Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

Glutathione S-Transferases

Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,394 · see citing works

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works

A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure

Zhang, Y., Talalay, P., Cho, C. G., & Posner, G. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2399 · Cited by 1,682 · see citing works

Chemoprevention of Cancer

Wattenberg, L. W. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_2795 · Cited by 1,243 · see citing works

INDUCTION OF CYTOCHROME P4501A1

Whitlock, J. P. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,126 · see citing works

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

Benson, A. M., Hunkeler, M. J., & Talalay, P. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5216 · Cited by 750 · see citing works

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Enomoto, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.169 · Cited by 728 · see citing works

Down-Regulation of the Antitumor Immune Response

North, R. J. (1985) · Advances in cancer research · doi:10.1016/s0065-230x(08)60265-1 · Cited by 684 · see citing works

Benzo[ a ]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor

Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii‐Kuriyama, Y., & Ishikawa, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.779 · Cited by 640 · see citing works

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

Talalay, P., Long, M. J., & Prochaska, H. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8261 · Cited by 595 · see citing works

Nrf2 is essential for protection against acute pulmonary injury in mice

Chan, K., & Kan, Y. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12731 · Cited by 574 · see citing works

MECHANISMS OF CHEMICAL CARCINOGENESIS: NATURE OF PROXIMATE CARCINOGENS AND INTERACTIONS WITH MACROMOLECULES

Miller, E. C., & MILLERE, J. A. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07235-7 · Cited by 502 · see citing works

Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers

Prochaska, H. J., & Santamaria, A. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90292-8 · Cited by 495 · see citing works

Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enzymes

Fahey, J. W., & Talalay, P. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00082-4 · Cited by 482 · see citing works

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

Rushmore, T. H., King, R. G., Paulson, K. E., & Pickett, C. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3826 · Cited by 423 · see citing works

Chemical and molecular regulation of enzymes that detoxify carcinogens.

Prestera, T., Holtzclaw, W. D., Zhang, Y., & Talalay, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2965 · Cited by 416 · see citing works

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

Prochaska, H. J., & Talalay, P. (1988) · PubMed · Cited by 408 · see citing works

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

Conney, A. H., Miller, E. C., & Miller, J. A. (1956) · PubMed · Cited by 394 · see citing works

Increased skin tumorigenesis in mice lacking pi class glutathione S -transferases

Henderson, C. J., Smith, A. G., Ure, J. M., Brown, K., Bacon, E. J., & Wolf, C. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5275 · Cited by 376 · see citing works

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

Benson, A. M., Batzinger, R. P., Ou, S.-Y. L., Bueding, E., Cha, Y., & Talalay, P. (1978) · PubMed · Cited by 337 · see citing works

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.

Kwak, M.-K., Itoh, K., Yamamoto, M. P., Sutter, T. R., & Kensler, T. W. (2001) · PubMed Central · Cited by 330 · see citing works

Inhibition of Chemical Carcinogenesis

Wattenberg, L. W. (1978) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/60.1.11 · Cited by 315 · see citing works

Protective Alterations in Phase 1 and 2 Metabolism of Aflatoxin B1 by Oltipraz in Residents of Qidong, People's Republic of China

Wang, J., Wang, J.-S., He, X., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.4.347 · Cited by 312 · see citing works

Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons

Cavalieri, E. L., & Rogan, E. G. (1995) · Xenobiotica · doi:10.3109/00498259509061885 · Cited by 298 · see citing works

Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes.

Mahéo, K., Morel, F., Langouët, S., Kramer, H., Ferrec, E. L., KETTERER, B., & Guillouzo, A. (1997) · PubMed · Cited by 231 · see citing works

Targeted Disruption of the Microsomal Epoxide Hydrolase Gene

Miyata, M., Kudo, G., Lee, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23963 · Cited by 199 · see citing works

Chemoprevention of Cancer

Wattenberg, L. W. (1996) · Preventive Medicine · doi:10.1006/pmed.1996.0015 · Cited by 177 · see citing works

Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver.

Boberg, E. W., Miller, E. C., MILLER, J. A., et al. (1983) · PubMed · Cited by 166 · see citing works

Biochemical effects of dithiolthiones

Ansher, S. S., Dolan, P., & Bueding, E. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90205-x · Cited by 162 · see citing works

Development of Cancer Chemopreventive Agents: Oltipraz as a Paradigm

Kensler, T. W., Groopman, J. D., Sutter, T. R., Curphey, T. J., & Roebuck, B. D. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980185b · Cited by 158 · see citing works

Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.

