The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Brain Genomic Response following Hypoxia and Re-oxygenation in the Neonatal Rat
Open accessAbstract
Hypoxic preconditioning (8% O2, 3 h) produces tolerance 24 h after hypoxic-ischemic brain injury in neonatal rats. To better understand the ischemic tolerance mechanisms induced by hypoxia, we used oligonucleotide microarrays to examine genomic responses in neonatal rat brain following 3 h of hypoxia (8% O2) and either 0, 6, 18, or 24 h of re-oxygenation. The results showed that hypoxia-inducible factor (HIF)-1- but not HIF-2-mediated gene expression may be involved in brain hypoxia-induced tolerance. Among the genes regulated by hypoxia, 12 genes were confirmed by real time reverse transcriptase-PCR as follows: VEGF, EPO, GLUT-1, adrenomedullin, propyl 4-hydroxylase alpha, MT-1, MKP-1, CELF, 12-lipoxygenase, t-PA, CAR-1, and an expressed sequence tag. Some genes, for example GLUT-1, MT-1, CELF, MKP-1, and t-PA did not show any hypoxic regulation in either astrocytes or neurons, suggesting that other cells are responsible for the up-regulation of these genes in the hypoxic brain. These genes were expressed in normal and hypoxic brain, heart, kidney, liver, and lung, with adrenomedullin, MT-1, and VEGF being prominently induced in brain by hypoxia. These results suggest that a number of endogenous molecular mechanisms may explain how hypoxic preconditioning protects against subsequent ischemia, and may provide novel therapeutic targets for treatment of cerebral ischemia.
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Cited by
Cerebral preconditioning and ischaemic tolerance
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The Role of Hypoxia in Development of the Mammalian Embryo
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Neuroglobin protects the brain from experimental stroke in vivo
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Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?
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Metadata
- Authors
- Bernaudin, M., Tang, Y., Reilly, M., Petit, E., & Sharp, F. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 277
- Issue
- 42
- Pages
- 39728-39738
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1982557954
- Cited by
- 301
- References
- 66
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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