Mediation of the DCC Apoptotic Signal by DIP13α
Open accessAbstract
DCC (deleted in colorectal cancer) is a candidate tumor suppressor gene. However the function of DCC remains elusive. Previously, we demonstrated that forced expression of DCC induces apoptosis or cell cycle arrest (Chen, Y. Q., Hsieh, J. T., Yao, F., Fang, B., Pong, R. C., Cipriano, S. C. & Krepulat, F. (1999) Oncogene 18, 2747-2754). To delineate the DCC-induced apoptotic pathway, we have identified a protein, DIP13 alpha, which interacts with DCC. The DIP13 alpha protein has a pleckstrin homology domain and a phosphotyrosine binding domain. It interacts with a region on the DCC cytoplasmic domain that is required for the induction of apoptosis. Although ectopic expression of DIP13 alpha alone causes only a slight increase in apoptosis, co-expression of DCC and DIP13 alpha results in an approximately 5-fold increase in apoptosis. Removal of the DCC-interacting domain on DIP13 alpha abolishes its ability to enhance DCC-induced apoptosis. Inhibition of endogenous DIP13 alpha expression by small interfering RNA blocks DCC-induced apoptosis. Our data suggest that DIP13 alpha is a mediator of the DCC apoptotic pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In absence of ligands, DCC is cleaved by CASP3 and this promotes its association with APPL1 and CASP9, resulting in activation of CASP9-CASP3 cascade.
“(1) DCC is cleaved by CASP3 and this promotes its association with adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) and CASP9, resulting in the activation of the CASP9-CASP3 cascade [350, 351]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [351]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works
<i>DPC4</i> , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337 · see citing works
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,738 · see citing works
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
Gyuris, J. (1993) · Cell · doi:10.1016/0092-8674(93)90498-f · Cited by 1,534 · see citing works
Coiled coils: a highly versatile protein folding motif.
Burkhard, P., Stetefeld, J., & Strelkov, S. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01898-5 · Cited by 1,055 · see citing works
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
Keino‐Masu, K., Masu, M., Hinck, L., Leonardo, E. D., Chan, S. S.-Y., Culotti, J. G., & Tessier‐Lavigne, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81336-7 · Cited by 1,013 · see citing works
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
Fazeli, A., Dickinson, S., Hermiston, M. L., Tighe, R., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino‐Masu, K., Masu, M., Rayburn, H., et al. (1997) · Nature · doi:10.1038/386796a0 · Cited by 778 · see citing works
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
Thiagalingam, S., Christoph Lengauer, C., Leach, F. S., Schutte, M. E. M., Hahn, S. A., Overhauser, J., Willson, J. K. V., Markowitz, S. D., Hamilton, S. R., Kern, S. E., et al. (1996) · Nature Genetics · doi:10.1038/ng0796-343 · Cited by 616 · see citing works
Chan, S., Zheng, H., Su, M., Wilk, R., Killeen, M. T., Hedgecock, E. M., & Culotti, J. G. (1996) · Cell · doi:10.1016/s0092-8674(00)81337-9 · Cited by 503 · see citing works
Kolodziej, P. A., Timpe, L. C., Mitchell, K. J., Fried, S. R., Goodman, C. S., Jan, L. Y., & Jan, Y. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81338-0 · Cited by 460 · see citing works
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
Mehlen, P., Rabizadeh, S., Snipas, S. J., Assa‐Munt, N., Salvesen, G. S., & Bredesen, D. E. (1998) · Nature · doi:10.1038/27441 · Cited by 437 · see citing works
Netrin‐1 acts as a survival factor via its receptors UNC5H and DCC
Llambi, F., Causeret, F., Bloch‐Gallego, E., & Mehlen, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2715 · Cited by 349 · see citing works
PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions
Rebecchi, M. J., & Scarlata, S. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.503 · Cited by 291 · see citing works
Homozygous deletion map at 18q21.1 in pancreatic cancer.
