Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E. J., Frisch, S. M., & Reed, J. C. (1998) · Science · doi:10.1126/science.282.5392.1318 · Cited by 3,118 · see citing works

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 2,985 · see citing works

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578 · see citing works

Biochemical Pathways of Caspase Activation During Apoptosis

Budihardjo, I. I., Oliver, H., Lutter, M. L., Luo, X., & Wang, X. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.269 · Cited by 2,562 · see citing works

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464 · see citing works

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099 · see citing works

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D., Gutiérrez, J., Towery, H., Burks, D., Ren, J.-M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,850 · see citing works

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574 · see citing works

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature · doi:10.1038/372186a0 · Cited by 1,252 · see citing works

Direct control of the Forkhead transcription factor AFX by protein kinase B

Kops, G. J. P. L., de Ruiter, N. D., de Vries-Smits, A. M. M., Powell, D. R., Bos, J. L., & Burgering, B. M. T. (1999) · Nature · doi:10.1038/19328 · Cited by 1,085 · see citing works

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., et al. (1994) · Nature · doi:10.1038/372182a0 · Cited by 1,082 · see citing works

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

Kulik, G., Klippel, A., & Weber, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1595 · Cited by 1,033 · see citing works

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854 · see citing works

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B*

Rena, G., Guo, S., Cichy, S. C., Unterman, T., & Cohen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17179 · Cited by 787 · see citing works

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

Tang, E., Núñez, G., Barr, F. G., & Guan, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16741 · Cited by 761 · see citing works

Mechanism of activation and function of protein kinase B

Alessi, D. R., & Cohen, P. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80062-2 · Cited by 743 · see citing works

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

Deisseroth, K. A., Heist, E. K., & Tsien, R. W. (1998) · Nature · doi:10.1038/32448 · Cited by 656 · see citing works

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

Párrizas, M., Saltiel, A. R., & LeRoith, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.154 · Cited by 653 · see citing works

FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.

Tan, Y., Rouse, J. W., Zhang, A., Cariati, S., Cohen, P., & Comb, M. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00840.x · Cited by 634 · see citing works

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

Madrid, L. V., Wang, C.-Y., D, D. C. G., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1626-1638.2000 · Cited by 634 · see citing works

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Nakamura, N., Ramaswamy, S., Vázquez, F., Signoretti, S., Loda, M. F., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8969-8982.2000 · Cited by 571 · see citing works

Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence

Guo, S., Rena, G., Cichy, S. B., He, X., Cohen, P., & Unterman, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17184 · Cited by 541 · see citing works

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

Peruzzi, F., di Prisco, M., Dews, M., Salomoni, P., Grassilli, E., Romano, G., Calabretta, B., & Baserga, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7203 · Cited by 497 · see citing works

A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

Lavan, B. E., Fantin, V. R., Chang, E. T., Lane, W. S., Keller, S. R., & Lienhard, G. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21403 · Cited by 381 · see citing works

The Antiapoptotic Gene <i>mcl-1</i> Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

Wang, J.-M., Chao, J.-R., Chen, W., Kuo, M.-L., Yen, J. J.-Y., & Yang-Yen, H.-F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6195 · Cited by 357 · see citing works

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

Kimura, K. D., Hattori, S., Kabuyama, Y., Shizawa, Y., Takayanagi, J., Nakamura, S., Toki, S., Matsuda, Y., Onodera, K., & Fukui, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32260-3 · Cited by 333 · see citing works

Differential regulation of gene expression by insulin and IGF‐1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

Nakae, J., Barr, V. A., & Accili, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.989 · Cited by 270 · see citing works

Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

Kulik, G., & Weber, M. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6711 · Cited by 244 · see citing works

β3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes

Klein, J. C., Faßhauer, M., Ito, M., Lowell, B. B., Benito, M., & Kahn, C. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34795 · Cited by 239 · see citing works

