The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress
Open accessAbstract
Abstract —Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis, hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. Many VSMC growth factors are secreted by VSMC and act in an autocrine manner. Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin family, is secreted by VSMCs in response to oxidative stress and mediates extracellular signal–regulated kinase (ERK1/2) activation and VSMC growth by reactive oxygen species. Human recombinant CyPA can mimic the effects of secreted CyPA to stimulate ERK1/2 and cell growth. The peptidyl-prolyl isomerase activity is required for ERK1/2 activation by CyPA. In vivo, CyPA expression and secretion are increased by oxidative stress and vascular injury. These findings are the first to identify CyPA as a secreted redox-sensitive mediator, establish CyPA as a VSMC growth factor, and suggest an important role for CyPA and enzymes with peptidyl-prolyl isomerase activity in the pathogenesis of vascular diseases.
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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Cited by
Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147
Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H.-C., Toole, B., Gallay, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201593200 · Cited by 334
Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy
Han, J. M., & Jung, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169341 · Cited by 75
Anandan, V., Thulaseedharan, T., Suresh Kumar, A., Chandran Latha, K., Revikumar, A., Mullasari, A., Kartha, C. C., Jaleel, A., & Ramachandran, S. (2021) · Cells · doi:10.3390/cells10123598 · Cited by 18
Metadata
- Authors
- Jin, Z.-G., Melaragno, M. G., Liao, D.-F., Yan, C., Haendeler, J., Suh, Y.-A., Lambeth, J. D., & Berk, B. C.
- Venue
- Circulation Research
- Published
- 2000-10-27
- Volume
- 87
- Issue
- 9
- Pages
- 789-796
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2166588241
- Cited by
- 398
- References
- 2
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jin, Z.-G., Melaragno, M. G., Liao, D.-F., Yan, C., Haendeler, J., Suh, Y.-A., Lambeth, J. D., & Berk, B. C. (2000). Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress. Circulation Research. https://doi.org/10.1161/01.res.87.9.789
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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