The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of Hsp90 as a Stimulatory Host Factor Involved in Influenza Virus RNA Synthesis
Open accessAbstract
Efficient transcription and replication of the influenza virus genome are dependent upon host-derived factors. Using an in vitro RNA synthesis system, we have purified and identified Hsp90 as one of the host factors that stimulate viral RNA polymerase activity. Hsp90 interacted with the PB2 subunit of the viral RNA polymerase through the amino-terminal chaperone domain and the middle region containing a highly acidic domain. The acidic middle region was also responsible for its stimulatory activity. We found that a portion of Hsp90 is re-localized to the cell nucleus after viral infection. A PB2 fragment containing a Hsp90 binding domain inhibited viral gene expression in a dominant-negative manner. These results suggest that Hsp90 is a host factor for the influenza virus RNA polymerase.
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Cites
Hsp90 as a capacitor for morphological evolution
Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270
Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., & Neckers, L. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8324 · Cited by 1,444
Hsp90 as a capacitor of phenotypic variation
Queitsch, C., Sangster, T. A., & Lindquist, S. (2002) · Nature · doi:10.1038/nature749 · Cited by 1,372
Cited by
The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones
Li, J., Soroka, J., & Buchner, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.09.003 · Cited by 498
Beck, J. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i1.48 · Cited by 494
At the centre: influenza A virus ribonucleoproteins
Eisfeld, A. J., Neumann, G., & Kawaoka, Y. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3367 · Cited by 476
The Hsp90 molecular chaperone: an open and shut case for treatment
Pearl, L. H., Prodromou, C., & Workman, P. (2008) · Biochemical Journal · doi:10.1042/bj20071640 · Cited by 447
Shinya, K., Hamm, S., Hatta, M., Ito, H., Ito, T., & Kawaoka, Y. (2004) · Virology · doi:10.1016/j.virol.2003.11.030 · Cited by 377
Metadata
- Authors
- Momose, F., Naito, T., Yano, K., Sugimoto, S., Morikawa, Y., & Nagata, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 277
- Issue
- 47
- Pages
- 45306-45314
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2045003839
- Cited by
- 213
- References
- 3
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Momose, F., Naito, T., Yano, K., Sugimoto, S., Morikawa, Y., & Nagata, K. (2002). Identification of Hsp90 as a Stimulatory Host Factor Involved in Influenza Virus RNA Synthesis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m206822200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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