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

Brüning, J. C., Winnay, J. N., Cheatham, B., & Kahn, C. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1513 · Cited by 210 · see citing works

Constitutively Activated Akt-1 Is Vital for the Survival of Human Monocyte-Differentiated Macrophages

Liu, H., Perlman, H., Pagliari, L. J., & Pope, R. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.113 · Cited by 207 · see citing works

Insulin-like Growth Factor-I Induces bcl-2 Promoter through the Transcription Factor cAMP-Response Element-binding Protein

Pugazhenthi, S., Miller, E., Sable, C. L., Young, P. R., Heidenreich, K. A., Boxer, L. M., & Reusch, J. E. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27529 · Cited by 199 · see citing works

Insulin Receptor Substrate 3 Is Not Essential for Growth or Glucose Homeostasis

Liu, S. C. H., Wang, Q., Lienhard, G. E., & Keller, S. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.18093 · Cited by 189 · see citing works

Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes

Fasshauer, M., Klein, J., Ueki, K., Kriauciunas, K. M., Benito, M., White, M. F., & Kahn, C. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004046200 · Cited by 176 · see citing works

Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes

Faßhauer, M., Klein, J. C., Kriauciunas, K. M., Ueki, K., Benito, M., & Kahn, C. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.319-329.2001 · Cited by 171 · see citing works

Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig.

Xie, H., & Rothstein, T. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.4.1717 · Cited by 155 · see citing works

Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling

Tsuruzoe, K., Emkey, R., Kriauciunas, K. M., Ueki, K., & Kahn, C. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.26-38.2001 · Cited by 113 · see citing works

Insulin-like Growth Factor I-mediated Activation of the Transcription Factor cAMP Response Element-binding Protein in PC12 Cells

Pugazhenthi, S., Boras, T., O’Connor, D., Meintzer, M. K., Heidenreich, K. A., & Reusch, J. E. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.2829 · Cited by 112 · see citing works

Insulin-like Growth Factor-I (IGF-I) Receptor Activation Rescues UV-damaged Cells through a p38 Signaling Pathway

Héron‐Milhavet, L., Karas, M., Goldsmith, C. M., Baum, B. J., & LeRoith, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011490200 · Cited by 91 · see citing works

Rad and Rad-related GTPases Interact with Calmodulin and Calmodulin-dependent Protein Kinase II

Moyers, J. S., Bilan, P. J., Zhu, J., & Kahn, C. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.11832 · Cited by 90 · see citing works

Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart

Algenstaedt, P., Antonetti, D. A., Yaffe, M. B., & Kahn, C. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23696 · Cited by 87 · see citing works

Brown Adipose Tissue Thermogenesis During Aging and Senescence

McDonald, R. B., & Horwitz, B. A. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005404708710 · Cited by 80 · see citing works

The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin

Yenush, L., Zanella, C. L., Uchida, T., Bernal, D., & White, M. F. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6784 · Cited by 79 · see citing works

Different Subcellular Localization and Phosphoinositides Binding of Insulin Receptor Substrate Protein Pleckstrin Homology Domains

Razzini, G., Ingrosso, A., Brancaccio, A., Sciacchitano, S., Esposito, D. L., & Falasca, M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.6.0486 · Cited by 73 · see citing works

IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis

Uchida, T., Myers, M. G., & White, M. F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.126-138.2000 · Cited by 67 · see citing works

Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR

Tomizawa, M., Kumar, A., Perrot, V., Nakae, J., Accili, D., & Rechler, M. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7289 · Cited by 65 · see citing works

Phosphatidylinositol 3′-Kinase, But Not S6-Kinase, Is Required for Insulin-Like Growth Factor-I and IL-4 To Maintain Expression of Bcl-2 and Promote Survival of Myeloid Progenitors

Minshall, C. T., Arkins, S., Dantzer, R., Freund, G. G., & Kelley, K. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4542 · Cited by 55 · see citing works

Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of theadenomatous polyposis coli (APC) tumor suppressor gene

Jaiswal, A. S., & Narayan, S. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010501)81:2 · Cited by 55 · see citing works

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde, Á. M., Kahn, C. R., & Benito, M. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2122 · Cited by 53 · see citing works

Transient Activation of Jun N-terminal Kinases and Protection from Apoptosis by the Insulin-like Growth Factor I Receptor Can Be Suppressed by Dicumarol

Krause, D., Lyons, A., Fennelly, C., & O’Connor, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008186200 · Cited by 46 · see citing works

Novel Signaling Pathway Through the β-Adrenergic Receptor

Ma, Y. C. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00138-4 · Cited by 37 · see citing works

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

Muscle-specific expression of IGF-1 blocks angiotensin II–induced skeletal muscle wasting

Song, Y., Li, Y., Du, J., Mitch, W. E., Rosenthal, N. A., & Delafontaine, P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22324 · Cited by 347 · see citing works

Deconstructing adipogenesis induced by β3-Adrenergic receptor activation with single-cell expression profiling

Burl, R. B., Ramseyer, V. D., Rondini, E. A., Pique-Regi, R., Lee, Y.-H., & Granneman, J. G. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.025 · Cited by 332 · see citing works

Mir193b–365 is essential for brown fat differentiation

Sun, L., Xie, H., Mori, M. A., Alexander, R., Yuan, B., Hattangadi, S. M., Liu, Q., Kahn, C. R., & Lodish, H. F. (2011) · Nature Cell Biology · doi:10.1038/ncb2286 · Cited by 310 · see citing works

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., Russell, S. J., Kirkland, J. L., Blackwell, T. K., & Kahn, C. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.017 · Cited by 279 · see citing works

Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

Guo, W., Wong, S., Xie, W., Lei, T., & Luo, Z. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00523.2006 · Cited by 248 · see citing works

Chronic Kidney Disease Causes Defects in Signaling through the Insulin Receptor Substrate/Phosphatidylinositol 3-Kinase/Akt Pathway

Bailey, J. L., Zheng, B., Hu, Z., Price, S. R., & Mitch, W. E. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004100842 · Cited by 238 · see citing works

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

Tseng, Y.-H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M., Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1259 · Cited by 222 · see citing works

Regulation of apoptosis by insulin-like growth factor (IGF)-I

Kooijman, R. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.02.002 · Cited by 201 · see citing works

Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells

Li, Y., Yu, X., Lin, S., Li, X., Zhang, S., & Song, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.049 · Cited by 196 · see citing works

Cancer Drug Discovery and Development

Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195 · see citing works

Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation

Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1918-1929.2004 · Cited by 173 · see citing works

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor

Sakaguchi, M., Fujisaka, S., Cai, W., Winnay, J. N., Konishi, M., O'Neill, B. T., Li, M., García-Martín, R., Takahashi, H., Hu, J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.008 · Cited by 125 · see citing works

Insulin-Like Growth Factor 1 Physiology

Yakar, S., & Adamo, M. L. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.04.008 · Cited by 123 · see citing works

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism

Sakaguchi, M., Cai, W., Wang, C., Cederquist, C., Damasio, M. P. S., Homan, E. P., Batista, T. M., Ramirez, A. K., Gupta, M. K., Steger, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09418-0 · Cited by 111 · see citing works

Peroxisome Proliferator-Activated Receptor Coactivator 1 in Caloric Restriction and Other Models of Longevity

Corton, J. C., & Brown-Borg, H. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1494 · Cited by 106 · see citing works

Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors

Denley, A., Carroll, J. M., Brierley, G. V., Cosgrove, L., Wallace, J., Forbes, B., & Roberts, C. T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01447-06 · Cited by 103 · see citing works