Langouët, S., Coles, B. C., Morel, F., et al. (1995) · PubMed · Cited by 152 · see citing works

Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithioI-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard

Wattenberg, L. W., & Bueding, E. (1986) · Carcinogenesis · doi:10.1093/carcin/7.8.1379 · Cited by 142 · see citing works

NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.

Long, D. J., Waikel, R. L., Wang, X., Perlaky, L., Roop, D. R., & Jaiswal, A. (2000) · PubMed · Cited by 142 · see citing works

Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.

Houlston, R. S. (1999) · PubMed · Cited by 140 · see citing works

Untitled work

(1982) · PubMed · Cited by 138 · see citing works

New agents for cancer chemoprevention

Keiloff, G. J., Boone, C. W., Crowell, J. A., Steele, V. E., Lubet, R. A., Doody, L. A., Malone, W. F., Hawk, E. T., & Sigman, C. C. (1996) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240630703 · Cited by 135 · see citing works

Inhibition of Human Cytochrome P450 Enzymes by 1,2-Dithiole-3-thione, Oltipraz and Its Derivatives, and Sulforaphane

Langouët, S., Furge, L. L., Kerriguy, N., et al. (2000) · Chemical Research in Toxicology · doi:10.1021/tx990189w · Cited by 114 · see citing works

Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.

Primiano, T., Egner, P. A., Sutter, T. R., Kelloff, G. J., Roebuck, B. D., & Kensler, T. W. (1995) · PubMed · Cited by 105 · see citing works

Benzene, NQO1, and genetic susceptibility to cancer

Smith, M. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7624 · Cited by 99 · see citing works

Complementary DNA cloning, messenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues.

Buetler, T. M., & Eaton, D. L. (1992) · PubMed · Cited by 71 · see citing works

Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones

Primiano, T., Kensler, T. W., Kuppusamy, P., Zweier, J. L., & Sutter, T. R. (1996) · Carcinogenesis · doi:10.1093/carcin/17.11.2291 · Cited by 67 · see citing works

Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine

Schweer, H., Méese, C. O., Fürst, O., et al. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90380-0 · Cited by 64 · see citing works

Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.

Gupta, E., Olopade, O. I., Ratain, M. J., et al. (1995) · PubMed · Cited by 64 · see citing works

Comprehensive Analysis of Proteins Which Interact with the Antioxidant Responsive Element: Correlation of ARE-BP-1 with the Chemoprotective Induction Response

Wasserman, W. W., & Fahl, W. E. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0215 · Cited by 62 · see citing works

1, 2-Dithiol-3-thione analogs: effects on NAD(P)H: quinone reductase and glutathione levels in murine hepatoma cells

Long, M. J., Dolan, P., Santamaria, A. B., et al. (1986) · Carcinogenesis · doi:10.1093/carcin/7.6.977 · Cited by 46 · see citing works

Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis

Gonzalez, F. J., & Kimura, S. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00125-1 · Cited by 46 · see citing works

SHORT COMMUNICATION: Inhibition of aflatoxin M1 excretion in rat urine during dietary intervention with oltipraz

Scholl, P. F., Musser, S. M., Kensler, T. W., et al. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1385 · Cited by 21 · see citing works

Genetic alterations as clonal markers for bladder cancer detection in urine

Mao, L. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1996)25+ · Cited by 14 · see citing works

Dibenz[a,h]anthracene-induced subcutaneous tumors in mice. Strain sensitivity and the role of carcinogen metabolism

Lubet, R. A., Connolly, G. M., Nebert, D. W., et al. (1983) · Carcinogenesis · doi:10.1093/carcin/4.5.513 · Cited by 11 · see citing works

Apc Gene Knockout Mice as a Model for Familial Adenomatous Polyposis

Taketo, M. M. (1999) · KARGER eBooks · doi:10.1159/000062007 · Cited by 8 · see citing works

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works

Cancer chemoprevention with dietary phytochemicals

Surh, Y.-J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1189 · Cited by 2,955 · see citing works

Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900 · see citing works

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654 · see citing works

The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Yamamoto, M., Kensler, T. W., & Motohashi, H. (2018) · Physiological Reviews · doi:10.1152/physrev.00023.2017 · Cited by 1,968 · see citing works

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947 · see citing works

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · see citing works

NRF2 and the Hallmarks of Cancer

Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672 · see citing works

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

Zhang, D. D., & Hannink, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8137-8151.2003 · Cited by 1,480 · see citing works

From NASH to HCC: current concepts and future challenges

Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

NRF2 and cancer: the good, the bad and the importance of context

Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067 · see citing works

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · see citing works

Molecular basis of the Keap1–Nrf2 system

Suzuki, T., & Yamamoto, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.006 · Cited by 995 · see citing works

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986 · see citing works

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839 · see citing works

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837 · see citing works

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818 · see citing works

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature · doi:10.1038/nature01819 · Cited by 801 · see citing works

