The DOI matches its Crossref record, with a small difference in title or year; 57 of the 58 references it cites were found in a registry or an index.
Homologues of Human Macrophage Migration Inhibitory Factor from a Parasitic Nematode
Open accessAbstract
Cytokines are the molecular messengers of the vertebrate immune system, coordinating the local and systemic immune responses to infective organisms. We report here functional and structural data on cytokine-like proteins from a eukaryotic pathogen. Two homologues of the human cytokine macrophage migration inhibitory factor (MIF) have been isolated from the parasitic nematode Brugia malayi. Both molecules (Bm-MIF-1 and Bm-MIF-2) show parallel functions to human MIF. They are chemotactic for human monocytes and activate them to produce IL-8, TNF-alpha, and endogenous MIF. The human and nematode MIF homologues share a tautomerase enzyme activity, which is in each case abolished by the mutation of the N-terminal proline residue. The crystal structure of Bm-MIF-2 at 1.8-A resolution has been determined, revealing a trimeric assembly with an inner pore created by beta-stranded sheets from each subunit. Both biological activity and crystal structure reveal remarkable conservation between a human cytokine and its parasite counterpart despite the considerable phylogenetic divide among these organisms. The strength of the similarity implies that MIF-mediated pathways play an important role in nematode immune evasion strategies.
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“those from Brugia malayi (Zang et al., 2002) and Trichinella spiralis (Tan et al., 2001) mirror the activity of the host protein, inducing IL-8 release from monocytes”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Zang et al., 2002
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MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
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Viral Strategies of Immune Evasion
Ploegh, H. L. (1998) · Science · doi:10.1126/science.280.5361.248 · Cited by 786
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra, T., Echtenacher, B., Roy, D. L., Pugin, J., Metz, C. N., Hültner, L., Heumann, D., Männel, D. N., Bucala, R., & Glauser, M. P. (2000) · Nature Medicine · doi:10.1038/72262 · Cited by 724
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MIF regulates innate immune responses through modulation of Toll-like receptor 4
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Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1
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Immune Regulation by helminth parasites: cellular and molecular mechanisms
Maizels, R. M., & Yazdanbakhsh, M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1183 · Cited by 1,167
Self-citationHelminth parasites – masters of regulation
Maizels, R. M., Balic, A., Gomez‐Escobar, N., Nair, M. G., Taylor, M. D., & Allen, J. E. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00191.x · Cited by 882
Self-citationHelminth immunoregulation: The role of parasite secreted proteins in modulating host immunity
Hewitson, J. P., Grainger, J. R., & Maizels, R. M. (2009) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2009.04.008 · Cited by 743
Self-citationModulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435
Self-citationAl‐Abed, Y., Dabideen, D. R., Aljabari, B., Valster, A. H., Messmer, D., Ochani, M., Tanovic, M., Ochani, K., Bacher, M., Nicoletti, F., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500243200 · Cited by 309
Metadata
- Authors
- Zang, X., Taylor, P., Wang, J. M., Meyer, D. J., Scott, A. L., Walkinshaw, M. D., & Maizels, R. M.
- Affiliations
- University of Edinburgh (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Johns Hopkins University (US)
- Corresponding author
- Zang, Xingxing
- Maizels, Rick M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 277
- Issue
- 46
- Pages
- 44261-44267
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2002006009
- Cited by
- 108
- References
- 58
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Funders
- Wellcome Trust
- European Commission
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- macrophage migration inhibitory factor, Brugia malayi, tautomerase activity, N-terminal proline, crystal structure, immune evasion, interleukin-8, TNF-α
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Cloning, Molecular, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Escherichia coli, Humans, Macrophage Migration-Inhibitory Factors, Models, Molecular, Molecular Sequence Data, Monocytes, Protein Conformation, Tumor Necrosis Factor-alpha, Blotting, Western, Protozoan Proteins, Interleukin-8, Brugia malayi, Protein Structure, Secondary, Protein Structure, Tertiary, Crystallography, X-Ray, Reverse Transcriptase Polymerase Chain Reaction
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