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

Hiraike, Y., Waki, H., Yu, J., Nakamura, M., Miyake, K., Nagano, G., Nakaki, R., Ken, S., Kobayashi, H., Yamamoto, S., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3590 · Cited by 102 · see citing works

Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis

Nagano, I., Ilieva, H. S., Shiote, M., Murakami, T., Yokoyama, M., Shoji, M., & Abe, K. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.04.011 · Cited by 96 · see citing works

New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics

Wada, A., Yokoo, H., Yanagita, T., & Kobayashi, H. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05006x · Cited by 95 · see citing works

Overexpression of Insulin Receptor Substrate-2 in Human and Murine Hepatocellular Carcinoma

Boissan, M., Beurel, E., Wendum, D., Rey, C., Lécluse, Y., Housset, C., Lacombe, M., & Desbois‐Mouthon, C. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62058-5 · Cited by 92 · see citing works

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements

Rozovskaia, T., Ravid-Amir, O., Tillib, S. V., Getz, G. A., Feinstein, E., Agrawal, H., Nagler, A., Rappaport, E. F., Issaeva, I., Matsuo, Y., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1132115100 · Cited by 87 · see citing works

A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis

Boucher, J., Macotela, Y., Bézy, O., Mori, M. A., Kriauciunas, K. M., & Kahn, C. R. (2010) · Science Signaling · doi:10.1126/scisignal.2001173 · Cited by 86 · see citing works

CREB Downregulation in Vascular Disease

Schauer, I. E., Knaub, L. A., Lloyd, M. I., Watson, P. A., Gliwa, C., Lewis, K. E., Chait, A., Klemm, D. J., Gunter, J., Bouchard, R. J., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.199133 · Cited by 84 · see citing works

Focal adhesion kinase mediates cell survival via NF-κB and ERK signaling pathways

Huang, D., Khoe, M., Befekadu, M., Chung, S., Takata, Y., Ilić, D., & Bryer‐Ash, M. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2006 · Cited by 74 · see citing works

Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease

Tarantino, G. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i48.5280 · Cited by 72 · see citing works

Insulin‐like growth factors and pancreas beta cells

van Haeften, T. W., & Twickler, T. B. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01337.x · Cited by 69 · see citing works

Insulin-Like Growth Factor-I Is an Important Antiapoptotic Factor for Rat Leydig Cells during Postnatal Development

Colón, E., Zaman, F., Axelson, M., Larsson, O., Carlsson‐Skwirut, C., Svechnikov, K. V., & Söder, O. (2006) · Endocrinology · doi:10.1210/en.2006-0835 · Cited by 66 · see citing works

Upregulation of the Insulin Receptor and Type I Insulin-Like Growth Factor Receptor Are Early Events in Hepatocarcinogenesis

Aleem, E. A., Nehrbass, D., Klimek, F., Mayer, D., & Bannasch, P. (2011) · Toxicologic Pathology · doi:10.1177/0192623310396905 · Cited by 62 · see citing works

Identification of miR-106b-93 as a negative regulator of brown adipocyte differentiation

Wu, Y., Zuo, J., Zhang, Y., Xie, Y., Hu, F., Chen, L., Liu, B., & Liu, F. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.016 · Cited by 61 · see citing works

Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells

Park, K., Li, Q., Rask‐Madsen, C., Mima, A., Mizutani, K., Winnay, J. N., Maeda, Y., D’Aquino, K. E., White, M. F., Feener, E. P., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00506-13 · Cited by 60 · see citing works

Psychological stress and aging: role of glucocorticoids (GCs)

Hasan, K., Rahman, M. S., Arif, K. M. T., & Sobhani, M. E. (2011) · AGE · doi:10.1007/s11357-011-9319-0 · Cited by 59 · see citing works

An inflammatory micro-environment promotes human adipocyte apoptosis

Keuper, M., Blüher, M., Schön, M. R., Möller, P., Dzyakanchuk, A. A., Amrein, K. E., Debatin, K., Wabitsch, M., & Fischer‐Posovszky, P. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.004 · Cited by 60 · see citing works