Hahn, S. A., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Schutte, M. E. M., Rozenblum, E., Seymour, A. B., Weinstein, C. L., Yeo, C. J., Hruban, R. H., et al. (1996) · PubMed · Cited by 265 · see citing works
Yee, K. T., Simon, H. H., Tessier‐Lavigne, M., & O’Leary, D. D. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81116-2 · Cited by 262 · see citing works
The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas
Cho, K. R., Oliner, J. D., Simons, J. W., Hedrick, L., Fearon, E. R., Preisinger, A. C., Hedge, P., Silverman, G. A., & Vogelstein, B. (1994) · Genomics · doi:10.1006/geno.1994.1102 · Cited by 224 · see citing works
Forcet, C., Ye, X., Granger, L., Corset, V., Shin, H., Bredesen, D. E., & Mehlen, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051378298 · Cited by 208 · see citing works
Mitsuuchi, Y., Johnson, S. W., Sonoda, G., Tanno, S., Golemis, E. A., & Testa, J. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203080 · Cited by 202 · see citing works
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathwayPreprint
Hu, G., Zhang, S., Vidal, M., Baer, J. L., Xu, T., & Fearon, E. R. (1997) · Genes & Development · doi:10.1101/gad.11.20.2701 · Cited by 191 · see citing works
Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons
Bloch‐Gallego, E., Ezan, F., Tessier‐Lavigne, M., & Sotelo, C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04407.1999 · Cited by 187 · see citing works
Gao, X., Honn, K. V., Grignon, D. J., Sakr, W., & Chen, Y. Q. (1993) · PubMed · Cited by 139 · see citing works
Self-citationThe function of PTB domain proteins
Margolis, B. L., Borg, J., Straight, S. W., & Meyer, D. J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00700.x · Cited by 80 · see citing works
Induction of apoptosis and G2/M cell cycle arrest by DCC
Chen, Y. Q., Hsieh, J., Yao, F., Fang, B., Pong, R.-C., Cipriano, S. C., & Krepulat, F. (1999) · Oncogene · doi:10.1038/sj.onc.1202629 · Cited by 71 · see citing works
Self-citationThe PTB Domain: The Name Doesn't Say It All
Margolis, B. L. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00168-x · Cited by 25 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Forcet, C., Ye, X., Granger, L., Corset, V., Shin, H., Bredesen, D. E. & Mehlen, P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3416 -3421
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationAPPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
Mao, X., Kikani, C. K., Riojas, R. A., Langlais, P. R., Wang, L., Ramos, F. J., Fang, Q., Christ-Roberts, C. Y., Hong, J., Kim, R. Y., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1404 · Cited by 661 · see citing works
The Role of Adiponectin in Cancer: A Review of Current Evidence
Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 639 · see citing works
APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment
Miączyńska, M., Christoforidis, S., Giner, A., Shevchenko, A., Uttenweiler‐Joseph, S., Habermann, B. H., Wilm, M. S., Parton, R. G., & Zerial, M. (2004) · Cell · doi:10.1016/s0092-8674(04)00117-5 · Cited by 536 · see citing works
Adiponectin signaling and function in insulin target tissues
Ruan, H., & Dong, L. Q. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw014 · Cited by 395 · see citing works
The concept of intrinsic versus extrinsic apoptosis
Lossi, L. (2022) · Biochemical Journal · doi:10.1042/bcj20210854 · Cited by 355 · see citing works
Schenck, A., Goto‐Silva, L., Collinet, C., Rhinn, M., Giner, A., Habermann, B. H., Brand, M., & Zerial, M. (2008) · Cell · doi:10.1016/j.cell.2008.02.044 · Cited by 333 · see citing works
Adiponectin action from head to toe
Brochu‐Gaudreau, K., Rehfeldt, C., Blouin, R., Bordignon, V., Murphy, B. D., & Palin, M. (2009) · Endocrine · doi:10.1007/s12020-009-9278-8 · Cited by 323 · see citing works
Cheng, K. K. Y., Lam, K. S. L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., & Xu, A. (2007) · Diabetes · doi:10.2337/db06-1580 · Cited by 318 · see citing works
Colorectal carcinogenesis: Review of human and experimental animal studies
