The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm

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2. Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein
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3. Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation
   Stefan W. Ryter · 2021 · Cells
4. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
   Yasutake Katoh, Katsuyuki Iida, Moon-Il Kang, Akira Kobayashi, Mio Mizukami, Kit I. Tong, Michael J. McMahon, John D. Hayes, Ken Itoh, Masayuki P. Yamamoto · 2004 · Archives of Biochemistry and Biophysics
5. Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism
   Kansanen, Emilia, Bonacci, Gustavo, Schopfer, Francisco J., Kuosmanen, Suvi M., Tong, Kit I., Leinonen, Hanna, Woodcock, Steven R., Yamamoto, Masayuki, Carlberg, Carsten, Ylä-Herttuala, Seppo et al. · 2011 · Journal of Biological Chemistry
6. A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases
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7. Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization
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8. Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
   Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova‐Kostova, Takuma Kasai, Takashi Kamei et al. · 2021 · Communications Biology
9. Regulation of Nrf2 Transactivation Domain Activity
   Guoxiang Shen, Vidya Hebbar, Sujit Nair, Changjiang Xu, Wenge Li, Wen Lin, Young-Sam Keum, Jiahuai Han, Michael A. Gallo, A.-N. Tony Kong · 2004 · Journal of Biological Chemistry
10. Sites of alkylation of human Keap1 by natural chemoprevention agents
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11. NRF2: KEAPing Tumors Protected
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12. Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory
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13. Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
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14. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
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15. Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease
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16. Cullins 3a and 3b Assemble with Members of the Broad Complex/Tramtrack/Bric-a-Brac (BTB) Protein Family to Form Essential Ubiquitin-Protein Ligases (E3s) in Arabidopsis
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17. Reversible Cysteine Oxidation in Hydrogen Peroxide Sensing and Signal Transduction
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18. Keap Calm, and Carry on Covalently
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19. Electrophilic tuning of the chemoprotective natural product sulforaphane
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20. Nrf2 as regulator of innate immunity: A molecular Swiss army knife!
    Maurizio Antonio Battino, Francesca Giampieri, Francesca Pistollato, Antoni Sureda, Marcos Roberto de Oliveira, Valeria Pittalà, Francesca Fallarino, Seyed Fazel Nabavi, Atanas G. Atanasov, Seyed Mohammad Nabavi · 2017 · Biotechnology Advances
21. Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
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22. Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2
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23. Nrf2 Negatively Regulates Osteoblast Differentiation via Interfering with Runx2-dependent Transcriptional Activation
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24. The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism
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25. The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury
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26. Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals
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27. Kelch proteins: emerging roles in skeletal muscle development and diseases
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28. Cysteine-based regulation of the CUL3 adaptor protein Keap1
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29. Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1
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30. Structural basis and regulation of the reductive stress response
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31. Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease
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32. Reactive Oxygen Species and Oxidative Stress
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33. Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers
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34. Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
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35. Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage
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36. Subcellular localization and cytoplasmic complex status of endogenous Keap1
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37. Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
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38. Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance
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39. Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
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40. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
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41. Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
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42. Role of NRF2 in Lung Cancer
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43. Keap1 as the redox sensor of the antioxidant response
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44. Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
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45. Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin
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46. Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals
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47. Molecular Evolution of Keap1
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48. Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL
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49. Chemistry of the Cysteine Sensors in Kelch-Like ECH-Associated Protein 1
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50. Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders
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51. Molecular Mechanisms Involved in Enhancing HO-1 Expression: De-Repression by Heme and Activation by Nrf2, The "One-Two" Punch
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52. Glycosylation of KEAP1 links nutrient sensing to redox stress signaling
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53. Optimization of Fluorescently Labeled Nrf2 Peptide Probes and the Development of a Fluorescence Polarization Assay for the Discovery of Inhibitors of Keap1-Nrf2 Interaction
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54. Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance
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55. Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities
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56. Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism
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57. NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
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58. Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif
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59. Prospective Type 1 and Type 2 Disulfides of Keap1 Protein
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60. Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
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61. The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity
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62. Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease
    Joanne Clark, David K. Simon · 2008 · Antioxidants and Redox Signaling
63. Involvement of Nrf2 in Ocular Diseases
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64. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin
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65. Baicalin ameliorates oxidative stress and apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-κB and Nrf2/HO-1 signaling pathway during Mycoplasma gallisepticum infection
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66. Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer
    Feilong Chen, Mei Xiao, Shaofan Hu, Meng Wang · 2024 · Frontiers in Oncology
67. Dimerization quality control ensures neuronal development and survival
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68. An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders
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69. Kinetic Analyses of Keap1–Nrf2 Interaction and Determination of the Minimal Nrf2 Peptide Sequence Required for Keap1 Binding Using Surface Plasmon Resonance
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70. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2
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71. Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
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72. Reactive Oxygen Species and Oxidative Stress
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73. The Role of Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches
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74. Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
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75. The BTB-kelch Protein LZTR-1 Is a Novel Golgi Protein That Is Degraded upon Induction of Apoptosis
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76. Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review
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77. Natural Nrf2 Modulators for Skin Protection
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78. Regulation of Keap1-Nrf2 signaling in health and diseases
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79. Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy
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80. Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Protein–Protein Interaction
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81. Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
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82. Protective effect of N-acetylcysteine (NAC) on renal ischemia/reperfusion injury through Nrf2 signaling pathway
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83. The see-saw of Keap1-Nrf2 pathway in cancer
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84. Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells
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85. Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells — Evidence for cullin dimerization
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86. Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment
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87. The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1
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88. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery
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89. 4-Hydroxynonenal Induces Rat γ-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase–Mediated Electrophile Response Element/Nuclear Factor Erythroid 2–Related Factor 2 Signaling
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90. Screening Method for the Discovery of Potential Cancer Chemoprevention Agents Based on Mass Spectrometric Detection of Alkylated Keap1
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91. A possible protective role of Nrf2 in preeclampsia
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92. PI3K, RSK, and mTOR Signal Networks for the GST Gene Regulation
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93. Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds
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94. Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders
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95. Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway
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96. Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo
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97. Modulations of Keap1-Nrf2 signaling axis by TIIA ameliorated the oxidative stress-induced myocardial apoptosis
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98. 3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway
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99. A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations
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100. Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane
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