IRS1 Regulation by Wnt/β-Catenin Signaling and Varied Contribution of IRS1 to the Neoplastic Phenotype

Bommer, G. T., Feng, Y., Iura, A., Giordano, T. J., Kuick, R. D., Kadikoy, H., Sikorski, D., WU, R. T., Cho, K. R., & Fearon, E. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060319 · Cited by 59 · see citing works

Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis

Zhang, H., Schulz, T. J., Espinoza, D., Huang, T. L., Emanuelli, B., Kristiansen, K., & Tseng, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00363-10 · Cited by 58 · see citing works

The role of insulin signaling in the development of β-cell dysfunction and diabetes

Wang, Q., & Jin, T. (2009) · Islets · doi:10.4161/isl.1.2.9263 · Cited by 56 · see citing works

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum‐deprived hepatocytes

González‐Rodríguez, Á., Escribano, Ó., Alba, J., Rondinone, C. M., Benito, M., & Valverde, Á. M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21004 · Cited by 55 · see citing works

T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer’s Disease

Tong, M., Deochand, C., Didsbury, J. R., & de la Monte, S. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151013 · Cited by 56 · see citing works

Irs–2 Mediates the Antiapoptotic Effect of Insulin in Neonatal Hepatocytes

Valverde, Á. M., Fabregat, I., Burks, D. J., White, M. F., & Benito, M. (2004) · Hepatology · doi:10.1002/hep.20485 · Cited by 54 · see citing works

Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-Associated Pathways

Cypess, A. M., Zhang, H., Schulz, T. J., Huang, T. L., Espinoza, D., Kristiansen, K., Unterman, T. G., & Tseng, Y. (2011) · Endocrinology · doi:10.1210/en.2011-1229 · Cited by 49 · see citing works

CD8 + T Regulatory Cells Use a Novel Genetic Program that Includes CD103 to Suppress Th1 Immunity in Eye-Derived Tolerance

Keino, H., Masli, S., Sasaki, S., Streilein, J. W., & Stein‐Streilein, J. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1454 · Cited by 50 · see citing works

[LysB3, GluB29] insulin: a novel insulin analog with enhanced β-cell protective action

Rakatzi, I., Seipke, G., & Eckel, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.090 · Cited by 44 · see citing works

The 14q32 MicroRNA-487b Targets the Antiapoptotic Insulin Receptor Substrate 1 in Hypertension-Induced Remodeling of the Aorta

Nossent, A. Y., Eskildsen, T. V., Andersen, L. B., Bie, P., Brønnum, H., Schneider, M., Andersen, D. C., Welten, S. M. J., Jeppesen, P. L., Hamming, J. F., et al. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a6aac0 · Cited by 43 · see citing works

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient β-cells

Hennige, A. M., Özcan, U., Okada, T., Jhala, U. S., Schubert, M., White, M. F., & Kulkarni, R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00032.2004 · Cited by 42 · see citing works

Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Dise ase Pathologies

Tong, M., & Dominguez, C. (2016) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000238 · Cited by 43 · see citing works

Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes

Ito, M., Nagasawa, M., Hara, T., Ide, T., & Murakami, K. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002147 · Cited by 43 · see citing works

Tissue-Specific Differences in Activation of Atypical Protein Kinase C and Protein Kinase B in Muscle, Liver, and Adipocytes of Insulin Receptor Substrate-1 Knockout Mice

Sajan, M. P., Standaert, M. L., Miura, A., Kahn, C. R., & Farese, R. V. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0045 · Cited by 41 · see citing works

Clinical Approaches to Preserve β-Cell Function in Diabetes

WAJCHENBERG, B. L. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_23 · Cited by 38 · see citing works

TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

Bailey, K. L., Agarwal, E., Chowdhury, S., Luo, J., Brattain, M. G., Black, J. D., & Wang, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176096 · Cited by 37 · see citing works

Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTRΔ508 in the Lung

Xu, Y. J., Liu, C., Clark, J. C., & Whitsett, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512072200 · Cited by 37 · see citing works

3′-Azido-3′-deoxythymidine (AZT) induces apoptosis and alters metabolic enzyme activity in human placenta

Collier, A. C. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00274-6 · Cited by 35 · see citing works

Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice

Narai, H., Nagano, I., Ilieva, H., Shiote, M., Nagata, T., Hayashi, T., Shoji, M., & Abe, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20668 · Cited by 33 · see citing works

Enhancement of insulin‐induced PI3K/Akt/GSK‐3β and ERK signaling by neuronal nicotinic receptor/PKC‐α/ERK pathway: up‐regulation of IRS‐1/‐2 mRNA and protein in adrenal chromaffin cells

Sugano, T., Yanagita, T., Yokoo, H., Satoh, S., Kobayashi, H., & Wada, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03846.x · Cited by 31 · see citing works

Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death

Tseng, Y., Hsu, H., Lee, T., Chang, W., & Lo, Y. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1594554 · Cited by 28 · see citing works

Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells

Bucris, E. D., Beck, A., Boura‐Halfon, S., Isaac, R., Vinik, Y., Rosenzweig, T., Sampson, S. R., & Zick, Y. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0505 · Cited by 28 · see citing works

Susceptibility to Apoptosis in Insulin-like Growth Factor-I Receptor-deficient Brown Adipocytes

Valverde, Á. M., Mur, C., Brownlee, M., & Benito, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0853 · Cited by 24 · see citing works

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis

Kim, B., & Feldman, E. L. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0331-0 · Cited by 23 · see citing works

Effects of Pioglitazone Mediated Activation of PPAR-γ on CIDEC and Obesity Related Changes in Mice

Shamsi, B. H., Ma, C., Naqvi, S., & Xiao, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106992 · Cited by 21 · see citing works

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp, M. E., Wiley, A. A., Boulos, M. B., Rahman, K. M., Bartol, F. F., & Bagnell, C. A. (2014) · Reproduction · doi:10.1530/rep-14-0257 · Cited by 21 · see citing works

Effects of insulin-sensitising agents in mice with hepatic insulin resistance

Cohen, S. E., Tseng, Y., Michael, M. D., & Kahn, C. R. (2004) · Diabetologia · doi:10.1007/s00125-003-1320-4 · Cited by 21 · see citing works

RNAi‐mediated silencing of insulin receptor substrate‐4 enhances actinomycin D‐ and tumor necrosis factor‐α‐induced cell death in hepatocarcinoma cancer cell lines

Cuevas, E. P., Escribano, Ó., Monserrat, J., Martı́nez-Botas, J., Sánchez, M. G., Chiloeches, A., Hernández‐Breijo, B., Sánchez-Alonso, V., Román, I. D., Fernández-Moreno, D., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22359 · Cited by 17 · see citing works

PKCδ and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells

Mingo-Sion, A. M., Ferguson, H. A., Koller, E., Reyland, M. E., & Berg, C. L. V. D. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-0669-0 · Cited by 17 · see citing works

Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients

Sanmartín-Salinas, P., Toledo-Lobo, M. V., Noguerales-Fraguas, F., Fernández-Contreras, M. E., & Guijarro, L. G. (2017) · Journal of Molecular Histology · doi:10.1007/s10735-017-9745-0 · Cited by 16 · see citing works

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-κB activity

Kabuta, T., Hakuno, F., Cho, Y., Yamanaka, D., Chida, K., Asano, T., Wada, K., & Takahashi, S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.054 · Cited by 15 · see citing works

Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells

Zhang, H., Hoff, H. B., & Sell, C. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00286-6 · Cited by 15 · see citing works