Tanaka, T. (2009) · Journal of Carcinogenesis · doi:10.4103/1477-3163.49014 · Cited by 309 · see citing works
APPL1: role in adiponectin signaling and beyond
Deepa, S. S., & Dong, L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90731.2008 · Cited by 287 · see citing works
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
Berquin, I. M., Min, Y.-N., Wu, R., Wu, J., Perry, D. L., Cline, J. M., Thomas, M. J., Thornburg, T., Kulik, G., Smith, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31494 · Cited by 280 · see citing works
Self-citationA Role of the Lowe Syndrome Protein OCRL in Early Steps of the Endocytic Pathway
Erdmann, K. S., Mao, Y., McCrea, H. J., Zoncu, R., Lee, S., Paradise, S., Modregger, J., Biemesderfer, D., Toomre, D. K., & Camilli, P. V. D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.004 · Cited by 271 · see citing works
Netrin-1 and its receptors in tumorigenesis
Arakawa, H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1504 · Cited by 261 · see citing works
The brain within the tumor: new roles for axon guidance molecules in cancers
Chédotal, A., Kerjan, G., & Moreau‐Fauvarque, C. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401707 · Cited by 222 · see citing works
The Netrin family of guidance factors: emphasis on Netrin-1 signalling
Barallobre, M. J., Pascual, M., del Rı́o, J. A., & Soriano, E. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.11.003 · Cited by 211 · see citing works
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment
Thiébault, K., Mazelin, L., Pays, L., Llambi, F., Joly, M., Scoazec, J., Saurin, J., Romeo, G., & Mehlen, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0738063100 · Cited by 202 · see citing works
Dependence receptors: a new paradigm in cell signaling and cancer therapy
Goldschneider, D., & Mehlen, P. (2010) · Oncogene · doi:10.1038/onc.2010.13 · Cited by 169 · see citing works
Lee, E., Song, C.-H., Bae, S.-J., Ha, K.-T., & Karki, R. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01069-y · Cited by 164 · see citing works
Regulation of the Akt kinase by interacting proteins
Du, K., & Tsichlis, P. N. (2005) · Oncogene · doi:10.1038/sj.onc.1209099 · Cited by 144 · see citing works
The dependence receptor hypothesis
Mehlen, P., & Bredesen, D. E. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000012120.66221.b2 · Cited by 138 · see citing works
Role of the Dependence Receptor DCC in Colorectal Cancer Pathogenesis
Mehlen, P., & Fearon, E. R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.019 · Cited by 139 · see citing works
GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling
Varsano, T., Dong, M., Niesman, I. R., Gacula, H., Lou, X., Ma, T., Testa, J. R., Yates, J. R., & Farquhar, M. G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00305-06 · Cited by 132 · see citing works
Cheng, K. K. Y., Iglesias, M. A., Lam, K. S. L., Wang, Y., Sweeney, G., Zhu, W., Vanhoutte, P. M., Kraegen, E. W., & Xu, A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.013 · Cited by 130 · see citing works
APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor
Ryu, J., Galan-Davila, A. K., Xin, X., Dong, F., Abdul-Ghani, M. A., Zhou, L., Wang, C., Li, C., Holmes, B. M., Sloane, L. B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.006 · Cited by 128 · see citing works
Structure of the APPL1 BAR‐PH domain and characterization of its interaction with Rab5
Zhu, G., Chen, J., Liu, J., Brunzelle, J. S., Huang, B., Wakeham, N., Terzyan, S. S., Li, X., Rao, Z., Li, G., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601771 · Cited by 127 · see citing works
Self-citationBax Mediates the Apoptosis-Sensitizing Effect of Maspin
Liu, J., Yin, S., Reddy, N., Spencer, C., & Sheng, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2568 · Cited by 114 · see citing works
Self-citationNetrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis
Mehlen, P., & Furne, C. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5191-3 · Cited by 113 · see citing works
