Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Myofibroblasts and mechano-regulation of connective tissue remodelling

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TGF-β: the master regulator of fibrosis

Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528 · see citing works

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

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Mechanotransduction and extracellular matrix homeostasis

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The Myofibroblast

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Non-muscle myosin II takes centre stage in cell adhesion and migration

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Cell adhesion: integrating cytoskeletal dynamics and cellular tension

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ROCKs: multifunctional kinases in cell behaviour

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Cardiac Fibrosis: The Fibroblast Awakens

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Stretching Single Talin Rod Molecules Activates Vinculin Binding

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Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

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Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

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Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity

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TGF-β signaling in fibrosis

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Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

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YAP/TAZ upstream signals and downstream responses

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Integrin-mediated mechanotransduction

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Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055 · see citing works

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

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Actin stress fibers – assembly, dynamics and biological roles

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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

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Mechanisms of Mechanotransduction

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The myofibroblast matrix: implications for tissue repair and fibrosis

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The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer

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Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

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The myofibroblast: Paradigm for a mechanically active cell

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Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

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Forcing cells into shape: the mechanics of actomyosin contractility

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Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

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YAP regulates cell mechanics by controlling focal adhesion assembly

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

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Integrins and Extracellular Matrix in Mechanotransduction

Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662 · see citing works

Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Fu, X., Khalil, H., Kanisicak, O., Boyer, J. G., Vagnozzi, R. J., Maliken, B. D., Sargent, M. A., Prasad, V., Valiente-Alandi, I., Blaxall, B. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98215 · Cited by 636 · see citing works

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 618 · see citing works

Extracellular matrix as a driver of progressive fibrosis

Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 616 · see citing works

Myofibroblast Differentiation by Transforming Growth Factor-1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase

Thannickal, V. J., Lee, D. Y., White, E. S., Cui, Z., Larios, J. M., Chacon, R., Horowitz, J. C., Day, R. M., & Thomas, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208544200 · Cited by 606 · see citing works

Preparing the ground for tissue regeneration: from mechanism to therapy

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Regeneration of fat cells from myofibroblasts during wound healing

Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584 · see citing works

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

Pasapera, A. M., Schneider, I. C., Rericha, E. C., Schlaepfer, D. D., & Waterman, C. M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200906012 · Cited by 573 · see citing works

Targeting extracellular matrix stiffness to attenuate disease: from molecular mechanisms to clinical trials

Lampi, M. C., & Reinhart-King, C. A. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0475 · Cited by 551 · see citing works

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530 · see citing works

Fibroblasts in myocardial infarction: A role in inflammation and repair

Shinde, A. V., & Frangogiannis, N. G. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.015 · Cited by 516 · see citing works

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

Wong, V. W., Rustad, K. C., Akaishi, S., Sorkin, M., Glotzbach, J. P., Januszyk, M., Nelson, E. R., Levi, K., Paterno, J., Vial, I. N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2574 · Cited by 515 · see citing works

The good and the bad collagens of fibrosis – Their role in signaling and organ function

Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509 · see citing works

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis

Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 463 · see citing works

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 452 · see citing works

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449 · see citing works

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Schuppan, D., Ashfaq–Khan, M., Yang, A. T., & Kim, Y. O. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.04.006 · Cited by 440 · see citing works

Extracellular matrix remodeling and cardiac fibrosis

Li, L., Zhao, Q., & Kong, W. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.013 · Cited by 428 · see citing works

Myofibroblasts

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Focal adhesions, stress fibers and mechanical tension

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The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works

Sensing extracellular matrix: An update on discoidin domain receptor function

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Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

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Resolution of organ fibrosis

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Extracellular rigidity sensing by talin isoform-specific mechanical linkages

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The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

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"CONTRACTILE INTERSTITIAL CELLS" IN PULMONARY ALVEOLAR SEPTA: A POSSIBLE REGULATOR OF VENTILATION/PERFUSION RATIO?

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Signaling Networks that Regulate Cell MigrationPreprint

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Mechanosensing and fibrosis

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Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway

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Ligation of protease-activated receptor 1 enhances v 6 integrin-dependent TGF- activation and promotes acute lung injury

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Control of Mechanotransduction by Molecular Clutch Dynamics

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The α _v β ₁ integrin plays a critical in vivo role in tissue fibrosis

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Diverse origins of the myofibroblast—implications for kidney fibrosis

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Second harmonic imaging and scoring of collagen in fibrotic tissues

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Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

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Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

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Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

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The integrin–collagen connection – a glue for tissue repair?

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Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts

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Extracellular matrix: The driving force of mammalian diseases

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A comparison of the rates of synthesis and turnover of collagen and non-collagen proteins in adult rat periodontal tissues and skin using a microassay

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Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution

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The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

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β- and γ-cytoplasmic actins display distinct distribution and functional diversity

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The origin of fibrogenic myofibroblasts in fibrotic liver

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Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

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PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

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Lysophosphatidic acid as a lipid mediator with multiple biological actions

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Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis

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Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gαq

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Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

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Vinculin controls talin engagement with the actomyosin machinery

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Integrin-mediated regulation of TGFβ in fibrosis

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Discoidin domain receptors in disease

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Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

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Tension, contraction and tissue morphogenesis

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Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

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Cell–collagen interactions: the use of peptide Toolkits to investigate collagen–receptor interactions

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Distinct focal adhesion protein modules control different aspects of mechanotransduction

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Long-range self-organization of cytoskeletal myosin II filament stacks

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