Kinase CK2 by Target of Rapamycin Complex 1 Signaling and the Cdc-like Kinase Kns1
Open accessAbstract
Transcriptional regulation of ribosome and tRNA synthesis plays a central role in determining protein synthetic capacity and is tightly controlled in response to nutrient availability and cellular stress. In Saccharomyces cerevisiae, the regulation of ribosome and tRNA synthesis was recently shown to involve the Cdc-like kinase Kns1 and the GSK-3 kinase Mck1. In this study, we explored additional roles for these conserved kinases in processes connected to the target of rapamycin complex 1 (TORC1). We conducted a synthetic chemical-genetic screen in a kns1Δ mck1Δ strain and identified many novel rapamycin-hypersensitive genes. Gene ontology analysis showed enrichment for TORC1-regulated processes (vesicle-mediated transport, autophagy, and regulation of cell size) and identified new connections to protein complexes including the protein kinase CK2. CK2 is considered to be a constitutively active kinase and in budding yeast, the holoenzyme comprises two regulatory subunits, Ckb1 and Ckb2, and two catalytic subunits, Cka1 and Cka2. We show that Ckb1 is differentially phosphorylated in vivo and that Kns1 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions. We determined that the phosphorylation of Ckb1 does not detectably affect the stability of the CK2 holoenzyme but correlates with the reduced occupancy of Ckb1 on tRNA genes after rapamycin treatment. Thus, the differential occupancy of tRNA genes by CK2 is likely to modulate its activation of RNA polymerase III transcription. Our data suggest that TORC1, via its effector kinase Kns1, may regulate the association of CK2 with some of its substrates by phosphorylating Ckb1.
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TORC1 regulates phosphorylation of CK2 via the effector kinase Kns1.
“TORC1 regulates phosphorylation of CK2 via the effector kinase Kns121.”
From Dual action antifungal small molecule modulates multidrug efflux and TOR signaling (2016) · cites this paper as [21]
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works
Warde-Farley, D., Donaldson, S. L., Comes, O., Zuberi, K., Badrawi, R., Chao, P., Franz, M., Grouios, C., Kazi, F., Lopes, C. T., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq537 · Cited by 4,835 · see citing works
Global analysis of protein expression in yeast
Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750 · see citing works
The Genetic Landscape of a Cell
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162 · see citing works
The economics of ribosome biosynthesis in yeast
Warner, J. R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01460-7 · Cited by 1,933 · see citing works
Saccharomyces Genome Database: the genomics resource of budding yeast
Cherry, J., Hong, E., Amundsen, C., Balakrishnan, R., Binkley, G., Chan, E. T., Christie, K., Costanzo, M., Dwight, S., Engel, S., et al. (2011) · Nucleic Acids Res. · doi:10.1093/nar/gkr1029 · Cited by 1,886 · see citing works
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,720 · see citing works
Collins, S. R., Miller, K. M., Maas, N. L., Roguev, A., Fillingham, J., Chu, C. S., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., et al. (2007) · Nature · doi:10.1038/nature05649 · Cited by 869 · see citing works
Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution
Holt, L. J., Tuch, B. B., Villén, J., Johnson, A. D., Gygi, S. P., & Morgan, D. O. (2009) · Science · doi:10.1126/science.1172867 · Cited by 859 · see citing works
Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae
Collins, S. R., Kemmeren, P., Zhao, X.-C., Greenblatt, J. F., Spencer, F., Holstege, F. C. P., Weissman, J. S., & Krogan, N. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600381-mcp200 · Cited by 795 · see citing works
Bywater, M. J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C. M., Wall, M., Cluse, L. A., Drygin, D., Anderes, K. L., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.019 · Cited by 561 · see citing works
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme
Niefind, K., Guerra, B., Ermakowa, I., & Issinger, O. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5320 · Cited by 448 · see citing works
An early step in wobble uridine tRNA modification requires the Elongator complex
Huang, B., Johansson, M., & Byström, A. S. (2005) · RNA · doi:10.1261/rna.7247705 · Cited by 435 · see citing works
Bodenmiller, B., Wanka, S., Kraft, C., Urban, J., Campbell, D. S., Pedrioli, P. G. A., Gerrits, B., Picotti, P., Lam, H., Olga Vitek, A., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2001182 · Cited by 306 · see citing works
Aparicio, O. M., Geisberg, J. V., Sekinger, E. A., Yang, A., Moqtaderi, Z., & Struhl, K. (2005) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2103s69 · Cited by 277 · see citing works
Protein Kinase CK2 in Health and Disease