Nechamen, C. A., Thomas, R. M., Cohen, B. D., Acevedo, G., Poulikakos, P. I., Testa, J. R., & Dias, J. A. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.025833 · Cited by 106 · see citing works
Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction
Bredesen, D. E., Mehlen, P., & Rabizadeh, S. (2004) · Physiological Reviews · doi:10.1152/physrev.00027.2003 · Cited by 98 · see citing works
Ise, R., Han, D., Takahashi, Y., Terasaka, S., Inoue, A., Tanji, M., & Kiyama, R. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.033 · Cited by 94 · see citing works
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex
Nechamen, C. A., Thomas, R. M., & Dias, J. A. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.08.014 · Cited by 92 · see citing works
Receptors that mediate cellular dependence
Bredesen, D. E., Mehlen, P., & Rabizadeh, S. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401680 · Cited by 89 · see citing works
Netrin-1 and its dependence receptors as original targets for cancer therapy
Mehlen, P., & Guenebeaud, C. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328333dcd1 · Cited by 89 · see citing works
Filtering of Ineffective siRNAs and Improved siRNA Design Tool
Yiu, S., Wong, P. W. H., Lam, T., Mui, Y.-C., Kung, H. F., Lin, M. C. M., & Cheung, Y.-T. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth498 · Cited by 81 · see citing works
p53, apoptosis and axon-guidance molecules
Arakawa, H. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401601 · Cited by 81 · see citing works
The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival
Mehlen, P., & Mazelin, L. (2003) · Biology of the Cell · doi:10.1016/s0248-4900(03)00072-8 · Cited by 80 · see citing works
RNAi as a gene therapy approach
Caplen, N. J. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.4.575 · Cited by 77 · see citing works
Dependence receptors: between life and death
Mehlen, P., & Thibert, C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3467-7 · Cited by 76 · see citing works
Crystal Structures of the BAR-PH and PTB Domains of Human APPL1
Li, J., Mao, X., Dong, L., Liu, F., & Tong, L. (2007) · Structure · doi:10.1016/j.str.2007.03.011 · Cited by 67 · see citing works
Signal transduction gRABs attention
Bucci, C., & Chiariello, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.07.001 · Cited by 66 · see citing works
Rashid, S., Pilecka, I., Toruń, A., Brewińska‐Olchowik, M., Bielińska, B., & Miączyńska, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007237 · Cited by 61 · see citing works
APPL1 is a multifunctional endosomal signaling adaptor protein
Diggins, N. L., & Webb, D. J. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160191 · Cited by 61 · see citing works
APPLs: More than just adiponectin receptor binding proteins
Liu, Z., Xiao, T., Peng, X., Li, G., & Hu, F. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.01.018 · Cited by 58 · see citing works
Sánchez‐Tena, S., Reyes‐Zurita, F. J., Díaz‐Moralli, S., Vinardell, M. P., Reed, M. A. C., Garcia‐García, F., Dopazo, J., Lupiáñez, J. A., Günther, U. L., & Cascante, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059392 · Cited by 58 · see citing works
Cdo Interacts with APPL1 and Activates AKT in Myoblast Differentiation
Bae, G., Lee, J.-R., Kim, B.-G., Han, J., Leem, Y.-E., Lee, H.-J., Ho, S., Hahn, M., & Kang, J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-12-1011 · Cited by 56 · see citing works
Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers
Mehlen, P., & Llambi, F. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602656 · Cited by 56 · see citing works
Wang, Y., Wang, J., Wang, S., Liu, S., Cao, J., Li, X.-M., Qiu, S., & Luo, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3852-11.2012 · Cited by 52 · see citing works
Tan, Y., You, H., Wu, C., Altomare, D. A., & Testa, J. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068452 · Cited by 51 · see citing works
Netrin-1 in cancer: Potential biomarker and therapeutic target?
