Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

Mutations in GNA11 in Uveal Melanoma

Raamsdonk, C. D. V., Griewank, K., Crosby, M. B., Garrido, M. C., Vemula, S. S., Wiesner, T., Obenauf, A. C., Wackernagel, W., Green, G., Bouvier, N., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000584 · Cited by 1,477 · see citing works

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF ^β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418 · see citing works

G-protein-coupled receptors and cancer

Dorsam, R. T., & Gutkind, J. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2069 · Cited by 1,399 · see citing works

Lipidomics reveals a remarkable diversity of lipids in human plasma

Quehenberger, O., Armando, A. M., Brown, A., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S. L., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,322 · see citing works

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works

Mammalian G Proteins and Their Cell Type Specific Functions

Wettschureck, N., & Offermanns, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2005 · Cited by 1,161 · see citing works

The Hippo–YAP pathway in organ size control and tumorigenesis: an updated versionPreprint

Zhao, B., Li, L., Lei, Q., & Guan, K. (2010) · Genes & Development · doi:10.1101/gad.1909210 · Cited by 1,140 · see citing works

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065 · see citing works

Diverse somatic mutation patterns and pathway alterations in human cancers

Kan, Z., Jaiswal, B. S., Stinson, J., Janakiraman, V., Bhatt, D., Stern, H. M., Yue, P., Haverty, P. M., Bourgon, R., Zheng, J., et al. (2010) · Nature · doi:10.1038/nature09208 · Cited by 1,018 · see citing works

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

Lei, Q., Zhang, H., Zhao, B., Zha, Z., Bai, F., Pei, X., Zhao, S., Xiong, Y., & Guan, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01874-07 · Cited by 925 · see citing works

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

Stork, P. A., & Schmitt, J. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02294-8 · Cited by 897 · see citing works

Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon

Overholtzer, M., Zhang, J., Smolen, G. A., Muir, B., Li, W., Sgroi, D. C., Deng, C., Brugge, J. S., & Haber, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605579103 · Cited by 885 · see citing works

LPA Receptors: Subtypes and Biological Actions

Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C., Mutoh, T., Lin, M., Teo, S. T., Park, K. E., Austin, A. M., et al. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105753 · Cited by 840 · see citing works

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

van Corven, E. J., Groenink, A., Jalink, K., Eichholtz, T. J., & Moolenaar, W. H. (1989) · Cell · doi:10.1016/0092-8674(89)90868-4 · Cited by 836 · see citing works

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804 · see citing works

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikisPreprint

Zhao, B., Li, L., Wang, L., Wang, C.-Y., Yu, J., & Guan, K. (2012) · Genes & Development · doi:10.1101/gad.173435.111 · Cited by 794 · see citing works

Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP

Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 780 · see citing works

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721 · see citing works

Hippo signaling in organ size controlPreprint

Pan, D. (2007) · Genes & Development · doi:10.1101/gad.1536007 · Cited by 648 · see citing works

Endocrine Regulation of Male Fertility by the Skeleton

Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C. E., Hermo, L., Suarez, S., Roth, B. L., Ducy, P., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.004 · Cited by 628 · see citing works

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A., & Anders, R. A. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.04.012 · Cited by 552 · see citing works

Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma

Xu, M. Z., Yao, T., Lee, N. P. Y., Ng, I. O. L., Chan, Y., Zender, L., Lowe, S. W., Poon, R. T. P., & Luk, J. M. (2009) · Cancer · doi:10.1002/cncr.24495 · Cited by 528 · see citing works

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525 · see citing works

The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 494 · see citing works

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programPreprint

Cai, J., Zhang, N., Zheng, Y., de Wilde, R. F., Maitra, A., & Pan, D. (2010) · Genes & Development · doi:10.1101/gad.1978810 · Cited by 491 · see citing works

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I. Y., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 480 · see citing works

Modulating F‐actin organization induces organ growth by affecting the Hippo pathway

