TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism
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sphingosine 1-phosphate) that induced nuclear TAZ translocation. In conclusion, our results uncover an important aspect of the cross-talk between TGFβ and Hippo signaling, showing that TGFβ induces TAZ via a Smad3-independent, p38- and MRTF-mediated and yet MRTF translocation-independent mechanism.
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TGF-β regulates the stability of TAZ and MRTFs.
“it has been reported that TGF‐β regulates the stability of TAZ and MRTFs [41, 42].”
From Mechanical stiffness orchestrates distinct regulation of <scp>MRTFs</scp> and <scp>YAP</scp> / <scp>TAZ</scp> transcriptional cofactors in hepatocytes (2026) · cites this paper as [41]
In “Inhibition of TAZ degradation cannot account for the TGF-β-induced rise in TAZ expression” (page unavailable), the authors report similar TAZ loss with and without TGF-β and find no significant TAZ-stabilizing effect. They instead attribute the rise in TAZ chiefly to transcriptional mechanisms mediated by MRTF; the passages describe MRTF activation, not a change in MRTF stability. (LLM, conf=0.90)
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Cites
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- Authors
- Miranda, M. Z., Bialik, J. F., Speight, P., Dan, Q., Yeung, T., Szászi, K., Pedersen, S. F., & Kapus, A.
- Affiliations
- St. Michael's Hospital (CA)
- University of Copenhagen (DK)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 292
- Issue
- 36
- Pages
- 14902-14920
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC5592669
- OpenAlex
- W2737033892
- Cited by
- 103
- References
- 8
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 19 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 2
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-106625, MOP-130463)
- Kidney Foundation of Canada
- Natural Sciences and Engineering Research Council of Canada (RGPIN227-908-13, RGPIN 327407)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- TGF-β1, TAZ, MRTF, p38 MAPK, Hippo signaling pathway, sphingosine-1-phosphate, transcriptional regulation
- MeSH terms
- YAP-Signaling Proteins, Acyltransferases, Animals, Cells, Cultured, Phosphoproteins, RNA, Messenger, Transcription Factors, Trans-Activators, Cell Cycle Proteins, p38 Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Mice, Smad3 Protein, Transforming Growth Factor beta1
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