Kefeli, U., Kefeli, A. Ü., Çabuk, D., Işık, U., Sonkaya, A., Açıkgöz, Ö., Özden, E., & Uygun, K. (2017) · Tumor Biology · doi:10.1177/1010428317698388 · Cited by 49 · see citing works
Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides
Chial, H. J., Wu, R., Ustach, C. V., McPhail, L. C., Mobley, W. C., & Chen, Y. Q. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00680.x · Cited by 48 · see citing works
Self-citationXie, Z., Huang, L., Enkhjargal, B., Reis, C., Wan, W., Tang, J., Cheng, Y. Z., & Zhang, J. H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.025 · Cited by 47 · see citing works
Majumdar, D., Nebhan, C. A., Hu, L., Anderson, B., & Webb, D. J. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.01.003 · Cited by 45 · see citing works
Dias, J. A., Mahale, S. D., Nechamen, C. A., Davydenko, O., Thomas, R. M., & Ulloa‐Aguirre, A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.05.009 · Cited by 42 · see citing works
RNA interference: gene silencing in the fast lane
Kittler, R., & Buchholz, F. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00039-7 · Cited by 40 · see citing works
Lefebvre, J., Muharram, G., Leroy, C., Kherrouche, Z., Montagne, R., Ichim, G., Tauszig-Delamasure, S., Chotteau‐Lelièvre, A., Brenner, C., Mehlen, P., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.377 · Cited by 39 · see citing works
Netrin-1 and its receptors in tumour growth promotion
Bernet, A., & Fitamant, J. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.8.995 · Cited by 38 · see citing works
Liao, S., Gong, Q., Chen, X.-R., Ye, L.-X., Ding, Q., Zeng, J., & Yu, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.059 · Cited by 37 · see citing works
Holmes, R. M., Yi, Z., Filippis, E. D., Berria, R., Shahani, S., Sathyanarayana, P., Sherman, V., Fujiwara, K., Meyer, C., Christ-Roberts, C. Y., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2173-x · Cited by 36 · see citing works
Adiponectin as a Potential Therapeutic Target for Prostate Cancer
Karnati, H. K., Panigrahi, M. K., Li, Y., Tweedie, D., & Greig, N. H. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170208123553 · Cited by 36 · see citing works
APPLied mechanics: Uncovering how adiponectin modulates insulin action
Hosch, S. E., Olefsky, J. M., & Kim, J. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.003 · Cited by 33 · see citing works
Caspases and receptor cleavage
Graf, D., Bode, J. G., & Häussinger, D. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.029 · Cited by 33 · see citing works
Broussard, J. A., Lin, W., Majumdar, D., Anderson, B., Eason, B., Brown, C. M., & Webb, D. J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-02-0124 · Cited by 29 · see citing works
Chen, H., Youling, F., Huang, F., Huihua, P., Zhong, J., & Zhou, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26536 · Cited by 28 · see citing works
Banach‐Orlowska, M., Pilecka, I., Toruń, A., Pyrzyńska, B., & Miączyńska, M. (2009) · Biochemical Journal · doi:10.1042/bj20090086 · Cited by 28 · see citing works
Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment
Urbanska, A. S., Sadowski, Ł., Kalaidzidis, Y. L., & Miączyńska, M. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01226.x · Cited by 27 · see citing works
Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue
Liao, S., Yu, J., & Luo, Y. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302150723 · Cited by 26 · see citing works
Song, J., Mu, Y., Li, C., Bergh, A. R. J., Miączyńska, M., Heldin, C., & Landström, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6346 · Cited by 26 · see citing works
