The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions
Open accessAbstract
Mammalian homologues of the Drosophila polarity proteins Stardust, Discs Lost, and Crumbs have been identified as Pals1, Pals1-associated tight junction protein (PATJ), and human Crumbs homologue 1 (CRB1), respectively. We have previously demonstrated that PATJ, Pals1, and CRB1 can form a tripartite tight junction complex in epithelial cells and that PATJ recruits Pals1 to tight junctions. Here, we observed that the Pals1/PATJ interaction was not crucial for the ultimate targeting of PATJ itself to tight junctions. This prompted us to examine if any of the 10 post-synaptic density-95/Discs Large/zona occludens-1 (PDZ) domains of PATJ could bind to the carboxyl termini of known tight junction constituents. We found that the 6th and 8th PDZ domains of PATJ can interact with the carboxyl termini of zona occludens-3 (ZO-3) and claudin 1, respectively. PATJ missing the 6th PDZ domain was found to mislocalize away from cell contacts. Surprisingly, deleting the 8th PDZ domain had little effect on PATJ localization. Finally, reciprocal co-immunoprecipitation experiments revealed that full-length ZO-3 can associate with PATJ. Hence, the PATJ/ZO-3 interaction is likely important for recruiting PATJ and its associated proteins to tight junctions.
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Cites
Occludin: a novel integral membrane protein localizing at tight junctions.
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Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
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A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
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Transmembrane proteins in the tight junction barrier
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Cited by
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
Physiology and function of the tight junction
Anderson, J. M., & Van Itallie, C. M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002584 · Cited by 1,059
Assémat, E., Bazellières, E., Pallesi-Pocachard, E., Le Bivic, A., & Massey-Harroche, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 470
Transmembrane proteins of tight junctions
Chiba, H., Osanai, M., Murata, M., Kojima, T., & Sawada, N. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.017 · Cited by 464
Composition and Formation of Intercellular Junctions in Epithelial Cells
Knust, E., & Bossinger, O. (2002) · Science · doi:10.1126/science.1072161 · Cited by 423
Metadata
- Authors
- Roh, M. H., Liu, C.-J., Laurinec, S., & Margolis, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 277
- Issue
- 30
- Pages
- 27501-27509
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2091470454
- Cited by
- 181
- References
- 6
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Roh, M. H., Liu, C.-J., Laurinec, S., & Margolis, B. (2002). The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m201177200
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