The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Alam, J., Stewart, D. P., Touchard, C. L., Boinapally, S., Choi, A. M. K., & Cook, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26071 · Cited by 1,284

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034

An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

Chan, K., Han, X.-D., & Kan, Y. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081082098 · Cited by 766

The POZ domain: a conserved protein-protein interaction motif.Preprint

Bardwell, V. J., & Treisman, R. (1994) · Genes & Development · doi:10.1101/gad.8.14.1664 · Cited by 749

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Enomoto, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.169 · Cited by 728

Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

Cho, H., Jedlicka, A., Reddy, S. P., Kensler, T. W., Yamamoto, M. P., Zhang, L.-Y., & Kleeberger, S. R. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4501 · Cited by 660

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

McMahon, M. J., Itoh, K., Yamamoto, M. P., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C., & Hayes, J. D. (2001) · PubMed · Cited by 657

Delayed Mechanism for Induction of γ-Glutamylcysteine Synthetase Heavy Subunit mRNA Stability by Oxidative Stress Involving p38 Mitogen-activated Protein Kinase Signaling

Song, I., Tatebe, S., Dai, W., & Kuo, M. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413103200 · Cited by 50

The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis

Zhou, X., Zhu, C.-Y., Wu, Z., Guo, X., & Zou, W. (2019) · Oncogene · doi:10.1038/s41388-019-0698-5 · Cited by 50

Structural analysis of the complex of Keap1 with a prothymosin α peptide

Padmanabhan, B., Nakamura, Y., & Yokoyama, S. (2008) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309108004995 · Cited by 50

Post-translational modifications of Keap1: the state of the art

Song, Y., Qu, Y., Mao, C., Zhang, R., Jiang, D., & Sun, X. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1332049 · Cited by 52

Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells

Panieri, E., & Saso, L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8146 · Cited by 46

Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression

Liu, D., Zhang, Y., Wei, Y., Liu, G., Liu, Y., Gao, Q., Zou, L., Zeng, W., & Zhang, N. (2016) · Oncotarget · doi:10.18632/oncotarget.11700 · Cited by 47

The Role of Cyclo(His-Pro) in Neurodegeneration

Grottelli, S., Ferrari, I., Pietrini, G., Peirce, M. J., Minelli, A., & Bellezza, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081332 · Cited by 47

Regulation of the cadmium stress response through SCF-like ubiquitin ligases: comparison between Saccharomyces cerevisiae, Schizosaccharomyces pombe and mammalian cells

Baudouin‐Cornu, P., & Labarre, J. (2006) · Biochimie · doi:10.1016/j.biochi.2006.03.001 · Cited by 46

The molecular biology and therapeutic potential of Nrf2 in leukemia

Khodakarami, A., Adibfar, S., Karpisheh, V., Abolhasani, S., Jalali, P., Mohammadi, H., Navashenaq, J. G., Hojjat‐Farsangi, M., & Jadidi‐Niaragh, F. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02660-5 · Cited by 46

The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling

Tian, D., Shi, Y., Chen, D., Liu, Q., & Fan, F. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4042 · Cited by 43

3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.

Kuo, P.-C., Brown, D. A., Scofield, B., Yu, I.-C., Chang, F.-L. F., Wang, P., & Yen, J. (2016) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2016.03.015 · Cited by 43

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

Bischoff, L. J. M., Kuijper, I. A., Schimming, J. P., Wolters, L., ter Braak, B., Langenberg, J. P., Noort, D., Beltman, J. B., & van de Water, B. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2353-2 · Cited by 40

Ectodermal-Neural Cortex 1 Down-Regulates Nrf2 at the Translational Level

Wang, X.-J., & Zhang, D. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005492 · Cited by 38

Characterization and Expression of a Human KCTD1 Gene Containing the BTB Domain, Which Mediates Transcriptional Repression and Homomeric Interactions

Ding, X., Luo, C., Ren, K., Zhang, J., Zhou, J., Hu, X., Liu, R., Wang, Y., Gao, X., & Zhang, J. (2008) · DNA and Cell Biology · doi:10.1089/dna.2007.0662 · Cited by 38

Physiological relevance of covalent protein modification by dietary isothiocyanates

Nakamura, T., Abe‐Kanoh, N., & Nakamura, Y. (2017) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.17-91 · Cited by 36

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés, C. M. C., de la Lastra, J. M. P., Munguira, E. B., Andrés, C., Plou, F. J., & Lebeña, E. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063521 · Cited by 34

Fetal Alz-50 Clone 1 Interacts with the Human Orthologue of the Kelch-like Ech-Associated Protein