Najafi, H., Soltani, B. M., Dokanehiifard, S., Nasiri, S., & Mowla, S. J. (2016) · RNA · doi:10.1261/rna.056317.116 · Cited by 25 · see citing works
Wimmer, H., Gundacker, N. C., Griss, J., Haudek, V. J., Stättner, S., Mohr, T. T., Zwickl, H., Paulitschke, V., Baron, D. M., Trittner, W., et al. (2009) · Electrophoresis · doi:10.1002/elps.200900072 · Cited by 23 · see citing works
The Melanosome: Dark Pigment Granule Shines Bright Light on Vesicle Biogenesis and More
Setaluri, V. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12500.x · Cited by 23 · see citing works
Wang, J., Lu, W., Chen, L., Zhang, P., Qian, T., Cao, W., & Luo, J. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0042-9 · Cited by 21 · see citing works
Use of the Gateway System for Protein Expression in Multiple Hosts
Hartley, J. L. (2002) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps0517s30 · Cited by 20 · see citing works
Identification of Phosphorylation Sites within the Signaling Adaptor APPL1 by Mass Spectrometry
Gant-Branum, R. L., Broussard, J. A., Mahsut, A., Webb, D. J., & MCLEAN, J. A. J. (2010) · Journal of Proteome Research · doi:10.1021/pr901043e · Cited by 20 · see citing works
Chial, H. J., Lénárt, P., & Chen, Y. Q. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012471 · Cited by 20 · see citing works
Self-citationLi, L., Huang, Y., Gao, Y., Shi, T., Xu, Y., Li, H., Hyytiäinen, M. M., Keski‐Oja, J., Jiang, Q., Hu, Y., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-5056-4 · Cited by 20 · see citing works
Dependence Receptors: What Is the Mechanism?
Chao, M. V. (2003) · Science s STKE · doi:10.1126/stke.2003.200.pe38 · Cited by 20 · see citing works
Lee, J.-R., Hahn, H.-S., Kim, Y., Nguyen, H.-H., Yang, J., Kang, J., & Hahn, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.064 · Cited by 19 · see citing works
Adaptor protein APPL1 interacts with EGFR to orchestrate EGF-stimulated signaling
Zhou, J., Liu, H., Zhou, S. F., He, P., & Liu, X. (2016) · 中国科学通报:英文版 · doi:10.1007/s11434-016-1157-0 · Cited by 18 · see citing works
Apoptosis initiated by dependence receptors: a new paradigm for cell death?
Porter, A. G., & Dhakshinamoorthy, S. (2004) · BioEssays · doi:10.1002/bies.20037 · Cited by 17 · see citing works
Multifunctional protein APPL2 contributes to survival of human glioma cells
Pyrzyńska, B., Banach‐Orlowska, M., Teperek, M., Miękus, K., Drabik, G., Majka, M., & Miączyńska, M. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.08.003 · Cited by 16 · see citing works
Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D.-H., & Chen, Y.-L. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22356 · Cited by 16 · see citing works
Self-citationSingle-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research
Chen, J., Zhou, Q., Wang, Y., & Ning, K. (2016) · Scientific Reports · doi:10.1038/srep34420 · Cited by 16 · see citing works
Diggins, N. L., Kang, H., Weaver, A. M., & Webb, D. J. (2018) · Journal of Cell Science · doi:10.1242/jcs.207019 · Cited by 16 · see citing works
Appl1 is dispensable for Akt signaling in vivo and mouse T‐cell development
Tan, Y., You, H., Coffey, F. J., Wiest, D. L., & Testa, J. R. (2010) · genesis · doi:10.1002/dvg.20657 · Cited by 16 · see citing works
Kato, H., Kondoh, H., Inoue, T., Asanoma, K., Matsuda, T., Arima, T., Kato, K., Yoshikawa, T., & Wake, N. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.07.050 · Cited by 16 · see citing works
Lost expression of DCC gene in ovarian cancer and its inhibition in ovarian cancer cells