Sansores-García, L., Bossuyt, W., Wada, K., Yonemura, S., Tao, C., Sasaki, H., & Halder, G. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.157 · Cited by 430 · see citing works

Sphingosine 1-Phosphate Receptor Signaling

Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103733 · Cited by 404 · see citing works

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

Ohta, H., Sato, K., Murata, N., Damirin, A., Malchinkhuu, E., Kon, J., Kimura, T., Tobo, M., Yamazaki, Y., Watanabe, T., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.4.994 · Cited by 402 · see citing works

YAP regulates neural progenitor cell number via the TEA domain transcription factorPreprint

Cao, X., Pfaff, S. L., & Gage, F. H. (2008) · Genes & Development · doi:10.1101/gad.1726608 · Cited by 398 · see citing works

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

Liu, S., Umezu‐Goto, M., Murph, M. M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L. C., Cui, X., Murrow, G., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.027 · Cited by 385 · see citing works

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

Fernández, B. G., Gaspar, P., Brás‐Pereira, C., Jezowska, B., Rebelo, S. P., & Janody, F. (2011) · Development · doi:10.1242/dev.063545 · Cited by 293 · see citing works

Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint

Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269 · see citing works

CD44 Attenuates Activation of the Hippo Signaling Pathway and Is a Prime Therapeutic Target for Glioblastoma

Xu, Y., Stamenkovic, I., & Yu, Q. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2505 · Cited by 215 · see citing works

Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.

Shida, D., Kitayama, J., Yamaguchi, H., Okaji, Y., Tsuno, N. H., Watanabe, T., Takuwa, Y., & Nagawa, H. (2003) · PubMed · Cited by 214 · see citing works

Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids

Wellendorph, P., Hansen, K. B., Balsgaard, A., Greenwood, J. R., Egebjerg, J., & Bräuner‐Osborne, H. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.007559 · Cited by 207 · see citing works

mTOR pathway as a target in tissue hypertrophy

Lee, C.-H., Inoki, K., & Guan, K.-L. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105359 · Cited by 179 · see citing works

Zyxin Links Fat Signaling to the Hippo Pathway

Rauskolb, C., Pan, G., Reddy, B. V. V. G., Oh, H., & Irvine, K. D. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000624 · Cited by 176 · see citing works

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

Prickett, T. D., Wei, X., Cárdenas-Navia, I., Teer, J. K., Lin, J., Walia, V., Gartner, J. J., Jiang, J., Cherukuri, P. F., Molinolo, A. A., et al. (2011) · Nature Genetics · doi:10.1038/ng.950 · Cited by 150 · see citing works

Cloning and characterization of a Family C orphan G‐protein coupled receptor

Kuang, D., Yao, Y., Lam, J., Tsushima, R. G., & Hampson, D. R. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03025.x · Cited by 133 · see citing works

Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory

Li, L., Yun, S. H., Keblesh, J., Trommer, B. L., Xiong, H., Radulovic, J., & Tourtellotte, W. G. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.02.004 · Cited by 124 · cited 1× · see citing works

Early Growth Response 4 Mediates BDNF Induction of Potassium Chloride Cotransporter 2 Transcription

Ludwig, A., Uvarov, P., Soni, S., Thomas-Crusells, J., Airaksinen, M. S., & Rivera, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2006-10.2011 · Cited by 119 · see citing works

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206 · see citing works

YAP/TAZ at the Roots of Cancer

Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works

The Hippo pathway and human cancer

Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,852 · see citing works

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works

Mechanisms of Hippo pathway regulation

Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667 · see citing works

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Mechanobiology of YAP and TAZ in physiology and disease

Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works

The Hippo Pathway: Biology and Pathophysiology

Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works

YAP/TAZ upstream signals and downstream responses

Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086 · see citing works

The emerging roles of YAP and TAZ in cancer

Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,156 · see citing works

The Hippo pathway: regulators and regulations.

Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981 · see citing works

Hippo pathway effector Yap promotes cardiac regeneration

Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895 · see citing works

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Johnson, R. L., & Halder, G. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4161 · Cited by 884 · see citing works

The Hippo Signaling Pathway in Development and Disease

Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867 · see citing works

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874 · see citing works

Metabolic control of YAP and TAZ by the mevalonate pathway

Sorrentino, G., Ruggeri, N., Specchia, V., Cordenonsi, M., Mano, M., Dupont, S., Manfrin, A., Ingallina, E., Sommaggio, R., Piazza, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2936 · Cited by 779 · see citing works

The Hippo signalling pathway and its implications in human health and diseases

Fu, M., Hu, Y., Lan, T., Guan, K., Luo, T., & Luo, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01191-9 · Cited by 767 · see citing works

LPA receptor signaling: pharmacology, physiology, and pathophysiology

Yung, Y. C., Lummis, N. C., & Chun, J. J. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046458 · Cited by 717 · see citing works

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works

Intraovarian Control of Early Folliculogenesis

Hsueh, A. J. W., Kawamura, K., Cheng, Y., & Fauser, B. C. J. M. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1020 · Cited by 708 · see citing works

The Hippo signaling pathway in stem cell biology and cancer

Mo, J., Park, H. W., & Guan, K. (2014) · EMBO Reports · doi:10.15252/embr.201438638 · Cited by 682 · see citing works

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 672 · see citing works

A gp130–Src–YAP module links inflammation to epithelial regeneration

Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature · doi:10.1038/nature14228 · Cited by 633 · see citing works

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

Varelas, X. (2014) · Development · doi:10.1242/dev.102376 · Cited by 665 · see citing works

Molecular mechanisms linking exercise to cancer prevention and treatment

Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.015 · Cited by 600 · see citing works

Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling

Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y. H., Macchini, M., Middelhoff, M. A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.005 · Cited by 577 · see citing works

YAP and TAZ: a nexus for Hippo signaling and beyond

Hansen, C. G., Moroishi, T., & Guan, K. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.05.002 · Cited by 573 · see citing works

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557 · see citing works

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

Feng, X., Degese, M. S., Iglesias‐Bartolomé, R., Vaque, J. P., Molinolo, A., Rodrigues, M. W., Zaidi, M. R., Ksander, B. R., Merlino, G. T., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 559 · see citing works

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3113 · Cited by 549 · see citing works

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

O’Hayre, M., Vázquez‐Prado, J., Kufareva, I., Stawiski, E. W., Handel, T. M., Seshagiri, S., & Gutkind, J. S. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3521 · Cited by 559 · see citing works

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Park, J. H., Pyun, W. Y., & Park, H. W. (2020) · Cells · doi:10.3390/cells9102308 · Cited by 558 · see citing works

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J., Lü, W., Lu, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9357 · Cited by 524 · see citing works

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

Rice, A. J., Cortes, E., Lachowski, D., Cheung, B. C. H., Karim, S. A., Morton, J. P., & Hernández, A. E. D. R. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.54 · Cited by 524 · see citing works

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works

Human blastoids model blastocyst development and implantation

Kagawa, H., Javali, A., Khoei, H. H., Sommer, T. M., Sestini, G., Novatchkova, M., Reimer, Y. S. O., Castel, G., Bruneau, A., Maenhoudt, N., et al. (2021) · Nature · doi:10.1038/s41586-021-04267-8 · Cited by 505 · see citing works

The Hippo Signaling Network and Its Biological Functions

Misra, J. R., & Irvine, K. D. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031621 · Cited by 496 · see citing works

YAP/TAZ Signaling and Resistance to Cancer Therapy

Nguyen, C. D. K., & Yi, C. (2019) · Trends in Cancer · doi:10.1016/j.trecan.2019.02.010 · Cited by 437 · see citing works

Interplay between YAP/TAZ and Metabolism

Koo, J. H., & Guan, K. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.010 · Cited by 468 · see citing works