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works

Stress-activated cap’n’collar transcription factors in aging and human disease

Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · see citing works

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

Kensler, T. W., Roebuck, B. D., Wogan, G. N., & Groopman, J. D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfq283 · Cited by 703 · see citing works

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

Ren, D., Villeneuve, N. F., Jiang, T., Wu, T., Lau, A., Toppin, H. A., & Zhang, D. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014275108 · Cited by 673 · see citing works

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works

The Dual Roles of NRF2 in Cancer

Menegon, S., Columbano, A., & Giordano, S. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.002 · Cited by 633 · see citing works

Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

Nguyen, T., Sherratt, P. J., Huang, H.-C., Yang, C. S., & Pickett, C. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207293200 · Cited by 615 · see citing works

Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580 · see citing works

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

Cullinan, S. B., & Diehl, J. A. (2006) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2005.09.018 · Cited by 554 · see citing works

Nrf2, a multi‐organ protector?

Lee, J., Li, J., Johnson, D. A., Stein, T. D., Kraft, A. D., Calkins, M. J., Jakel, R. J., & Johnson, J. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-2591hyp · Cited by 532 · see citing works

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

Stewart, D., Killeen, E., Naquin, R., Alam, S., & Alam, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209195200 · Cited by 463 · see citing works

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

Chen, C.-Y., Jang, J.-H., Li, M.-H., & Surh, Y.-J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.237 · Cited by 428 · see citing works

A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia<i>In Vivo</i>

Shih, A. Y., Li, P., & Murphy, T. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4014-05.2005 · Cited by 413 · see citing works

Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ^12,14-Prostaglandin J₂

Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.36-45.2004 · Cited by 407 · see citing works

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

Zipper, L. M., & Mulcahy, R. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206530200 · Cited by 366 · see citing works

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Ma, Q., & He, X. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004333 · Cited by 317 · see citing works

NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons

Lee, J.-M., Shih, A. Y., Murphy, T. H., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305204200 · Cited by 308 · see citing works

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K., & Zhang, D. D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1439 · Cited by 291 · see citing works

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

Jiang, T., Chen, N., Zhao, F., Wang, X.-J., Kong, B., Zheng, W., & Zhang, D. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0713 · Cited by 286 · see citing works

Induction of the Nrf2-driven Antioxidant Response Confers Neuroprotection during Mitochondrial Stress in Vivo

Shih, A. Y., Imbeault, S., Barakauskas, V., Erb, H., Jiang, L., Li, P., & Murphy, T. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414635200 · Cited by 273 · see citing works

Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., Foster, B. J., Goldring, C. E., & Park, B. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096545 · Cited by 260 · see citing works

Thirty years of NRF2: advances and therapeutic challenges.

Zhang, D. D. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01145-0 · Cited by 282 · see citing works

Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema

Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T., IIzuka, T., Hegab, A. E., Hosoya, T., Nomura, A., Sakamoto, T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6968 · Cited by 248 · see citing works

Protection from mitochondrial complex II inhibition <i>in vitro</i> and <i>in vivo</i> by Nrf2-mediated transcription

Calkins, M. J., Jakel, R. J., Johnson, D. A., Chan, K., Kan, Y. W., & Johnson, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408487101 · Cited by 247 · see citing works

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Nioi, P., & Nguyen, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.051 · Cited by 212 · see citing works

Cancer cell signaling pathways targeted by spice-derived nutraceuticals

Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204 · see citing works

A genomic screen for activators of the antioxidant response element

Liu, Y., Kern, J. T., Walker, J. R., Johnson, J. A., Schultz, P. G., & Luesch, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700898104 · Cited by 196 · see citing works

Biological activity of lycopene metabolites: implications for cancer prevention: Nutrition Reviews©, Vol. 66, No. 12

Mein, J. R., Lian, F., & Wang, X.-D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00120.x · Cited by 191 · see citing works

Heme oxygenase–1 protects human melanocytes from H2O2–induced oxidative stress via the Nrf2–ARE pathway

Jian, Z., Li, K., Liu, L., Zhang, Y., Zhou, Z., Li, C., & Gao, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.56 · Cited by 175 · see citing works

Redox signaling: an evolution from free radicals to aging

Forman, H. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.003 · Cited by 172 · see citing works

Regulatory Potential for Concerted Modulation of Nrf2- and Nfkb1-Mediated Gene Expression in Inflammation and Carcinogenesis

Nair, S., Doh, S. T., Chan, J. Y., Kong, A.-N., & Cai, L. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604703 · Cited by 167 · see citing works

HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

Malec, V., Gottschald, O. R., Li, S., Rose, F., Seeger, W., & Hänze, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.008 · Cited by 149 · see citing works