Constitutive activity of glycogen synthase kinase-3β: Positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells

Nemoto, T., Yokoo, H., Satoh, S., Yanagita, T., Sugano, T., Yoshikawa, N., Maruta, T., Kobayashi, H., & Wada, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.053 · Cited by 15 · see citing works

Morphology of the pancreas of some species belonging to the genera Phelsuma and Gecko (family Gekkonidae): evidence of apoptotic process during the seasonal cycle

Buono, S., Odierna, G., & Putti, R. (2006) · Anatomy and Embryology · doi:10.1007/s00429-006-0090-4 · Cited by 14 · see citing works

Caspase-mediated Cleavage of Insulin Receptor Substrate

Green, K. A., Naylor, M. J., Lowe, E. T., Wang, P., Marshman, E., & Streuli, C. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402395200 · Cited by 12 · see citing works

Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

Lomperta, K., Jakubowska, K., Grudzińska, M., Koda, M., Wincewicz, A., Surmacz, E., Sulkowski, S., & Koda, M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i28.4140 · Cited by 10 · see citing works

Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cells

Kim, B., Oh, S., van Golen, C. M., & Feldman, E. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.11.001 · Cited by 9 · see citing works

Preserving insulin secretion in Type 2 diabetes mellitus

Tibaldi, J. M. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.2.147 · Cited by 8 · see citing works

Receptor Tyrosine Kinase Signal Transduction and the Molecular Basis of Signalling Specificity

MEYTS, P. D. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2053-2_4 · Cited by 8 · see citing works

Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis

Kaburagi, Y., Satoh, S., Yamamoto‐Honda, R., Ito, Y., Akanuma, Y., Sekihara, H., Yasuda, K., Sasazuki, T., Kadowaki, T., & Yazaki, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02855-3 · Cited by 7 · see citing works

Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury†

Korkmaz‐Icöz, S., Li, S., Loganathan, S., Radovits, T., Ruppert, M., Brlecic, P., Sayour, A. A., Veres, G., Fleming, T., Brune, M., et al. (2018) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivy188 · Cited by 6 · see citing works

Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells

Yoshikawa, N., Nemoto, T., Satoh, S., Maruta, T., Yanagita, T., Chosa, E., & Wada, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.013 · Cited by 6 · see citing works

Is there U-turn from Insulin Back to Pills in Diabetes?

Ertek, S., & Çetinkalp, Ş. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113119990122 · Cited by 5 · see citing works

Sequential testicular atrophy involves changes in cellular proliferation and apoptosis associated with variations in aromatase P450 expression levels in Irs‐2‐deficient mice

Catalano-Iniesta, L. A., Sánchez‐Robledo, V., Osma, M. D. C. I., García‐Barrado, M. J., Carretero‐Hernández, M., Blanco, E. J., Vicente‐García, T., Burks, D. J., & Carretero, J. (2018) · Journal of Anatomy · doi:10.1111/joa.12917 · Cited by 4 · see citing works

Different Effects of the Insulin Receptor Isoforms on 32D Cell Growth and Differentiation

Sciacchitano, S. (2017) · doi:10.29199/demd.101013 · Cited by 4 · see citing works

Signal Transduction in Child Health: Closing the Gap Between Clinical and Basic ResearchA report on the third NICHe Conference, “New Inroads to Child Health—Child Health and Signal Transduction,” Varberg, Sweden, 21 to 23 May 2010

Chan, L. F., Albertsson-Wikland, K. G., Camacho‐Hübner, C., & Hochberg, Z. (2010) · Science Signaling · doi:10.1126/scisignal.3143mr3 · Cited by 3 · see citing works

Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene.