St‐Denis, N., & Litchfield, D. W. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-9150-2 · Cited by 276 · see citing works
Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270 · see citing works
Buchou, T., Vernet, M., Blond, O., Jensen, H. H., Pointu, H., Olsen, B. B., Cochet, C., Issinger, O., & Boldyreff, B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.908-915.2003 · Cited by 262 · see citing works
Transcription by RNA polymerase III: more complex than we thought
White, R. J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3001 · Cited by 250 · see citing works
Protein Kinase CK2 in Human Diseases
Guerra, B., & Issinger, O. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785132933 · Cited by 246 · see citing works
Bibby, A., & Litchfield, D. W. (2005) · International Journal of Biological Sciences · doi:10.7150/ijbs.1.67 · Cited by 197 · see citing works
On the Physiological Role of Casein Kinase II in Saccharomyces cerevisiae
Glover, C. V. C. (1997) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)61030-2 · Cited by 195 · see citing works
RNA polymerases I and III, non-coding RNAs and cancer
White, R. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.003 · Cited by 190 · see citing works
Chantalat, L., Leroy, D., Filhol, O., Nueda, A., Benítez, M. J., CHAMBAZ, E. M., Cochet, C., & Dideberg, O. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2930 · Cited by 176 · see citing works
Dysregulation of RNA polymerase I transcription during disease
Hannan, K. M., Sanij, E., Rothblum, L. I., Hannan, R. D., & Pearson, R. B. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.10.014 · Cited by 137 · see citing works
Ghavidel, A., & Schultz, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00473-1 · Cited by 131 · see citing works
Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1
Moir, R. D., Lee, J. H., Haeusler, R. A., Desai, N. V., Engelke, D. R., & Willis, I. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607129103 · Cited by 126 · see citing works
Self-citation16 High-Throughput Strain Construction and Systematic Synthetic Lethal Screening in
Tong, A. H. Y., & Boone, C. M. (2007) · Methods in microbiology · doi:10.1016/s0580-9517(06)36016-3 · Cited by 121 · see citing works
Regulation of pol III transcription by nutrient and stress signaling pathways
Moir, R. D., & Willis, I. M. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.11.001 · Cited by 121 · see citing works
Self-citationEnhanced RNA Polymerase III-dependent Transcription Is Required for Oncogenic Transformation*
Johnson, S. A. S., Dubeau, L., & Johnson, D. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802872200 · Cited by 112 · see citing works
Two Steps in Maf1-dependent Repression of Transcription by RNA Polymerase III
Desai, N. V., Lee, J. H., Upadhya, R., Chu, Y., Moir, R. D., & Willis, I. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412375200 · Cited by 110 · see citing works
Self-citationPotential Interface between Ribosomal Protein Production and Pre-rRNA Processing
Rudra, D., Mallick, J., Zhao, Y., & Warner, J. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02062-06 · Cited by 108 · see citing works
Padmanabha, R., & Glover, C. V. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75714-7 · Cited by 99 · see citing works
Bidwai, A. P., Reed, J., & Glover, C. V. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10395 · Cited by 98 · see citing works
The Regulatory β Subunit of Protein Kinase CK2 Mediates Formation of Tetrameric CK2 Complexes
Graham, K. C., & Litchfield, D. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5003 · Cited by 97 · see citing works
MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and IIIPreprint
Campbell, K. J., & White, R. J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018408 · Cited by 95 · see citing works
Phosphorylation regulates the stability of the regulatory CK2β subunit
Zhang, C., Vilk, G., Canton, D. A., & Litchfield, D. W. (2002) · Oncogene · doi:10.1038/sj.onc.1205467 · Cited by 87 · see citing works
TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases
Lee, J., Moir, R. D., McIntosh, K. B., & Willis, I. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.018 · Cited by 85 · see citing works
Self-citationKinoshita, E., Kinoshita‐Kikuta, E., & Koike, T. (2011) · PROTEOMICS · doi:10.1002/pmic.201100524 · Cited by 80 · see citing works
CK2 Forms a Stable Complex with TFIIIB and Activates RNA Polymerase III Transcription in Human Cells
Johnston, I., Allison, S. J., Morton, J. P., Schramm, L., Scott, P., & White, R. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3757-3768.2002 · Cited by 80 · see citing works
Faresse, N. J., Canella, D., Praz, V., Michaud, J., Romascano, D., & Hernandez, N. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003028 · Cited by 75 · see citing works
Graczyk, D., Dȩbski, J., Muszyńska, G., Bretner, M., Lefebvre, O., & Boguta, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010010108 · Cited by 63 · see citing works