Role of p62/SQSTM1 in liver physiology and pathogenesis

Manley, S., Williams, J. A., & Ding, W.-X. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213489446 · Cited by 135 · see citing works

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Eriksson, S. E., Ceder, S., Bykov, V. J. N., & Wiman, K. G. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz005 · Cited by 123 · see citing works

Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance

Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130 · see citing works

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

Senger, D. R., Li, D., Jaminet, S.-C., & Cao, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0148042 · Cited by 124 · see citing works

Inhibition of Nuclear Factor κB by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression

Ma, Q., Kinneer, K., Ye, J., & Chen, B. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.211 · Cited by 107 · see citing works

Phylogenies of glutathione transferase families

Pearson, W. R. (2005) · Methods in Enzymology · doi:10.1016/s0076-6879(05)01012-8 · Cited by 105 · see citing works

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

Long, M., Tao, S., Rojo de la Vega, M., Jiang, T., Wen, Q., Park, S. L., Zhang, D. D., & Wondrak, G. T. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0359 · Cited by 86 · see citing works

p62/SQSTM1 and Nrf2 are essential for exercise‐mediated enhancement of antioxidant protein expression in oxidative muscle

Yamada, M., Iwata, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M. (2019) · The FASEB Journal · doi:10.1096/fj.201900133r · Cited by 63 · see citing works

Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo

Shi, Z., Niu, Y., Wang, Q., Shi, L., Guo, H., Liu, Y., Zhu, Y., Liu, S., Liu, C., Chen, X., et al. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.05.043 · Cited by 56 · see citing works

Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage

Hwang, Y. P., Yun, H. J., Chun, H. K., Chung, Y. C., Kim, H. K., Jeong, M. H., Yoon, T. R., & Jeong, H. G. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.07.017 · Cited by 56 · see citing works

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

DeBlasi, J. M., Falzone, A., Caldwell, S., Prieto-Farigua, N., Prigge, J. R., Schmidt, E. E., Chio, I. I. C., Karreth, F. A., & DeNicola, G. M. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3848 · Cited by 49 · see citing works

Dietary phytochemicals targeting Nrf2 for chemoprevention in breast cancer

Wang, P., Long, F., Lin, H., & Wang, T. (2022) · Food &amp; Function · doi:10.1039/d2fo00186a · Cited by 28 · see citing works

Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

Cuadrado, A., Cazalla, E., Bach, A., Bathish, B., Naidu, S. D., DeNicola, G. M., Dinkova-Kostova, A. T., Fernández-Ginés, R., Grochot-Przeczek, A., Hayes, J. D., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103569 · Cited by 28 · see citing works

CDDO-Me Protects Normal Lung and Breast Epithelial Cells but Not Cancer Cells from Radiation

El-Ashmawy, M., Delgado, O., Cardentey, A., Wright, W. E., & Shay, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115600 · Cited by 19 · see citing works

Epigallocatechin-3-gallate reduces cytotoxic effects caused by dental monomers: a hypothesis

Jiao, Y., Ma, S., Wang, Y., Li, J., Shan, L., & Chen, J. (2015) · Medical Science Monitor · doi:10.12659/msm.895628 · Cited by 18 · see citing works

The complex role of NRF2 in cancer: A genomic view

Praslicka, B. J., Kerins, M. J., & Ooi, A. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.09.003 · Cited by 14 · see citing works

Probiotics for the Chemoprotective Role against the Toxic Effect of Cancer Chemotherapy

Waziri, A., Bharti, C., Aslam, M., Jamil, P., Mirza, M. A., Javed, M. N., Pottoo, U., Ahmadi, A., & Alam, M. S. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210514000615 · Cited by 17 · see citing works

Tuning the metabolism of the anticancer drug cisplatin with chemoprotective agents to improve its safety and efficacy

Sooriyaarachchi, M., George, G. N., Pickering, I. J., et al. (2016) · Metallomics · doi:10.1039/c6mt00183a · Cited by 40 · see citing works

Dietary Carotenoids and their Metabolites as Potentially Useful Chemoprotective Agents against Cancer

Khachik, F., Bertram, J. S., Huang, M., Fahey, J. W., & Talalay, P. (1999) · Elsevier eBooks · doi:10.1016/b978-012543590-1/50015-9 · Cited by 30 · see citing works

Comparison of the Tumorigenic Effects of Chemical Carcinogens and Hormones

Nandi, S. (1975) · Journal of Animal Science · doi:10.2527/jas1975.4061263x

Chemoprevention of cancer: Phenolic antioxidants (BHT, BHA)

Hocman, G. (1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90158-9 · Cited by 116 · see citing works