Strachan, G. D., Morgan, K. L., Otis, L. L., Caltagarone, J., Gittis, A. H., Bowser, R. P., & Jordan‐Sciutto, K. L. (2004) · Biochemistry · doi:10.1021/bi0494166 · Cited by 34

Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling

Liu, S., Pi, J., & Zhang, Q. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102139 · Cited by 35

Regulation of Antioxidant Response Element–Dependent Induction of Detoxifying Enzyme Synthesis

Jaiswal, A. K. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78018-0 · Cited by 33

Actin Cytoskeleton Is Required For Nuclear Accumulation of Gln3 in Response to Nitrogen Limitation but Not Rapamycin Treatment in Saccharomyces cerevisiae

Cox, K. H., Tate, J. J., & Cooper, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309240200 · Cited by 33

The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario

Mukherjee, A. G., & Gopalakrishnan, A. V. (2023) · Medical Oncology · doi:10.1007/s12032-023-02124-4 · Cited by 33

Nuclear factor erythroid 2-related factor 2 (Nrf2) as a potential therapeutic target for vitiligo

Lin, X., Meng, X., Song, Z., & Lin, J. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108670 · Cited by 32

The Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway

Caruso, G., Privitera, A., Antunes, B. M., Lazzarino, G., Lunte, S. M., Aldini, G., & Caraci, F. (2022) · Molecules · doi:10.3390/molecules27144452 · Cited by 34

Ginsenoside CK targeting KEAP1-DGR/Kelch domain disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage

Cheng, C., Zhang, J., Liu, K., Xu, Y., Shen, F., Han, Y., Hou, Y., Zhang, T., & Bai, G. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154992 · Cited by 31

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

Padmanabhan, B., Tong, K. I., Kobayashi, A., Yamamoto, M. P., & Yokoyama, S. (2008) · Journal of Synchrotron Radiation · doi:10.1107/s090904950705114x · Cited by 31

Small Molecular Nrf2 Inhibitors as Chemosensitizers for Cancer Therapy

Lin, H., Qiao, Y., Yang, H., Nan, Q., Qu, W., Feng, F., Liu, W., Chen, Y., & Sun, H. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0285 · Cited by 30

Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization

Choo, Y. Y., & Hagen, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041350 · Cited by 30

MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis

Tian, H., Zhang, D., Gao, Z., Li, H., Zhang, B., Zhang, Q., Li, L., Cheng, Q., Pei, D., & Zheng, J. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.45 · Cited by 29

Gene regulatory effects of disease-associated variation in the NRF2 network

Lacher, S. E., & Slattery, M. G. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.09.001 · Cited by 27

Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases

Hu, Y. H., Luo, Y., & Zheng, Y. (2022) · Antioxidants · doi:10.3390/antiox11091747 · Cited by 29

Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors

Zhao, Z., Dong, R., You, Q., & Jiang, Z. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00712 · Cited by 28

Advances in Nrf2 Signaling Pathway by Targeted Nanostructured-Based Drug Delivery Systems

Saha, S., Павловна, С. Н., Karamyan, A. S., Novikova, E., & Chubenko, T. V. (2024) · Biomedicines · doi:10.3390/biomedicines12020403 · Cited by 29

Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity

Murray, D. L., Mirzayans, R., & McBride, W. H. (2018) · Radiation Research · doi:10.1667/rr15101.1 · Cited by 28

Antiapoptotic Effects of EGb 761

Serrano‐García, N., Pedraza‐Chaverrí, J., Mares-Sámano, J. J., Orozco‐Ibarra, M., Cruz-Salgado, A., Jiménez‐Anguiano, A., Sotelo, J., & Trejo‐Solís, C. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/495703 · Cited by 30

Oxidative stress-induced alterations in seminal plasma antioxidants: Is there any association with keap1 gene methylation in human spermatozoa?

Darbandi, M., Darbandi, S., Agarwal, A. K., Baskaran, S., Sengupta, P., Dutta, S., Mokarram, P., Saliminejad, K., & Sadeghi, M. R. (2018) · Andrologia · doi:10.1111/and.13159 · Cited by 26

NRF2 , a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer

Panieri, E., Telkoparan‐Akillilar, P., & Saso, L. (2022) · BioFactors · doi:10.1002/biof.1912 · Cited by 27

The Nuclear Matrix Protein, NRP/B, Enhances Nrf2-Mediated Oxidative Stress Responses in Breast Cancer Cells

Seng, S., Avraham, H. K., Jiang, S., Yang, S., Sekine, M., Kimelman, N., Li, H., & Avraham, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3785 · Cited by 26

Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory Networks

Xiao, H., Lu, F.-L., Stewart, D., & Zhang, Y. (2013) · Current Chemical Biology · doi:10.2174/2212796811307020008 · Cited by 25

Keap1 Inhibits Metastatic Properties of NSCLC Cells by Stabilizing Architectures of F-Actin and Focal Adhesions

Wu, B., Yang, S., Sun, H., Sun, T., Ji, F., Wang, Y., Xu, L., & Zhou, D. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0544 · Cited by 24

Non-canonical Hippo signaling regulates immune responses

Chen, L. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.07.001 · Cited by 24

Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

Cheng, L., Zhang, H., Wu, F., Liu, Z., Cheng, Y., & Wang, C. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4683943 · Cited by 26

Limited expression of Nrf2 in neurons across the central nervous system

Levings, D. C., Pathak, S. S., Yang, Y., & Slattery, M. G. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102830 · Cited by 23

Dual role of Heme oxygenase-1 in disease progression and treatment: A literature review

Ma, Y., Zhang, D., & Li, Z. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146272 · Cited by 26

Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System

Yukitake, H., Takizawa, M., & Kimura, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8584930 · Cited by 23

Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression

Bousquet, M. S., Ratnayake, R., Pope, J. L., Chen, Q.-Y., Zhu, F., Chen, S., Carney, T. J., Gharaibeh, R. Z., Jobin, C., Paul, V. J., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.013 · Cited by 23

Nuclear Matrix Protein (NRP/B) Modulates the Nuclear Factor (Erythroid-derived 2)-related 2 (NRF2)-dependent Oxidative Stress Response

Seng, S., Avraham, H. K., Birrane, G., Jiang, S., & Avraham, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095786 · Cited by 23

Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer

Sahu, M., & Jain, U. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167764 · Cited by 24

Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer

Wang, P., Long, F., Lin, H., Wang, S., & Wang, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7848811 · Cited by 22

NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors

Seng, S., Avraham, H. K., Birrane, G., Jiang, S. S., Li, H., Katz, G., Bass, C. E., Zagożdżon, R., & Avraham, S. (2008) · Oncogene · doi:10.1038/onc.2008.396 · Cited by 21

Nrf2

Kim, K. M., & Ki, S. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00028-x · Cited by 22

3 H-1,2-Dithiole-3-thione Targets Nuclear Factor κB to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats

Karuri, A. R., Huang, Y., Bodreddigari, S., Sutter, C. H., Roebuck, B. D., Kensler, T. W., & Sutter, T. R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096396 · Cited by 21

Redox-dependent signaling system Nrf2/ARE in inflammation

Брониславовна, М. Е., Tkachev, V., & Зенков, Н. К. (2010) · Molecular Biology · doi:10.1134/s0026893310030015 · Cited by 20

A Prolyl-hydroxylase Inhibitor, Ethyl-3,4-dihydroxybenzoate, Induces Haem Oxygenase-1 Expression in Human Cells Through a Mechanism Independent of Hypoxia-inducible Factor-1

Li, B., Takeda, K., Yokoyama, S., & Shibahara, S. (2008) · The Journal of Biochemistry · doi:10.1093/jb/mvn115 · Cited by 20

Transcriptomics provides mechanistic indicators of mixture toxicology for IMX-101 and IMX-104 formulations in fathead minnows (Pimephales promelas)

Gust, K. A., Lotufo, G. R., Stanley, J. K., Wilbanks, M. S., Chappell, P., & Barker, N. D. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.03.019 · Cited by 21

Peptidyl‐prolyl cis‐trans isomerase NIMA‐interacting 1 directly binds and stabilizes Nrf2 in breast cancer

Saeidi, S., Kim, S., Quispe, Y. N. G., Jagadeesh, A., Han, H., Kim, S. H., Zhong, X., Piao, J., Kim, S., Jeong, J., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100776rr · Cited by 19

Carbamate compounds induced toxic effects by affecting Nrf2 signaling pathways

Nasrabadi, M., Nazarian, M., Darroudi, M., Marouzi, S., Harifi-Mood, M. S., Samarghandian, S., & Farkhondeh, T. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2023.12.004 · Cited by 21

Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications

Wang, J., Shi, H., Yang, Y. S., & Gong, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1505794 · Cited by 21

The role of non-canonical Hippo pathway in regulating immune homeostasis

Tang, D., Xu, H., & Du, X. (2023) · European journal of medical research · doi:10.1186/s40001-023-01484-x · Cited by 19

15‐Deoxy‐Δ12,14‐prostaglandin J2Induces Upregulation of Multidrug Resistance‐Associated Protein 1 via Nrf2 Activation in Human Breast Cancer Cells