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology · doi:10.1038/ncb2615 · Cited by 453 · see citing works

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, K.-C., Yeh, Y.-T., Nguyen, P., Limqueco, E., Lopez, J., Thorossian, S., Guan, K.-L., Li, Y.-S. J., & Chien, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613121113 · Cited by 471 · see citing works

A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling

Schirone, L., Forte, M., Palmerio, S., Yee, D., Nocella, C., Angelini, F., Pagano, F., Schiavon, S., Bordin, A., Carrizzo, A., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3920195 · Cited by 432 · see citing works

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

Kim, N., & Gumbiner, B. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201501025 · Cited by 423 · see citing works

Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

Feng, J., Yang, H., Zhang, Y., Wei, H., Zhu, Z., Zhu, B., Yang, M., Cao, W., Wang, L., & Wu, Z. (2017) · Oncogene · doi:10.1038/onc.2017.188 · Cited by 421 · see citing works

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M., & Sheetz, M. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.012 · Cited by 412 · see citing works

Control of cellular responses to mechanical cues through YAP/TAZ regulation

Dasgupta, I., & McCollum, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007963 · Cited by 360 · see citing works

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis

Zhou, X., Li, W., Wang, S., Zhang, P., Wang, Q., Xiao, J., Zhang, C., Zheng, X. M., Xu, X., Xue, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.028 · Cited by 376 · see citing works

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Ganem, N. J., Cornils, H., Chiu, S.-Y., O’Rourke, K. P., Arnaud, J., Yimlamai, D., Théry, M., Camargo, F. D., & Pellman, D. S. (2014) · Cell · doi:10.1016/j.cell.2014.06.029 · Cited by 375 · see citing works

YAP/TAZ functions and their regulation at a glance

Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 369 · see citing works

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

Lu, Y., Wu, T., Gutman, O., Lu, H., Zhou, Q., Henis, Y. I., & Luo, K. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0485-0 · Cited by 373 · see citing works

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasisPreprint

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F., Karin, M., Pan, D., et al. (2015) · Genes & Development · doi:10.1101/gad.262816.115 · Cited by 369 · see citing works

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

Wang, X., Valls, A. F., Schermann, G., Shen, Y., Moya, I. M., Castro, L., Urban, S., Solecki, G. M., Winkler, F., Riedemann, L., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.08.002 · Cited by 369 · see citing works

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblastsPreprint

Esnault, C., Stewart, A., Gualdrini, F., East, P., Horswell, S. D., Matthews, N., & Treisman, R. (2014) · Genes & Development · doi:10.1101/gad.239327.114 · Cited by 355 · see citing works

Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00685.2018 · Cited by 357 · see citing works

Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis

Gandhi, T. K. B., & Hong, W. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00049 · Cited by 349 · see citing works

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

Mori, M., Triboulet, R., Mohseni, M., Schlegelmilch, K., Shrestha, K., Camargo, F. D., & Gregory, R. I. (2014) · Cell · doi:10.1016/j.cell.2013.12.043 · Cited by 335 · see citing works

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

Fan, R., Kim, N., & Gumbiner, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216462110 · Cited by 339 · see citing works

The Hippo-YAP signaling pathway and contact inhibition of growth

Gumbiner, B. M., & Kim, N. (2014) · Journal of Cell Science · doi:10.1242/jcs.140103 · Cited by 339 · see citing works

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiationPreprint

Yu, F., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z.-C., & Guan, K. (2013) · Genes & Development · doi:10.1101/gad.219402.113 · Cited by 337 · see citing works

Mechanosensing and fibrosis

Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 338 · see citing works

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Cunningham, R., & Hansen, C. G. (2022) · Clinical Science · doi:10.1042/cs20201474 · Cited by 331 · see citing works

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

Deng, Y.-J., Lu, J., Li, W., Wu, A.-L., Zhang, X., Tong, W.-X., Ho, K., Qin, L., Song, H., & Mak, K. K. (2018) · Nature Communications · doi:10.1038/s41467-018-07022-2 · Cited by 305 · see citing works