Liu, M., Li, P., Li, B., Li, C., Ru-jin, Z., & Hu, C. (2010) · Medical Oncology · doi:10.1007/s12032-009-9400-z · Cited by 14 · see citing works
Zhang, K.-N., An, X., Zhu, Y., Huang, L., Yao, X., Zeng, X., Liang, S., & Yu, J. (2023) · Cancer Biology & Therapy · doi:10.1080/15384047.2023.2200705 · Cited by 11 · see citing works
Dependence receptors: Mechanisms of an announced death
Thibert, C., & Fombonne, J. (2010) · Cell Cycle · doi:10.4161/cc.9.11.11809 · Cited by 11 · see citing works
Kedlaya, R., Kandala, G., Liu, T. F., Maddodi, N., Devi, S., & Setaluri, V. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.01.021 · Cited by 11 · see citing works
Mekki, M. S., Mougel, A., Vinchent, A., Paquet, C., Copin, M., Leroy, C., Kherrouche, Z., Bonte, J., Melnyk, O., Vicogne, J., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25472 · Cited by 10 · see citing works
Zhai, J., Song, J. G., Zhu, C. H., Wu, K., Yao, Y., & Li, N. (2016) · Current Oncology · doi:10.3747/co.23.2775 · Cited by 10 · see citing works
Saleh, A. J., Soltani, B. M., Dokanehiifard, S., Medlej, A. A., Tavallaei, M., & Mowla, S. J. (2016) · Tumor Biology · doi:10.1007/s13277-016-5264-y · Cited by 10 · see citing works
Mehlen, P., & Bredesen, D. E. (2003) · Science s STKE · doi:10.1126/stke.2132003pe55 · Cited by 9 · see citing works
Insulin and adipokine signaling and their cross-regulation in postmortem human brain
Wang, H.-Y., Capuano, A. W., Khan, A., Pei, Z., Lee, K.-C., Bennett, D. A., Ahima, R. S., Arnold, S. E., & Arvanitakis, Z. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.012 · Cited by 8 · see citing works
Ogawa, A., Yamazaki, Y., Nakamori, M., Takahashi, T., Kurashige, T., Hiji, M., Nagano, Y., Yamawaki, T., & Matsumoto, M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.12.010 · Cited by 8 · see citing works
Padarti, A., Abou‐Fadel, J., & Zhang, J. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.129977 · Cited by 4 · see citing works
Endosomal Protein Traffic Meets Nuclear Signal Transduction Head On
Horazdovsky, B. F. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00035-8 · Cited by 4 · see citing works
Regulatory mechanisms of apoptosis in regularly dividing cells
Darwish, R. (2010) · Cell Health and Cytoskeleton · doi:10.2147/chc.s10036 · Cited by 3 · see citing works
DCC (deleted in colorectal carcinoma)
Sarah Derks, A., & van Engeland, M. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44867 · Cited by 2 · see citing works
- Authors
- Liu, J., Yao, F., Wu, R., Morgan, M., Thorburn, A., Finley, R. L., & Chen, Y. Q.
- Affiliations
- Wayne State University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Chen, Yong Q.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 277
- Issue
- 29
- Pages
- 26281-26285
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2046818223
- Cited by
- 120
- References
- 25
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 8
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca077489-06)
- National Cancer Institute (R01CA77489)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- DCC, apoptosis, tumor suppressor, protein-protein interaction, pleckstrin homology domain, phosphotyrosine binding domain, cytoplasmic domain, cell cycle arrest, siRNA knockdown
- MeSH terms
- Animals, Carrier Proteins, Molecular Sequence Data, Peptide Mapping, Rabbits, Tumor Cells, Cultured, Yeasts, Colorectal Neoplasms, Genes, DCC, Apoptosis, Phosphotyrosine, RNA, Untranslated, RNA, Small Interfering, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review