Melkersson, K. I. (2013) · PubMed · Cited by 3 · see citing works

The GH/IGF-1 Axis: Insights from Animal Models

Holzenberger, M., Kappeler, L., Filho, C. D. D. M., & Bouc, Y. L. (2005) · Springer eBooks · doi:10.1007/3-540-28902-x_4 · Cited by 3 · see citing works

Is there any difference in insulin resistance status between cases of benign and malignant ovarian neoplasms? A study on surrogate markers of insulin resistance in Indonesian non‑diabetic women

Winarto, H., Habiburrahman, M., Febriana, I. S., Kusuma, F., Nuryanto, K. H., Anggraeni, T. D., Utami, T. W., & Putra, A. D. (2022) · Oncology Letters · doi:10.3892/ol.2022.13609 · Cited by 2 · see citing works

Clinical Approaches to Preserving β-Cell Function in Diabetes

WAJCHENBERG, B. L., & de Carvalho, R. M. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_17 · Cited by 1 · see citing works

The malignant transformation event as a clonal transformation of apoptosis to anti-apoptosis pathways and of cell cycle dynamics

Agius, L. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.10.016 · Cited by 1 · see citing works

Aging-related changes in the expression of apoptosis-associated molecules in neurosecretory cells of the mouse hypothalamus

Бажанова, Е. Д., Molodtsov, V., & Павлов, К. И. (2007) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-008-0006-2 · Cited by 1 · see citing works

IGF-1 Cellular Action and its Relationship to Cancer: Evidence from in Vitro and in Vivo Studies

Ferguson, R. D., Alikhani, N., Vijayakumar, A., Fierz, Y., Cannata, D., & Yakar, S. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0598-6_6 · Cited by 1 · see citing works

Insulin-like growth factor 1 signalling and its role in cell survival and radiation sensitivity.

Hematulin, A. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works

Mechanisms of Cardiac Hypertrophy and the Development of Heart Failure

Delafontaine, P., Brink, M., & Song, Y.-H. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-795-6_17

THE ROLE OF NBS1 IN THE INSULIN-LIKE GROWTH FACTOR-1 SIGNALING

der Fakultät, D., & Biologie, F. (2008)

Lactocrine signaling and neonatal porcine reproductive tract development

Camp, M. E. (2015) · doi:10.7282/t35b046f

Clinical Approaches to Preserving b-Cell Function in Diabetes 33

WAJCHENBERG, B. L., & de Carvalho, R. M. (2015)

The Role and Regulation of Insulin-Like Growth Factor Binding Protein-4 in the Rodent Intestinal Mucosa

Austin, K. (2017) · TSpace (University of Toronto)

Clinical Approaches to Preserving β-Cell Function in Diabetes

WAJCHENBERG, B. L., & de Carvalho, R. M. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_17-3

CHANGES IN EXPRESSION OF APOPTOSIS-ASSOCIATED MOLECULES IN HYPOTHALAMIC NEUROSECRETORY CELLS OF MICEDURING AGING

Бажанова, Е. Д., Molodtsov, V. N., Pavlov, K. I., Bazhanova, Y. D., Molodtzov, V. N., & Pavlov, K. I. (2006) · Morphology · doi:10.17816/morph.402446

Differential roles of insulin receptor substrates in the anti-apoptotic function of insulinlike growth factor-1

Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., Kahn, R., Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., & Kahn, C. R. (2002)

A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis

Boucher, J., Macotela, Y., Bézy, O., Mori, M. A., Kriauciunas, K. M., & Kahn, C. R. (2010) · Science Signaling · doi:10.1126/scisignal.2001173 · Cited by 86 · see citing works

IGF-I receptor protection from apoptosis in cells lacking the IRS proteins.

Dews, M., Nishimoto, I., & Baserga, R. (1997) · PubMed · Cited by 26 · see citing works

The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin

Yenush, L., Zanella, C. L., Uchida, T., Bernal, D., & White, M. F. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6784 · Cited by 79 · see citing works

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

di Prisco, M., Romano, G., Peruzzi, F., Valentinis, B., & Baserga, R. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978703 · Cited by 131 · see citing works