The Hippo pathway in intestinal regeneration and disease

Hong, A. W., Meng, Z., & Guan, K. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.59 · Cited by 326 · see citing works

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

DeRan, M., Yang, J., Shen, C.-H., Peters, E. C., Fitamant, J., Chan, P., Hsieh, M., Zhu, S., Asara, J. M., Zheng, B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.036 · Cited by 316 · see citing works

Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies

Geraldo, L. H., Spohr, T. C. L. D. S. E., do Amaral, R. F., da Fonseca, A. C. C., Garcia, C., Mendes, F. A., Freitas, C., DosSantos, M. F. H., & Lima, F. R. S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00367-5 · Cited by 325 · see citing works

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

Li, C., Wang, S., Xing, Z., Lin, A., Liang, K., Song, J. H., Hu, Q., Yao, J., Chen, Z., Park, P. K., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3464 · Cited by 318 · see citing works

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., Zhang, X., Zhang, F., Chen, H., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319190110 · Cited by 317 · see citing works

Integrin signalling regulates YAP/TAZ to control skin homeostasis

Elbediwy, A., Vincent‐Mistiaen, Z. I., Spencer‐Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., et al. (2016) · Development · doi:10.1242/dev.133728 · Cited by 307 · see citing works

Sphingosine 1-phosphate signalling

Mendelson, K., Evans, T., & Hla, T. (2013) · Development · doi:10.1242/dev.094805 · Cited by 310 · see citing works

Fibrosis—a lethal component of systemic sclerosis

Ho, Y. Y., Lagares, D., Tager, A. M., & Kapoor, M. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.53 · Cited by 307 · see citing works

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1

van Rensburg, H. J. J., Azad, T., Ling, M., Hao, Y., Snetsinger, B., Khanal, P., Minassian, L. M., Graham, C. H., Rauh, M. J., & Yang, X. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3139 · Cited by 307 · see citing works

The role of mammalian target of rapamycin (mTOR) in insulin signaling

Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300 · see citing works

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

Roulis, M., Kaklamanos, A., Schernthanner, M., Bielecki, P., Zhao, J., Kaffe, E., Frommelt, L.-S., Qu, R., Knapp, M. S., Henriques, A. R., et al. (2020) · Nature · doi:10.1038/s41586-020-2166-3 · Cited by 298 · see citing works

Novel insights into G protein and G protein-coupled receptor signaling in cancer

O’Hayre, M., Degese, M. S., & Gutkind, J. S. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.01.005 · Cited by 296 · see citing works

Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

Patel, S. H., Camargo, F. D., & Yimlamai, D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.047 · Cited by 296 · see citing works

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Reginensi, A., Scott, R. P., Gregorieff, A., Bagherie-Lachidan, M., Chung, C., Lim, D., Pawson, T. J., Wrana, J. L., & McNeill, H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003380 · Cited by 295 · see citing works

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

Cappello, S., Gray, M. J., Badouel, C., Lange, S., Einsiedler, M., Srour, M., Chitayat, D. A., Hamdan, F. F., Jenkins, Z. A., Morgan, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2765 · Cited by 285 · see citing works

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

Peng, C., Zhu, Y., Zhang, W., Liao, Q., Chen, Y., Zhao, X., Guo, Q., Shen, P., Zhen, B., Qian, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.010 · Cited by 283 · see citing works

Regulation of the Hippo–YAP pathway by protease-activated receptors (PARs)Preprint

Mo, J., Yu, F., Gong, R., Brown, J. H., & Guan, K. (2012) · Genes & Development · doi:10.1101/gad.197582.112 · Cited by 282 · see citing works

The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

Rausch, V., & Hansen, C. G. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.10.005 · Cited by 279 · see citing works

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

Noguchi, S. F., Saito, A., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113674 · Cited by 280 · see citing works