Boldyreff, B., Meggio, F., Pinna, L. A., & Issinger, O.-G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37618-4 · Cited by 61 · see citing works
CK2 Phosphorylation of Bdp1 Executes Cell Cycle-Specific RNA Polymerase III Transcription Repression
Hu, P., Samudre, K. R., Wu, S., Sun, Y., & Hernandez, N. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.008 · Cited by 61 · see citing works
Balony:a software package for analysis of data generated by synthetic genetic array experiments
Young, B. P., & Loewen, C. J. R. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-354 · Cited by 61 · see citing works
Silva, A. C., Xu, X., Kim, H. S., Fillingham, J., Kislinger, T., Mennella, T. A., & Keogh, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316489 · Cited by 60 · see citing works
Protein Kinase CK2 in Health and Disease
Pinna, L. A., & Allende, J. E. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-9148-9 · Cited by 60 · see citing works
Yeast RNA polymerase III transcription factors and effectors
Acker, J., Conesa, C., & Lefebvre, O. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.10.002 · Cited by 58 · see citing works
Casein kinase II regulation of yeast TFIIIB is mediated by the TATA-binding proteinPreprint
Ghavidel, A., & Schultz, M. C. (1997) · Genes & Development · doi:10.1101/gad.11.21.2780 · Cited by 56 · see citing works
Casein Kinase II Is Required for Efficient Transcription by RNA Polymerase III
Hockman, D. J., & Schultz, M. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.892 · Cited by 53 · see citing works
Casein Kinase II of Saccharomyces cerevisiae Contains Two Distinct Regulatory Subunits, β and β′
Bidwai, A. P., Reed, J., & Glover, C. V. C. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1123 · Cited by 47 · see citing works
RNA polymerase III repression by the retinoblastoma tumor suppressor protein
Gjidoda, A., & Henry, R. W. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.09.011 · Cited by 33 · see citing works
The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective
Umekawa, M., & Klionsky, D. J. (2012) · International Journal of Cell Biology · doi:10.1155/2012/142634 · Cited by 28 · see citing works
Absolute Gene Occupancies by RNA Polymerase III, TFIIIB, and TFIIIC in Saccharomyces cerevisiae
Soragni, E., & Kassavetis, G. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803769200 · Cited by 26 · see citing works
Cho, B., Lee, P., & Hahn, J. (2014) · Molecular Microbiology · doi:10.1111/mmi.12660 · Cited by 22 · see citing works
Kim, H. S., Mukhopadhyay, R., Rothbart, S. B., Silva, A. C., Vanoosthuyse, V., Radovani, E., Kislinger, T., Roguev, A., Ryan, C. J., Xu, J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.029 · Cited by 19 · see citing works
Assessing the Components of the eIF3 Complex and their Phosphorylation Status
Farley, A. R., Powell, D. W., Weaver, C. M., Jennings, J. L., & Link, A. J. (2011) · Journal of Proteome Research · doi:10.1021/pr100877m · Cited by 18 · see citing works
Recovery of RNA Polymerase III Transcription from the Glycerol-repressed State
Moir, R. D., Lee, J., & Willis, I. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.378828 · Cited by 15 · see citing works
Self-citationTripodi, F., Cirulli, C., Reghellin, V., Brambilla, L., Marin, O., & Coccetti, P. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0958-3 · Cited by 8 · see citing works
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- Sanchez-Casalongue, M. (2014) A link between TORC1 and CK2 in S. cerevisiae via the Cdc-like kinase Kns1. Ph.D. thesis, Albert Einstein Col- lege of Medicine, New York
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Shekhar‐Guturja, T. (2016) · TSpace (University of Toronto)
- Authors
- Sanchez-Casalongue, M. E., Lee, J., Diamond, A., Shuldiner, S., Moir, R. D., & Willis, I. M.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Willis, Ian M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 290
- Issue
- 11
- Pages
- 7221-7233
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4358141
- OpenAlex
- W2025678066
- Cited by
- 36
- References
- 61
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (T32-GM007288, RO1 GM085177)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- casein kinase 2, TORC1 signaling, ribosome biogenesis, tRNA gene transcription, RNA polymerase III, nutrient limitation, cellular stress, vesicle trafficking, autophagy, cell size control, Saccharomyces cerevisiae
- MeSH terms
- Antifungal Agents, Mutation, Phosphorylation, RNA Polymerase III, Saccharomyces cerevisiae, Stress, Physiological, Transcription Factors, Signal Transduction, Transcriptional Activation, Gene Expression Regulation, Fungal, Protein Serine-Threonine Kinases, Gene Deletion, Sirolimus, Protein Subunits, Saccharomyces cerevisiae Proteins, Casein Kinase II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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