Song, N., Kim, D., Kim, E., Na, H., & Surh, Y. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04914.x · Cited by 19

Enteral glutamine differentially regulates Nrf 2 along the villus‐crypt axis of the intestine to enhance glutathione levels

Venoji, R., Amirtharaj, G. J., Kini, A., Vanaparthi, S., Venkatraman, A., & Ramachandran, A. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13019 · Cited by 17

Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2

Wei, S., Pei, Y., Wang, Y., Guan, H., Huang, Y., Xing, T. Y., Johnson, R. W., & Wang, D. (2018) · Biochimie · doi:10.1016/j.biochi.2018.12.008 · Cited by 17

Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1

Haider, N., & Larose, L. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-019-0506-4 · Cited by 17

Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: A novel pathway for cancer chemoprevention

Velayutham, M., Muthukumaran, R. B., Sostaric, J. Z., McCraken, J., Fishbein, J. C., & Zweier, J. L. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.022 · Cited by 17

The Keap1-Nrf2 pathway: From mechanism to medical applications

Baird, L., & Yamamoto, M. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00009-2 · Cited by 16

Altered transcription factor trafficking in oxidatively-stressed neuronal cells

Patel, V. P., DeFranco, D. B., & Chu, C. T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.002 · Cited by 16

Association of single-nucleotide polymorphisms of the KEAP1 gene with the risk of various human diseases and its functional impact using in silico analysis

Umapathy, D., Balashanmugam, P., Sireesh, D., Bhakkiyalakshmi, E., & Ramkumar, K. M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.003 · Cited by 15

Quercetin 3-O-rutinoside prevents radiation induced oxidative damage and inflammation by coordinated regulation of Nrf2/ NF-κB/ NLRP3- inflammasome signaling in gastrointestine

Sharma, S., Dahiya, A., Kumar, S., Verma, Y. K., & Dutta, A. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100385 · Cited by 15

Involvement of Nrf2 Signaling in Lead-induced Toxicity

Arabnezhad, M., Haghani, F., Ghaffarian‐Bahraman, A., Jafarzadeh, E., Mohammadi, H., Yadegari, J. G., Farkhondeh, T., Aschner, M., Darroudi, M., Marouzi, S., et al. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230522143341 · Cited by 15

Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives

Zhou, Y., Zhang, Q., Zhao, Z., Hu, X., You, Q., & Jiang, Z. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116270 · Cited by 15

Road to Alzheimer’s Disease: The Pathomechanism Underlying

Anand, R., Kaushal, A., Wani, W. Y., & Gill, K. D. (2011) · Pathobiology · doi:10.1159/000332218 · Cited by 16

The bridge between cell survival and cell death: reactive oxygen species-mediated cellular stress

Acar, N. V., & Özgül, R. K. (2023) · EXCLI journal · doi:10.17179/excli2023-6221 · Cited by 19

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

Obuobi, S. A. O., Karatayev, S., Chai, C. L. L., Ee, P. L. R., & Mátyus, P. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1205047 · Cited by 15

Genomic Discovery Reveals a Molecular System for Resistance to Oxidative and Endoplasmic Reticulum Stress in Cultured Glioma

Fathallah‐Shaykh, H. M. (2005) · Archives of Neurology · doi:10.1001/archneur.62.2.233 · Cited by 14

The effects of phospholipids (PL) addition in the high fat diet on growth performance, oxidative stress, lipid and protein metabolism, and muscle development in yellow catfish Pelteobagrus fulvidraco

Li, Q., Wang, B., Zheng, H., Wu, L., Xu, P.-C., & Tan, X.-Y. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741947 · Cited by 13

Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression

Du, L., Li, C., He, Q., Li, X., Yang, L., Zou, Y., Yang, Z., Zhang, D., & Xing, X. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00226-7 · Cited by 15

NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation

Goess, C., Terrillon, S., Mayo, M., Bousquet, P. F., Wallace, C. D., Hart, M., Mathieu, S., Twomey, R., Donnelly‐Roberts, D. L., Namovic, M. T., et al. (2020) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2020.100079 · Cited by 13

GENES AND GENETICS OF MURINE LUPUS

Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2004) · Elsevier eBooks · doi:10.1016/b9-78-012433-9/01950-0119 · Cited by 13

A systematic review of natural products targeting Nrf2-Keap1-ARE pathway and their influence on neurodegenerative disorders

Gote, S. A., Dubey, S., Nargund, S. L., & Thapa, S. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01917-5 · Cited by 12

Identification of Nrf2/Keap1 pathway and its transcriptional regulation of antioxidant genes after exposure to microcystins in freshwater mussel Cristaria plicata

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