Characterization of Hippo Pathway Components by Gene Inactivation

Plouffe, S. W., Meng, Z., Lin, K. C., Lin, B., Hong, A. W., Chun, J. V., & Guan, K.-L. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.034 · Cited by 275 · see citing works

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

Kim, M. H., Kim, J., Hong, H., Lee, J. J.-K., Lee, J., Jung, E., & Kim, J. (2015) · The EMBO Journal · doi:10.15252/embj.201592081 · Cited by 259 · see citing works

Cytokinesis defects and cancer

Lens, S. M. A., & Medema, R. H. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0084-6 · Cited by 266 · see citing works

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of <i>NF2</i> -deficient Mesothelioma

Tang, T. T., Konradi, A. W., Feng, Y., Peng, X., Ma, M., Li, J., Yu, F.-X., Guan, K.-L., & Post, L. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0717 · Cited by 245 · see citing works

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Neto, F., Klaus‐Bergmann, A., Ong, Y. T., Alt, S., Vion, A.-C., Szymborska, A., Carvalho, J. R., Hollfinger, I., Bartels‐Klein, E., Franco, C. A., et al. (2018) · eLife · doi:10.7554/elife.31037 · Cited by 260 · see citing works

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

Thompson, B. J. (2020) · BioEssays · doi:10.1002/bies.201900162 · Cited by 262 · see citing works

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H., & Fu, J. (2014) · Nature Materials · doi:10.1038/nmat3945 · Cited by 259 · see citing works

Emerging roles of TEAD transcription factors and its coactivators in cancers

Pobbati, A. V., & Hong, W. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.23788 · Cited by 256 · see citing works

The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell

Plouffe, S. W., Lin, K. C., Moore, J. L., Tan, F. E., Ma, S., Ye, Z., Qiu, Y., Ren, B., & Guan, K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002715 · Cited by 255 · see citing works

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

Liu, B., Zheng, Y., Yin, F., Yu, J., Silverman, N. S., & Pan, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.029 · Cited by 249 · see citing works

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

Das, A., Fischer, R. S., Pan, D., & Waterman, C. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708313 · Cited by 246 · see citing works

Metabolite Concentration Changes in Humans After a Bout of Exercise: a Systematic Review of Exercise Metabolomics Studies

Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch‐Margl, W., & Wackerhage, H. (2020) · Sports Medicine - Open · doi:10.1186/s40798-020-0238-4 · Cited by 250 · see citing works

YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

Piccolo, S., Panciera, T., Contessotto, P., & Cordenonsi, M. (2022) · Nature Cancer · doi:10.1038/s43018-022-00473-z · Cited by 250 · see citing works

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

Li, W., Cooper, J. M., Zhou, L., Yang, C., Erdjument‐Bromage, H., Zagzag, D., Snuderl, M., Ladanyi, M., Hanemann, C. O., Zhou, P., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.001 · Cited by 243 · see citing works

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

Kim, W., Khan, S. K., Gvozdenovic-Jeremic, J., Kim, Y., Dahlman, J., Kim, H., Park, O., Ishitani, T., Jho, E.-H., Gao, B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88486 · Cited by 244 · see citing works

G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway

Zhou, X., Wang, Z., Huang, W., & Lei, Q. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu108 · Cited by 28 · see citing works

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

Zindel, D., Mensat, P., Vol, C., Homayed, Z., Charrier‐Savournin, F., Trinquet, E., Banères, J., Pin, J., Pannequin, J., Roux, T., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002159r · Cited by 33 · see citing works

The mammalian Hippo

Gα, O. (2016)

GPCR-Hippo Signaling in Cancer

Luo, J., & Yu, F. (2019) · Cells · doi:10.3390/cells8050426 · Cited by 104 · see citing works

G protein‐coupled receptors engage the mammalian Hippo pathway through F‐actin

Regué, L., Mou, F., & Avruch, J. (2013) · BioEssays · doi:10.1002/bies.201200163 · Cited by 28 · see citing works