Hsp90 as a capacitor for morphological evolution

Rutherford, Suzanne L.; Lindquist, Susan

doi:10.1038/24550

Cited by 2,270Heat shock proteins researchEvolution and Genetic DynamicsMorphological variations and asymmetry

Hsp90 as a capacitor for morphological evolution

Rutherford, Suzanne L., Lindquist, Susan·1998·Nature

DOI 10.1038/24550

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Abstract

The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at the interface of several developmental pathways. We report here that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants depending on the genetic background and occurring both in laboratory strains and in wild populations. Multiple, previously silent, genetic determinants produced these variants and, when enriched by selection, they rapidly became independent of the Hsp90 mutation. Therefore, widespread variation affecting morphogenic pathways exists in nature, but is usually silent; Hsp90 buffers this variation, allowing it to accumulate under neutral conditions. When Hsp90 buffering is compromised, for example by temperature, cryptic variants are expressed and selection can lead to the continued expression of these traits, even when Hsp90 function is restored. This provides a plausible mechanism for promoting evolutionary change in otherwise entrenched developmental processes.

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Hsp90 has acted as an evolutionary capacitor during eukaryotic evolution.
“Hence Hsp90 has acted as an evolutionary capacitor during eukaryotic evolution19-21.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [19]
Hsp90 can buffer the effects of genetic or epigenetic variation, keeping it silent until released when the chaperone reservoir is compromised in response to stress.
“First, Hsp90 can buffer the effects of genetic or epigenetic variation, keeping it silent until released when the chaperone reservoir is compromised in response to stress.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [19]
Hsp90's role as a capacitor for variation has been observed in diverse eukaryotes including flies, plants, and fungi.
“This role as a capacitor for variation has been observed in diverse eukaryotes including flies, plants, and fungi18,19,129-134.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [19]

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Authors: Rutherford, S. L., & Lindquist, S.
Affiliations: Howard Hughes Medical Institute (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-11
Volume: 396
Issue: 6709
Pages: 336-342
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/24550
OpenAlex: W1554180547
Cited by: 2,270
References: 38
Citations by year: 2026: 45 · 2025: 57 · 2024: 53 · 2023: 58 · 2022: 60 · 2021: 54 · 2020: 56 · 2019: 86 · 2018: 95 · 2017: 77 · 2016: 84 · 2015: 93 · 2014: 104 · 2013: 108 · 2012: 93
FWCI: 18.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Physical Sciences › Mathematics › Geometry and Topology › Morphological variations and asymmetry
Keywords: HSP90, morphological evolution, cryptic genetic variation, Drosophila, developmental pathways, signal transduction, genetic background effects, temperature effects, morphological variation
MeSH terms: Animals, Drosophila, Heat-Shock Proteins, Models, Genetic, Mutation, Phenotype, Temperature, Genetic Variation, HSP90 Heat-Shock Proteins, Directed Molecular Evolution, Drosophila Proteins

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Hsp90 as a capacitor for morphological evolution

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